Tubulocystic carcinoma of the kidney - Revision history

Michael: /* Microscopic */

2017-02-28T18:14:16Z

Microscopic

← Older revision		Revision as of 18:14, 28 February 2017
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	DDx:		DDx:
	*[[Papillary renal cell carcinoma]] (oncocytic variant).		*[[Papillary renal cell carcinoma]] (oncocytic variant).
			*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]].
	*[[Renal oncocytoma]].		*[[Renal oncocytoma]].
	*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].		*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].
	*[[Multilocular cystic renal neoplasm of low malignant potential]] (multilocular cystic renal cell carcinoma).		*[[Multilocular cystic renal neoplasm of low malignant potential]] (multilocular cystic renal cell carcinoma).
	*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]].

	===Images===		===Images===

Michael: /* Microscopic */

2017-02-28T18:14:00Z

Microscopic

← Older revision		Revision as of 18:14, 28 February 2017
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	*[[Renal oncocytoma]].		*[[Renal oncocytoma]].
	*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].		*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]].
	*[[Multilocular cystic renal cell carcinoma]].		*[[Multilocular cystic renal neoplasm of low malignant potential]] (multilocular cystic renal cell carcinoma).
	*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]].		*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]].

Michael at 03:32, 18 November 2015

2015-11-18T03:32:56Z

← Older revision		Revision as of 03:32, 18 November 2015
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	\| Gross = multicystic lesion (bubble wrap-like appearance)		\| Gross = multicystic lesion (bubble wrap-like appearance)
	\| Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]]		\| Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]]
			\| Staging = [[kidney cancer staging]]
	\| Site = [[kidney]]		\| Site = [[kidney]]
	\| Assdx =		\| Assdx =

Michael: /* IHC */

2015-10-31T03:04:09Z

IHC

← Older revision		Revision as of 03:04, 31 October 2015
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	*RCC +ve.		*RCC +ve.
	*Vimentin +ve.		*Vimentin +ve.
	*AMACR +ve.		*[[AMACR]] +ve.
	*CK7 -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal \| last1 = Zhang \| first1 = SH. \| last2 = Shi \| first2 = SF. \| last3 = Huang \| first3 = SF. \| last4 = Zhang \| first4 = YN. \| last5 = Zheng \| first5 = YY. \| last6 = Chen \| first6 = GY. \| title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. \| journal = Zhonghua Bing Li Xue Za Zhi \| volume = 41 \| issue = 8 \| pages = 543-6 \| month = Aug \| year = 2012 \| doi = \| PMID = 23157747 }}</ref>).		*[[CK7]] -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal \| last1 = Zhang \| first1 = SH. \| last2 = Shi \| first2 = SF. \| last3 = Huang \| first3 = SF. \| last4 = Zhang \| first4 = YN. \| last5 = Zheng \| first5 = YY. \| last6 = Chen \| first6 = GY. \| title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. \| journal = Zhonghua Bing Li Xue Za Zhi \| volume = 41 \| issue = 8 \| pages = 543-6 \| month = Aug \| year = 2012 \| doi = \| PMID = 23157747 }}</ref>).

	Notes:		Notes:

Michael at 03:03, 31 October 2015

2015-10-31T03:03:39Z

← Older revision		Revision as of 03:03, 31 October 2015
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	\| Caption = Tubulocystic renal cell carcinoma. [[H&E stain]].		\| Caption = Tubulocystic renal cell carcinoma. [[H&E stain]].
	\| Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma		\| Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma
	\| Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma		\| Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or [[hobnail morphology]], eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[papillary renal cell carcinoma]] - especially oncocytic variant, [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]]		\| LMDDx = [[papillary renal cell carcinoma]] - especially oncocytic variant, [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]]
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	Features:.<ref name=pmid19011562/>		Features:.<ref name=pmid19011562/>
	*Cysts of variable size lined by a single layer of epithelium that has a:		*Cysts of variable size lined by a single layer of epithelium that has a:
	**Cuboidal, flat, or hobnail morphology.		**Cuboidal, flat, or [[hobnail morphology]].
	**Eosinophilic cytoplasm.		**Eosinophilic cytoplasm.
	**Large nuclei with prominent nucleoli.		**Large nuclei with prominent nucleoli.

Michael: /* Images */

2015-07-17T01:28:45Z

Images

← Older revision		Revision as of 01:28, 17 July 2015
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	===Images===		===Images===
			====Case 1====
	<gallery>		<gallery>
	Image: Tubulocystic renal cell carcinoma -- very low mag.jpg \| TC-RCC - very low mag.		Image: Tubulocystic renal cell carcinoma -- very low mag.jpg \| TC-RCC - very low mag.
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	Image: Tubulocystic renal cell carcinoma - alt -- very high mag.jpg \| TC-RCC - very high mag.		Image: Tubulocystic renal cell carcinoma - alt -- very high mag.jpg \| TC-RCC - very high mag.
	</gallery>		</gallery>
			====Case 2====
			<gallery>
			Image: Tubulocystic carcinoma of the kidney -- low mag.jpg \| TC - low mag.
			Image: Tubulocystic carcinoma of the kidney -- intermed mag.jpg \| TC - intermed. mag.
			Image: Tubulocystic carcinoma of the kidney -- high mag.jpg \| TC - high mag.
			Image: Tubulocystic carcinoma of the kidney -- very high mag.jpg \| TC - very high mag.
			</gallery>
			====www====
	*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref>		*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref>
	*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)].		*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)].

Michael: re-order

2015-05-12T17:44:19Z

re-order

← Older revision		Revision as of 17:44, 12 May 2015
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	}}		}}
	'''Tubulocystic carcinoma of the kidney''', abbreviated '''TCCK''', is a very rare [[kidney tumour]].		'''Tubulocystic carcinoma of the kidney''', abbreviated '''TCCK''', is a very rare [[kidney tumour]].

			In the [[Vancouver classification\|Vancouver modification]] of the WHO classification of renal neoplasia, it is refered to as '''tubulocystic renal cell carcinoma''' (abbreviated '''TC-RCC''').<ref name=pmid24025519>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| last3 = Eble \| first3 = JN. \| last4 = Egevad \| first4 = L. \| last5 = Epstein \| first5 = JI. \| last6 = Grignon \| first6 = D. \| last7 = Hes \| first7 = O. \| last8 = Moch \| first8 = H. \| last9 = Montironi \| first9 = R. \| title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 10 \| pages = 1469-89 \| month = Oct \| year = 2013 \| doi = 10.1097/PAS.0b013e318299f2d1 \| PMID = 24025519 }}</ref>

	It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal \| last1 = Amin \| first1 = MB. \| last2 = MacLennan \| first2 = GT. \| last3 = Gupta \| first3 = R. \| last4 = Grignon \| first4 = D. \| last5 = Paraf \| first5 = F. \| last6 = Vieillefond \| first6 = A. \| last7 = Paner \| first7 = GP. \| last8 = Stovsky \| first8 = M. \| last9 = Young \| first9 = AN. \| title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 3 \| pages = 384-92 \| month = Mar \| year = 2009 \| doi = 10.1097/PAS.0b013e3181872d3f \| PMID = 19011562 }}</ref>		It is also known as '''low-grade collecting duct carcinoma'''.<ref name=pmid19011562 >{{Cite journal \| last1 = Amin \| first1 = MB. \| last2 = MacLennan \| first2 = GT. \| last3 = Gupta \| first3 = R. \| last4 = Grignon \| first4 = D. \| last5 = Paraf \| first5 = F. \| last6 = Vieillefond \| first6 = A. \| last7 = Paner \| first7 = GP. \| last8 = Stovsky \| first8 = M. \| last9 = Young \| first9 = AN. \| title = Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. \| journal = Am J Surg Pathol \| volume = 33 \| issue = 3 \| pages = 384-92 \| month = Mar \| year = 2009 \| doi = 10.1097/PAS.0b013e3181872d3f \| PMID = 19011562 }}</ref>

	In the [[Vancouver classification\|Vancouver modification]] of the WHO classification of renal neoplasia, it is refered to as '''tubulocystic renal cell carcinoma''' (abbreviated '''TC-RCC''').<ref name=pmid24025519>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| last3 = Eble \| first3 = JN. \| last4 = Egevad \| first4 = L. \| last5 = Epstein \| first5 = JI. \| last6 = Grignon \| first6 = D. \| last7 = Hes \| first7 = O. \| last8 = Moch \| first8 = H. \| last9 = Montironi \| first9 = R. \| title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 10 \| pages = 1469-89 \| month = Oct \| year = 2013 \| doi = 10.1097/PAS.0b013e318299f2d1 \| PMID = 24025519 }}</ref>

	It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours\|renal tumour]].		It should '''not''' be confused with ''[[collecting duct carcinoma]]'', a very aggressive [[renal tumours\|renal tumour]].

Michael: /* IHC */

2015-03-05T21:06:40Z

IHC

← Older revision		Revision as of 21:06, 5 March 2015
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	*AMACR +ve.		*AMACR +ve.
	*CK7 -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal \| last1 = Zhang \| first1 = SH. \| last2 = Shi \| first2 = SF. \| last3 = Huang \| first3 = SF. \| last4 = Zhang \| first4 = YN. \| last5 = Zheng \| first5 = YY. \| last6 = Chen \| first6 = GY. \| title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. \| journal = Zhonghua Bing Li Xue Za Zhi \| volume = 41 \| issue = 8 \| pages = 543-6 \| month = Aug \| year = 2012 \| doi = \| PMID = 23157747 }}</ref>).		*CK7 -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal \| last1 = Zhang \| first1 = SH. \| last2 = Shi \| first2 = SF. \| last3 = Huang \| first3 = SF. \| last4 = Zhang \| first4 = YN. \| last5 = Zheng \| first5 = YY. \| last6 = Chen \| first6 = GY. \| title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. \| journal = Zhonghua Bing Li Xue Za Zhi \| volume = 41 \| issue = 8 \| pages = 543-6 \| month = Aug \| year = 2012 \| doi = \| PMID = 23157747 }}</ref>).

			Notes:
			*IHC profile essentially that of [[PaRCC]].{{fact}}

	==See also==		==See also==

Michael at 21:05, 5 March 2015

2015-03-05T21:05:09Z

← Older revision		Revision as of 21:05, 5 March 2015
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	\| IF =		\| IF =
	\| Gross = multicystic lesion (bubble wrap-like appearance)		\| Gross = multicystic lesion (bubble wrap-like appearance)
	\| Grossing =		\| Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]]
	\| Site = [[kidney]]		\| Site = [[kidney]]
	\| Assdx =		\| Assdx =

Michael: +images

2015-02-26T06:15:28Z

+images

← Older revision		Revision as of 06:15, 26 February 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Tubulocystic renal cell carcinoma -- low mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Tubulocystic renal cell carcinoma. [[H&E stain]].
	\| Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma		\| Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma
	\| Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma		\| Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma
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	===Images===		===Images===
			<gallery>
			Image: Tubulocystic renal cell carcinoma -- very low mag.jpg \| TC-RCC - very low mag.
			Image: Tubulocystic renal cell carcinoma -- low mag.jpg \| TC-RCC - low mag.
			Image: Tubulocystic renal cell carcinoma -- intermed mag.jpg \| TC-RCC - intermed. mag.
			Image: Tubulocystic renal cell carcinoma -- high mag.jpg \| TC-RCC - high mag.
			Image: Tubulocystic renal cell carcinoma -- very high mag.jpg \| TC-RCC - very high mag.

			Image: Tubulocystic renal cell carcinoma - alt -- low mag.jpg \| TC-RCC - low mag.
			Image: Tubulocystic renal cell carcinoma - alt -- intermed mag.jpg \| TC-RCC - intermed. mag.
			Image: Tubulocystic renal cell carcinoma - alt -- high mag.jpg \| TC-RCC - high mag.
			Image: Tubulocystic renal cell carcinoma - alt -- very high mag.jpg \| TC-RCC - very high mag.
			</gallery>
	*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref>		*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref>
	*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)].		*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)].