Difference between revisions of "Systemic lupus erythematosus"
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*Hematologic abnormality. | *Hematologic abnormality. | ||
*Immunologic abnormality. | *Immunologic abnormality. | ||
**Anti-Smith antibody. | |||
*Neurologic abnormality, e.g. seizures, psychosis. | *Neurologic abnormality, e.g. seizures, psychosis. | ||
*Oral ulcer or nasal ulcer. | *Oral ulcer or nasal ulcer. | ||
Revision as of 22:40, 3 December 2011
Systemic lupus erythematosus, abbreviated SLE, is a common autoimmune disorder that typically affects multiple organs.
Diagnosis
The diagnosis rests on the evaluation of eleven clinical/laboratory criteria; if four of the eleven criteria are present, the diagnosis is made.[1]
Criteria
Mnemonic DAMP AS RHINO:[2]
- Discoid rash.
- ANA +ve.
- Malar rash.
- Photosensitive.
- Arthritis.
- Serositis (pericardial or pleural).
- Renal dysfunction.
- Hematologic abnormality.
- Immunologic abnormality.
- Anti-Smith antibody.
- Neurologic abnormality, e.g. seizures, psychosis.
- Oral ulcer or nasal ulcer.
Prognosis
Survival:[3]
- ~90% @ 10 years.
Mortality (leading causes):[3]
- Active SLE - esp. kidney involvement.
- Infections.
- Thrombosis.
Lymph node pathology
Skin
Pancreas
Kidney disease
Main article: Medical_kidney_diseases#Lupus_nephritis
References
- ↑ Gill, JM.; Quisel, AM.; Rocca, PV.; Walters, DT. (Dec 2003). "Diagnosis of systemic lupus erythematosus.". Am Fam Physician 68 (11): 2179-86. PMID 14677663.
- ↑ URL: http://www.medicalmnemonics.com/cgi-bin/return_browse.cfm?browse=1&discipline=Rheumatology%20%2F%20Allergy. Accessed on: 11 September 2011.
- ↑ 3.0 3.1 Madhok, R.; Wu, O. (Nov 2007). "Systemic lupus erythematosus.". Am Fam Physician 76 (9): 1351-3. PMID 18019880.