Difference between revisions of "Lung carcinoma with ALK rearrangement"
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*[[Signet ring cell carcinoma]]. (?) | *[[Signet ring cell carcinoma]]. (?) | ||
*[[Mucinous carcinoma]]. (?) | *[[Mucinous carcinoma]]. (?) | ||
===Images=== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400179/figure/f1-cln_67p845/ Lung carcinoma with ALK rearrangement (nih.gov)].<ref name=pmid22892933>{{Cite journal | last1 = Lopes | first1 = LF. | last2 = Bacchi | first2 = CE. | title = Anaplastic lymphoma kinase gene rearrangement in non-small-cell lung cancer in a Brazilian population. | journal = Clinics (Sao Paulo) | volume = 67 | issue = 7 | pages = 845-7 | month = Jul | year = 2012 | doi = | PMID = 22892933 }}</ref> | |||
==IHC== | ==IHC== | ||
Revision as of 11:40, 26 December 2013
Lung carcinoma with ALK rearrangement is subset of lung adenocarcinoma.
General
Microscopic
Features:[1]
- Adenocarcinoma - at least focally.
- Solid signet-ring cell pattern - common.
- Mucinous cribriform pattern - common.
DDx:
Images
IHC
Features:[1]
- p63 +ve.
- TTF-1 +ve.
Molecular
- EML4-ALK fusion -- inv(2)(p21p23).[4]
See also
References
- ↑ 1.0 1.1 1.2 Yoshida, A.; Tsuta, K.; Nakamura, H.; Kohno, T.; Takahashi, F.; Asamura, H.; Sekine, I.; Fukayama, M. et al. (Aug 2011). "Comprehensive histologic analysis of ALK-rearranged lung carcinomas.". Am J Surg Pathol 35 (8): 1226-34. doi:10.1097/PAS.0b013e3182233e06. PMID 21753699.
- ↑ Crystal, AS.; Shaw, AT. (Mar 2011). "New targets in advanced NSCLC: EML4-ALK.". Clin Adv Hematol Oncol 9 (3): 207-14. PMID 21475126.
- ↑ Lopes, LF.; Bacchi, CE. (Jul 2012). "Anaplastic lymphoma kinase gene rearrangement in non-small-cell lung cancer in a Brazilian population.". Clinics (Sao Paulo) 67 (7): 845-7. PMID 22892933.
- ↑ Li, Y.; Ye, X.; Liu, J.; Zha, J.; Pei, L. (Jan 2011). "Evaluation of EML4-ALK fusion proteins in non-small cell lung cancer using small molecule inhibitors.". Neoplasia 13 (1): 1-11. PMID 21245935.