Difference between revisions of "Uterine cervix with atrophic changes"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Atrophic cervix -- very high mag.jpg
| Width      =
| Caption    = Atrophic cervix. [[H&E stain]].
| Synonyms  =
| Micro      = small squamous cells with grey/blue cytoplasm, no "dancing"/"sparkling" chromatin, no mitoses
| Subtypes  =
| LMDDx      = [[HSIL]]
| Stains    =
| IHC        = p16 -ve, Ki-67 rare basal cells
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[uterine cervix]] - exocervix
| Assdx      =
| Syndromes  =
| Clinicalhx = old
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      = normal - postmenopausal
| ClinDDx    =
| Tx        =
}}
'''Uterine cervix with atrophic changes''' is relatively common and is important to recognize as it can mimic [[HSIL]].
'''Uterine cervix with atrophic changes''' is relatively common and is important to recognize as it can mimic [[HSIL]].


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===Images===
===Images===
<gallery>
Image: Atrophic cervix -- intermed mag.jpg | AC - intermed. mag.
Image: Atrophic cervix - alt -- high mag.jpg | AC - high mag.
Image: Atrophic cervix -- high mag.jpg | AC - high mag.
Image: Atrophic cervix -- very high mag.jpg | AC - very high mag.
</gallery>
<gallery>
Image: Atrophic cervix - 2 -- intermed mag.jpg | AC - intermed. mag.
Image: Atrophic cervix - 2 -- high mag.jpg | AC - high mag.
Image: Atrophic cervix - 2 -- very high mag.jpg | AC - very high mag.
</gallery>
www:
www:
*[http://nih.techriver.net/view.php?patientId=93 Atrophic cervix (nih.techriver.net)].
*[http://nih.techriver.net/view.php?patientId=93 Atrophic cervix (nih.techriver.net)].

Revision as of 03:57, 18 January 2014

Uterine cervix with atrophic changes
Diagnosis in short

Atrophic cervix. H&E stain.
LM small squamous cells with grey/blue cytoplasm, no "dancing"/"sparkling" chromatin, no mitoses
LM DDx HSIL
IHC p16 -ve, Ki-67 rare basal cells
Site uterine cervix - exocervix
Clinical history old
Prevalence common
Prognosis benign
Other normal - postmenopausal

Uterine cervix with atrophic changes is relatively common and is important to recognize as it can mimic HSIL.

It is also known as atrophy of the uterine cervix, cervical atrophy, atrophy of the cervix and cervix with atrophic changes.

General

  • Common.
  • Post-menupausal.
  • Important to recognize and differentiate from HSIL.

Microscopic

Features:

  • Cells smaller.
  • Cytoplasm grey/blue.
  • No "dancing"/"sparkling" chromatin.
  • No mitoses.

DDx:

Images

  • AC - intermed. mag.

  • AC - high mag.

  • AC - high mag.

  • AC - very high mag.

  • AC - intermed. mag.

  • AC - high mag.

  • AC - very high mag.

www:

IHC

  • p16 -ve.
  • Ki-67 rare basal cells.

Sign out

UTERINE CERVIX, BIOPSY:
- SQUAMOUS MUCOSA WITH ATROPHIC CHANGES.
- BENIGN ENDOCERVICAL EPITHELIUM.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
A p16 immunostain is negative. A Ki-67 immunostain marks rare basal cells.

See also

References

  1. ↑ URL: http://www.eurocytology.eu/static/eurocytology/TUR/cervical/LP1ContentLcontC.html. Accessed on: 13 December 2013.
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