Total nephrectomy for tumour grossing - Revision history

Michael at 15:16, 22 October 2024

2024-10-22T15:16:03Z

← Older revision		Revision as of 15:16, 22 October 2024
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	[[Image:Renal oncocytoma.jpg\|right\|thumb\|A kidney tumour ([[renal oncocytoma]]) at the time of grossing.]]		[[Image:Renal oncocytoma.jpg\|right\|thumb\|A kidney tumour ([[renal oncocytoma]]) at the time of grossing.]]
	This article deals with the [[cut-up]] of '''total nephrectomy for tumour''' specimens. It also includes '''radical nephrectomy''' with or without an adrenal gland.		This article deals with the [[cut-up]] of '''total [[nephrectomy]] for tumour''' specimens. It also includes '''radical nephrectomy''' with or without an adrenal gland.

	''[[Partial nephrectomy]]'' specimens and ''[[nephroureterectomy]]'' specimens are dealt with separately.		''[[Partial nephrectomy]]'' specimens and ''[[nephroureterectomy]]'' specimens are dealt with separately.

Michael at 15:08, 22 October 2024

2024-10-22T15:08:54Z

← Older revision		Revision as of 15:08, 22 October 2024
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	Resections for tumours generally are ''radical nephrectomies'' or ''partial nephrectomies''.		Resections for tumours generally are ''radical nephrectomies'' or ''partial nephrectomies''.

			Nephrectomies without tumour are uncommon; thus, it is pertinent negative if a tumour does not have an identifiable tumour.

	==Specimen opening==		==Specimen opening==

Michael: /* Protocol notes */

2017-07-06T16:21:41Z

Protocol notes

← Older revision		Revision as of 16:21, 6 July 2017
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	*[[Kidney cancer staging\|Kidney tumour stage]] size cut points: <=4 cm, <=7 cm.		*[[Kidney cancer staging\|Kidney tumour stage]] size cut points: <=4 cm, <=7 cm.
	**The 7th edition of the [[TNM staging system]] divides pT2 into pT2a (>7 cm and <=10 cm) and pT2b (>10 cm); however, evidence does not support this subdivision.<ref name=pmid21030143>{{Cite journal \| last1 = Waalkes \| first1 = S. \| last2 = Becker \| first2 = F. \| last3 = Schrader \| first3 = AJ. \| last4 = Janssen \| first4 = M. \| last5 = Wegener \| first5 = G. \| last6 = Merseburger \| first6 = AS. \| last7 = Schrader \| first7 = M. \| last8 = Hofmann \| first8 = R. \| last9 = Stöckle \| first9 = M. \| title = Is there a need to further subclassify pT2 renal cell cancers as implemented by the revised 7th TNM version? \| journal = Eur Urol \| volume = 59 \| issue = 2 \| pages = 258-63 \| month = Feb \| year = 2011 \| doi = 10.1016/j.eururo.2010.10.005 \| PMID = 21030143 }}</ref>		**The 7th edition of the [[TNM staging system]] divides pT2 into pT2a (>7 cm and <=10 cm) and pT2b (>10 cm); however, evidence does not support this subdivision.<ref name=pmid21030143>{{Cite journal \| last1 = Waalkes \| first1 = S. \| last2 = Becker \| first2 = F. \| last3 = Schrader \| first3 = AJ. \| last4 = Janssen \| first4 = M. \| last5 = Wegener \| first5 = G. \| last6 = Merseburger \| first6 = AS. \| last7 = Schrader \| first7 = M. \| last8 = Hofmann \| first8 = R. \| last9 = Stöckle \| first9 = M. \| title = Is there a need to further subclassify pT2 renal cell cancers as implemented by the revised 7th TNM version? \| journal = Eur Urol \| volume = 59 \| issue = 2 \| pages = 258-63 \| month = Feb \| year = 2011 \| doi = 10.1016/j.eururo.2010.10.005 \| PMID = 21030143 }}</ref>
	*‡ It is important to sample the renal vein wall if tumour thrombus projecting out of the renal vein, as a positive margin is called based on microscopic involvement of/adherence to the vein wall.<ref name=pmid24025521>{{Cite journal \| last1 = Trpkov \| first1 = K. \| last2 = Grignon \| first2 = DJ. \| last3 = Bonsib \| first3 = SM. \| last4 = Amin \| first4 = MB. \| last5 = Billis \| first5 = A. \| last6 = Lopez-Beltran \| first6 = A. \| last7 = Samaratunga \| first7 = H. \| last8 = Tamboli \| first8 = P. \| last9 = Delahunt \| first9 = B. \| title = Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 10 \| pages = 1505-17 \| month = Oct \| year = 2013 \| doi = 10.1097/PAS.0b013e31829a85d0 \| PMID = 24025521 }}</ref>		*‡ It is important to sample the renal vein wall if tumour thrombus is projecting out of the renal vein, as a positive margin is called based on microscopic involvement of the vein or tumour adherence to the vein wall at microscopy.<ref name=pmid24025521>{{Cite journal \| last1 = Trpkov \| first1 = K. \| last2 = Grignon \| first2 = DJ. \| last3 = Bonsib \| first3 = SM. \| last4 = Amin \| first4 = MB. \| last5 = Billis \| first5 = A. \| last6 = Lopez-Beltran \| first6 = A. \| last7 = Samaratunga \| first7 = H. \| last8 = Tamboli \| first8 = P. \| last9 = Delahunt \| first9 = B. \| title = Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 10 \| pages = 1505-17 \| month = Oct \| year = 2013 \| doi = 10.1097/PAS.0b013e31829a85d0 \| PMID = 24025521 }}</ref>
	**Tumour projecting out of the vein (i.e. at the surface of specimen), at the time of grossing, is presumed to be due to retraction of the vein after it is cut.		**Tumour projecting out of the vein (i.e. at the surface of specimen), at the time of grossing, is presumed to be due to retraction of the vein after it is cut.
	*† If fat invasion obvious = 1 section.		*† If fat invasion obvious = 1 section.

Michael: /* Introduction */

2017-06-23T16:13:28Z

Introduction

← Older revision		Revision as of 16:13, 23 June 2017
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	*Radical nephrectomy - includes Gerota's fascia.		*Radical nephrectomy - includes Gerota's fascia.
	**Gerota's fascia is the fascia overlying the perinephric fat.		**Gerota's fascia is the fascia overlying the perinephric fat.
	**''Radical ~~nephrecomty~~'' by definition does ''not'' require removal of the [[adrenal gland]].<ref name=pmid26425218>{{Cite journal \| last1 = Nason \| first1 = GJ. \| last2 = Walsh \| first2 = LG. \| last3 = Redmond \| first3 = CE. \| last4 = Kelly \| first4 = NP. \| last5 = McGuire \| first5 = BB. \| last6 = Sharma \| first6 = V. \| last7 = Kelly \| first7 = ME. \| last8 = Galvin \| first8 = DJ. \| last9 = Mulvin \| first9 = DW. \| title = Comparative effectiveness of adrenal sparing radical nephrectomy and non-adrenal sparing radical nephrectomy in clear cell renal cell carcinoma: Observational study of survival outcomes. \| journal = Can Urol Assoc J \| volume = 9 \| issue = 9-10 \| pages = E583-8 \| month = \| year = \| doi = 10.5489/cuaj.2842 \| PMID = 26425218 }}</ref><ref name=pmid23039377>{{Cite journal \| last1 = Yap \| first1 = SA. \| last2 = Alibhai \| first2 = SM. \| last3 = Abouassaly \| first3 = R. \| last4 = Timilshina \| first4 = N. \| last5 = Margel \| first5 = D. \| last6 = Finelli \| first6 = A. \| title = Ipsilateral adrenalectomy at the time of radical nephrectomy impacts overall survival. \| journal = BJU Int \| volume = 111 \| issue = 3 Pt B \| pages = E54-8 \| month = Mar \| year = 2013 \| doi = 10.1111/j.1464-410X.2012.11435.x \| PMID = 23039377 }}</ref>		**''Radical nephrectomy'' by definition does ''not'' require removal of the [[adrenal gland]].<ref name=pmid26425218>{{Cite journal \| last1 = Nason \| first1 = GJ. \| last2 = Walsh \| first2 = LG. \| last3 = Redmond \| first3 = CE. \| last4 = Kelly \| first4 = NP. \| last5 = McGuire \| first5 = BB. \| last6 = Sharma \| first6 = V. \| last7 = Kelly \| first7 = ME. \| last8 = Galvin \| first8 = DJ. \| last9 = Mulvin \| first9 = DW. \| title = Comparative effectiveness of adrenal sparing radical nephrectomy and non-adrenal sparing radical nephrectomy in clear cell renal cell carcinoma: Observational study of survival outcomes. \| journal = Can Urol Assoc J \| volume = 9 \| issue = 9-10 \| pages = E583-8 \| month = \| year = \| doi = 10.5489/cuaj.2842 \| PMID = 26425218 }}</ref><ref name=pmid23039377>{{Cite journal \| last1 = Yap \| first1 = SA. \| last2 = Alibhai \| first2 = SM. \| last3 = Abouassaly \| first3 = R. \| last4 = Timilshina \| first4 = N. \| last5 = Margel \| first5 = D. \| last6 = Finelli \| first6 = A. \| title = Ipsilateral adrenalectomy at the time of radical nephrectomy impacts overall survival. \| journal = BJU Int \| volume = 111 \| issue = 3 Pt B \| pages = E54-8 \| month = Mar \| year = 2013 \| doi = 10.1111/j.1464-410X.2012.11435.x \| PMID = 23039377 }}</ref>

	Resections for tumours generally are ''radical nephrectomies'' or ''partial nephrectomies''.		Resections for tumours generally are ''radical nephrectomies'' or ''partial nephrectomies''.

Michael: /* Introduction */

2017-06-23T16:12:38Z

Introduction

← Older revision		Revision as of 16:12, 23 June 2017
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	*Radical nephrectomy - includes Gerota's fascia.		*Radical nephrectomy - includes Gerota's fascia.
	**Gerota's fascia is the fascia overlying the perinephric fat.		**Gerota's fascia is the fascia overlying the perinephric fat.
			**''Radical nephrecomty'' by definition does ''not'' require removal of the [[adrenal gland]].<ref name=pmid26425218>{{Cite journal \| last1 = Nason \| first1 = GJ. \| last2 = Walsh \| first2 = LG. \| last3 = Redmond \| first3 = CE. \| last4 = Kelly \| first4 = NP. \| last5 = McGuire \| first5 = BB. \| last6 = Sharma \| first6 = V. \| last7 = Kelly \| first7 = ME. \| last8 = Galvin \| first8 = DJ. \| last9 = Mulvin \| first9 = DW. \| title = Comparative effectiveness of adrenal sparing radical nephrectomy and non-adrenal sparing radical nephrectomy in clear cell renal cell carcinoma: Observational study of survival outcomes. \| journal = Can Urol Assoc J \| volume = 9 \| issue = 9-10 \| pages = E583-8 \| month = \| year = \| doi = 10.5489/cuaj.2842 \| PMID = 26425218 }}</ref><ref name=pmid23039377>{{Cite journal \| last1 = Yap \| first1 = SA. \| last2 = Alibhai \| first2 = SM. \| last3 = Abouassaly \| first3 = R. \| last4 = Timilshina \| first4 = N. \| last5 = Margel \| first5 = D. \| last6 = Finelli \| first6 = A. \| title = Ipsilateral adrenalectomy at the time of radical nephrectomy impacts overall survival. \| journal = BJU Int \| volume = 111 \| issue = 3 Pt B \| pages = E54-8 \| month = Mar \| year = 2013 \| doi = 10.1111/j.1464-410X.2012.11435.x \| PMID = 23039377 }}</ref>

	Resections for tumours generally are ''radical nephrectomies'' or ''partial nephrectomies''.		Resections for tumours generally are ''radical nephrectomies'' or ''partial nephrectomies''.

Michael at 03:13, 11 October 2016

2016-10-11T03:13:08Z

← Older revision		Revision as of 03:13, 11 October 2016
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	===Opening notes===		===Opening notes===
	*It is reasonable to skip the inking step as if the tumour is at the surface it is usually obvious.		*It is reasonable to skip the [[inking]] step as if the tumour is at the surface it is usually obvious.

	==Protocol==		==Protocol==
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	==See also==		==See also==
	*[[Kidney cancer staging]].		*[[Kidney cancer staging]].
			*[[Marking ink]].
	===Related protocols===		===Related protocols===
	*[[Partial nephrectomy]].		*[[Partial nephrectomy]].

Michael: /* Protocol notes */

2016-02-06T12:52:00Z

Protocol notes

← Older revision		Revision as of 12:52, 6 February 2016
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	===Protocol notes===		===Protocol notes===
	*[[Kidney cancer staging\|~~Tumour~~ stage]] size cut points: <=4 cm, <=7 cm.		*[[Kidney cancer staging\|Kidney tumour stage]] size cut points: <=4 cm, <=7 cm.
	**The 7th edition of the [[TNM staging system]] divides pT2 into pT2a (>7 cm and <=10 cm) and pT2b (>10 cm); however, evidence does not support this subdivision.<ref name=pmid21030143>{{Cite journal \| last1 = Waalkes \| first1 = S. \| last2 = Becker \| first2 = F. \| last3 = Schrader \| first3 = AJ. \| last4 = Janssen \| first4 = M. \| last5 = Wegener \| first5 = G. \| last6 = Merseburger \| first6 = AS. \| last7 = Schrader \| first7 = M. \| last8 = Hofmann \| first8 = R. \| last9 = Stöckle \| first9 = M. \| title = Is there a need to further subclassify pT2 renal cell cancers as implemented by the revised 7th TNM version? \| journal = Eur Urol \| volume = 59 \| issue = 2 \| pages = 258-63 \| month = Feb \| year = 2011 \| doi = 10.1016/j.eururo.2010.10.005 \| PMID = 21030143 }}</ref>		**The 7th edition of the [[TNM staging system]] divides pT2 into pT2a (>7 cm and <=10 cm) and pT2b (>10 cm); however, evidence does not support this subdivision.<ref name=pmid21030143>{{Cite journal \| last1 = Waalkes \| first1 = S. \| last2 = Becker \| first2 = F. \| last3 = Schrader \| first3 = AJ. \| last4 = Janssen \| first4 = M. \| last5 = Wegener \| first5 = G. \| last6 = Merseburger \| first6 = AS. \| last7 = Schrader \| first7 = M. \| last8 = Hofmann \| first8 = R. \| last9 = Stöckle \| first9 = M. \| title = Is there a need to further subclassify pT2 renal cell cancers as implemented by the revised 7th TNM version? \| journal = Eur Urol \| volume = 59 \| issue = 2 \| pages = 258-63 \| month = Feb \| year = 2011 \| doi = 10.1016/j.eururo.2010.10.005 \| PMID = 21030143 }}</ref>
	*‡ It is important to sample the renal vein wall if tumour thrombus projecting out of the renal vein, as a positive margin is called based on microscopic involvement of/adherence to the vein wall.<ref name=pmid24025521>{{Cite journal \| last1 = Trpkov \| first1 = K. \| last2 = Grignon \| first2 = DJ. \| last3 = Bonsib \| first3 = SM. \| last4 = Amin \| first4 = MB. \| last5 = Billis \| first5 = A. \| last6 = Lopez-Beltran \| first6 = A. \| last7 = Samaratunga \| first7 = H. \| last8 = Tamboli \| first8 = P. \| last9 = Delahunt \| first9 = B. \| title = Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 10 \| pages = 1505-17 \| month = Oct \| year = 2013 \| doi = 10.1097/PAS.0b013e31829a85d0 \| PMID = 24025521 }}</ref>		*‡ It is important to sample the renal vein wall if tumour thrombus projecting out of the renal vein, as a positive margin is called based on microscopic involvement of/adherence to the vein wall.<ref name=pmid24025521>{{Cite journal \| last1 = Trpkov \| first1 = K. \| last2 = Grignon \| first2 = DJ. \| last3 = Bonsib \| first3 = SM. \| last4 = Amin \| first4 = MB. \| last5 = Billis \| first5 = A. \| last6 = Lopez-Beltran \| first6 = A. \| last7 = Samaratunga \| first7 = H. \| last8 = Tamboli \| first8 = P. \| last9 = Delahunt \| first9 = B. \| title = Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 10 \| pages = 1505-17 \| month = Oct \| year = 2013 \| doi = 10.1097/PAS.0b013e31829a85d0 \| PMID = 24025521 }}</ref>

Michael: /* See also */

2016-02-05T13:53:30Z

Michael: /* Protocol notes */

2016-02-05T13:45:59Z

Protocol notes

← Older revision		Revision as of 13:45, 5 February 2016
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	===Protocol notes===		===Protocol notes===
	*~~Tumour~~ [[stage]] size cut points: <=4 cm, <=7 cm.		*[[Kidney cancer staging\|Tumour stage]] size cut points: <=4 cm, <=7 cm.
	**The 7th edition of the [[TNM staging system]] divides pT2 into pT2a (>7 cm and <=10 cm) and pT2b (>10 cm); however, evidence does not support this subdivision.<ref name=pmid21030143>{{Cite journal \| last1 = Waalkes \| first1 = S. \| last2 = Becker \| first2 = F. \| last3 = Schrader \| first3 = AJ. \| last4 = Janssen \| first4 = M. \| last5 = Wegener \| first5 = G. \| last6 = Merseburger \| first6 = AS. \| last7 = Schrader \| first7 = M. \| last8 = Hofmann \| first8 = R. \| last9 = Stöckle \| first9 = M. \| title = Is there a need to further subclassify pT2 renal cell cancers as implemented by the revised 7th TNM version? \| journal = Eur Urol \| volume = 59 \| issue = 2 \| pages = 258-63 \| month = Feb \| year = 2011 \| doi = 10.1016/j.eururo.2010.10.005 \| PMID = 21030143 }}</ref>		**The 7th edition of the [[TNM staging system]] divides pT2 into pT2a (>7 cm and <=10 cm) and pT2b (>10 cm); however, evidence does not support this subdivision.<ref name=pmid21030143>{{Cite journal \| last1 = Waalkes \| first1 = S. \| last2 = Becker \| first2 = F. \| last3 = Schrader \| first3 = AJ. \| last4 = Janssen \| first4 = M. \| last5 = Wegener \| first5 = G. \| last6 = Merseburger \| first6 = AS. \| last7 = Schrader \| first7 = M. \| last8 = Hofmann \| first8 = R. \| last9 = Stöckle \| first9 = M. \| title = Is there a need to further subclassify pT2 renal cell cancers as implemented by the revised 7th TNM version? \| journal = Eur Urol \| volume = 59 \| issue = 2 \| pages = 258-63 \| month = Feb \| year = 2011 \| doi = 10.1016/j.eururo.2010.10.005 \| PMID = 21030143 }}</ref>
	*‡ It is important to sample the renal vein wall if tumour thrombus projecting out of the renal vein, as a positive margin is called based on microscopic involvement of/adherence to the vein wall.<ref name=pmid24025521>{{Cite journal \| last1 = Trpkov \| first1 = K. \| last2 = Grignon \| first2 = DJ. \| last3 = Bonsib \| first3 = SM. \| last4 = Amin \| first4 = MB. \| last5 = Billis \| first5 = A. \| last6 = Lopez-Beltran \| first6 = A. \| last7 = Samaratunga \| first7 = H. \| last8 = Tamboli \| first8 = P. \| last9 = Delahunt \| first9 = B. \| title = Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 10 \| pages = 1505-17 \| month = Oct \| year = 2013 \| doi = 10.1097/PAS.0b013e31829a85d0 \| PMID = 24025521 }}</ref>		*‡ It is important to sample the renal vein wall if tumour thrombus projecting out of the renal vein, as a positive margin is called based on microscopic involvement of/adherence to the vein wall.<ref name=pmid24025521>{{Cite journal \| last1 = Trpkov \| first1 = K. \| last2 = Grignon \| first2 = DJ. \| last3 = Bonsib \| first3 = SM. \| last4 = Amin \| first4 = MB. \| last5 = Billis \| first5 = A. \| last6 = Lopez-Beltran \| first6 = A. \| last7 = Samaratunga \| first7 = H. \| last8 = Tamboli \| first8 = P. \| last9 = Delahunt \| first9 = B. \| title = Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 10 \| pages = 1505-17 \| month = Oct \| year = 2013 \| doi = 10.1097/PAS.0b013e31829a85d0 \| PMID = 24025521 }}</ref>

Michael: /* Protocol notes */

2016-01-13T14:47:36Z

Protocol notes

← Older revision		Revision as of 14:47, 13 January 2016
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	*† If fat invasion obvious = 1 section.		*† If fat invasion obvious = 1 section.
	**Suspicion of fat invasion = 3 sections.		**Suspicion of fat invasion = 3 sections.
			***It should be noted that as per Trpkov ''et al.''<ref name=pmid24025521/>: "<nowiki>[A]</nowiki> circumscribed, pushing ... border, even if extending well beyond the normal outline of the renal cortex, is '''not''' <nowiki>[emphasis added]</nowiki> diagnostic of perinephric fat invasion."

	===Alternate approaches===		===Alternate approaches===

← Older revision		Revision as of 13:53, 5 February 2016
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	==See also==		==See also==
			*[[Kidney cancer staging]].
	===Related protocols===		===Related protocols===
	*[[Partial nephrectomy]].		*[[Partial nephrectomy]].
	*[[Nephroureterectomy]].		*[[Nephroureterectomy]].

	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|1}}