Tumour budding - Revision history

Michael at 15:50, 25 August 2023

2023-08-25T15:50:39Z

← Older revision		Revision as of 15:50, 25 August 2023
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	*[[Tumour deposits]].		*[[Tumour deposits]].
	*[[Worst pattern of invasion]].		*[[Worst pattern of invasion]].
			*[[Spread through air spaces]].

	==References==		==References==

Michael at 15:46, 20 June 2023

2023-06-20T15:46:48Z

← Older revision		Revision as of 15:46, 20 June 2023
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	*[[In-transit metastasis]].		*[[In-transit metastasis]].
	*[[Tumour deposits]].		*[[Tumour deposits]].
			*[[Worst pattern of invasion]].

	==References==		==References==

Michael: /* Microscopic */ mucinous

2022-10-27T14:45:30Z

Microscopic: mucinous

← Older revision		Revision as of 14:45, 27 October 2022
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	*Microscopes with a 22 mm eye pieces typically have a 0.2376 mmmm field area with the 40x objective; thus, three fields is 0.7128 mm*mm.		*Microscopes with a 22 mm eye pieces typically have a 0.2376 mmmm field area with the 40x objective; thus, three fields is 0.7128 mm*mm.
	**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>		**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>
			*"Tumour buds suspended in pools of mucin should not be counted" as per the consensus.<ref name=pmid28548122/>

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Michael: /* Sign out */ fix typo

2019-08-09T18:40:19Z

Sign out: fix typo

← Older revision		Revision as of 18:40, 9 August 2019
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	</pre>		</pre>
	<pre>		<pre>
	There are 5-9 tumour buds/0.785 mm*mm; this tumour has ~~intermediated~~ grade tumour budding.		There are 5-9 tumour buds/0.785 mm*mm; this tumour has intermediate grade tumour budding.
	</pre>		</pre>
	<pre>		<pre>

Michael: /* See also */

2019-05-29T19:15:50Z

Michael: /* Microscopic */

2018-11-29T14:40:04Z

Microscopic

← Older revision		Revision as of 14:40, 29 November 2018
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	Note:		Note:
	*Assessed in a field area of 0.785 mm<sup>2</sup>.<ref name=pmid28548122/>		*Assessed in a field area of 0.785 mm<sup>2</sup>.<ref name=pmid28548122/>
			*Microscopes with a 22 mm eye pieces typically have a 0.2376 mmmm field area with the 40x objective; thus, three fields is 0.7128 mm*mm.
	**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>		**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>

Michael: /* Microscopic */

2017-09-06T16:15:07Z

Microscopic

← Older revision		Revision as of 16:15, 6 September 2017
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	==Microscopic==		==Microscopic==
	Definition - rectal carcinoma:<ref name=pmid28548122>{{Cite journal \| last1 = Lugli \| first1 = A. \| last2 = Kirsch \| first2 = R. \| last3 = Ajioka \| first3 = Y. \| last4 = Bosman \| first4 = F. \| last5 = Cathomas \| first5 = G. \| last6 = Dawson \| first6 = H. \| last7 = El Zimaity \| first7 = H. \| last8 = Fléjou \| first8 = JF. \| last9 = Hansen \| first9 = TP. \| title = Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. \| journal = Mod Pathol \| volume = 30 \| issue = 9 \| pages = 1299-1311 \| month = Sep \| year = 2017 \| doi = 10.1038/modpathol.2017.46 \| PMID = 28548122 }}</ref>		Definition in rectal carcinoma - based on international consensus:<ref name=pmid28548122>{{Cite journal \| last1 = Lugli \| first1 = A. \| last2 = Kirsch \| first2 = R. \| last3 = Ajioka \| first3 = Y. \| last4 = Bosman \| first4 = F. \| last5 = Cathomas \| first5 = G. \| last6 = Dawson \| first6 = H. \| last7 = El Zimaity \| first7 = H. \| last8 = Fléjou \| first8 = JF. \| last9 = Hansen \| first9 = TP. \| title = Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. \| journal = Mod Pathol \| volume = 30 \| issue = 9 \| pages = 1299-1311 \| month = Sep \| year = 2017 \| doi = 10.1038/modpathol.2017.46 \| PMID = 28548122 }}</ref>
	*Tumour bud = 1-4 cell(s) -- at the tumour front.		*Tumour bud = 1-4 cell(s) -- at the tumour front.

Michael: /* Microscopic */

2017-09-06T16:14:23Z

Microscopic

← Older revision		Revision as of 16:14, 6 September 2017
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	Note:		Note:
	*Assessed in a field area of 0.~~385~~ mm<sup>2</sup>.<ref name=pmid28548122/>		*Assessed in a field area of 0.785 mm<sup>2</sup>.<ref name=pmid28548122/>
	**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>		**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>

Michael: /* Microscopic */

2017-09-06T16:14:03Z

Microscopic

← Older revision		Revision as of 16:14, 6 September 2017
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	==Microscopic==		==Microscopic==
	Definition - rectal carcinoma:		Definition - rectal carcinoma:<ref name=pmid28548122>{{Cite journal \| last1 = Lugli \| first1 = A. \| last2 = Kirsch \| first2 = R. \| last3 = Ajioka \| first3 = Y. \| last4 = Bosman \| first4 = F. \| last5 = Cathomas \| first5 = G. \| last6 = Dawson \| first6 = H. \| last7 = El Zimaity \| first7 = H. \| last8 = Fléjou \| first8 = JF. \| last9 = Hansen \| first9 = TP. \| title = Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. \| journal = Mod Pathol \| volume = 30 \| issue = 9 \| pages = 1299-1311 \| month = Sep \| year = 2017 \| doi = 10.1038/modpathol.2017.46 \| PMID = 28548122 }}</ref>
	*Tumour bud = 1-4 cell(s) -- at the tumour front.		*Tumour bud = 1-4 cell(s) -- at the tumour front.
	*"High-grade ~~budding" is~~ >=10 tumour buds ~~in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H~~. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>
			Grading:
			*Low grade: 0-4 tumour buds.
			*Intermediate grade: 5-9 tumour buds.
			*High grade: >=10 tumour buds.

	Note:		Note:
	*~~If the microscope has~~ a ~~22 mm eye piece and...~~		*Assessed in a field area of 0.385 mm<sup>2</sup>.<ref name=pmid28548122/>
	**A 20x objective, the field ~~is approximately~~ 0.~~950~~ mm<sup>2</sup> ~~-- to match the buds/area -- it would be 24~~.~~68 buds/0.950 mm<sup>2~~</~~sup~~>.		**Tumour budding was '''previously''' assessed in a field of 0.385 mm<sup>2</sup>.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>
	**~~A 40x objective, the~~ field ~~is approximately~~ 0.~~238~~ mm<sup>2</sup> -- to ~~match~~ the ~~buds/area -- it would be 6~~.~~17 buds/0.238 mm<sup>~~2</~~sup~~>.

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Michael at 14:27, 24 June 2016

2016-06-24T14:27:24Z

← Older revision		Revision as of 14:27, 24 June 2016
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			[[Image:Tumour budding in colorectal carcinoma - high mag.jpg\|thumb\|Tumour budding in [[colorectal carcinoma]]. [[H&E stain]]. (WC/Nephron)]]
	'''Tumour budding''' refers to lone tumour cells ''or'' small clusters of tumour cells at the advancing front of a tumour.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>		'''Tumour budding''' refers to lone tumour cells ''or'' small clusters of tumour cells at the advancing front of a tumour.<ref name=pmid11952856>{{Cite journal \| last1 = Ueno \| first1 = H. \| last2 = Murphy \| first2 = J. \| last3 = Jass \| first3 = JR. \| last4 = Mochizuki \| first4 = H. \| last5 = Talbot \| first5 = IC. \| title = Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. \| journal = Histopathology \| volume = 40 \| issue = 2 \| pages = 127-32 \| month = Feb \| year = 2002 \| doi = \| PMID = 11952856 }}</ref>

← Older revision		Revision as of 19:15, 29 May 2019
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	Image: Tumour budding in colorectal carcinoma - very high mag.jpg \| Tumour budding in CRC - very high mag. (WC)		Image: Tumour budding in colorectal carcinoma - very high mag.jpg \| Tumour budding in CRC - very high mag. (WC)
	</gallery>		</gallery>

			== Sign out ==
			<pre>
			There are <5 tumour buds/0.785 mm*mm; this tumour has low grade tumour budding.
			</pre>
			<pre>
			There are 5-9 tumour buds/0.785 mm*mm; this tumour has intermediated grade tumour budding.
			</pre>
			<pre>
			There are >=10 tumour buds/0.785 mm*mm; this tumour has high grade tumour budding.
			</pre>
			===Alternate===
			<pre>
			The tumour is NEGATIVE for significant tumour budding (<5 buds/0.785 mm*mm).
			</pre>

	==See also==		==See also==