Difference between revisions of "Uterus"
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*'''Clinical diagnosis'''. | *'''Clinical diagnosis'''. | ||
*A common indication for a total hysterectomy. | *A common indication for a total hysterectomy. | ||
*Hysterectomy specimen usually comes with some | *Hysterectomy specimen usually comes with some [[vagina]]l mucosa. | ||
===Gross=== | ===Gross=== | ||
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Uterus: non-specific | *Uterus: non-specific. | ||
*Vaginal mucosa: (focal) keratinization due to rubbing - '''common finding'''. | *Vaginal mucosa: (focal) keratinization due to rubbing - '''common finding'''. | ||
Revision as of 01:03, 18 January 2012
The uterus is essential for survival of the species. It is commonly afflicted with tumours.
Endometrium and its pathology is dealt with in the endometrium, endometrial hyperplasia and endometrial carcinoma articles.
Other tumours are dealt with in uterine tumours.
Operations
- Subtotal hysterectomy.
- Discouraged... as the cervix remains and can develop a cancer.
- Total hysterectomy.
- Indications: endometrial cancer (low stage, good histologic type), endometrial hyperplasia, uterine prolapse, uterine adenomyosis, uterine leiomyomas.
- Radical hysterectomy - total hysterectomy + parametrial tissue.[1]
- Indications: cervical cancers, advanced uterine cancers.
- This is typically done by gynecologists with additional training at larger centres.
- Usually done with a bilateral salpingo-opherectomy (both tubes and ovaries) and pelvic lymph node dissection.
- Indications: cervical cancers, advanced uterine cancers.
Notes:
- There are almost no quality of life differences between total & subtotal hysterectomy.[2]
Tumours of the corpus
Main article: Uterine tumours
The most common is leiomyoma (uterine fibroids).
Endometrium
Main article: Endometrium
Dealt with in endometrium, endometrial hyperplasia and endometrial carcinoma articles.
Specific conditions
Congenital absence
- Often in association with vaginal absence; ergo congenital absence of the uterus and vagina (CAUV).
Features:[3]
- Subdivided - as etiologies differ.
- Thought to have a genetic component - autosomal dominant with variable penetration.
Treatment:
- Uterine transplant - attempted.[4]
Uterine adenomyosis
General
- Common - may be a cause of bleeding.[5]
- Associated with endometriosis. (???)
Microscopic
Features:
- Endometrial glands within uterine muscle - key feature.
- Endometrial glands:
- Circular.
- Simple epithelial or pseudostratified epithelium +/- mitoses.
- +/-Surrounded by endometrial stroma.
- Densely packed spindle cells without nuclear atypia.
- Blood:
- Within glands.
- Hemosiderin-laden macrophages.
- Endometrial glands:
Note:
- Can be thought of as endometriosis of the myometrium.
DDx:
Uterine prolapse
General
- Clinical diagnosis.
- A common indication for a total hysterectomy.
- Hysterectomy specimen usually comes with some vaginal mucosa.
Gross
- Long cervix.
Microscopic
Features:
- Uterus: non-specific.
- Vaginal mucosa: (focal) keratinization due to rubbing - common finding.
See also
References
- ↑ Frumovitz, M.; Sun, CC.; Schmeler, KM.; Deavers, MT.; Dos Reis, R.; Levenback, CF.; Ramirez, PT. (Jul 2009). "Parametrial involvement in radical hysterectomy specimens for women with early-stage cervical cancer.". Obstet Gynecol 114 (1): 93-9. doi:10.1097/AOG.0b013e3181ab474d. PMID 19546764.
- ↑ Thakar, R.; Ayers, S.; Clarkson, P.; Stanton, S.; Manyonda, I. (Oct 2002). "Outcomes after total versus subtotal abdominal hysterectomy.". N Engl J Med 347 (17): 1318-25. doi:10.1056/NEJMoa013336. PMID 12397189.
- ↑ 3.0 3.1 URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1832178/.
- ↑ URL: http://singularityhub.com/2011/06/18/in-a-medical-first-infertile-daughter-will-receive-uterus-from-mother-video/. Accessed on: 17 June 2011.
- ↑ Reinhold, C.; Tafazoli, F.; Mehio, A.; Wang, L.; Atri, M.; Siegelman, ES.; Rohoman, L. (Oct 1999). "Uterine adenomyosis: endovaginal US and MR imaging features with histopathologic correlation.". Radiographics 19 Spec No: S147-60. PMID 10517451.