Whipple's disease - Revision history

Alessandro: /* General */ typo

2020-05-30T15:01:11Z

General: typo

← Older revision		Revision as of 15:01, 30 May 2020
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	==General==		==General==
	Etiology:		Etiology:
	*Infection - caused by ''Tropheryma whipplei''<ref name=pmid11777846>{{cite journal \|author=Liang Z, La Scola B, Raoult D \|title=Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei \|journal=Clin. Diagn. Lab. Immunol. \|volume=9 \|issue=1 \|pages=156?9 \|year=2002 \|month=January \|pmid=11777846 \|pmc=119894 \|doi= \|url=http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=11777846}}</ref> a rod-shaped ~~organisms~~.<ref name=pmid11764080>{{Cite journal \| last1 = Alkan \| first1 = S. \| last2 = Beals \| first2 = TF. \| last3 = Schnitzer \| first3 = B. \| title = Primary diagnosis of whipple disease manifesting as lymphadenopathy: use of polymerase chain reaction for detection of Tropheryma whippelii. \| journal = Am J Clin Pathol \| volume = 116 \| issue = 6 \| pages = 898-904 \| month = Dec \| year = 2001 \| doi = 10.1309/7678-E2DW-HFJ5-QYUJ \| PMID = 11764080 }}</ref>		*Infection - caused by ''Tropheryma whipplei''<ref name=pmid11777846>{{cite journal \|author=Liang Z, La Scola B, Raoult D \|title=Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei \|journal=Clin. Diagn. Lab. Immunol. \|volume=9 \|issue=1 \|pages=156?9 \|year=2002 \|month=January \|pmid=11777846 \|pmc=119894 \|doi= \|url=http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=11777846}}</ref> a rod-shaped organism.<ref name=pmid11764080>{{Cite journal \| last1 = Alkan \| first1 = S. \| last2 = Beals \| first2 = TF. \| last3 = Schnitzer \| first3 = B. \| title = Primary diagnosis of whipple disease manifesting as lymphadenopathy: use of polymerase chain reaction for detection of Tropheryma whippelii. \| journal = Am J Clin Pathol \| volume = 116 \| issue = 6 \| pages = 898-904 \| month = Dec \| year = 2001 \| doi = 10.1309/7678-E2DW-HFJ5-QYUJ \| PMID = 11764080 }}</ref>

	Epidemiology:		Epidemiology:

Michael: /* Microscopic */ +DDx

2014-09-04T17:32:58Z

Microscopic: +DDx

← Older revision		Revision as of 17:32, 4 September 2014
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	DDx:		DDx:
	*[[Mycobacterium avium complex]] (MAC).		*[[Mycobacterium avium complex]] (MAC) - not hole-y.
			*Crushed Brunner's glands - PAS-Alcian blue stain +ve (like Whipple's disease).

	===Images===		===Images===

Michael: /* See also */

2014-05-22T02:50:49Z

Michael: /* Stains */

2014-04-20T00:03:00Z

Stains

← Older revision		Revision as of 00:03, 20 April 2014
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	*[[AFB stain]] -ve -- to r/o [[MAI]].		*[[AFB stain]] -ve -- to r/o [[MAI]].

	~~Image:~~		===Images===
	*[http://www.biomedcentral.com/content/figures/1472-6823-6-3-2-l.jpg Whipple disease - PAS stain (biomedcentral.com)].		*[http://www.biomedcentral.com/content/figures/1472-6823-6-3-2-l.jpg Whipple disease - PAS stain (biomedcentral.com)].
			*[https://www.flickr.com/photos/euthman/6881958781/ Whipple disease - PAS (flickr.com/euthman)].

	==See also==		==See also==

Michael: more

2014-01-26T18:27:13Z

← Older revision		Revision as of 18:27, 26 January 2014
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	Treatment:		Treatment:
	*Antibiotics - for months and months.		*Antibiotics - for months and months.

			==Gross==
			*Pale yellow or white spots.<ref>{{Cite journal \| last1 = Salkic \| first1 = NN. \| last2 = Alibegovic \| first2 = E. \| last3 = Jovanovic \| first3 = P. \| title = Endoscopic appearance of duodenal mucosa in Whipple's disease. \| journal = Gastrointest Endosc \| volume = 77 \| issue = 5 \| pages = 822-3; discussion 823 \| month = May \| year = 2013 \| doi = 10.1016/j.gie.2013.01.016 \| PMID = 23490230 }}</ref>

	==Microscopic==		==Microscopic==

Michael: w

2013-12-24T04:02:24Z

← Older revision		Revision as of 04:02, 24 December 2013
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	\| Tx = antibiotics		\| Tx = antibiotics
	}}		}}
	'''Whipple's disease''' is a rare infectious disease that is classically in the [[duodenum]].		'''Whipple's disease''' is a rare infectious disease that is classically found in the [[duodenum]].

	==General==		==General==

Michael: /* Microscopic */

2013-12-24T03:57:45Z

Microscopic

← Older revision		Revision as of 03:57, 24 December 2013
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid15476147>{{cite journal \| author=Bai J, Mazure R, Vazquez H, Niveloni S, Smecuol E, Pedreira S, Mauriño E \| title=Whipple's disease \| journal=Clin Gastroenterol Hepatol \| volume=2 \| issue=10 \| pages=849?60 \| year=2004 \| pmid=15476147 \| doi=10.1016/S1542-3565(04)00387-8}}</ref>		Features:<ref name=pmid15476147>{{cite journal \| author=Bai J, Mazure R, Vazquez H, Niveloni S, Smecuol E, Pedreira S, Mauriño E \| title=Whipple's disease \| journal=Clin Gastroenterol Hepatol \| volume=2 \| issue=10 \| pages=849?60 \| year=2004 \| pmid=15476147 \| doi=10.1016/S1542-3565(04)00387-8}}</ref>
	*~~Infectious microorganism~~ typically found in macrophages.		*Rod-shaped microorganisms - typically found in macrophages.
	**Macrophages usually abundant - '''key feature''' that should raise Dx in DDx.		**Macrophages usually abundant - '''key feature''' that should raise Dx in DDx.
	**Organisms periodic acid-Schiff (PAS) positive.		**Organisms periodic acid-Schiff (PAS) positive.
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	Image:Whipple2.jpg \| Whipple disease - poor quality - low mag. (WC)		Image:Whipple2.jpg \| Whipple disease - poor quality - low mag. (WC)
	</gallery>		</gallery>


	==Stains==		==Stains==

Michael at 03:57, 24 December 2013

2013-12-24T03:57:09Z

← Older revision		Revision as of 03:57, 24 December 2013
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	\| Caption = Whipple's disease. [[H&E stain]].		\| Caption = Whipple's disease. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = ~~infectious~~ microorganisms - typically in macrophages; macrophages usually abundant		\| Micro = rod-shaped microorganisms - typically in macrophages; lamina propria macrophages usually abundant
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[mycobacterium avium complex]]		\| LMDDx = [[mycobacterium avium complex]]

Michael at 03:56, 24 December 2013

2013-12-24T03:56:10Z

← Older revision		Revision as of 03:56, 24 December 2013
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~Whipple_disease_~~-~~a-_high_mag~~.jpg		\| Image = Whipple disease - very high mag.jpg
	\| Width =		\| Width =
	\| Caption = Whipple's disease. [[H&E stain]].		\| Caption = Whipple's disease. [[H&E stain]].
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	===Images===		===Images===
	<gallery>		<gallery>
	Image:~~Whipple_disease_~~-~~_intermed_mag~~.jpg \| Whipple disease - intermed. mag. ~~(WC)~~		Image: Whipple disease - low mag.jpg \| Low mag.
	Image:~~Whipple_disease_~~-a-~~_high_mag~~.jpg \| Whipple disease - high mag. ~~(WC)~~		Image: Whipple disease - intermed mag.jpg \| Intermed. mag.
			Image: Whipple disease - high mag.jpg \| High mag.
			Image: Whipple disease - very high mag.jpg \| Very high mag.
			</gallery>
			<gallery>
			Image: Whipple disease -a- high mag.jpg \| High mag.
			Image: Whipple disease -a- very high mag.jpg \| Very high mag.
			</gallery>
			<gallery>
	Image:Whipple2.jpg \| Whipple disease - poor quality - low mag. (WC)		Image:Whipple2.jpg \| Whipple disease - poor quality - low mag. (WC)
	</gallery>		</gallery>


	==Stains==		==Stains==
	*PAS +ve organisms.		*PAS +ve organisms.

Michael: +infobox

2013-12-24T03:54:59Z

+infobox

← Older revision		Revision as of 03:54, 24 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Whipple_disease_-a-_high_mag.jpg
			\| Width =
			\| Caption = Whipple's disease. [[H&E stain]].
			\| Synonyms =
			\| Micro = infectious microorganisms - typically in macrophages; macrophages usually abundant
			\| Subtypes =
			\| LMDDx = [[mycobacterium avium complex]]
			\| Stains = PAS +ve (microorganisms), AFB -ve
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[duodenum]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = usu. middle aged men
			\| Signs = diarrhea
			\| Symptoms =
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = good
			\| Other =
			\| ClinDDx =
			\| Tx = antibiotics
			}}
	'''Whipple's disease''' is a rare infectious disease that is classically in the [[duodenum]].		'''Whipple's disease''' is a rare infectious disease that is classically in the [[duodenum]].

← Older revision		Revision as of 02:50, 22 May 2014
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	==See also==		==See also==
	*[[Duodenum]].		*[[Duodenum]].
			*[[Colorectal xanthomatous polyp]].

	==References==		==References==