Tumour deposit - Revision history

Mark: tnm8

2021-08-08T21:00:05Z

tnm8

← Older revision		Revision as of 21:00, 8 August 2021
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	==Definition==		==Definition==
			Definition - TNM/AJCC 8th edition for colorectal cancer:
			"Tumor deposits are defined as discrete tumor nodules within the lymph drainage area of the primary carcinoma without identifiable lymph node tissue or identifiable vascular or neural structure. The shape, contour, and size of the deposit are not considered in these designations."

	Definition - TNM/AJCC 7th edition for colorectal cancer:<ref name=pmid21555695/>		Definition - TNM/AJCC 7th edition for colorectal cancer:<ref name=pmid21555695/>
	*Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour.		*Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour.
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	Notes:		Notes:
	*The definition of ''tumour deposit'' has changed significantly between the TMN/AJCC fifth, sixth ~~and~~ seventh editions.<ref name=pmid21555695/>		*The definition of ''tumour deposit'' has changed significantly between the TMN/AJCC fifth, sixth, seventh editions.<ref name=pmid21555695/>
	*Lesions that are ''not'' in the drainage bed of the tumour are [[Colorectal_cancer_staging#Metastasis_stage\|metastatic disease]], pM1b.		*Lesions that are ''not'' in the drainage bed of the tumour are [[Colorectal_cancer_staging#Metastasis_stage\|metastatic disease]], pM1b.

	===Ueno criteria===		===Ueno criteria===
	Ueno ''et al.'' propose that a tumour deposit is either:<ref name=pmid24112678/>		Ueno ''et al.'' propose that a tumour deposit is either:<ref name=pmid24112678/>

Michael: /* Definition */

2016-08-10T17:27:37Z

Definition

← Older revision		Revision as of 17:27, 10 August 2016
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	Notes:		Notes:
	*The definition of ''tumour deposit'' has changed significantly between the TMN/AJCC fifth, sixth and seventh editions.<ref name=pmid21555695/>		*The definition of ''tumour deposit'' has changed significantly between the TMN/AJCC fifth, sixth and seventh editions.<ref name=pmid21555695/>
	*Lesions that are ''not'' in the drainage bed of tumour are [[Colorectal_cancer_staging#Metastasis_stage\|metastatic disease]], pM1b.		*Lesions that are ''not'' in the drainage bed of the tumour are [[Colorectal_cancer_staging#Metastasis_stage\|metastatic disease]], pM1b.
	===Ueno criteria===		===Ueno criteria===
	Ueno ''et al.'' propose that a tumour deposit is either:<ref name=pmid24112678/>		Ueno ''et al.'' propose that a tumour deposit is either:<ref name=pmid24112678/>

Michael: /* Definition */

2016-08-10T17:19:16Z

Definition

← Older revision		Revision as of 17:19, 10 August 2016
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	==Definition==		==Definition==
	Definition - TNM/AJCC 7th edition:<ref name=pmid21555695/>		Definition - TNM/AJCC 7th edition for colorectal cancer:<ref name=pmid21555695/>
	*Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour.		*Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour.
	**No standardized distance (from tumour) criteria are defined.<ref name=pmid24112678>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Hashiguchi \| first2 = Y. \| last3 = Shimazaki \| first3 = H. \| last4 = Shinto \| first4 = E. \| last5 = Kajiwara \| first5 = Y. \| last6 = Nakanishi \| first6 = K. \| last7 = Kato \| first7 = K. \| last8 = Maekawa \| first8 = K. \| last9 = Nakamura \| first9 = T. \| title = Peritumoral deposits as an adverse prognostic indicator of colorectal cancer. \| journal = Am J Surg \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.amjsurg.2013.04.009 \| PMID = 24112678 }}</ref>		**No standardized distance (from tumour) criteria are defined.<ref name=pmid24112678>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Hashiguchi \| first2 = Y. \| last3 = Shimazaki \| first3 = H. \| last4 = Shinto \| first4 = E. \| last5 = Kajiwara \| first5 = Y. \| last6 = Nakanishi \| first6 = K. \| last7 = Kato \| first7 = K. \| last8 = Maekawa \| first8 = K. \| last9 = Nakamura \| first9 = T. \| title = Peritumoral deposits as an adverse prognostic indicator of colorectal cancer. \| journal = Am J Surg \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.amjsurg.2013.04.009 \| PMID = 24112678 }}</ref>

Michael at 17:00, 10 August 2016

2016-08-10T17:00:15Z

← Older revision		Revision as of 17:00, 10 August 2016
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	It is also known as '''discoutinuous extramural extension''' and '''peritumoural deposit'''.		It is also known as '''discoutinuous extramural extension''' and '''peritumoural deposit'''.

	Conceptually, tumour deposits are like the ''[[in-transit metastases]]'' of [[malignant melanoma]]<ref name=pmid19136930>{{Cite journal \| last1 = Puppa \| first1 = G. \| last2 = Ueno \| first2 = H. \| last3 = Kayahara \| first3 = M. \| last4 = Capelli \| first4 = P. \| last5 = Canzonieri \| first5 = V. \| last6 = Colombari \| first6 = R. \| last7 = Maisonneuve \| first7 = P. \| last8 = Pelosi \| first8 = G. \| title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. \| journal = Mod Pathol \| volume = 22 \| issue = 3 \| pages = 410-5 \| month = Mar \| year = 2009 \| doi = 10.1038/modpathol.2008.198 \| PMID = 19136930 }}</ref> and [[dermatopathology]].		Conceptually, tumour deposits are like the ''[[in-transit metastases]]'' of [[malignant melanoma]]<ref name=pmid19136930>{{Cite journal \| last1 = Puppa \| first1 = G. \| last2 = Ueno \| first2 = H. \| last3 = Kayahara \| first3 = M. \| last4 = Capelli \| first4 = P. \| last5 = Canzonieri \| first5 = V. \| last6 = Colombari \| first6 = R. \| last7 = Maisonneuve \| first7 = P. \| last8 = Pelosi \| first8 = G. \| title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. \| journal = Mod Pathol \| volume = 22 \| issue = 3 \| pages = 410-5 \| month = Mar \| year = 2009 \| doi = 10.1038/modpathol.2008.198 \| PMID = 19136930 }}</ref> and [[dermatopathology]]; however, it is important to note that on a practical level the specific (morphologic/clinical) definitions of ''tumour deposit'' and ''in-transit metastasis'' are different.

	==General==		==General==

Michael at 16:56, 10 August 2016

2016-08-10T16:56:16Z

← Older revision		Revision as of 16:56, 10 August 2016
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	A '''tumour deposit''' is a microscopic or macroscopic tumour nodule in the lymphatic drainage bed of the (primary) tumour. The term is applied in [[colorectal adenocarcinoma]] and has also been described in [[gastric cancer]].<ref name=pmid23184289>{{Cite journal \| last1 = Lee \| first1 = HS. \| last2 = Lee \| first2 = HE. \| last3 = Yang \| first3 = HK. \| last4 = Kim \| first4 = WH. \| title = Perigastric tumor deposits in primary gastric cancer: implications for patient prognosis and staging. \| journal = Ann Surg Oncol \| volume = 20 \| issue = 5 \| pages = 1604-13 \| month = May \| year = 2013 \| doi = 10.1245/s10434-012-2692-9 \| PMID = 23184289 }}</ref>		A '''tumour deposit''' is a microscopic or macroscopic tumour nodule in the lymphatic drainage bed of the (primary) tumour. The term is applied in [[colorectal adenocarcinoma]] and has also been described in [[gastric cancer]].<ref name=pmid23184289>{{Cite journal \| last1 = Lee \| first1 = HS. \| last2 = Lee \| first2 = HE. \| last3 = Yang \| first3 = HK. \| last4 = Kim \| first4 = WH. \| title = Perigastric tumor deposits in primary gastric cancer: implications for patient prognosis and staging. \| journal = Ann Surg Oncol \| volume = 20 \| issue = 5 \| pages = 1604-13 \| month = May \| year = 2013 \| doi = 10.1245/s10434-012-2692-9 \| PMID = 23184289 }}</ref>

	It is also known as '''discoutinuous extramural extension''' and '''~~peritumoral~~ deposit'''.		It is also known as '''discoutinuous extramural extension''' and '''peritumoural deposit'''.

	Conceptually, tumour deposits are like the ''[[in-transit metastases]]'' of [[malignant melanoma]]<ref name=pmid19136930>{{Cite journal \| last1 = Puppa \| first1 = G. \| last2 = Ueno \| first2 = H. \| last3 = Kayahara \| first3 = M. \| last4 = Capelli \| first4 = P. \| last5 = Canzonieri \| first5 = V. \| last6 = Colombari \| first6 = R. \| last7 = Maisonneuve \| first7 = P. \| last8 = Pelosi \| first8 = G. \| title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. \| journal = Mod Pathol \| volume = 22 \| issue = 3 \| pages = 410-5 \| month = Mar \| year = 2009 \| doi = 10.1038/modpathol.2008.198 \| PMID = 19136930 }}</ref> and [[dermatopathology]].		Conceptually, tumour deposits are like the ''[[in-transit metastases]]'' of [[malignant melanoma]]<ref name=pmid19136930>{{Cite journal \| last1 = Puppa \| first1 = G. \| last2 = Ueno \| first2 = H. \| last3 = Kayahara \| first3 = M. \| last4 = Capelli \| first4 = P. \| last5 = Canzonieri \| first5 = V. \| last6 = Colombari \| first6 = R. \| last7 = Maisonneuve \| first7 = P. \| last8 = Pelosi \| first8 = G. \| title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. \| journal = Mod Pathol \| volume = 22 \| issue = 3 \| pages = 410-5 \| month = Mar \| year = 2009 \| doi = 10.1038/modpathol.2008.198 \| PMID = 19136930 }}</ref> and [[dermatopathology]].

Michael: /* Staging */

2016-08-10T16:54:41Z

Staging

← Older revision		Revision as of 16:54, 10 August 2016
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	==Staging==		==Staging==
	Staging implications:		Staging implications in [[colorectal cancer]]:
	*Tumour deposits are '''not''' counted as (positive) lymph nodes<ref name=pmid21555695>{{Cite journal \| last1 = Nagtegaal \| first1 = ID. \| last2 = Tot \| first2 = T. \| last3 = Jayne \| first3 = DG. \| last4 = McShane \| first4 = P. \| last5 = Nihlberg \| first5 = A. \| last6 = Marshall \| first6 = HC. \| last7 = Påhlman \| first7 = L. \| last8 = Brown \| first8 = JM. \| last9 = Guillou \| first9 = PJ. \| title = Lymph nodes, tumor deposits, and TNM: are we getting better? \| journal = J Clin Oncol \| volume = 29 \| issue = 18 \| pages = 2487-92 \| month = Jun \| year = 2011 \| doi = 10.1200/JCO.2011.34.6429 \| PMID = 21555695 }}</ref> and in the context of positive lymph nodes do not change the [[Colorectal_cancer_staging#Nodal_stage\|N stage]].		*Tumour deposits are '''not''' counted as (positive) lymph nodes<ref name=pmid21555695>{{Cite journal \| last1 = Nagtegaal \| first1 = ID. \| last2 = Tot \| first2 = T. \| last3 = Jayne \| first3 = DG. \| last4 = McShane \| first4 = P. \| last5 = Nihlberg \| first5 = A. \| last6 = Marshall \| first6 = HC. \| last7 = Påhlman \| first7 = L. \| last8 = Brown \| first8 = JM. \| last9 = Guillou \| first9 = PJ. \| title = Lymph nodes, tumor deposits, and TNM: are we getting better? \| journal = J Clin Oncol \| volume = 29 \| issue = 18 \| pages = 2487-92 \| month = Jun \| year = 2011 \| doi = 10.1200/JCO.2011.34.6429 \| PMID = 21555695 }}</ref> and in the context of positive lymph nodes do not change the [[Colorectal_cancer_staging#Nodal_stage\|N stage]].
	**If no positive lymph nodes are present, the N stage is pN1c.		**If no positive lymph nodes are present, the N stage is pN1c.

Michael at 16:53, 10 August 2016

2016-08-10T16:53:55Z

← Older revision		Revision as of 16:53, 10 August 2016
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	A '''tumour deposit''' is a microscopic or macroscopic tumour nodule in the lymphatic drainage bed of the (primary) tumour.		A '''tumour deposit''' is a microscopic or macroscopic tumour nodule in the lymphatic drainage bed of the (primary) tumour. The term is applied in [[colorectal adenocarcinoma]] and has also been described in [[gastric cancer]].<ref name=pmid23184289>{{Cite journal \| last1 = Lee \| first1 = HS. \| last2 = Lee \| first2 = HE. \| last3 = Yang \| first3 = HK. \| last4 = Kim \| first4 = WH. \| title = Perigastric tumor deposits in primary gastric cancer: implications for patient prognosis and staging. \| journal = Ann Surg Oncol \| volume = 20 \| issue = 5 \| pages = 1604-13 \| month = May \| year = 2013 \| doi = 10.1245/s10434-012-2692-9 \| PMID = 23184289 }}</ref>

	It is also known as '''discoutinuous extramural extension''' and '''peritumoral deposit'''.		It is also known as '''discoutinuous extramural extension''' and '''peritumoral deposit'''.

Michael at 16:51, 10 August 2016

2016-08-10T16:51:51Z

← Older revision		Revision as of 16:51, 10 August 2016
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	==General==		==General==
			Significance:
			*Poor prognosticator.
			**Can be understood as a type of invasive front/border, e.g. ''well-circumscribed border'' versus ''infiltrative border''.<ref name=pmid24112678/>

			==Definition==
	Definition - TNM/AJCC 7th edition:<ref name=pmid21555695/>		Definition - TNM/AJCC 7th edition:<ref name=pmid21555695/>
	*Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour.		*Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour.
Line 13:		Line 18:
	*#Irregular contour.		*#Irregular contour.
	#Round nodules of tumour are considered lymph nodes that are replaced by tumour.		#Round nodules of tumour are considered lymph nodes that are replaced by tumour.

	~~Significance:~~
	*Poor prognosticator.
	**Can be understood as a type of invasive front/border, e.g. ''well-circumscribed border'' versus ''infiltrative border''.<ref name=pmid24112678/>

	~~Staging implications:~~
	*Tumour deposits are '''not''' counted as (positive) lymph nodes<ref name=pmid21555695>{{Cite journal \| last1 = Nagtegaal \| first1 = ID. \| last2 = Tot \| first2 = T. \| last3 = Jayne \| first3 = DG. \| last4 = McShane \| first4 = P. \| last5 = Nihlberg \| first5 = A. \| last6 = Marshall \| first6 = HC. \| last7 = Påhlman \| first7 = L. \| last8 = Brown \| first8 = JM. \| last9 = Guillou \| first9 = PJ. \| title = Lymph nodes, tumor deposits, and TNM: are we getting better? \| journal = J Clin Oncol \| volume = 29 \| issue = 18 \| pages = 2487-92 \| month = Jun \| year = 2011 \| doi = 10.1200/JCO.2011.34.6429 \| PMID = 21555695 }}</ref> and in the context of positive lymph nodes do not change the [[Colorectal_cancer_staging#Nodal_stage\|N stage]].
	**If no positive lymph nodes are present, the N stage is pN1c.
	*The T stage is ''not'' affected by tumour deposits.<ref name=pmid21555695/>

	Notes:		Notes:
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	#>=2 mm from the tumour front.		#>=2 mm from the tumour front.
	#>=2 mm (radially) from the deepest aspect of the muscularis propria, if the tumour is not present in the plane of section.		#>=2 mm (radially) from the deepest aspect of the muscularis propria, if the tumour is not present in the plane of section.

			==Staging==
			Staging implications:
			*Tumour deposits are '''not''' counted as (positive) lymph nodes<ref name=pmid21555695>{{Cite journal \| last1 = Nagtegaal \| first1 = ID. \| last2 = Tot \| first2 = T. \| last3 = Jayne \| first3 = DG. \| last4 = McShane \| first4 = P. \| last5 = Nihlberg \| first5 = A. \| last6 = Marshall \| first6 = HC. \| last7 = Påhlman \| first7 = L. \| last8 = Brown \| first8 = JM. \| last9 = Guillou \| first9 = PJ. \| title = Lymph nodes, tumor deposits, and TNM: are we getting better? \| journal = J Clin Oncol \| volume = 29 \| issue = 18 \| pages = 2487-92 \| month = Jun \| year = 2011 \| doi = 10.1200/JCO.2011.34.6429 \| PMID = 21555695 }}</ref> and in the context of positive lymph nodes do not change the [[Colorectal_cancer_staging#Nodal_stage\|N stage]].
			**If no positive lymph nodes are present, the N stage is pN1c.
			*The T stage is ''not'' affected by tumour deposits.<ref name=pmid21555695/>

	==See also==		==See also==

Michael: split out

2016-08-10T16:50:16Z

split out

← Older revision		Revision as of 16:50, 10 August 2016
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	#~~redirect~~ [[~~Colorectal adenocarcinoma~~#~~Tumour~~ deposits]]		A '''tumour deposit''' is a microscopic or macroscopic tumour nodule in the lymphatic drainage bed of the (primary) tumour.

			It is also known as '''discoutinuous extramural extension''' and '''peritumoral deposit'''.

			Conceptually, tumour deposits are like the ''[[in-transit metastases]]'' of [[malignant melanoma]]<ref name=pmid19136930>{{Cite journal \| last1 = Puppa \| first1 = G. \| last2 = Ueno \| first2 = H. \| last3 = Kayahara \| first3 = M. \| last4 = Capelli \| first4 = P. \| last5 = Canzonieri \| first5 = V. \| last6 = Colombari \| first6 = R. \| last7 = Maisonneuve \| first7 = P. \| last8 = Pelosi \| first8 = G. \| title = Tumor deposits are encountered in advanced colorectal cancer and other adenocarcinomas: an expanded classification with implications for colorectal cancer staging system including a unifying concept of in-transit metastases. \| journal = Mod Pathol \| volume = 22 \| issue = 3 \| pages = 410-5 \| month = Mar \| year = 2009 \| doi = 10.1038/modpathol.2008.198 \| PMID = 19136930 }}</ref> and [[dermatopathology]].

			==General==
			Definition - TNM/AJCC 7th edition:<ref name=pmid21555695/>
			*Microscopic or macroscopic nodule in the lymphatic drainage bed of the tumour.
			**No standardized distance (from tumour) criteria are defined.<ref name=pmid24112678>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Hashiguchi \| first2 = Y. \| last3 = Shimazaki \| first3 = H. \| last4 = Shinto \| first4 = E. \| last5 = Kajiwara \| first5 = Y. \| last6 = Nakanishi \| first6 = K. \| last7 = Kato \| first7 = K. \| last8 = Maekawa \| first8 = K. \| last9 = Nakamura \| first9 = T. \| title = Peritumoral deposits as an adverse prognostic indicator of colorectal cancer. \| journal = Am J Surg \| volume = \| issue = \| pages = \| month = Oct \| year = 2013 \| doi = 10.1016/j.amjsurg.2013.04.009 \| PMID = 24112678 }}</ref>
			*No findings suggestive of it being a lymph node replaced by tumour:
			*#No significant lymphoid tissue.
			*#Irregular contour.
			#Round nodules of tumour are considered lymph nodes that are replaced by tumour.

			Significance:
			*Poor prognosticator.
			**Can be understood as a type of invasive front/border, e.g. ''well-circumscribed border'' versus ''infiltrative border''.<ref name=pmid24112678/>

			Staging implications:
			*Tumour deposits are '''not''' counted as (positive) lymph nodes<ref name=pmid21555695>{{Cite journal \| last1 = Nagtegaal \| first1 = ID. \| last2 = Tot \| first2 = T. \| last3 = Jayne \| first3 = DG. \| last4 = McShane \| first4 = P. \| last5 = Nihlberg \| first5 = A. \| last6 = Marshall \| first6 = HC. \| last7 = Påhlman \| first7 = L. \| last8 = Brown \| first8 = JM. \| last9 = Guillou \| first9 = PJ. \| title = Lymph nodes, tumor deposits, and TNM: are we getting better? \| journal = J Clin Oncol \| volume = 29 \| issue = 18 \| pages = 2487-92 \| month = Jun \| year = 2011 \| doi = 10.1200/JCO.2011.34.6429 \| PMID = 21555695 }}</ref> and in the context of positive lymph nodes do not change the [[Colorectal_cancer_staging#Nodal_stage\|N stage]].
			**If no positive lymph nodes are present, the N stage is pN1c.
			*The T stage is ''not'' affected by tumour deposits.<ref name=pmid21555695/>

			Notes:
			*The definition of ''tumour deposit'' has changed significantly between the TMN/AJCC fifth, sixth and seventh editions.<ref name=pmid21555695/>
			*Lesions that are ''not'' in the drainage bed of tumour are [[Colorectal_cancer_staging#Metastasis_stage\|metastatic disease]], pM1b.
			===Ueno criteria===
			Ueno ''et al.'' propose that a tumour deposit is either:<ref name=pmid24112678/>
			#>=2 mm from the tumour front.
			#>=2 mm (radially) from the deepest aspect of the muscularis propria, if the tumour is not present in the plane of section.

			==See also==
			*[[Colorectal carcinoma]].
			*[[Metastasis]].

			==References==
			{{Reflist\|1}}

			[[Category:Gastrointestinal pathology]]

Michael: redirect

2013-12-20T15:16:49Z

redirect

New page

#redirect [[Colorectal adenocarcinoma#Tumour deposits]]