Thymus - Revision history

Michael: /* General */

2019-05-06T17:02:34Z

General

← Older revision		Revision as of 17:02, 6 May 2019
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	*One of two ''[[primary lymphoid organs]]'' - the other one is the [[bone marrow]].<ref>URL: [http://www.life.umd.edu/classroom/bsci423/song/Lab1.html http://www.life.umd.edu/classroom/bsci423/song/Lab1.html]. Accessed on: 28 March 2012.</ref>		*One of two ''[[primary lymphoid organs]]'' - the other one is the [[bone marrow]].<ref>URL: [http://www.life.umd.edu/classroom/bsci423/song/Lab1.html http://www.life.umd.edu/classroom/bsci423/song/Lab1.html]. Accessed on: 28 March 2012.</ref>
	*Thymus involutes after childhood.		*Thymus involutes after childhood.
	**The line between ''thymoma'' and ''persistent normal thymus in the adult'' is not well-defined in the radiologic context.<ref name=pmid25925358>{{Cite journal \| last1 = Araki \| first1 = T. \| last2 = Nishino \| first2 = M. \| last3 = Gao \| first3 = W. \| last4 = Dupuis \| first4 = J. \| last5 = Hunninghake \| first5 = GM. \| last6 = Murakami \| first6 = T. \| last7 = Washko \| first7 = GR. \| last8 = O'Connor \| first8 = GT. \| last9 = Hatabu \| first9 = H. \| title = Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking. \| journal = Eur Radiol \| volume = 26 \| issue = 1 \| pages = 15-24 \| month = Jan \| year = 2016 \| doi = 10.1007/s00330-015-3796-y \| PMID = 25925358 }}</ref>		**The line between ''[[thymoma]]'' and ''persistent normal thymus in the adult'' is not well-defined in the radiologic context.<ref name=pmid25925358>{{Cite journal \| last1 = Araki \| first1 = T. \| last2 = Nishino \| first2 = M. \| last3 = Gao \| first3 = W. \| last4 = Dupuis \| first4 = J. \| last5 = Hunninghake \| first5 = GM. \| last6 = Murakami \| first6 = T. \| last7 = Washko \| first7 = GR. \| last8 = O'Connor \| first8 = GT. \| last9 = Hatabu \| first9 = H. \| title = Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking. \| journal = Eur Radiol \| volume = 26 \| issue = 1 \| pages = 15-24 \| month = Jan \| year = 2016 \| doi = 10.1007/s00330-015-3796-y \| PMID = 25925358 }}</ref>
	*May be absent due to genetic abnormalities, e.g. [[DiGeorge syndrome]].		*May be absent due to genetic abnormalities, e.g. [[DiGeorge syndrome]].

Michael: /* General */

2019-05-06T17:02:19Z

General

← Older revision		Revision as of 17:02, 6 May 2019
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	*One of two ''[[primary lymphoid organs]]'' - the other one is the [[bone marrow]].<ref>URL: [http://www.life.umd.edu/classroom/bsci423/song/Lab1.html http://www.life.umd.edu/classroom/bsci423/song/Lab1.html]. Accessed on: 28 March 2012.</ref>		*One of two ''[[primary lymphoid organs]]'' - the other one is the [[bone marrow]].<ref>URL: [http://www.life.umd.edu/classroom/bsci423/song/Lab1.html http://www.life.umd.edu/classroom/bsci423/song/Lab1.html]. Accessed on: 28 March 2012.</ref>
	*Thymus involutes after childhood.		*Thymus involutes after childhood.
			**The line between ''thymoma'' and ''persistent normal thymus in the adult'' is not well-defined in the radiologic context.<ref name=pmid25925358>{{Cite journal \| last1 = Araki \| first1 = T. \| last2 = Nishino \| first2 = M. \| last3 = Gao \| first3 = W. \| last4 = Dupuis \| first4 = J. \| last5 = Hunninghake \| first5 = GM. \| last6 = Murakami \| first6 = T. \| last7 = Washko \| first7 = GR. \| last8 = O'Connor \| first8 = GT. \| last9 = Hatabu \| first9 = H. \| title = Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking. \| journal = Eur Radiol \| volume = 26 \| issue = 1 \| pages = 15-24 \| month = Jan \| year = 2016 \| doi = 10.1007/s00330-015-3796-y \| PMID = 25925358 }}</ref>
	*May be absent due to genetic abnormalities, e.g. [[DiGeorge syndrome]].		*May be absent due to genetic abnormalities, e.g. [[DiGeorge syndrome]].

Michael at 16:55, 14 October 2018

2018-10-14T16:55:54Z

← Older revision		Revision as of 16:55, 14 October 2018
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	[[Image:Thymic corpuscle.jpg\|thumb\|right\|225px\|[[Micrograph]] of a thymic corpusle (Hassall's corpusle). [[H&E stain]].]]		[[Image:Thymic corpuscle.jpg\|thumb\|right\|225px\|[[Micrograph]] of a thymic corpusle (Hassall's corpusle). [[H&E stain]].]]
	'''Thymus''' is ~~an annoying~~ little organ that is in the [[mediastinum]]. It is often removed in pediatric cardiac surgery 'cause it is in the way. In adults, it is commonly removed 'cause the patient has myasthenia gravis.		'''Thymus''' is a little organ that is in the [[mediastinum]]. It is often removed in pediatric cardiac surgery 'cause it is in the way. In adults, it is commonly removed 'cause the patient has myasthenia gravis.

	=Overview=		=Overview=

Michael: /* Thymic carcinoma */ split out

2018-03-20T02:53:11Z

Thymic carcinoma: split out

← Older revision		Revision as of 02:53, 20 March 2018
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	==Thymic carcinoma==		==Thymic carcinoma==
	*Previously ''Thymic tumour type C''.		{{Main\|Thymic carcinoma}}
	~~===General===~~
	*Rare.
	*Usually arise ''de novo'', i.e. thymoma is not generally a precursor.
	*Risk factors - possibly: [[smoking]], radiation.<ref name=pmid23319214/>

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP147>{{Ref WMSP\|147}}</ref>~~
	*Cytologically malignant - variable morphology.
	**[[Squamous cell carcinoma]] is the most common (65-73% of cases<ref name=pmid23319214>{{Cite journal \| last1 = Thomas de Montpréville \| first1 = V. \| last2 = Ghigna \| first2 = MR. \| last3 = Lacroix \| first3 = L. \| last4 = Besse \| first4 = B. \| last5 = Broet \| first5 = P. \| last6 = Dartevelle \| first6 = P. \| last7 = Fadel \| first7 = E. \| last8 = Dorfmuller \| first8 = P. \| title = Thymic carcinomas: clinicopathologic study of 37 cases from a single institution. \| journal = Virchows Arch \| volume = 462 \| issue = 3 \| pages = 307-13 \| month = Mar \| year = 2013 \| doi = 10.1007/s00428-013-1371-y \| PMID = 23319214 }}</ref><ref name=pmid23866799>{{Cite journal \| last1 = Zhao \| first1 = Y. \| last2 = Zhao \| first2 = H. \| last3 = Hu \| first3 = D. \| last4 = Fan \| first4 = L. \| last5 = Shi \| first5 = J. \| last6 = Fang \| first6 = W. \| title = Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases. \| journal = Ann Thorac Surg \| volume = 96 \| issue = 3 \| pages = 1019-24 \| month = Sep \| year = 2013 \| doi = 10.1016/j.athoracsur.2013.04.078 \| PMID = 23866799 }}</ref>).
	*+/-Squamous differentiation.

	~~Notes:~~
	*Staging depends on capsular invasion.

	~~DDx:~~
	*[[Thymoma]].
	*[[Lung cancer\|Lung carcinoma]].
	*[[Gastrointestinal stromal tumour]].<ref name=pmid23375402>{{Cite journal \| last1 = Rossi \| first1 = V. \| last2 = Donini \| first2 = M. \| last3 = Sergio \| first3 = P. \| last4 = Passalacqua \| first4 = R. \| last5 = Rossi \| first5 = G. \| last6 = Buti \| first6 = S. \| title = When a thymic carcinoma becomes a GIST. \| ~~journal = Lung Cancer \| volume = 80 \| issue = 1 \| pages = 106-8 \| month = Apr \| year = 2013 \| doi = 10.1016/j.lungcan.2013.01.003 \| PMID = 23375402 }}</ref>~~

	~~====Images====~~
	*[http://www.webpathology.com/image.asp?n=1&Case=653 Thymic carcinoma ~~- low mag. (webpathology.com)].~~
	*[http://www.webpathology.com/image.asp?n=2&Case=653 Thymic carcinoma - high mag. (webpathology.com)].
	*[http://www.webpathology.com/image.asp?n=4&Case=653 Thymic carcinoma - lymphoepithelioma-like - high mag. (webpathology.com)].

	~~===IHC===~~
	~~Features:<ref name=Ref_WMSP147>{{Ref WMSP\|147}}</ref>~~
	*CD5 +ve (90% of cases<ref name=pmid23319214/>).<ref name=Ref_PBoD708>{{Ref PBoD\|708}}~~</ref>~~
	*CD117 +ve (87% of cases<ref name=pmid23319214/>).
	*CD7 +ve.
	*[[TTF-1]] -ve.

	~~Note:~~
	*Should stain with [[keratins]].

	=See also=		=See also=

Michael at 03:09, 2 August 2016

2016-08-02T03:09:47Z

← Older revision		Revision as of 03:09, 2 August 2016
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	Note:		Note:
	*Should stain with keratins.		*Should stain with [[keratins]].

	=See also=		=See also=

Michael at 20:41, 5 May 2016

2016-05-05T20:41:11Z

← Older revision		Revision as of 20:41, 5 May 2016
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	==IHC and thymus==		==IHC and thymus==
	Types A, AB, B:<ref name=cjs>CJS. January 2010.</ref>		Types A, AB, B:<ref name=cjs>CJS. January 2010.</ref>
	*[[CK7]] -ve, [[CK20]] -ve, CAM5.2 +ve, CK5/6 +ve, p63 +ve, CD5 -ve.		*[[CK7]] -ve, [[CK20]] -ve, CAM5.2 +ve, [[CK5/6]] +ve, [[p63]] +ve, CD5 -ve.

	Type C:		Type C:

Michael: /* Thymoma */ split-out

2015-12-20T22:31:35Z

Thymoma: split-out

Show changes

Michael: /* IHC */

2015-09-01T20:11:53Z

IHC

← Older revision		Revision as of 20:11, 1 September 2015
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	*[[p63]] +ve.<ref name=pmid24923897>{{cite journal \|author=Adam P, Hakroush S, Hofmann I, Reidenbach S, Marx A, Ströbel P \|title=Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall \|journal=Virchows Arch. \|volume= \|issue= \|pages= \|year=2014 \|month=June \|pmid=24923897 \|doi=10.1007/s00428-014-1606-6 \|url=}}</ref>		*[[p63]] +ve.<ref name=pmid24923897>{{cite journal \|author=Adam P, Hakroush S, Hofmann I, Reidenbach S, Marx A, Ströbel P \|title=Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall \|journal=Virchows Arch. \|volume= \|issue= \|pages= \|year=2014 \|month=June \|pmid=24923897 \|doi=10.1007/s00428-014-1606-6 \|url=}}</ref>
	*TdT +ve.		*TdT +ve.
			*Ki-67 variable.<ref name=pmid24585679>{{Cite journal \| last1 = Viti \| first1 = A. \| last2 = Bertolaccini \| first2 = L. \| last3 = Cavallo \| first3 = A. \| last4 = Fortunato \| first4 = M. \| last5 = Bianchi \| first5 = A. \| last6 = Terzi \| first6 = A. \| title = 18-Fluorine fluorodeoxyglucose positron emission tomography in the pretreatment evaluation of thymic epithelial neoplasms: a metabolic biopsy confirmed by Ki-67 expression. \| journal = Eur J Cardiothorac Surg \| volume = 46 \| issue = 3 \| pages = 369-74; discussion 374 \| month = Sep \| year = 2014 \| doi = 10.1093/ejcts/ezu030 \| PMID = 24585679 }}</ref>
			**~5-70% for A, AB & B1.
			**~80-100% for B2 & B3.

	A panel:		A panel:

Michael: /* IHC */

2015-09-01T15:29:32Z

IHC

← Older revision		Revision as of 15:29, 1 September 2015
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	*[[p63]] +ve.<ref name=pmid24923897>{{cite journal \|author=Adam P, Hakroush S, Hofmann I, Reidenbach S, Marx A, Ströbel P \|title=Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall \|journal=Virchows Arch. \|volume= \|issue= \|pages= \|year=2014 \|month=June \|pmid=24923897 \|doi=10.1007/s00428-014-1606-6 \|url=}}</ref>		*[[p63]] +ve.<ref name=pmid24923897>{{cite journal \|author=Adam P, Hakroush S, Hofmann I, Reidenbach S, Marx A, Ströbel P \|title=Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall \|journal=Virchows Arch. \|volume= \|issue= \|pages= \|year=2014 \|month=June \|pmid=24923897 \|doi=10.1007/s00428-014-1606-6 \|url=}}</ref>
	*TdT +ve.		*TdT +ve.

			A panel:
			*TdT, CD1a, CD3, CD5, CD20, Ki-67, CD117, p63, CK5/6.

	===Sign out===		===Sign out===

Michael: /* Thymoma */

2015-09-01T15:13:22Z

Thymoma

← Older revision		Revision as of 15:13, 1 September 2015
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	*[[p63]] +ve.<ref name=pmid24923897>{{cite journal \|author=Adam P, Hakroush S, Hofmann I, Reidenbach S, Marx A, Ströbel P \|title=Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall \|journal=Virchows Arch. \|volume= \|issue= \|pages= \|year=2014 \|month=June \|pmid=24923897 \|doi=10.1007/s00428-014-1606-6 \|url=}}</ref>		*[[p63]] +ve.<ref name=pmid24923897>{{cite journal \|author=Adam P, Hakroush S, Hofmann I, Reidenbach S, Marx A, Ströbel P \|title=Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall \|journal=Virchows Arch. \|volume= \|issue= \|pages= \|year=2014 \|month=June \|pmid=24923897 \|doi=10.1007/s00428-014-1606-6 \|url=}}</ref>
	*TdT +ve.		*TdT +ve.

			===Sign out===
			<pre>
			A. Lymph Node, Station 6, Lymphadenectomy:
			- One benign lymph node (0/1).

			B. Submitted as "Anterior Mediastinal Tumour (Thymus)", Excision:
			- Thymoma, WHO type B2.
			- Modified Masaoka stage IIa.
			- Three benign lymph nodes (0/3).
			- Rim of benign thymus.
			- Please see synoptic report.
			</pre>

	==Metaplastic thymoma==		==Metaplastic thymoma==