Difference between revisions of "Cutaneous calcinosis"

Cutaneous calcinosis
	Diagnosis in short
	; Cutaneous calcinosis. H&E stain.
LM	dermal calcification - usu. well-circumscribed
Gross	firm nodule
Site	skin, scrotum
Clinical history	+/-trauma at the site
Signs	firm nodule
Prevalence	uncommon
Prognosis	benign
Treatment	excision

Revision as of 02:58, 2 January 2014

Cutaneous calcinosis, also calcinosis cutis, is calcification of the skin. It is benign in itself; however, the underlying cause not be.

General

Benign in itself; underlying cause may not be benign.
May be a scrotal lesion - known as scrotal calcinosis.^[1]

Subtypes:^[2]

Dystrophic - due to death of cells; may be related to a tumour.
Metastatic - due to chronic renal failure; hyperkalemia; paraneoplastic phenomenon.
Iatrogenic - post surgical.
Idiopathic.

Gross

Firm nodule.

Microscopic

Features:

Dermal calcification:
- Acellular purple blobs on H&E.
  - +/-Artefactual tearing of surrounding tissue due to processing (cutting).
  - +/-Small artefactual lines ~1-2 micrometers due to processing (cutting).
  - +/-Greyish rim of paucicellular material.
- Usu. well-circumscribed.
  - May be surrounded by a palisading granuloma & giant cells.

Images

CC - very low mag.
CC - low mag.
CC - intermed. mag.

www:

Calcinosis cutis (dermatopathonline.com).

Sign out

SKIN AND SUBCUTANEOUS LESION, LEFT HIP, EXCISION:
- SUBCUTANEOUS CALCIFICATION SURROUNDED BY BENIGN FIBROUS TISSUE.
- DERMAL SCAR.
- NEGATIVE FOR MALIGNANCY.

SUBCUTANEOUS MASS, OVER BURSA OF ELBOW, EXCISION:
- CALCINOSIS CUTIS.

Micro

The sections show subcutaneous calcifications surrounded by macrophages and giant cells. No nuclear atypia is apparent. The overlying skin is unremarkable.

References

↑ Dubey, S.; Sharma, R.; Maheshwari, V. (2010). "Scrotal calcinosis: idiopathic or dystrophic?". Dermatol Online J 16 (2): 5. PMID 20178701.
↑ URL: http://emedicine.medscape.com/article/1103137-overview. Accessed on: 21 September 2011.

[pmid20178701-1] Dubey, S.; Sharma, R.; Maheshwari, V. (2010). "Scrotal calcinosis: idiopathic or dystrophic?". Dermatol Online J 16 (2): 5. PMID 20178701.

[emed-2] URL: http://emedicine.medscape.com/article/1103137-overview. Accessed on: 21 September 2011.

[1]

[2]

@@ Line 1: / Line 1: @@
-#redirect [[Non-malignant_skin_disease#Cutaneous_calcinosis]]
+{{ Infobox diagnosis
+| Name       = {{PAGENAME}}
+| Image      = Calcinosis cutis -- low mag.jpg
+| Width      =
+| Caption    = Cutaneous calcinosis. [[H&E stain]].
+| Synonyms   =
+| Micro      = dermal calcification - usu. well-circumscribed
+| Subtypes   =
+| LMDDx      =
+| Stains     =
+| IHC        =
+| EM         =
+| Molecular  =
+| IF         =
+| Gross      = firm nodule
+| Grossing   =
+| Site       = [[skin]], [[scrotum]]
+| Assdx      =
+| Syndromes  =
+| Clinicalhx = +/-trauma at the site
+| Signs      = firm nodule
+| Symptoms   =
+| Prevalence = uncommon
+| Bloodwork  =
+| Rads       =
+| Endoscopy  =
+| Prognosis  = benign
+| Other      =
+| ClinDDx    =
+| Tx         = excision
+}}
+'''Cutaneous calcinosis''', also '''calcinosis cutis''', is calcification of the [[skin]]. It is benign in itself; however, the underlying cause not be.
+==General==
+*Benign in itself; underlying cause may not be benign.
+*May be a [[scrotum|scrotal]] lesion - known as ''scrotal calcinosis''.<ref name=pmid20178701>{{Cite journal  | last1 = Dubey | first1 = S. | last2 = Sharma | first2 = R. | last3 = Maheshwari | first3 = V. | title = Scrotal calcinosis: idiopathic or dystrophic? | journal = Dermatol Online J | volume = 16 | issue = 2 | pages = 5 | month =  | year = 2010 | doi =  | PMID = 20178701 }}</ref>
+Subtypes:<ref name=emed>URL: [http://emedicine.medscape.com/article/1103137-overview http://emedicine.medscape.com/article/1103137-overview]. Accessed on: 21 September 2011.</ref>
+#Dystrophic - due to death of cells; may be related to a tumour.
+#Metastatic - due to chronic renal failure; hyperkalemia; paraneoplastic phenomenon.
+#Iatrogenic - post surgical.
+#Idiopathic.
+==Gross==
+*Firm nodule.
+==Microscopic==
+Features:
+*Dermal calcification:
+**Acellular purple blobs on [[H&E]].
+***+/-Artefactual tearing of surrounding tissue due to processing (cutting).
+***+/-Small artefactual lines ~1-2 micrometers due to processing (cutting).
+***+/-Greyish rim of paucicellular material.
+**Usu. well-circumscribed.
+***May be surrounded by a palisading granuloma & [[giant cell]]s.
+===Images===
+<gallery>
+Image: Calcinosis cutis -- very low mag.jpg | CC - very low mag.
+Image: Calcinosis cutis -- low mag.jpg | CC - low mag.
+Image: Calcinosis cutis -- intermed mag.jpg | CC - intermed. mag.
+</gallery>
+www:
+*[http://www.dermatopathonline.com/calcinosis%20cutis2.html Calcinosis cutis (dermatopathonline.com)].
+==Sign out==
+<pre>
+SKIN AND SUBCUTANEOUS LESION, LEFT HIP, EXCISION:
+- SUBCUTANEOUS CALCIFICATION SURROUNDED BY BENIGN FIBROUS TISSUE.
+- DERMAL SCAR.
+- NEGATIVE FOR MALIGNANCY.
+</pre>
+<pre>
+SUBCUTANEOUS MASS, OVER BURSA OF ELBOW, EXCISION:
+- CALCINOSIS CUTIS.
+</pre>
+===Micro===
+The sections show subcutaneous calcifications surrounded by macrophages and giant cells. No nuclear atypia is apparent. The overlying skin is unremarkable.
+==See also==
+*[[Non-malignant skin disease]].
+==References==
+{{Reflist|2}}
 [[Category:Diagnosis]]
+[[Category:Non-malignant skin disease]]

Difference between revisions of "Cutaneous calcinosis"

Revision as of 02:58, 2 January 2014

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