Urinary bladder amyloidosis - Revision history

Michael: /* General */

2015-10-23T03:44:11Z

General

← Older revision		Revision as of 03:44, 23 October 2015
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	*Primary bladder amyloidosis is rare - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645/>		*Primary bladder amyloidosis is rare - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645/>
	**Systemic [[amyloidosis]] should be excluded.<ref name=pmid24857645>{{Cite journal \| last1 = Schou-Jensen \| first1 = KS. \| last2 = Dahl \| first2 = C. \| last3 = Pilt \| first3 = AP. \| last4 = Azawi \| first4 = NH. \| title = Amyloidosis in the bladder: three cases with different appearance. \| journal = Scand J Urol \| volume = 48 \| issue = 5 \| pages = 489-92 \| month = Oct \| year = 2014 \| doi = 10.3109/21681805.2014.920414 \| PMID = 24857645 }}</ref>		**Systemic [[amyloidosis]] should be excluded.<ref name=pmid24857645>{{Cite journal \| last1 = Schou-Jensen \| first1 = KS. \| last2 = Dahl \| first2 = C. \| last3 = Pilt \| first3 = AP. \| last4 = Azawi \| first4 = NH. \| title = Amyloidosis in the bladder: three cases with different appearance. \| journal = Scand J Urol \| volume = 48 \| issue = 5 \| pages = 489-92 \| month = Oct \| year = 2014 \| doi = 10.3109/21681805.2014.920414 \| PMID = 24857645 }}</ref>
	*May clinically mimic bladder cancer.<ref name=pmid25366012/>		*May clinically mimic [[bladder cancer]].<ref name=pmid25366012/>

	==Gross==		==Gross==

Michael: /* Microscopic */

2015-10-04T13:04:20Z

Microscopic

← Older revision		Revision as of 13:04, 4 October 2015
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	==Microscopic==		==Microscopic==
	Features:		Features:
	*Lamina propria with amyloid (amorphous, paucicellular, pink ~~material~~ on H&E - classically "cracked").		*Lamina propria with amyloid.
			**Amyloid = amorphous, paucicellular material that is [[pink on H&E]], classically has "cracked" appearance.
			***"Cracked": irregular fragments where the edges and centre of fragments are homogeneous.

	DDx:		DDx:

Michael at 03:43, 3 October 2015

2015-10-03T03:43:15Z

← Older revision		Revision as of 03:43, 3 October 2015
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Urinary bladder amyloidosis -- low mag.jpg
			\| Width =
			\| Caption = Urinary bladder amyloidosis. [[H&E stain]].
			\| Synonyms = amyloidosis of the urinary bladder
			\| Micro = lamina propria with amyloid (amorphous, paucicellular, pink material on H&E - classically "cracked")
			\| Subtypes =
			\| LMDDx = fibrosis, fibrin, [[leiomyoma]]
			\| Stains = [[Congo red]] +ve
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[urinary bladder]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = very rare
			\| Bloodwork =
			\| Rads = thickened bladder wall
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx = other urinary bladder tumours - esp. malignant ones
			\| Tx =
			}}
	'''Urinary bladder amyloidosis''', more formally '''primary urinary bladder amyloidosis''', is a rare benign condition of [[urinary bladder]] that can mimic [[cancer]] of the [[urinary bladder]].<ref name=pmid25366012>{{Cite journal \| last1 = Kobayashi \| first1 = T. \| last2 = Roberts \| first2 = J. \| last3 = Levine \| first3 = J. \| last4 = Degrado \| first4 = J. \| title = Primary bladder amyloidosis. \| journal = Intern Med \| volume = 53 \| issue = 21 \| pages = 2511-3 \| month = \| year = 2014 \| doi = \| PMID = 25366012 }}</ref>		'''Urinary bladder amyloidosis''', more formally '''primary urinary bladder amyloidosis''', is a rare benign condition of [[urinary bladder]] that can mimic [[cancer]] of the [[urinary bladder]].<ref name=pmid25366012>{{Cite journal \| last1 = Kobayashi \| first1 = T. \| last2 = Roberts \| first2 = J. \| last3 = Levine \| first3 = J. \| last4 = Degrado \| first4 = J. \| title = Primary bladder amyloidosis. \| journal = Intern Med \| volume = 53 \| issue = 21 \| pages = 2511-3 \| month = \| year = 2014 \| doi = \| PMID = 25366012 }}</ref>

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	Features:		Features:
	*Lamina propria with amyloid (amorphous, paucicellular, pink material on H&E - classically "cracked").		*Lamina propria with amyloid (amorphous, paucicellular, pink material on H&E - classically "cracked").

			DDx:
			*Fibrin.
			*Fibrosis.
			*[[Leiomyoma]].

			===Images===
			<gallery>
			Image: Urinary bladder amyloidosis -- very low mag.jpg \| UBA - very low mag. (WC)
			Image: Urinary bladder amyloidosis -- low mag.jpg \| UBA - low mag. (WC)
			Image: Urinary bladder amyloidosis -- intermed mag.jpg \| UBA - intermed. mag. (WC)
			Image: Urinary bladder amyloidosis -- high mag.jpg \| UBA - high mag. (WC)
			</gallery>

	==Stains==		==Stains==
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	==References==		==References==
	{{Reflist\|2}}		{{Reflist\|2}}


	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Genitourinary pathology]]		[[Category:Genitourinary pathology]]

Michael: /* Sign out */

2015-10-02T18:25:55Z

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← Older revision		Revision as of 18:25, 2 October 2015
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	- Benign muscularis propria present.		- Benign muscularis propria present.
	- NEGATIVE for urothelial carcinoma in situ.		- NEGATIVE for urothelial carcinoma in situ.
	- NEGATIVE for malignancy.		- NEGATIVE for evidence of malignancy.

	Comment:		Comment:

Michael: /* Sign out */

2015-10-02T18:20:34Z

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← Older revision		Revision as of 18:20, 2 October 2015
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	Congo red staining and polarization confirm the presence of amyloid.		Congo red staining and polarization confirm the presence of amyloid.

	~~Systemic~~ causes of amyloidosis should be considered ~~clinically~~.		Primary bladder amyloidosis is rare; systemic causes of amyloidosis should
			be considered.
	</pre>		</pre>

Michael: /* General */

2015-10-02T18:19:53Z

General

← Older revision		Revision as of 18:19, 2 October 2015
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	==General==		==General==
	*~~Rare~~ - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645>{{Cite journal \| last1 = Schou-Jensen \| first1 = KS. \| last2 = Dahl \| first2 = C. \| last3 = Pilt \| first3 = AP. \| last4 = Azawi \| first4 = NH. \| title = Amyloidosis in the bladder: three cases with different appearance. \| journal = Scand J Urol \| volume = 48 \| issue = 5 \| pages = 489-92 \| month = Oct \| year = 2014 \| doi = 10.3109/21681805.2014.920414 \| PMID = 24857645 }}</ref>		*Primary bladder amyloidosis is rare - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645/>
			**Systemic [[amyloidosis]] should be excluded.<ref name=pmid24857645>{{Cite journal \| last1 = Schou-Jensen \| first1 = KS. \| last2 = Dahl \| first2 = C. \| last3 = Pilt \| first3 = AP. \| last4 = Azawi \| first4 = NH. \| title = Amyloidosis in the bladder: three cases with different appearance. \| journal = Scand J Urol \| volume = 48 \| issue = 5 \| pages = 489-92 \| month = Oct \| year = 2014 \| doi = 10.3109/21681805.2014.920414 \| PMID = 24857645 }}</ref>
	*May clinically mimic bladder cancer.<ref name=pmid25366012/>		*May clinically mimic bladder cancer.<ref name=pmid25366012/>

Michael: /* Sign out */

2015-10-02T18:18:13Z

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← Older revision		Revision as of 18:18, 2 October 2015
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	Comment:		Comment:
	Congo red staining and polarization confirm the presence of amyloid.		Congo red staining and polarization confirm the presence of amyloid.

			Systemic causes of amyloidosis should be considered clinically.
	</pre>		</pre>

Michael: /* Stains */ +SO

2015-10-02T18:15:36Z

Stains: +SO

← Older revision		Revision as of 18:15, 2 October 2015
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	==Stains==		==Stains==
	*[[Congo red]] +ve.		*[[Congo red]] +ve.

			==Sign out==
			<pre>
			Urinary Bladder, Transurethral Resection:
			- Urothelial mucosa with amyloidosis and mild chronic inflammation.
			- Benign muscularis propria present.
			- NEGATIVE for urothelial carcinoma in situ.
			- NEGATIVE for malignancy.

			Comment:
			Congo red staining and polarization confirm the presence of amyloid.
			</pre>

	==See also==		==See also==

Michael: /* See also */

2015-10-02T18:13:01Z

Michael: /* See also */

2015-10-02T18:12:56Z

← Older revision		Revision as of 18:13, 2 October 2015
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	==See also==		==See also==
	*[[Amyloidosis]].		*[[Amyloidosis]].
	*[[Urinary bladder].		*[[Urinary bladder]].

	==References==		==References==

← Older revision		Revision as of 18:12, 2 October 2015
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	==See also==		==See also==
	*[[Amyloidosis]].		*[[Amyloidosis]].
			*[[Urinary bladder].

	==References==		==References==