Difference between revisions of "Collagenous spherulosis"
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==General== | ==General== | ||
*Benign. | *Benign. | ||
* | *Usually an incidental (microscopic) finding.<ref name=pmid12523815/> | ||
*Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal | last1 = Resetkova | first1 = E. | last2 = Albarracin | first2 = C. | last3 = Sneige | first3 = N. | title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 20-7 | month = Jan | year = 2006 | doi = | PMID = 16330938 }}</ref> | *Can mimic [[ADH]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast|adenoid cystic carcinoma]].<ref name=pmid16330938>{{Cite journal | last1 = Resetkova | first1 = E. | last2 = Albarracin | first2 = C. | last3 = Sneige | first3 = N. | title = Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 20-7 | month = Jan | year = 2006 | doi = | PMID = 16330938 }}</ref> | ||
**Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/> | **Epidemiologically, it may be associated with [[LCIS]].<ref name=pmid16330938/> | ||
==Gross== | |||
*Usually small. | |||
Note: | |||
*May present as a larger mass.<ref name=pmid18476887>{{Cite journal | last1 = Hill | first1 = P. | last2 = Cawson | first2 = J. | title = Collagenous spherulosis presenting as a mass lesion on imaging. | journal = Breast J | volume = 14 | issue = 3 | pages = 301-3 | month = | year = | doi = 10.1111/j.1524-4741.2008.00580.x | PMID = 18476887 }}</ref><ref>{{Cite journal | last1 = Jan | first1 = YJ. | last2 = Li | first2 = MC. | last3 = Ho | first3 = WL. | title = Collagenous spherulosis presenting as a mass of the breast. | journal = Zhonghua Yi Xue Za Zhi (Taipei) | volume = 65 | issue = 10 | pages = 494-7 | month = Oct | year = 2002 | doi = | PMID = 12523815 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 20:41, 16 February 2014
Collagenous spherulosis is a benign change of the breast that can be confused for a malignancy.
It is also known as mucinous spherulosis, and spherulosis.[1]
General
- Benign.
- Usually an incidental (microscopic) finding.[2]
- Can mimic ADH, cribriform DCIS, adenoid cystic carcinoma.[3]
Gross
- Usually small.
Note:
Microscopic
- Tubular/cribriform architecture.
- Intratubular eosinophilic material - key feature.
- Classical: Arranged like the spokes of a wheel ("radial spikes").
- Atypical: Granules ~ 1-2 micrometers.
- No mitotic activity.
- Two cells populations (epithelial & myoepithelial) - like a well-behaved breast gland.
Notes:
- Usually small lesions: < 50 spherules per lesion, <100 micrometers.
- May be multifocal.
- +/-Calcifications - may prompt biopsy.
DDx:
Images
Collagenous spherulosis - intermed. mag. (WC/Nephron)
Collagenous spherulosis - high mag. (WC/Nephron)
Collagenous spherulosis - very high mag. (WC/Nephron)
www:
See also
References
- ↑ 1.0 1.1 URL: http://surgpathcriteria.stanford.edu/breast/collspher/. Accessed on: 4 September 2011.
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedpmid12523815 - ↑ 3.0 3.1 Resetkova, E.; Albarracin, C.; Sneige, N. (Jan 2006). "Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature.". Am J Surg Pathol 30 (1): 20-7. PMID 16330938.
- ↑ Hill, P.; Cawson, J.. "Collagenous spherulosis presenting as a mass lesion on imaging.". Breast J 14 (3): 301-3. doi:10.1111/j.1524-4741.2008.00580.x. PMID 18476887.
- ↑ Jan, YJ.; Li, MC.; Ho, WL. (Oct 2002). "Collagenous spherulosis presenting as a mass of the breast.". Zhonghua Yi Xue Za Zhi (Taipei) 65 (10): 494-7. PMID 12523815.
- ↑ URL: http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm. Accessed on: 31 August 2011.