Difference between revisions of "Mucinous carcinoma"
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Prognostic significance dependent on the primary site: | Prognostic significance dependent on the primary site: | ||
*[[Mucinous breast carcinoma|Breast mucinous carcinoma]] has a better prognosis. | *[[Mucinous breast carcinoma|Breast mucinous carcinoma]] has a better prognosis. | ||
*Colorectal mucinous carcinoma has a worse prognosis.<ref name=pmid22476818>PMID 22476818 | *Colorectal mucinous carcinoma has a worse prognosis.<ref name=pmid22476818>{{Cite journal | last1 = Hyngstrom | first1 = JR. | last2 = Hu | first2 = CY. | last3 = Xing | first3 = Y. | last4 = You | first4 = YN. | last5 = Feig | first5 = BW. | last6 = Skibber | first6 = JM. | last7 = Rodriguez-Bigas | first7 = MA. | last8 = Cormier | first8 = JN. | last9 = Chang | first9 = GJ. | title = Clinicopathology and Outcomes for Mucinous and Signet Ring Colorectal Adenocarcinoma: Analysis from the National Cancer Data Base. | journal = Ann Surg Oncol | volume = | issue = | pages = | month = Apr | year = 2012 | doi = 10.1245/s10434-012-2321-7 | PMID = 22476818 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Revision as of 22:32, 13 August 2012
Mucinous carcinoma is an epithelial neoplasm that produces mucin. Mucinous carcinoma can arise in a number of sites.
General
Prognostic significance dependent on the primary site:
- Breast mucinous carcinoma has a better prognosis.
- Colorectal mucinous carcinoma has a worse prognosis.[1]
Microscopic
Features:
- Mucin - amphormous whispy or cream material.
- Cytologically atypical cells within the mucin.
- +/-Tumour without mucin.
- Maximum amount acceptable depends on the primary site (see proportion of mucin section below).
Note:
- Mucin alone -- should prompt a search for atypical cells, i.e. levels should be done.
DDx:
- Benign mucocele.
- Mucin extravasation (pseudocarcinoma).[2]
- Adenocarcinoma with mucinous features.
Proportion of mucin
The criteria for diagnosing "mucinous carcinoma" varies by the anatomical site:
- Mucinous prostate carcinoma: > 25% of the tumour.[3]
- Mucinous colorectal carcinoma: > 50% of the tumour.[4]
- Mucinous gastric carcinoma: > 50% of the tumour.
- Mucinous breast carcinoma: > 90% of the tumour.[5]
- One source suggests: > 50% of the tumour.[6]
See also
References
- ↑ Hyngstrom, JR.; Hu, CY.; Xing, Y.; You, YN.; Feig, BW.; Skibber, JM.; Rodriguez-Bigas, MA.; Cormier, JN. et al. (Apr 2012). "Clinicopathology and Outcomes for Mucinous and Signet Ring Colorectal Adenocarcinoma: Analysis from the National Cancer Data Base.". Ann Surg Oncol. doi:10.1245/s10434-012-2321-7. PMID 22476818.
- ↑ Odze, Robert D.; Goldblum, John R. (2009). Surgical pathology of the GI tract, liver, biliary tract and pancreas (2nd ed.). Saunders. pp. 512. ISBN 978-1416040590.
- ↑ Grignon DJ (March 2004). "Unusual subtypes of prostate cancer". Mod. Pathol. 17 (3): 316–27. doi:10.1038/modpathol.3800052. PMID 14976541.
- ↑ Tozawa E, Ajioka Y, Watanabe H, et al. (2007). "Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity?". Pathol. Res. Pract. 203 (8): 567–74. doi:10.1016/j.prp.2007.04.013. PMID 17679024.
- ↑ Dogan, E.; Aksoy, S.; Dizdar, O.; Arslan, C.; Dede, DS.; Ozisik, Y.; Altundag, K.. "Pure mucinous carcinoma of the breast: a single center experience.". J BUON 16 (3): 565-7. PMID 22006768.
- ↑ Park S, Koo J, Kim JH, Yang WI, Park BW, Lee KS (March 2010). "Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified". J. Korean Med. Sci. 25 (3): 361–8. doi:10.3346/jkms.2010.25.3.361. PMC 2826751. PMID 20191033. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826751/.