Difference between revisions of "Radiation colitis"
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==Gross== | ==Gross== | ||
*Superficial bowel wall injury - shallow ulceration.<ref name=pmid9378391/> | *Superficial bowel wall injury - shallow ulceration.<ref name=pmid9378391/> | ||
*Telangiectatic lesions. | |||
Image: | |||
*[http://www.nature.com/nrgastro/journal/v5/n1/fig_tab/ncpgasthep1005_F4.html#figure-title Telangiectatic lesions (nature.com)].<ref name=pmid18174905>{{Cite journal | last1 = Nielsen | first1 = OH. | last2 = Vainer | first2 = B. | last3 = Rask-Madsen | first3 = J. | title = Non-IBD and noninfectious colitis. | journal = Nat Clin Pract Gastroenterol Hepatol | volume = 5 | issue = 1 | pages = 28-39 | month = Jan | year = 2008 | doi = 10.1038/ncpgasthep1005 | PMID = 18174905 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features - acute:<ref name=pmid9378391>{{Cite journal | last1 = Yano | first1 = Y. | last2 = Yao | first2 = H. | last3 = Aoyagi | first3 = K. | last4 = Kawakubo | first4 = K. | last5 = Nakamura | first5 = S. | last6 = Doi | first6 = K. | last7 = Ibayashi | first7 = S. | last8 = Fujishima | first8 = M. | title = Photochemically induced colonic ischaemic lesions: a new model of ischaemic colitis in rats. | journal = Gut | volume = 41 | issue = 3 | pages = 354-7 | month = Sep | year = 1997 | doi = | PMID = 9378391 }}</ref> | Features - acute:<ref name=pmid9378391>{{Cite journal | last1 = Yano | first1 = Y. | last2 = Yao | first2 = H. | last3 = Aoyagi | first3 = K. | last4 = Kawakubo | first4 = K. | last5 = Nakamura | first5 = S. | last6 = Doi | first6 = K. | last7 = Ibayashi | first7 = S. | last8 = Fujishima | first8 = M. | title = Photochemically induced colonic ischaemic lesions: a new model of ischaemic colitis in rats. | journal = Gut | volume = 41 | issue = 3 | pages = 354-7 | month = Sep | year = 1997 | doi = | PMID = 9378391 }}</ref> | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Gastrointestinal pathology]] | [[Category:Gastrointestinal pathology]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 02:48, 22 February 2013
Radiation colitis is inflammation of the colon due to radiation.
General
- Diagnosis should be supported by clinical history.
Cause of colitides:
- IBD.
- Infection.
- Ischemia.
- Radiation.
Gross
- Superficial bowel wall injury - shallow ulceration.[1]
- Telangiectatic lesions.
Image:
Microscopic
Features - acute:[1]
- Mucosal changes:
- Necrosis of epithelium.
- "Ghost cells" = cells without nuclei.
- Hemorrhage.
- Necrosis of epithelium.
- Submucosa edema with neutrophilic infiltrate.
- +/-Fibrin thrombi.
Features - chronic:
- Nuclear atypia - esp. of the stromal cells.
- The epithelium is shed and regenerates... therefore usually does not have the changes.
- Fibrosis - esp. of the submucosa.
DDx:
- Ischemic colitis.
- Inflammatory bowel disease.
- Infectious colitis.
Images:
See also
References
- ↑ 1.0 1.1 1.2 Yano, Y.; Yao, H.; Aoyagi, K.; Kawakubo, K.; Nakamura, S.; Doi, K.; Ibayashi, S.; Fujishima, M. (Sep 1997). "Photochemically induced colonic ischaemic lesions: a new model of ischaemic colitis in rats.". Gut 41 (3): 354-7. PMID 9378391.
- ↑ 2.0 2.1 Nielsen, OH.; Vainer, B.; Rask-Madsen, J. (Jan 2008). "Non-IBD and noninfectious colitis.". Nat Clin Pract Gastroenterol Hepatol 5 (1): 28-39. doi:10.1038/ncpgasthep1005. PMID 18174905.