Urothelial carcinoma of the urethra - Revision history

Michael at 21:01, 19 December 2024

2024-12-19T21:01:10Z

← Older revision		Revision as of 21:01, 19 December 2024
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	'''Prostatic urothelial carcinoma''' and '''urothelial carcinoma of the prostate gland''' redirect here.		'''Prostatic urothelial carcinoma''' and '''urothelial carcinoma of the prostate gland''' redirect here.

			''[[Distal urethral cancers of the penis]]'' are dealt with separately.

	==General==		==General==

Michael at 22:16, 16 February 2016

2016-02-16T22:16:05Z

← Older revision		Revision as of 22:16, 16 February 2016
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	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[prostatic carcinoma]] - especially [[urothelial carcinoma-like prostatic carcinoma]]		\| LMDDx = [[prostatic carcinoma]] - especially poorly differentiated and [[urothelial carcinoma-like prostatic carcinoma]]
	\| Stains = [[GATA3]] +ve, [[p63]] +ve, [[CK5/6]] +ve, [[PSA]] -ve, [[PSAP]] -ve		\| Stains = [[GATA3]] +ve, [[p63]] +ve, CK5/6 +ve, [[PSA]] -ve, [[PSAP]] -ve
	\| IHC =		\| IHC =
	\| EM =		\| EM =
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	\| IF =		\| IF =
	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing = [[cystoprostatectomy grossing]], [[TURP grossing]]
	\| Staging =		\| Staging =
	\| Site = [[urethra]] - also see [[prostate]] ([[prostate cancer]])		\| Site = [[urethra]] - also see [[prostate]] ([[prostate cancer]])

Michael at 22:12, 16 February 2016

2016-02-16T22:12:19Z

← Older revision		Revision as of 22:12, 16 February 2016
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Urothelial carcinoma in prostate - 2 -- high mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Urothelial carcinoma and benign prostatic tissue in keeping with urethral urothelial carcinoma. [[H&E stain]]. (WC/Nephron)
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = [[prostatic carcinoma]] - especially [[urothelial carcinoma-like prostatic carcinoma]]
	\| Stains =		\| Stains = [[GATA3]] +ve, [[p63]] +ve, [[CK5/6]] +ve, [[PSA]] -ve, [[PSAP]] -ve
	\| IHC =		\| IHC =
	\| EM =		\| EM =
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	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = +/-radiation therapy, [[bladder cancer]]		\| Clinicalhx = +/-radiation therapy, [[bladder cancer]]
	\| Signs =		\| Signs = +/-[[hematuria]]
	\| Symptoms =		\| Symptoms =
	\| Prevalence = uncommon		\| Prevalence = uncommon
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	\| Prognosis =		\| Prognosis =
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = benign urethral stricture
	\| Tx = [[cystoprostatectomy]]/cystectomy or endoscopic resection		\| Tx = [[cystoprostatectomy]]/cystectomy or endoscopic resection
	}}		}}

Michael: fix

2016-02-16T22:07:01Z

fix

← Older revision		Revision as of 22:07, 16 February 2016
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	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
	\| Tx = [[~~cystoprostatecomy~~]]/cystectomy or endoscopic resection		\| Tx = [[cystoprostatectomy]]/cystectomy or endoscopic resection
	}}		}}
	'''Urothelial carcinoma of the urethra''' is an uncommon epithelial [[malignancy]] of the [[urethra]]. It may be primary, i.e. arises in the urethra, or secondary (spreads from the bladder or upper genitourinary tract).		'''Urothelial carcinoma of the urethra''' is an uncommon epithelial [[malignancy]] of the [[urethra]]. It may be primary, i.e. arises in the urethra, or secondary (spreads from the bladder or upper genitourinary tract).

Michael at 22:06, 16 February 2016

2016-02-16T22:06:39Z

← Older revision		Revision as of 22:06, 16 February 2016
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	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx =
	\| Tx = [[~~cytoprostatecomy~~]]/cystectomy or endoscopic resection		\| Tx = [[cystoprostatecomy]]/cystectomy or endoscopic resection
	}}		}}
	'''Urothelial carcinoma of the urethra''' is an uncommon epithelial [[malignancy]] of the [[urethra]]. It may be primary, i.e. arises in the urethra, or secondary (spreads from the bladder or upper genitourinary tract).		'''Urothelial carcinoma of the urethra''' is an uncommon epithelial [[malignancy]] of the [[urethra]]. It may be primary, i.e. arises in the urethra, or secondary (spreads from the bladder or upper genitourinary tract).

Michael: +infobox

2016-02-16T22:06:22Z

+infobox

← Older revision		Revision as of 22:06, 16 February 2016
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	'''Urothelial carcinoma of the urethra''' is uncommon. It may be primary, i.e. arises in the [[urethra]], or secondary (spreads from the bladder or upper genitourinary tract).		{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx =
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Staging =
			\| Site = [[urethra]] - also see [[prostate]] ([[prostate cancer]])
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = +/-radiation therapy, [[bladder cancer]]
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx = [[cytoprostatecomy]]/cystectomy or endoscopic resection
			}}
			'''Urothelial carcinoma of the urethra''' is an uncommon epithelial [[malignancy]] of the [[urethra]]. It may be primary, i.e. arises in the urethra, or secondary (spreads from the bladder or upper genitourinary tract).

	'''Prostatic urothelial carcinoma''' and '''urothelial carcinoma of the prostate gland''' redirect here.		'''Prostatic urothelial carcinoma''' and '''urothelial carcinoma of the prostate gland''' redirect here.

Michael at 22:03, 16 February 2016

2016-02-16T22:03:09Z

← Older revision		Revision as of 22:03, 16 February 2016
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	==General==		==General==
	*May arise secondary to radiotherapy for [[prostate cancer]].<ref name=pmid933273>{{Cite journal \| last1 = Novicki \| first1 = DE. \| last2 = Gehring \| first2 = GG. \| title = Urethral carcinoma after radiation therapy for mixed prostatic carcinoma. \| journal = J Urol \| volume = 116 \| issue = 1 \| pages = 122-3 \| month = Jul \| year = 1976 \| doi = \| PMID = 933273 }}</ref>		*May arise secondary to radiotherapy for [[prostate cancer]].<ref name=pmid933273>{{Cite journal \| last1 = Novicki \| first1 = DE. \| last2 = Gehring \| first2 = GG. \| title = Urethral carcinoma after radiation therapy for mixed prostatic carcinoma. \| journal = J Urol \| volume = 116 \| issue = 1 \| pages = 122-3 \| month = Jul \| year = 1976 \| doi = \| PMID = 933273 }}</ref><ref name=pmid1433634>{{Cite journal \| last1 = Winters \| first1 = JC. \| last2 = Fuselier \| first2 = HA. \| title = Invasive bladder cancer following 125iodine implants. \| journal = J Urol \| volume = 148 \| issue = 6 \| pages = 1898-900 \| month = Dec \| year = 1992 \| doi = \| PMID = 1433634 }}</ref>
	*Spreads from the [[urinary bladder]] usually - common.<ref name=pmid22520044>{{Cite journal \| last1 = Huguet \| first1 = J. \| title = [Prostatic involvement by urothelial carcinoma in patients with bladder cancer and their implications in the clinical practice]. \| journal = Actas Urol Esp \| volume = 36 \| issue = 9 \| pages = 545-53 \| month = Oct \| year = 2012 \| doi = 10.1016/j.acuro.2012.02.005 \| PMID = 22520044 }}</ref>		*Spreads from the [[urinary bladder]] usually - common.<ref name=pmid22520044>{{Cite journal \| last1 = Huguet \| first1 = J. \| title = [Prostatic involvement by urothelial carcinoma in patients with bladder cancer and their implications in the clinical practice]. \| journal = Actas Urol Esp \| volume = 36 \| issue = 9 \| pages = 545-53 \| month = Oct \| year = 2012 \| doi = 10.1016/j.acuro.2012.02.005 \| PMID = 22520044 }}</ref>
	*Identified by endoscopic loop biopsy<ref name=pmid17338657>{{Cite journal \| last1 = Liedberg \| first1 = F. \| last2 = Chebil \| first2 = G. \| last3 = Månsson \| first3 = W. \| title = Urothelial carcinoma in the prostatic urethra and prostate: current controversies. \| journal = Expert Rev Anticancer Ther \| volume = 7 \| issue = 3 \| pages = 383-90 \| month = Mar \| year = 2007 \| doi = 10.1586/14737140.7.3.383 \| PMID = 17338657 }}</ref> or [[TURP]].		*Identified by endoscopic loop biopsy<ref name=pmid17338657>{{Cite journal \| last1 = Liedberg \| first1 = F. \| last2 = Chebil \| first2 = G. \| last3 = Månsson \| first3 = W. \| title = Urothelial carcinoma in the prostatic urethra and prostate: current controversies. \| journal = Expert Rev Anticancer Ther \| volume = 7 \| issue = 3 \| pages = 383-90 \| month = Mar \| year = 2007 \| doi = 10.1586/14737140.7.3.383 \| PMID = 17338657 }}</ref> or [[TURP]].

Michael at 22:01, 16 February 2016

2016-02-16T22:01:42Z

← Older revision		Revision as of 22:01, 16 February 2016
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	==General==		==General==
	*May arise secondary to ~~radiation~~ for [[prostate cancer]].<ref name=pmid933273>{{Cite journal \| last1 = Novicki \| first1 = DE. \| last2 = Gehring \| first2 = GG. \| title = Urethral carcinoma after radiation therapy for mixed prostatic carcinoma. \| journal = J Urol \| volume = 116 \| issue = 1 \| pages = 122-3 \| month = Jul \| year = 1976 \| doi = \| PMID = 933273 }}</ref>		*May arise secondary to radiotherapy for [[prostate cancer]].<ref name=pmid933273>{{Cite journal \| last1 = Novicki \| first1 = DE. \| last2 = Gehring \| first2 = GG. \| title = Urethral carcinoma after radiation therapy for mixed prostatic carcinoma. \| journal = J Urol \| volume = 116 \| issue = 1 \| pages = 122-3 \| month = Jul \| year = 1976 \| doi = \| PMID = 933273 }}</ref>
	*Spreads from the [[urinary bladder]] usually - common.<ref name=pmid22520044>{{Cite journal \| last1 = Huguet \| first1 = J. \| title = [Prostatic involvement by urothelial carcinoma in patients with bladder cancer and their implications in the clinical practice]. \| journal = Actas Urol Esp \| volume = 36 \| issue = 9 \| pages = 545-53 \| month = Oct \| year = 2012 \| doi = 10.1016/j.acuro.2012.02.005 \| PMID = 22520044 }}</ref>		*Spreads from the [[urinary bladder]] usually - common.<ref name=pmid22520044>{{Cite journal \| last1 = Huguet \| first1 = J. \| title = [Prostatic involvement by urothelial carcinoma in patients with bladder cancer and their implications in the clinical practice]. \| journal = Actas Urol Esp \| volume = 36 \| issue = 9 \| pages = 545-53 \| month = Oct \| year = 2012 \| doi = 10.1016/j.acuro.2012.02.005 \| PMID = 22520044 }}</ref>
	*Identified by endoscopic loop biopsy<ref name=pmid17338657>{{Cite journal \| last1 = Liedberg \| first1 = F. \| last2 = Chebil \| first2 = G. \| last3 = Månsson \| first3 = W. \| title = Urothelial carcinoma in the prostatic urethra and prostate: current controversies. \| journal = Expert Rev Anticancer Ther \| volume = 7 \| issue = 3 \| pages = 383-90 \| month = Mar \| year = 2007 \| doi = 10.1586/14737140.7.3.383 \| PMID = 17338657 }}</ref> or [[TURP]].		*Identified by endoscopic loop biopsy<ref name=pmid17338657>{{Cite journal \| last1 = Liedberg \| first1 = F. \| last2 = Chebil \| first2 = G. \| last3 = Månsson \| first3 = W. \| title = Urothelial carcinoma in the prostatic urethra and prostate: current controversies. \| journal = Expert Rev Anticancer Ther \| volume = 7 \| issue = 3 \| pages = 383-90 \| month = Mar \| year = 2007 \| doi = 10.1586/14737140.7.3.383 \| PMID = 17338657 }}</ref> or [[TURP]].

Michael at 22:00, 16 February 2016

2016-02-16T22:00:26Z

← Older revision		Revision as of 22:00, 16 February 2016
Line 1:		Line 1:
	'''Urothelial carcinoma of the urethra''' is uncommon. It may be primary, i.e. arises in the [[urethra]], or secondary (spreads from the bladder or upper genitourinary tract).		'''Urothelial carcinoma of the urethra''' is uncommon. It may be primary, i.e. arises in the [[urethra]], or secondary (spreads from the bladder or upper genitourinary tract).

			'''Prostatic urothelial carcinoma''' and '''urothelial carcinoma of the prostate gland''' redirect here.

	==General==		==General==

Michael: split out

2016-02-16T21:58:42Z

split out

New page

'''Urothelial carcinoma of the urethra''' is uncommon. It may be primary, i.e. arises in the [[urethra]], or secondary (spreads from the bladder or upper genitourinary tract).

==General==
*May arise secondary to radiation for [[prostate cancer]].<ref name=pmid933273>{{Cite journal | last1 = Novicki | first1 = DE. | last2 = Gehring | first2 = GG. | title = Urethral carcinoma after radiation therapy for mixed prostatic carcinoma. | journal = J Urol | volume = 116 | issue = 1 | pages = 122-3 | month = Jul | year = 1976 | doi = | PMID = 933273 }}</ref>
*Spreads from the [[urinary bladder]] usually - common.<ref name=pmid22520044>{{Cite journal | last1 = Huguet | first1 = J. | title = [Prostatic involvement by urothelial carcinoma in patients with bladder cancer and their implications in the clinical practice]. | journal = Actas Urol Esp | volume = 36 | issue = 9 | pages = 545-53 | month = Oct | year = 2012 | doi = 10.1016/j.acuro.2012.02.005 | PMID = 22520044 }}</ref>
*Identified by endoscopic loop biopsy<ref name=pmid17338657>{{Cite journal | last1 = Liedberg | first1 = F. | last2 = Chebil | first2 = G. | last3 = Månsson | first3 = W. | title = Urothelial carcinoma in the prostatic urethra and prostate: current controversies. | journal = Expert Rev Anticancer Ther | volume = 7 | issue = 3 | pages = 383-90 | month = Mar | year = 2007 | doi = 10.1586/14737140.7.3.383 | PMID = 17338657 }}</ref> or [[TURP]].

Treatment:<ref name=pmid17338657/>
*[[Cystoprostatectomy]] - stromal invasion ''or'' extensive intraductal involvement.
*Endoscopic resection and BCG - limited extent without stromal invasion.

Clinical DDx:
*Benign urethral stricture.

==Microscopic==
Features:
*Divided into tumours with:
*#Stromal invasion.
*#Without stromal invasion.

Notes:
*Stromal involvement common ~ 75% of cases.<ref name=pmid23250619>{{Cite journal | last1 = Ichihara | first1 = K. | last2 = Masumori | first2 = N. | last3 = Kitamura | first3 = H. | last4 = Hasegawa | first4 = T. | last5 = Tsukamoto | first5 = T. | title = Clinical outcomes of urothelial carcinoma of the prostate detected in radical cystectomy specimens. | journal = Int J Clin Oncol | volume = | issue = | pages = | month = Dec | year = 2012 | doi = 10.1007/s10147-012-0508-3 | PMID = 23250619 }}</ref>

DDx:
*[[Urothelial carcinoma-like prostatic carcinoma]] - may have pseudopapillae.

===Images===
<gallery>
Image: Urothelial carcinoma in prostate -- low mag.jpg | UCC in prostate - low mag. (WC/Nephron)
Image: Urothelial carcinoma in prostate -- intermed mag.jpg | UCC in prostate - intermed. mag. (WC/Nephron)
Image: Urothelial carcinoma in prostate -- high mag.jpg | UCC in prostate - high mag. (WC/Nephron)
Image: Urothelial carcinoma in prostate - alt -- high mag.jpg | UCC in prostate - high mag. (WC/Nephron)

Image: Urothelial carcinoma in prostate - portrait -- intermed mag.jpg | UCC in prostate - intermed. mag. (WC/Nephron)
Image: Urothelial carcinoma in prostate - portrait -- high mag.jpg | UCC in prostate - high mag. (WC/Nephron)
Image: Urothelial carcinoma in prostate - portrait -- very high mag.jpg | UCC in prostate - very high mag. (WC/Nephron)

Image: Urothelial carcinoma in prostate - 2 -- intermed mag.jpg | UCC in prostate - intermed. mag. (WC/Nephron)
Image: Urothelial carcinoma in prostate - 2 -- high mag.jpg | UCC in prostate - high mag. (WC/Nephron)
Image: Urothelial carcinoma in prostate - 2 -- very high mag.jpg | UCC in prostate - very high mag. (WC/Nephron)
</gallery>

==Sign out==
<pre>
PROSTATE TISSUE, TRANSURETHRAL RESECTION:
- HIGH-GRADE UROTHELIAL CARCINOMA WITH FOCAL STROMAL INVASION, AND EXTENSIVE
INTRADUCTAL SPREAD IN FRAGMENTS WITH BENIGN PROSTATIC GLANDS.
</pre>

==See also==
*[[Urethra]].
*[[Prostate cancer]].
*[[Urothelium]].

==References==
{{Reflist|2}}

[[Category:Diagnosis]]
[[Category:Genitourinary pathology]]