Thyroid transcription factor-1 - Revision history

Michael at 20:50, 27 November 2023

2023-11-27T20:50:54Z

← Older revision		Revision as of 20:50, 27 November 2023
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	===Positive staining===		===Positive staining===
	*[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal \| last1 = Yatabe \| first1 = Y. \| last2 = Mitsudomi \| first2 = T. \| last3 = Takahashi \| first3 = T. \| title = TTF-1 expression in pulmonary adenocarcinomas. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 6 \| pages = 767-73 \| month = Jun \| year = 2002 \| doi = \| PMID = 12023581 }}</ref>		*[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal \| last1 = Yatabe \| first1 = Y. \| last2 = Mitsudomi \| first2 = T. \| last3 = Takahashi \| first3 = T. \| title = TTF-1 expression in pulmonary adenocarcinomas. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 6 \| pages = 767-73 \| month = Jun \| year = 2002 \| doi = \| PMID = 12023581 }}</ref>
	**[[Small cell carcinoma of the lung]].		**[[Small cell carcinoma of the lung]] ~ 91% positive (157 +ve of 173<ref name=pmid37139017>{{cite journal \|authors=Sayeda S, Naqvi A, Begum H, Juergens RA, Finley C, Coschi CH, Cutz JC, Bonert M \|title=Prevalence of Thyroid Transcription Factor-1 (TTF-1)-Negative Small Cell Carcinoma and Napsin A Positivity in Small Cell Carcinoma in a Cross-Sectional Study of Lung Core Biopsies \|journal=Cureus \|volume=15 \|issue=4 \|pages=e37015 \|date=April 2023 \|pmid=37139017 \|pmc=10151064 \|doi=10.7759/cureus.37015 \|url=}}</ref>).
	**[[Adenocarcinoma of the lung]].		**[[Adenocarcinoma of the lung]].
	*Thyroid carcinoma.		*Thyroid carcinoma.

Michael at 20:52, 30 October 2023

2023-10-30T20:52:42Z

← Older revision		Revision as of 20:52, 30 October 2023
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	**[[Adenocarcinoma of the lung]].		**[[Adenocarcinoma of the lung]].
	*Thyroid carcinoma.		*Thyroid carcinoma.
	*[[Hepatocellular carcinoma]] (cytoplasmic staining).<ref name=pmid22359993>{{Cite journal \| last1 = Mishra \| first1 = M. \| last2 = Morgan \| first2 = V. \| last3 = Hamati \| first3 = AK. \| last4 = Al-Abbadi \| first4 = M. \| title = Carcinoma of unknown primary: check the liver... thanks to TTF-1. \| journal = Tenn Med \| volume = 105 \| issue = 1 \| pages = 35-6, 40 \| month = Jan \| year = 2012 \| doi = \| PMID = 22359993 }}</ref>		*[[Hepatocellular carcinoma]] (cytoplasmic staining, nuclei negative).<ref name=pmid22359993>{{Cite journal \| last1 = Mishra \| first1 = M. \| last2 = Morgan \| first2 = V. \| last3 = Hamati \| first3 = AK. \| last4 = Al-Abbadi \| first4 = M. \| title = Carcinoma of unknown primary: check the liver... thanks to TTF-1. \| journal = Tenn Med \| volume = 105 \| issue = 1 \| pages = 35-6, 40 \| month = Jan \| year = 2012 \| doi = \| PMID = 22359993 }}</ref>
	* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal \| last1 = Mete \| first1 = O. \| last2 = Lopes \| first2 = MB. \| last3 = Asa \| first3 = SL. \| title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 11 \| pages = 1694-9 \| month = Nov \| year = 2013 \| doi = 10.1097/PAS.0b013e31829723e7 \| PMID = 23887161 }}</ref>		* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal \| last1 = Mete \| first1 = O. \| last2 = Lopes \| first2 = MB. \| last3 = Asa \| first3 = SL. \| title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 11 \| pages = 1694-9 \| month = Nov \| year = 2013 \| doi = 10.1097/PAS.0b013e31829723e7 \| PMID = 23887161 }}</ref>
	*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal \| last1 = Hewer \| first1 = E. \| last2 = Vajtai \| first2 = I. \| title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. \| journal = Clin Neuropathol \| volume = 34 \| issue = 3 \| pages = 128-31 \| month = \| year = \| doi = 10.5414/NP300818 \| PMID = 25669749 }}</ref>		*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal \| last1 = Hewer \| first1 = E. \| last2 = Vajtai \| first2 = I. \| title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. \| journal = Clin Neuropathol \| volume = 34 \| issue = 3 \| pages = 128-31 \| month = \| year = \| doi = 10.5414/NP300818 \| PMID = 25669749 }}</ref>

Michael at 20:51, 30 October 2023

2023-10-30T20:51:50Z

← Older revision		Revision as of 20:51, 30 October 2023
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	===Negative staining===		===Negative staining===
	*[[Squamous cell carcinoma of the lung]].		*[[Squamous cell carcinoma of the lung]].
			*[[SMARCA4-deficient non-small cell carcinoma of the lung]] - typically ~ 5% of [[lung adenocarcinoma]] is TTF-1 negative.
			**These cases are often [[CK7]] positive, [[HepPar-1]] positive.<ref name=pmid28038711>{{Cite journal \| last1 = Herpel \| first1 = E. \| last2 = Rieker \| first2 = RJ. \| last3 = Dienemann \| first3 = H. \| last4 = Muley \| first4 = T. \| last5 = Meister \| first5 = M. \| last6 = Hartmann \| first6 = A. \| last7 = Warth \| first7 = A. \| last8 = Agaimy \| first8 = A. \| title = SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens. \| journal = Ann Diagn Pathol \| volume = 26 \| issue = \| pages = 47-51 \| month = Feb \| year = 2017 \| doi = 10.1016/j.anndiagpath.2016.10.006 \| PMID = 28038711 }}</ref>

	===Images===		===Images===

Jensflorian: /* Negative staining */ image added

2017-04-19T08:59:31Z

Negative staining: image added

← Older revision		Revision as of 08:59, 19 April 2017
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	*[[Squamous cell carcinoma of the lung]].		*[[Squamous cell carcinoma of the lung]].

			===Images===
	<gallery>		<gallery>
	File:Adenocarcinoma-Acinar type TTF1 (5494540752).jpg \| TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen).		File:Adenocarcinoma-Acinar type TTF1 (5494540752).jpg \| TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen).
			File:Pituicytoma TTF1.jpg \| TTF1 in a [[Pituicytoma]] (WC/jensflorian).
	</gallery>		</gallery>

Michael: /* Positive staining */

2015-10-29T04:15:47Z

Positive staining

← Older revision		Revision as of 04:15, 29 October 2015
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	**[[Adenocarcinoma of the lung]].		**[[Adenocarcinoma of the lung]].
	*Thyroid carcinoma.		*Thyroid carcinoma.
	*[[Hepatocellular carcinoma]] (cytoplasmic staining).		*[[Hepatocellular carcinoma]] (cytoplasmic staining).<ref name=pmid22359993>{{Cite journal \| last1 = Mishra \| first1 = M. \| last2 = Morgan \| first2 = V. \| last3 = Hamati \| first3 = AK. \| last4 = Al-Abbadi \| first4 = M. \| title = Carcinoma of unknown primary: check the liver... thanks to TTF-1. \| journal = Tenn Med \| volume = 105 \| issue = 1 \| pages = 35-6, 40 \| month = Jan \| year = 2012 \| doi = \| PMID = 22359993 }}</ref>
	* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal \| last1 = Mete \| first1 = O. \| last2 = Lopes \| first2 = MB. \| last3 = Asa \| first3 = SL. \| title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 11 \| pages = 1694-9 \| month = Nov \| year = 2013 \| doi = 10.1097/PAS.0b013e31829723e7 \| PMID = 23887161 }}</ref>		* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal \| last1 = Mete \| first1 = O. \| last2 = Lopes \| first2 = MB. \| last3 = Asa \| first3 = SL. \| title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 11 \| pages = 1694-9 \| month = Nov \| year = 2013 \| doi = 10.1097/PAS.0b013e31829723e7 \| PMID = 23887161 }}</ref>
	*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal \| last1 = Hewer \| first1 = E. \| last2 = Vajtai \| first2 = I. \| title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. \| journal = Clin Neuropathol \| volume = 34 \| issue = 3 \| pages = 128-31 \| month = \| year = \| doi = 10.5414/NP300818 \| PMID = 25669749 }}</ref>		*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal \| last1 = Hewer \| first1 = E. \| last2 = Vajtai \| first2 = I. \| title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. \| journal = Clin Neuropathol \| volume = 34 \| issue = 3 \| pages = 128-31 \| month = \| year = \| doi = 10.5414/NP300818 \| PMID = 25669749 }}</ref>

Jensflorian: +image

2015-10-08T13:31:26Z

+image

← Older revision		Revision as of 13:31, 8 October 2015
Line 36:		Line 36:
	===Negative staining===		===Negative staining===
	*[[Squamous cell carcinoma of the lung]].		*[[Squamous cell carcinoma of the lung]].

			<gallery>
			File:Adenocarcinoma-Acinar type TTF1 (5494540752).jpg \| TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen).
			</gallery>

	==See also==		==See also==

Jensflorian: /* Positive staining */ SEGA + Oncocytoma

2015-10-05T09:18:39Z

Positive staining: SEGA + Oncocytoma

← Older revision		Revision as of 09:18, 5 October 2015
Line 31:		Line 31:
	*Thyroid carcinoma.		*Thyroid carcinoma.
	*[[Hepatocellular carcinoma]] (cytoplasmic staining).		*[[Hepatocellular carcinoma]] (cytoplasmic staining).
			* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal \| last1 = Mete \| first1 = O. \| last2 = Lopes \| first2 = MB. \| last3 = Asa \| first3 = SL. \| title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. \| journal = Am J Surg Pathol \| volume = 37 \| issue = 11 \| pages = 1694-9 \| month = Nov \| year = 2013 \| doi = 10.1097/PAS.0b013e31829723e7 \| PMID = 23887161 }}</ref>
			*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal \| last1 = Hewer \| first1 = E. \| last2 = Vajtai \| first2 = I. \| title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. \| journal = Clin Neuropathol \| volume = 34 \| issue = 3 \| pages = 128-31 \| month = \| year = \| doi = 10.5414/NP300818 \| PMID = 25669749 }}</ref>

	===Negative staining===		===Negative staining===

Michael: /* Tumours */

2015-10-05T04:53:25Z

Tumours

← Older revision		Revision as of 04:53, 5 October 2015
Line 29:		Line 29:
	**[[Small cell carcinoma of the lung]].		**[[Small cell carcinoma of the lung]].
	**[[Adenocarcinoma of the lung]].		**[[Adenocarcinoma of the lung]].
	*[[Thyroid carcinoma]].		*Thyroid carcinoma.
	*[[Hepatocellular carcinoma]] (cytoplasmic staining).		*[[Hepatocellular carcinoma]] (cytoplasmic staining).

Michael: /* Tumours */

2015-09-25T00:42:53Z

Tumours

← Older revision		Revision as of 00:42, 25 September 2015
Line 25:		Line 25:

	==Tumours==		==Tumours==
			===Positive staining===
	*[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal \| last1 = Yatabe \| first1 = Y. \| last2 = Mitsudomi \| first2 = T. \| last3 = Takahashi \| first3 = T. \| title = TTF-1 expression in pulmonary adenocarcinomas. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 6 \| pages = 767-73 \| month = Jun \| year = 2002 \| doi = \| PMID = 12023581 }}</ref>		*[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal \| last1 = Yatabe \| first1 = Y. \| last2 = Mitsudomi \| first2 = T. \| last3 = Takahashi \| first3 = T. \| title = TTF-1 expression in pulmonary adenocarcinomas. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 6 \| pages = 767-73 \| month = Jun \| year = 2002 \| doi = \| PMID = 12023581 }}</ref>
	*[[Small cell carcinoma of the lung]].		**[[Small cell carcinoma of the lung]].
			**[[Adenocarcinoma of the lung]].
			*[[Thyroid carcinoma]].
			*[[Hepatocellular carcinoma]] (cytoplasmic staining).

	===Negative===		===Negative staining===
	~~Negative staining:~~
	*[[Squamous cell carcinoma of the lung]].		*[[Squamous cell carcinoma of the lung]].

Michael at 00:41, 25 September 2015

2015-09-25T00:41:29Z

← Older revision		Revision as of 00:41, 25 September 2015
Line 1:		Line 1:
	[[Image:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg\|~~thumb\|right\|250px~~\|TTF-1 staining in [[lung adenocarcinoma]].]]		{{ Infobox immunostain
			\| Name = {{PAGENAME}}
			\| Image = Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg
			\| Width =
			\| Caption = TTF-1 staining in [[lung adenocarcinoma]]. (WC)
			\| Abbrev =
			\| Synonyms =
			\| Similar =
			\| Clones =
			\| Use =
			\| Subspecial =
			\| Pattern = nuclear staining
			\| Positive = [[adenocarcinoma of the lung]], [[small cell carcinoma of the lung]], thyroid, [[hepatocellular carcinoma]] (cytoplasmic staining)
			\| Negative = [[squamous cell carcinoma of the lung]]
			\| Other =
			}}
	'''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal \| last1 = Ordóñez \| first1 = NG. \| title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. \| journal = Adv Anat Pathol \| volume = 7 \| issue = 2 \| pages = 123-7 \| month = Mar \| year = 2000 \| doi = \| PMID = 10721419 }}</ref>		'''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal \| last1 = Ordóñez \| first1 = NG. \| title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. \| journal = Adv Anat Pathol \| volume = 7 \| issue = 2 \| pages = 123-7 \| month = Mar \| year = 2000 \| doi = \| PMID = 10721419 }}</ref>

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	==Tumours==		==Tumours==
	*[[Lung adenocarcinoma]].<ref>{{Cite journal \| last1 = Yatabe \| first1 = Y. \| last2 = Mitsudomi \| first2 = T. \| last3 = Takahashi \| first3 = T. \| title = TTF-1 expression in pulmonary adenocarcinomas. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 6 \| pages = 767-73 \| month = Jun \| year = 2002 \| doi = \| PMID = 12023581 }}</ref>		*[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal \| last1 = Yatabe \| first1 = Y. \| last2 = Mitsudomi \| first2 = T. \| last3 = Takahashi \| first3 = T. \| title = TTF-1 expression in pulmonary adenocarcinomas. \| journal = Am J Surg Pathol \| volume = 26 \| issue = 6 \| pages = 767-73 \| month = Jun \| year = 2002 \| doi = \| PMID = 12023581 }}</ref>
	*[[Small cell carcinoma of the lung]].		*[[Small cell carcinoma of the lung]].