Difference between revisions of "DNA repair genes"
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| [[colorectal carcinoma]], [[endometrial carcinoma]], gastric, pancreas, urothelial, biliary | | [[colorectal carcinoma|colorectal]], [[endometrial carcinoma|endometrial]], [[stomach cancer|gastric]], pancreas, urothelial, biliary | ||
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Revision as of 12:56, 4 May 2012
DNA repair genes fix broken DNA. Failure of DNA repair can lead to cancer.
There is a long and growing list of DNA repair genes.[1]
Examples
| Gene | Syndrome | Tumours |
|---|---|---|
| BRCA1 | familial breast and ovarian cancer | breast, ovary, prostate, pancreas, others |
| BRCA2 | familial breast and ovarian cancer 2 | breast, ovary, prostate, pancreas, stomach, others |
| MSH2 | Lynch syndrome | colorectal, endometrial, gastric, pancreas, urothelial, biliary |
References
- ↑ Wood, RD.; Mitchell, M.; Sgouros, J.; Lindahl, T. (Feb 2001). "Human DNA repair genes.". Science 291 (5507): 1284-9. doi:10.1126/science.1056154. PMID 11181991.