Traditional adenoma - Revision history

Michael at 06:33, 19 March 2018

2018-03-19T06:33:35Z

← Older revision		Revision as of 06:33, 19 March 2018
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	\| Micro = nuclear changes - esp. at the surface (hyperchromatic elongated nuclei or round cleared nuclei), nuclear crowding/pseudostratification, +/- loss of nuclear polarity, loss/decrease of goblet cells, cytoplasmic hyperchromasia		\| Micro = nuclear changes - esp. at the surface (hyperchromatic elongated nuclei or round cleared nuclei), nuclear crowding/pseudostratification, +/- loss of nuclear polarity, loss/decrease of goblet cells, cytoplasmic hyperchromasia
	\| Subtypes = [[tubular adenoma]], [[villous adenoma]], [[tubulovillous adenoma]]		\| Subtypes = [[tubular adenoma]], [[villous adenoma]], [[tubulovillous adenoma]]
	\| LMDDx = [[sessile serrated adenoma]] with dysplasia, [[gastrointestinal polyps]]		\| LMDDx = [[sessile serrated adenoma]] with dysplasia, reactive changes in other [[gastrointestinal polyps]], invasive adenocarcinoma, adenoma-like adenocarcinoma
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =

2018-03-19T06:32:27Z

Microscopic

← Older revision		Revision as of 06:32, 19 March 2018
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	***The base is more mature (more globlet cells, no nuclear changes -- less blue).		***The base is more mature (more globlet cells, no nuclear changes -- less blue).
	*[[Ampullary adenoma]]s often have less prominent pseudostratification and fine chromatin.		*[[Ampullary adenoma]]s often have less prominent pseudostratification and fine chromatin.

			DDx:
			*Reactive changes due to inflammation.
			*Invasive adenocarcinoma.
			**Adenoma-like adenocarcinoma.<ref name=pmid25913616>{{Cite journal \| last1 = Gonzalez \| first1 = RS. \| last2 = Cates \| first2 = JM. \| last3 = Washington \| first3 = MK. \| last4 = Beauchamp \| first4 = RD. \| last5 = Coffey \| first5 = RJ. \| last6 = Shi \| first6 = C. \| title = Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation. \| journal = Histopathology \| volume = 68 \| issue = 2 \| pages = 183-90 \| month = Jan \| year = 2016 \| doi = 10.1111/his.12725 \| PMID = 25913616 }}</ref>

	===Images===		===Images===

2017-11-02T12:54:15Z

Tubular adenoma with focal high-grade dysplasia

← Older revision		Revision as of 12:54, 2 November 2017
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	Note:		Note:
	*"Focal" is something that should prompt review~~, as~~ the management turns on high grade versus low grade.		*"Focal" is something that should prompt review; the management decision often turns on high grade versus low grade.

	===Tubular adenoma with high-grade dysplasia===		===Tubular adenoma with high-grade dysplasia===

2017-11-02T12:52:19Z

Tubular adenoma with focal high-grade dysplasia

← Older revision		Revision as of 12:52, 2 November 2017
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	<pre>		<pre>
	POLYP, TRANSVERSE COLON, BIOPSY:		POLYP, TRANSVERSE COLON, BIOPSY:
	- TUBULAR ADENOMA WITH FOCAL HIGH-GRADE DYSPLASIA.		- TUBULAR ADENOMA WITH FOCAL HIGH-GRADE DYSPLASIA, MARGINS CLEAR, SEE COMMENT.

			COMMENT:
			The case was partially reviewed internally by Dr. Pathology and there is agreement high-grade dysplasia is focally present.
	</pre>		</pre>

			Note:
			*"Focal" is something that should prompt review, as the management turns on high grade versus low grade.

	===Tubular adenoma with high-grade dysplasia===		===Tubular adenoma with high-grade dysplasia===

2017-11-02T12:49:29Z

Tubular adenoma with high-grade dysplasia

← Older revision		Revision as of 12:49, 2 November 2017
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	<pre>		<pre>
	POLYP, SIGMOID COLON, BIOPSY:		POLYP, SIGMOID COLON, BIOPSY:
	- TUBULAR ADENOMA WITH HIGH-GRADE DYSPLASIA.		- TUBULAR ADENOMA WITH HIGH-GRADE DYSPLASIA, MARGINS CLEAR.
	</pre>		</pre>

2016-06-07T21:55:54Z

Tubular-tubulovillous interface

← Older revision		Revision as of 21:55, 7 June 2016
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	A small number of rare finger-like epithelial projections (villi) are noted; however these appear to comprise less than 20% of the sampled tissue. It is possible that the villous component is higher or lower due to sampling.		A small number of rare finger-like epithelial projections (villi) are noted; however these appear to comprise less than 20% of the sampled tissue. It is possible that the villous component is higher or lower due to sampling.

	=====Abbreviated version=====		=====Abbreviated version 1=====
	The sections shows colorectal-type mucosa with a tubule-forming epithelium that has		The sections shows colorectal-type mucosa with a tubule-forming epithelium that has
	cellular pseudostratification and enlarged hyperchromatic nuclei, from the crypt base to		cellular pseudostratification and enlarged hyperchromatic nuclei, from the crypt base to
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	A small number of finger-like epithelial projections (villi) are noted; however, these		A small number of finger-like epithelial projections (villi) are noted; however, these
	appear to comprise less than 20% of the sampled tissue.		appear to comprise less than 20% of the sampled tissue.

			=====Abbreviated version 2=====
			A number of finger-like epithelial projections (villi) are noted; however, these appear to comprise less than 25% of the adenomatous tissue seen in section.

	=====More abbreviated=====		=====More abbreviated=====

2016-04-01T19:52:56Z

Tubular adenoma - negative for high-grade

← Older revision		Revision as of 19:52, 1 April 2016
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	</pre>		</pre>

			<pre>
			Polyp, Rectum, Polypectomy:
			- Tubular adenoma.
			-- NEGATIVE for high-grade dysplasia.
			</pre>

			====Block letters====
	<pre>		<pre>
	POLYP, RECTUM, POLYPECTOMY:		POLYP, RECTUM, POLYPECTOMY:

2016-02-13T15:51:20Z

← Older revision		Revision as of 15:51, 13 February 2016
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	\| Other =		\| Other =
	\| ClinDDx = invasive [[colorectal adenocarcinoma]], [[Normal_colorectal_mucosa\|benign colorectal mucosa]], [[hyperplastic polyp]], other [[gastrointestinal tract polyps]]		\| ClinDDx = invasive [[colorectal adenocarcinoma]], [[Normal_colorectal_mucosa\|benign colorectal mucosa]], [[hyperplastic polyp]], other [[gastrointestinal tract polyps]]
	\| Tx = usually endoscopic resection		\| Tx = usually endoscopic resection ([[polypectomy]])
	}}		}}
	{{ Infobox external links		{{ Infobox external links

2016-01-11T03:00:52Z

Images

← Older revision		Revision as of 03:00, 11 January 2016
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	Image:Tubular_adenoma_2_intermed_mag.jpg\| Tubular adenoma - intermed. mag. (WC/Nephron).		Image:Tubular_adenoma_2_intermed_mag.jpg\| Tubular adenoma - intermed. mag. (WC/Nephron).
	Image:Tubulovillous_adenoma.jpg\| Tubulovillous adenoma (WC/Nephron).		Image:Tubulovillous_adenoma.jpg\| Tubulovillous adenoma (WC/Nephron).
			Image: Tubular adenoma - ase -- low mag.jpg \| TA - low mag. (WC/Nephron)
			Image: Tubular adenoma - ase -- intermed mag.jpg \| TA - intermed. mag. (WC/Nephron)
	</gallery>		</gallery>

2015-12-03T16:33:53Z

Tubulovillous adenoma - negative for high-grade

← Older revision		Revision as of 16:33, 3 December 2015
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	===Tubulovillous adenoma - negative for high-grade===		===Tubulovillous adenoma - negative for high-grade===
	</pre>		<pre>
	Polyp, Sigmoid Colon at 30 cm, Biopsy:		Polyp, Sigmoid Colon at 30 cm, Biopsy:
	- Fragments of tubulovillous adenoma.		- Fragments of tubulovillous adenoma.