Urine cytopathology - Revision history

Michael: +ASC in urine

2024-01-30T22:45:51Z

+ASC in urine

← Older revision		Revision as of 22:45, 30 January 2024
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	*Trichomonas is found in approximately 0.1% of urine cytology specimens.<ref>{{cite journal \|authors=Doxtader EE, Elsheikh TM \|title=Diagnosis of trichomoniasis in men by urine cytology \|journal=Cancer Cytopathol \|volume=125 \|issue=1 \|pages=55–59 \|date=January 2017 \|pmid=27636204 \|doi=10.1002/cncy.21778 \|url=}}</ref>		*Trichomonas is found in approximately 0.1% of urine cytology specimens.<ref>{{cite journal \|authors=Doxtader EE, Elsheikh TM \|title=Diagnosis of trichomoniasis in men by urine cytology \|journal=Cancer Cytopathol \|volume=125 \|issue=1 \|pages=55–59 \|date=January 2017 \|pmid=27636204 \|doi=10.1002/cncy.21778 \|url=}}</ref>

			==Atypical squamous cells in urine==
			*Atypical squamous cells in urine cytology specimens are rare ~ 0.3%.<ref>{{cite journal \|authors=Velez Torres JM, Zhao J, Epstein JI, Kryvenko ON \|title=Condyloma acuminatum of the urinary tract demonstrates atypical squamous cells in urine cytology \|journal=Hum Pathol \|volume=130 \|issue= \|pages=110–116 \|date=December 2022 \|pmid=36244465 \|doi=10.1016/j.humpath.2022.10.006 \|url=}}</ref>
			*An older series describes an association with SCC/UCC of the bladder and SCC of the cervix.<ref>{{cite journal \|authors=Owens CL, Ali SZ \|title=Atypical squamous cells in exfoliative urinary cytology: clinicopathologic correlates \|journal=Diagn Cytopathol \|volume=33 \|issue=6 \|pages=394–8 \|date=December 2005 \|pmid=16299739 \|doi=10.1002/dc.20344 \|url=}}</ref>

			<pre>
			Atypical squamous cells present, see comment.
			Benign urothelial cells present in background.
			Negative for High-Grade Urothelial Carcinoma.

			Comment:
			Due to the atypical squamous cells, consideration of further work-up is suggested within the clinical context, based on reported associations.[1]

			1. Diagn Cytopathol. 2005 Dec;33(6):394-8. doi: 10.1002/dc.20344 - https://pubmed.ncbi.nlm.nih.gov/16299739/
			</pre>
	==See also==		==See also==
	*[[Cytopathology]].		*[[Cytopathology]].

Michael: /* Schistosoma */

2022-06-02T20:41:08Z

Schistosoma

← Older revision		Revision as of 20:41, 2 June 2022
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	Image:Schistosomiasis_haematobia.jpg\| Schistosoma haematobium. (WC)		Image:Schistosomiasis_haematobia.jpg\| Schistosoma haematobium. (WC)
	</gallery>		</gallery>

			==Trichomonas==
			{{Main\|Gynecologic_cytopathology#Trichomoniasis}}
			*Trichomonas is found in approximately 0.1% of urine cytology specimens.<ref>{{cite journal \|authors=Doxtader EE, Elsheikh TM \|title=Diagnosis of trichomoniasis in men by urine cytology \|journal=Cancer Cytopathol \|volume=125 \|issue=1 \|pages=55–59 \|date=January 2017 \|pmid=27636204 \|doi=10.1002/cncy.21778 \|url=}}</ref>

	==See also==		==See also==

Michael at 22:29, 9 October 2021

2021-10-09T22:29:52Z

← Older revision		Revision as of 22:29, 9 October 2021
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	*Polyomavirus.		*Polyomavirus.

	† Willner ''et al.'' require all of the following:<ref name=pmid33088909>{{cite journal \|~~vauthors~~=Willner J, Matloob A, Colanta A, Khader SN \|title=Educational Case: Urothelial Carcinoma: An Overview of Pathologic Diagnosis \|journal=Acad Pathol \|volume=7 \|issue= \|pages=2374289520958172 \|date=2020 \|pmid=33088909 \|doi=10.1177/2374289520958172 \|url=}}</ref>		† Willner ''et al.'' require all of the following:<ref name=pmid33088909>{{cite journal \|authors=Willner J, Matloob A, Colanta A, Khader SN \|title=Educational Case: Urothelial Carcinoma: An Overview of Pathologic Diagnosis \|journal=Acad Pathol \|volume=7 \|issue= \|pages=2374289520958172 \|date=2020 \|pmid=33088909 \|doi=10.1177/2374289520958172 \|url=}}</ref>
	#Nucleus-to-cytoplasm ratio >0.7.		#Nucleus-to-cytoplasm ratio >0.7.
	#Hyperchromasia (moderate or severe).		#Hyperchromasia (moderate or severe).

Michael: /* Cytology */ tweak order

2021-08-05T16:35:21Z

Cytology: tweak order

← Older revision		Revision as of 16:35, 5 August 2021
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	===Cytology===		===Cytology===
	Features:<ref>{{Ref APBR\|682}}</ref>		Features:<ref>{{Ref APBR\|682}}</ref>
	~~#"Large nuclei" (3-4X the size of a normal urothelial cell) - '''low power''' feature.~~
	~~#*These are not required for the diagnosis.<ref>SM. 12 January 2010.</ref>~~
	~~#*Large nuclei may be seen in benign umbrella cell, where the [[NC ratio]] is normal.~~
	#Hyperchromasia - '''low power''' feature.		#Hyperchromasia - '''low power''' feature.
	#Irregular nuclear membrane - '''key feature'''.		#Irregular nuclear membrane - '''key feature'''.
	#Increased NC ratio.		#Increased NC ratio.
	#*Often uniform - when comparing malignant cells.		#*Often uniform - when comparing malignant cells.
			#"Large nuclei" (3-4X the size of a normal urothelial cell) - '''low power''' feature.
			#*These are not required for the diagnosis.<ref>SM. 12 January 2010.</ref>
			#*Large nuclei may be seen in benign umbrella cell, where the [[NC ratio]] is normal.
	#Nuclear size variation, >=2X other malign. looking cells - very useful.		#Nuclear size variation, >=2X other malign. looking cells - very useful.
	#+/-Large irregular nucleoli - common.		#+/-Large irregular nucleoli - common.

	Minimal criteria:		Minimal criteria:
	*Criteria #2-4. †		*Criteria #1-3. †

	Notes:		Notes:

Michael: /* Cytology */

2021-08-05T16:34:46Z

Cytology

← Older revision		Revision as of 16:34, 5 August 2021
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	Features:<ref>{{Ref APBR\|682}}</ref>		Features:<ref>{{Ref APBR\|682}}</ref>
	#"Large nuclei" (3-4X the size of a normal urothelial cell) - '''low power''' feature.		#"Large nuclei" (3-4X the size of a normal urothelial cell) - '''low power''' feature.
	#*These are not required for the diagnosis.<ref>SM. 12 January 2010.</ref> -		#*These are not required for the diagnosis.<ref>SM. 12 January 2010.</ref>
	#*Large nuclei may be seen in benign umbrella cell, where the [[NC ratio]] is normal.		#*Large nuclei may be seen in benign umbrella cell, where the [[NC ratio]] is normal.
	#Hyperchromasia - '''low power''' feature.		#Hyperchromasia - '''low power''' feature.

Michael: /* Urothelial cell carcinoma */

2021-08-05T16:31:26Z

Urothelial cell carcinoma

← Older revision		Revision as of 16:31, 5 August 2021
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	*One does not usually call ''[[squamous cell carcinoma]]'' on cytology.		*One does not usually call ''[[squamous cell carcinoma]]'' on cytology.
	**If features of squamous differentiation are present one calls ''urothelial carcinoma with squamous features''.		**If features of squamous differentiation are present one calls ''urothelial carcinoma with squamous features''.

			DDx:
			*Degeneration.
			*Polyomavirus.

	† Willner ''et al.'' require all of the following:<ref name=pmid33088909>{{cite journal \|vauthors=Willner J, Matloob A, Colanta A, Khader SN \|title=Educational Case: Urothelial Carcinoma: An Overview of Pathologic Diagnosis \|journal=Acad Pathol \|volume=7 \|issue= \|pages=2374289520958172 \|date=2020 \|pmid=33088909 \|doi=10.1177/2374289520958172 \|url=}}</ref>		† Willner ''et al.'' require all of the following:<ref name=pmid33088909>{{cite journal \|vauthors=Willner J, Matloob A, Colanta A, Khader SN \|title=Educational Case: Urothelial Carcinoma: An Overview of Pathologic Diagnosis \|journal=Acad Pathol \|volume=7 \|issue= \|pages=2374289520958172 \|date=2020 \|pmid=33088909 \|doi=10.1177/2374289520958172 \|url=}}</ref>
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	#Coarse chromatin.		#Coarse chromatin.

	~~DDx:~~		Willner's criteria can be remember by ''CHIN'' = '''''c'''oarse chromatin, '''h'''yperchromasia, '''i'''rregular nuclear membrane, '''N'''C ratio increased''.
	*Degeneration.
	*Polyomavirus.

	==Schistosoma==		==Schistosoma==

Michael: /* Cytology */

2021-08-05T16:27:32Z

Cytology

← Older revision		Revision as of 16:27, 5 August 2021
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	**If features of squamous differentiation are present one calls ''urothelial carcinoma with squamous features''.		**If features of squamous differentiation are present one calls ''urothelial carcinoma with squamous features''.

	† Willner ''et al.'' require the following:<ref name=pmid33088909>{{cite journal \|vauthors=Willner J, Matloob A, Colanta A, Khader SN \|title=Educational Case: Urothelial Carcinoma: An Overview of Pathologic Diagnosis \|journal=Acad Pathol \|volume=7 \|issue= \|pages=2374289520958172 \|date=2020 \|pmid=33088909 \|doi=10.1177/2374289520958172 \|url=}}</ref>		† Willner ''et al.'' require all of the following:<ref name=pmid33088909>{{cite journal \|vauthors=Willner J, Matloob A, Colanta A, Khader SN \|title=Educational Case: Urothelial Carcinoma: An Overview of Pathologic Diagnosis \|journal=Acad Pathol \|volume=7 \|issue= \|pages=2374289520958172 \|date=2020 \|pmid=33088909 \|doi=10.1177/2374289520958172 \|url=}}</ref>
	#Nucleus-to-cytoplasm ratio >0.7.		#Nucleus-to-cytoplasm ratio >0.7.
	#Hyperchromasia (moderate or severe).		#Hyperchromasia (moderate or severe).

Michael: /* Urothelial cell carcinoma */

2021-08-05T16:27:19Z

Urothelial cell carcinoma

← Older revision		Revision as of 16:27, 5 August 2021
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	Minimal criteria:		Minimal criteria:
	*Criteria #2-4.		*Criteria #2-4. †

	Notes:		Notes:
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	*One does not usually call ''[[squamous cell carcinoma]]'' on cytology.		*One does not usually call ''[[squamous cell carcinoma]]'' on cytology.
	**If features of squamous differentiation are present one calls ''urothelial carcinoma with squamous features''.		**If features of squamous differentiation are present one calls ''urothelial carcinoma with squamous features''.

			† Willner ''et al.'' require the following:<ref name=pmid33088909>{{cite journal \|vauthors=Willner J, Matloob A, Colanta A, Khader SN \|title=Educational Case: Urothelial Carcinoma: An Overview of Pathologic Diagnosis \|journal=Acad Pathol \|volume=7 \|issue= \|pages=2374289520958172 \|date=2020 \|pmid=33088909 \|doi=10.1177/2374289520958172 \|url=}}</ref>
			#Nucleus-to-cytoplasm ratio >0.7.
			#Hyperchromasia (moderate or severe).
			#Irregular nuclear membranes, marked.
			#Coarse chromatin.

	DDx:		DDx:

Michael: /* Paris system for urinary cytology */ fix typo

2019-10-15T13:53:47Z

Paris system for urinary cytology: fix typo

← Older revision		Revision as of 13:53, 15 October 2019
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	#Negative for [[urothelial carcinoma\|high-grade urothelial carcinoma]]		#Negative for [[urothelial carcinoma\|high-grade urothelial carcinoma]]
	#Atypical urothelial cells		#Atypical urothelial cells
	#~~Suspicous~~ for high-grade urothelial carcinoma		#Suspicious for high-grade urothelial carcinoma
	#High-grade urothelial carcinoma		#High-grade urothelial carcinoma
	#Low-grade urothelial neoplasm		#Low-grade urothelial neoplasm

Michael: /* Paris system for urinary cytology */ tweak

2017-02-19T19:25:00Z

Paris system for urinary cytology: tweak

← Older revision		Revision as of 19:25, 19 February 2017
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	===Paris system for urinary cytology===		===Paris system for urinary cytology===
	This is a reporting standard with the following categories:<ref name=pmid27318895>{{Cite journal \| last1 = Barkan \| first1 = GA. \| last2 = Wojcik \| first2 = EM. \| last3 = Nayar \| first3 = R. \| last4 = Savic-Prince \| first4 = S. \| last5 = Quek \| first5 = ML. \| last6 = Kurtycz \| first6 = DF. \| last7 = Rosenthal \| first7 = DL. \| title = The Paris System for Reporting Urinary Cytology: The Quest to Develop a Standardized Terminology. \| journal = Acta Cytol \| volume = \| issue = \| pages = \| month = ~~Jun~~ \| year = 2016 \| doi = 10.1159/000446270 \| PMID = 27318895 }}</ref>		This is a reporting standard with the following categories:<ref name=pmid27318895>{{Cite journal \| last1 = Barkan \| first1 = GA. \| last2 = Wojcik \| first2 = EM. \| last3 = Nayar \| first3 = R. \| last4 = Savic-Prince \| first4 = S. \| last5 = Quek \| first5 = ML. \| last6 = Kurtycz \| first6 = DF. \| last7 = Rosenthal \| first7 = DL. \| title = The Paris System for Reporting Urinary Cytology: The Quest to Develop a Standardized Terminology. \| journal = Acta Cytol \| volume = 60 \| issue = 3 \| pages = 185-97 \| month = \| year = 2016 \| doi = 10.1159/000446270 \| PMID = 27318895 }}</ref>
	#Nondiagnostic/unsatisfactory		#Nondiagnostic/unsatisfactory
	#Negative for [[urothelial carcinoma\|high-grade urothelial carcinoma]]		#Negative for [[urothelial carcinoma\|high-grade urothelial carcinoma]]