Von Hippel-Lindau disease - Revision history

Michael at 03:19, 7 March 2025

2025-03-07T03:19:16Z

← Older revision		Revision as of 03:19, 7 March 2025
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	[[Image:Clear_cell_renal_cell_carcinoma_-_2_--_intermed_mag.jpg\|thumb\|right\|[[Clear cell renal cell carcinoma]] a tumour seen in von Hippel-Lindau disease. [[H&E stain]].]]		[[Image:Clear_cell_renal_cell_carcinoma_-_2_--_intermed_mag.jpg\|thumb\|right\|[[Clear cell renal cell carcinoma]] a tumour seen in von Hippel-Lindau disease. [[H&E stain]].]]
	The '''von Hippel-Lindau disease''', also '''von Hippel-Lindau syndrome''' is characterized by (mnemonic: ''HIPPEL''):<ref>URL: [http://www.medicalmnemonics.com/pdf/2002_09_full_abr_8x11.pdf http://www.medicalmnemonics.com/pdf/2002_09_full_abr_8x11.pdf]. Accessed on: 11 September 2008.</ref>		The '''von Hippel-Lindau disease''', also '''von Hippel-Lindau syndrome''' is characterized by (mnemonic: ''HIPPEL''):<ref>URL: [http://www.medicalmnemonics.com/pdf/2002_09_full_abr_8x11.pdf http://www.medicalmnemonics.com/pdf/2002_09_full_abr_8x11.pdf]. Accessed on: 11 September 2008.</ref>
	*[[Hemangioblastoma]]s.		*[[Hemangioblastoma]]s - brain and [[hemangioblastoma of the kidney]].
	*Increased [[Kidney_tumours#Hereditary_RCC\|renal cancer]] ([[clear cell renal cell carcinoma]]).		*Increased [[Kidney_tumours#Hereditary_RCC\|renal cancer]] ([[clear cell renal cell carcinoma]]).
	*[[Pheochromocytoma]], [[pancreatic neuroendocrine tumour]]s<ref name=pmid22370733>{{Cite journal \| last1 = Charlesworth \| first1 = M. \| last2 = Verbeke \| first2 = CS. \| last3 = Falk \| first3 = GA. \| last4 = Walsh \| first4 = M. \| last5 = Smith \| first5 = AM. \| last6 = Morris-Stiff \| first6 = G. \| title = Pancreatic Lesions in von Hippel-Lindau Disease? A Systematic Review and Meta-synthesis of the Literature. \| journal = J Gastrointest Surg \| volume = \| issue = \| pages = \| month = Feb \| year = 2012 \| doi = 10.1007/s11605-012-1847-0 \| PMID = 22370733 }}</ref> and [[papillary cystadenoma of the epididymis]].<ref name=pmid23708309>{{Cite journal \| last1 = Toutziaris \| first1 = C. \| last2 = Kampantais \| first2 = S. \| last3 = Perdikis \| first3 = I. \| last4 = Gourvas \| first4 = V. \| last5 = Laskaridis \| first5 = L. \| last6 = Gkagkalidis \| first6 = K. \| last7 = Lakis \| first7 = S. \| last8 = Ioannidis \| first8 = S. \| title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? \| journal = Int J Surg Case Rep \| volume = 4 \| issue = 7 \| pages = 616-8 \| month = \| year = 2013 \| doi = 10.1016/j.ijscr.2013.03.038 \| PMID = 23708309 }}</ref><ref name=pmid20367315>{{Cite journal \| last1 = Odrzywolski \| first1 = KJ. \| last2 = Mukhopadhyay \| first2 = S. \| title = Papillary cystadenoma of the epididymis. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 4 \| pages = 630-3 \| month = Apr \| year = 2010 \| doi = 10.1043/1543-2165-134.4.630 \| PMID = 20367315 }}</ref>		*[[Pheochromocytoma]], [[pancreatic neuroendocrine tumour]]s<ref name=pmid22370733>{{Cite journal \| last1 = Charlesworth \| first1 = M. \| last2 = Verbeke \| first2 = CS. \| last3 = Falk \| first3 = GA. \| last4 = Walsh \| first4 = M. \| last5 = Smith \| first5 = AM. \| last6 = Morris-Stiff \| first6 = G. \| title = Pancreatic Lesions in von Hippel-Lindau Disease? A Systematic Review and Meta-synthesis of the Literature. \| journal = J Gastrointest Surg \| volume = \| issue = \| pages = \| month = Feb \| year = 2012 \| doi = 10.1007/s11605-012-1847-0 \| PMID = 22370733 }}</ref> and [[papillary cystadenoma of the epididymis]].<ref name=pmid23708309>{{Cite journal \| last1 = Toutziaris \| first1 = C. \| last2 = Kampantais \| first2 = S. \| last3 = Perdikis \| first3 = I. \| last4 = Gourvas \| first4 = V. \| last5 = Laskaridis \| first5 = L. \| last6 = Gkagkalidis \| first6 = K. \| last7 = Lakis \| first7 = S. \| last8 = Ioannidis \| first8 = S. \| title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? \| journal = Int J Surg Case Rep \| volume = 4 \| issue = 7 \| pages = 616-8 \| month = \| year = 2013 \| doi = 10.1016/j.ijscr.2013.03.038 \| PMID = 23708309 }}</ref><ref name=pmid20367315>{{Cite journal \| last1 = Odrzywolski \| first1 = KJ. \| last2 = Mukhopadhyay \| first2 = S. \| title = Papillary cystadenoma of the epididymis. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 4 \| pages = 630-3 \| month = Apr \| year = 2010 \| doi = 10.1043/1543-2165-134.4.630 \| PMID = 20367315 }}</ref>

Michael at 18:21, 31 May 2016

2016-05-31T18:21:12Z

← Older revision		Revision as of 18:21, 31 May 2016
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			[[Image:Clear_cell_renal_cell_carcinoma_-_2_--_intermed_mag.jpg\|thumb\|right\|[[Clear cell renal cell carcinoma]] a tumour seen in von Hippel-Lindau disease. [[H&E stain]].]]
	The '''von Hippel-Lindau disease''', also '''von Hippel-Lindau syndrome''' is characterized by (mnemonic: ''HIPPEL''):<ref>URL: [http://www.medicalmnemonics.com/pdf/2002_09_full_abr_8x11.pdf http://www.medicalmnemonics.com/pdf/2002_09_full_abr_8x11.pdf]. Accessed on: 11 September 2008.</ref>		The '''von Hippel-Lindau disease''', also '''von Hippel-Lindau syndrome''' is characterized by (mnemonic: ''HIPPEL''):<ref>URL: [http://www.medicalmnemonics.com/pdf/2002_09_full_abr_8x11.pdf http://www.medicalmnemonics.com/pdf/2002_09_full_abr_8x11.pdf]. Accessed on: 11 September 2008.</ref>
	*[[Hemangioblastoma]]s.		*[[Hemangioblastoma]]s.

Michael: /* See also */

2015-06-12T07:44:11Z

Michael: +eye tumour

2015-03-03T17:17:08Z

+eye tumour

← Older revision		Revision as of 17:17, 3 March 2015
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	*[[Pheochromocytoma]], [[pancreatic neuroendocrine tumour]]s<ref name=pmid22370733>{{Cite journal \| last1 = Charlesworth \| first1 = M. \| last2 = Verbeke \| first2 = CS. \| last3 = Falk \| first3 = GA. \| last4 = Walsh \| first4 = M. \| last5 = Smith \| first5 = AM. \| last6 = Morris-Stiff \| first6 = G. \| title = Pancreatic Lesions in von Hippel-Lindau Disease? A Systematic Review and Meta-synthesis of the Literature. \| journal = J Gastrointest Surg \| volume = \| issue = \| pages = \| month = Feb \| year = 2012 \| doi = 10.1007/s11605-012-1847-0 \| PMID = 22370733 }}</ref> and [[papillary cystadenoma of the epididymis]].<ref name=pmid23708309>{{Cite journal \| last1 = Toutziaris \| first1 = C. \| last2 = Kampantais \| first2 = S. \| last3 = Perdikis \| first3 = I. \| last4 = Gourvas \| first4 = V. \| last5 = Laskaridis \| first5 = L. \| last6 = Gkagkalidis \| first6 = K. \| last7 = Lakis \| first7 = S. \| last8 = Ioannidis \| first8 = S. \| title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? \| journal = Int J Surg Case Rep \| volume = 4 \| issue = 7 \| pages = 616-8 \| month = \| year = 2013 \| doi = 10.1016/j.ijscr.2013.03.038 \| PMID = 23708309 }}</ref><ref name=pmid20367315>{{Cite journal \| last1 = Odrzywolski \| first1 = KJ. \| last2 = Mukhopadhyay \| first2 = S. \| title = Papillary cystadenoma of the epididymis. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 4 \| pages = 630-3 \| month = Apr \| year = 2010 \| doi = 10.1043/1543-2165-134.4.630 \| PMID = 20367315 }}</ref>		*[[Pheochromocytoma]], [[pancreatic neuroendocrine tumour]]s<ref name=pmid22370733>{{Cite journal \| last1 = Charlesworth \| first1 = M. \| last2 = Verbeke \| first2 = CS. \| last3 = Falk \| first3 = GA. \| last4 = Walsh \| first4 = M. \| last5 = Smith \| first5 = AM. \| last6 = Morris-Stiff \| first6 = G. \| title = Pancreatic Lesions in von Hippel-Lindau Disease? A Systematic Review and Meta-synthesis of the Literature. \| journal = J Gastrointest Surg \| volume = \| issue = \| pages = \| month = Feb \| year = 2012 \| doi = 10.1007/s11605-012-1847-0 \| PMID = 22370733 }}</ref> and [[papillary cystadenoma of the epididymis]].<ref name=pmid23708309>{{Cite journal \| last1 = Toutziaris \| first1 = C. \| last2 = Kampantais \| first2 = S. \| last3 = Perdikis \| first3 = I. \| last4 = Gourvas \| first4 = V. \| last5 = Laskaridis \| first5 = L. \| last6 = Gkagkalidis \| first6 = K. \| last7 = Lakis \| first7 = S. \| last8 = Ioannidis \| first8 = S. \| title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? \| journal = Int J Surg Case Rep \| volume = 4 \| issue = 7 \| pages = 616-8 \| month = \| year = 2013 \| doi = 10.1016/j.ijscr.2013.03.038 \| PMID = 23708309 }}</ref><ref name=pmid20367315>{{Cite journal \| last1 = Odrzywolski \| first1 = KJ. \| last2 = Mukhopadhyay \| first2 = S. \| title = Papillary cystadenoma of the epididymis. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 4 \| pages = 630-3 \| month = Apr \| year = 2010 \| doi = 10.1043/1543-2165-134.4.630 \| PMID = 20367315 }}</ref>
	*Port-wine stains, skin lesion - looks like spilled wine; think [http://commons.wikimedia.org/wiki/File:Gorbatschow_DR-Forum_129_b2.jpg ''Mikhail Gorbachev''].		*Port-wine stains, skin lesion - looks like spilled wine; think [http://commons.wikimedia.org/wiki/File:Gorbatschow_DR-Forum_129_b2.jpg ''Mikhail Gorbachev''].
	*Eye dysfunction and Endolymphatic sac ~~tumours~~.<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref>		*Eye dysfunction and [[Endolymphatic sac tumour]]s.<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref>
	**Eye dysfunction = retinal angiomas,<ref name=pmid10804089>{{cite journal \|author=Harris AL \|title=von Hippel-Lindau syndrome: target for anti-vascular endothelial growth factor (VEGF) receptor therapy \|journal=Oncologist \|volume=5 Suppl 1 \|issue= \|pages=32–6 \|year=2000 \|pmid=10804089 \|doi= \|url=http://theoncologist.alphamedpress.org/cgi/content-nw/full/5/suppl_1/32/T1}}</ref> (or ''retinal hemangioblastomas''<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref><ref name=pmid17057815>{{Cite journal \| last1 = Chew \| first1 = EY. \| title = Ocular manifestations of von Hippel-Lindau disease: clinical and genetic investigations. \| journal = Trans Am Ophthalmol Soc \| volume = 103 \| issue = \| pages = 495-511 \| month = \| year = 2005 \| doi = \| PMID = 17057815 \| PMC = 1447586 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447586/ }}</ref> -- depending on the source) .		**Eye dysfunction = retinal angiomas,<ref name=pmid10804089>{{cite journal \|author=Harris AL \|title=von Hippel-Lindau syndrome: target for anti-vascular endothelial growth factor (VEGF) receptor therapy \|journal=Oncologist \|volume=5 Suppl 1 \|issue= \|pages=32–6 \|year=2000 \|pmid=10804089 \|doi= \|url=http://theoncologist.alphamedpress.org/cgi/content-nw/full/5/suppl_1/32/T1}}</ref> (or ''retinal hemangioblastomas''<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref><ref name=pmid17057815>{{Cite journal \| last1 = Chew \| first1 = EY. \| title = Ocular manifestations of von Hippel-Lindau disease: clinical and genetic investigations. \| journal = Trans Am Ophthalmol Soc \| volume = 103 \| issue = \| pages = 495-511 \| month = \| year = 2005 \| doi = \| PMID = 17057815 \| PMC = 1447586 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447586/ }}</ref> -- depending on the source) .
	*[[Liver]] cysts, [[pancreas]] cysts ([[serous microcystic adenoma]]), pancreatic islet cell tumours & [[kidney]] cysts.		*[[Liver]] cysts, [[pancreas]] cysts ([[serous microcystic adenoma]]), pancreatic islet cell tumours & [[kidney]] cysts.

Michael: +epididymis

2014-10-09T16:07:29Z

+epididymis

← Older revision		Revision as of 16:07, 9 October 2014
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	*[[Hemangioblastoma]]s.		*[[Hemangioblastoma]]s.
	*Increased [[Kidney_tumours#Hereditary_RCC\|renal cancer]] ([[clear cell renal cell carcinoma]]).		*Increased [[Kidney_tumours#Hereditary_RCC\|renal cancer]] ([[clear cell renal cell carcinoma]]).
	*[[Pheochromocytoma]] & [[pancreatic neuroendocrine tumour]]s.<ref name=pmid22370733>{{Cite journal \| last1 = Charlesworth \| first1 = M. \| last2 = Verbeke \| first2 = CS. \| last3 = Falk \| first3 = GA. \| last4 = Walsh \| first4 = M. \| last5 = Smith \| first5 = AM. \| last6 = Morris-Stiff \| first6 = G. \| title = Pancreatic Lesions in von Hippel-Lindau Disease? A Systematic Review and Meta-synthesis of the Literature. \| journal = J Gastrointest Surg \| volume = \| issue = \| pages = \| month = Feb \| year = 2012 \| doi = 10.1007/s11605-012-1847-0 \| PMID = 22370733 }}</ref>		*[[Pheochromocytoma]], [[pancreatic neuroendocrine tumour]]s<ref name=pmid22370733>{{Cite journal \| last1 = Charlesworth \| first1 = M. \| last2 = Verbeke \| first2 = CS. \| last3 = Falk \| first3 = GA. \| last4 = Walsh \| first4 = M. \| last5 = Smith \| first5 = AM. \| last6 = Morris-Stiff \| first6 = G. \| title = Pancreatic Lesions in von Hippel-Lindau Disease? A Systematic Review and Meta-synthesis of the Literature. \| journal = J Gastrointest Surg \| volume = \| issue = \| pages = \| month = Feb \| year = 2012 \| doi = 10.1007/s11605-012-1847-0 \| PMID = 22370733 }}</ref> and [[papillary cystadenoma of the epididymis]].<ref name=pmid23708309>{{Cite journal \| last1 = Toutziaris \| first1 = C. \| last2 = Kampantais \| first2 = S. \| last3 = Perdikis \| first3 = I. \| last4 = Gourvas \| first4 = V. \| last5 = Laskaridis \| first5 = L. \| last6 = Gkagkalidis \| first6 = K. \| last7 = Lakis \| first7 = S. \| last8 = Ioannidis \| first8 = S. \| title = Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases? \| journal = Int J Surg Case Rep \| volume = 4 \| issue = 7 \| pages = 616-8 \| month = \| year = 2013 \| doi = 10.1016/j.ijscr.2013.03.038 \| PMID = 23708309 }}</ref><ref name=pmid20367315>{{Cite journal \| last1 = Odrzywolski \| first1 = KJ. \| last2 = Mukhopadhyay \| first2 = S. \| title = Papillary cystadenoma of the epididymis. \| journal = Arch Pathol Lab Med \| volume = 134 \| issue = 4 \| pages = 630-3 \| month = Apr \| year = 2010 \| doi = 10.1043/1543-2165-134.4.630 \| PMID = 20367315 }}</ref>
	*Port-wine stains, skin lesion - looks like spilled wine; think [http://commons.wikimedia.org/wiki/File:Gorbatschow_DR-Forum_129_b2.jpg ''Mikhail Gorbachev''].		*Port-wine stains, skin lesion - looks like spilled wine; think [http://commons.wikimedia.org/wiki/File:Gorbatschow_DR-Forum_129_b2.jpg ''Mikhail Gorbachev''].
	*Eye dysfunction and Endolymphatic sac tumours.<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref>		*Eye dysfunction and Endolymphatic sac tumours.<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref>

Michael: /* References */

2014-08-07T19:11:19Z

References

← Older revision		Revision as of 19:11, 7 August 2014
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	==References==		==References==
	{{reflist\|2}}		{{reflist\|2}}

			==External links==
			*[http://www.vhl.org/wordpress/medical-professionals/when-to-suspect-vhl/ When to suspect VHL (vhl.org)].

	[[Category:Syndromes]]		[[Category:Syndromes]]

Michael: /* See also */

2013-01-07T15:45:10Z

Michael: /* Pancreatic islet cell tumours */ tweak

2012-03-30T13:27:49Z

Pancreatic islet cell tumours: tweak

← Older revision		Revision as of 13:27, 30 March 2012
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	*1 in 40,000 live births.<ref name=pmid11578646>{{cite journal \|author=Singh AD, Shields CL, Shields JA \|title=von Hippel-Lindau disease \|journal=Surv Ophthalmol \|volume=46 \|issue=2 \|pages=117–42 \|year=2001 \|pmid=11578646 \|doi= \|url=}}</ref>		*1 in 40,000 live births.<ref name=pmid11578646>{{cite journal \|author=Singh AD, Shields CL, Shields JA \|title=von Hippel-Lindau disease \|journal=Surv Ophthalmol \|volume=46 \|issue=2 \|pages=117–42 \|year=2001 \|pmid=11578646 \|doi= \|url=}}</ref>

	==Pancreatic islet cell ~~tumours==~~		==Pancreatic neuroendocrine tumour==
			{{Main\|Pancreatic neuroendocrine tumour}}
			*[[AKA]] ''pancreatic islet cell tumour''

	In VHL these have distinct morphology:		In VHL these have distinct morphology:
	*Clear cells<ref name=pmid10740008>{{Cite journal \| last1 = Musso \| first1 = C. \| last2 = Paraf \| first2 = F. \| last3 = Petit \| first3 = B. \| last4 = Archambeaud-Mouveroux \| first4 = F. \| last5 = Valleix \| first5 = D. \| last6 = Labrousse \| first6 = F. \| title = [Pancreatic neuroendocrine tumors and von Hippel-Lindau disease]. \| journal = Ann Pathol \| volume = 20 \| issue = 2 \| pages = 130-3 \| month = Mar \| year = 2000 \| doi = \| PMID = 10740008 }}</ref> - unusual in [[neuroendocrine tumours]].		*Clear cells<ref name=pmid10740008>{{Cite journal \| last1 = Musso \| first1 = C. \| last2 = Paraf \| first2 = F. \| last3 = Petit \| first3 = B. \| last4 = Archambeaud-Mouveroux \| first4 = F. \| last5 = Valleix \| first5 = D. \| last6 = Labrousse \| first6 = F. \| title = [Pancreatic neuroendocrine tumors and von Hippel-Lindau disease]. \| journal = Ann Pathol \| volume = 20 \| issue = 2 \| pages = 130-3 \| month = Mar \| year = 2000 \| doi = \| PMID = 10740008 }}</ref> - unusual in [[neuroendocrine tumours]] otherwise.
	*Fibrosis. (???)		*Fibrosis. (???)

Michael: +pancreatic neuroendocrine tumour

2012-03-30T13:25:37Z

+pancreatic neuroendocrine tumour

← Older revision		Revision as of 13:25, 30 March 2012
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	*[[Hemangioblastoma]]s.		*[[Hemangioblastoma]]s.
	*Increased [[Kidney_tumours#Hereditary_RCC\|renal cancer]] ([[clear cell renal cell carcinoma]]).		*Increased [[Kidney_tumours#Hereditary_RCC\|renal cancer]] ([[clear cell renal cell carcinoma]]).
	*[[Pheochromocytoma]].		*[[Pheochromocytoma]] & [[pancreatic neuroendocrine tumour]]s.<ref name=pmid22370733>{{Cite journal \| last1 = Charlesworth \| first1 = M. \| last2 = Verbeke \| first2 = CS. \| last3 = Falk \| first3 = GA. \| last4 = Walsh \| first4 = M. \| last5 = Smith \| first5 = AM. \| last6 = Morris-Stiff \| first6 = G. \| title = Pancreatic Lesions in von Hippel-Lindau Disease? A Systematic Review and Meta-synthesis of the Literature. \| journal = J Gastrointest Surg \| volume = \| issue = \| pages = \| month = Feb \| year = 2012 \| doi = 10.1007/s11605-012-1847-0 \| PMID = 22370733 }}</ref>
	*Port-wine stains, skin lesion - looks like spilled wine; think [http://commons.wikimedia.org/wiki/File:Gorbatschow_DR-Forum_129_b2.jpg ''Mikhail Gorbachev''].		*Port-wine stains, skin lesion - looks like spilled wine; think [http://commons.wikimedia.org/wiki/File:Gorbatschow_DR-Forum_129_b2.jpg ''Mikhail Gorbachev''].
	*Eye dysfunction and Endolymphatic sac tumours.<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref>		*Eye dysfunction and Endolymphatic sac tumours.<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref>

Michael: more

2012-02-27T15:08:32Z

← Older revision		Revision as of 15:08, 27 February 2012
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	*Port-wine stains, skin lesion - looks like spilled wine; think [http://commons.wikimedia.org/wiki/File:Gorbatschow_DR-Forum_129_b2.jpg ''Mikhail Gorbachev''].		*Port-wine stains, skin lesion - looks like spilled wine; think [http://commons.wikimedia.org/wiki/File:Gorbatschow_DR-Forum_129_b2.jpg ''Mikhail Gorbachev''].
	*Eye dysfunction and Endolymphatic sac tumours.<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref>		*Eye dysfunction and Endolymphatic sac tumours.<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref>
	**Eye dysfunction = retinal angiomas,<ref name=pmid10804089>{{cite journal \|author=Harris AL \|title=von Hippel-Lindau syndrome: target for anti-vascular endothelial growth factor (VEGF) receptor therapy \|journal=Oncologist \|volume=5 Suppl 1 \|issue= \|pages=32–6 \|year=2000 \|pmid=10804089 \|doi= \|url=http://theoncologist.alphamedpress.org/cgi/content-nw/full/5/suppl_1/32/T1}}</ref> (or ''retinal hemangioblastomas''<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref> -- depending on the source) .		**Eye dysfunction = retinal angiomas,<ref name=pmid10804089>{{cite journal \|author=Harris AL \|title=von Hippel-Lindau syndrome: target for anti-vascular endothelial growth factor (VEGF) receptor therapy \|journal=Oncologist \|volume=5 Suppl 1 \|issue= \|pages=32–6 \|year=2000 \|pmid=10804089 \|doi= \|url=http://theoncologist.alphamedpress.org/cgi/content-nw/full/5/suppl_1/32/T1}}</ref> (or ''retinal hemangioblastomas''<ref name=Ref_PSNP440>{{Ref PSNP\|440}}</ref><ref name=pmid17057815>{{Cite journal \| last1 = Chew \| first1 = EY. \| title = Ocular manifestations of von Hippel-Lindau disease: clinical and genetic investigations. \| journal = Trans Am Ophthalmol Soc \| volume = 103 \| issue = \| pages = 495-511 \| month = \| year = 2005 \| doi = \| PMID = 17057815 \| PMC = 1447586 \| URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447586/ }}</ref> -- depending on the source) .
	*[[Liver]] cysts, [[pancreas]] cysts ([[serous microcystic adenoma]]), pancreatic islet cell tumours & [[kidney]] cysts.		*[[Liver]] cysts, [[pancreas]] cysts ([[serous microcystic adenoma]]), pancreatic islet cell tumours & [[kidney]] cysts.

← Older revision		Revision as of 07:44, 12 June 2015
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	*[[Neurocutaneous syndromes]].		*[[Neurocutaneous syndromes]].
	*[[Birt–Hogg–Dubé syndrome]].		*[[Birt–Hogg–Dubé syndrome]].
			*[[TCEB1-mutated renal cell carcinoma]].

	==References==		==References==

← Older revision		Revision as of 15:45, 7 January 2013
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	*[[Kidney tumours]].		*[[Kidney tumours]].
	*[[Neurocutaneous syndromes]].		*[[Neurocutaneous syndromes]].
			*[[Birt–Hogg–Dubé syndrome]].

	==References==		==References==