Thymoma - Revision history

Michael: /* Microscopic */

2025-02-26T19:59:38Z

Microscopic

← Older revision		Revision as of 19:59, 26 February 2025
Line 92:		Line 92:
	**Spindle cells - Type A.		**Spindle cells - Type A.
	**Epithelioid cells - Type B.		**Epithelioid cells - Type B.

			Notes:
			*Perivascular edema is typical of thymoma.

	DDx:		DDx:

Michael at 04:18, 1 November 2024

2024-11-01T04:18:46Z

← Older revision		Revision as of 04:18, 1 November 2024
Line 105:		Line 105:
	Image:Thymoma_B1_(3)_CK_CAM5-2.JPG \| Thymoma Type B1 - CAM5.2. (WC/KGH)		Image:Thymoma_B1_(3)_CK_CAM5-2.JPG \| Thymoma Type B1 - CAM5.2. (WC/KGH)
	</gallery>		</gallery>
			====Case 1====
	<gallery>		<gallery>
	Image: Thymoma type B1 -- low mag.jpg \| Thymoma B1 - low mag.		Image: Thymoma type B1 -- low mag.jpg \| Thymoma B1 - low mag.
Line 112:		Line 113:
	Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.		Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.
	</gallery>		</gallery>
	====Case====		====Case 2====
	<gallery>		<gallery>
	File:5 404717367 sl 1.png\|Thymoma type B1		File:5 404717367 sl 1.png\|Thymoma type B1
Line 122:		Line 123:
	</gallery>		</gallery>
	Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive.		Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive.

			====Case 3====
			<gallery>
			Image: Thymoma type B2 -- low mag.jpg \| Thymoma type B2 - low mag.
			Image: Thymoma type B2 -- intermed mag.jpg \| Thymoma type B2 - intermed. mag.
			Image: Thymoma type B2 -- high mag.jpg \| Thymoma type B2 - high mag.
			Image: Thymoma type B2 -- very high mag.jpg \| Thymoma type B2 - very high mag.
			</gallery>

	===Staging===		===Staging===

Michael: +gallery

2024-11-01T03:58:04Z

+gallery

← Older revision		Revision as of 03:58, 1 November 2024
Line 112:		Line 112:
	Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.		Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.
	</gallery>		</gallery>
	[[File:5 404717367 sl 1.png\|Thymoma type B1]]		====Case====
	[[File:5 404717367 sl 2.png\|Thymoma type B1]]		<gallery>
	[[File:5 404717367 sl 3.png\|Thymoma type B1]]		File:5 404717367 sl 1.png\|Thymoma type B1
	[[File:5 404717367 sl 4.png\|Thymoma type B1]]		File:5 404717367 sl 2.png\|Thymoma type B1
	[[File:5 404717367 sl 5.png\|Thymoma type B1]]		File:5 404717367 sl 3.png\|Thymoma type B1
	[[File:5 404717367 sl 6.png\|Thymoma type B1]]		File:5 404717367 sl 4.png\|Thymoma type B1
			File:5 404717367 sl 5.png\|Thymoma type B1
			File:5 404717367 sl 6.png\|Thymoma type B1
			</gallery>
	Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive.		Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive.

Michael: /* See also */

2019-10-22T18:29:02Z

Michael: /* Microscopic */

2019-05-06T17:04:26Z

Microscopic

← Older revision		Revision as of 17:04, 6 May 2019
Line 97:		Line 97:
	*[[Lymphoma]].		*[[Lymphoma]].
	*[[Follicular dendritic cell sarcoma]].		*[[Follicular dendritic cell sarcoma]].
			*Normal persistent [[thymus]].

	===Images===		===Images===

Michael: /* Gross */

2019-05-06T17:01:22Z

Gross

← Older revision		Revision as of 17:01, 6 May 2019
Line 82:		Line 82:
	Image:		Image:
	*[http://www.sciencephoto.com/media/253251/enlarge Thymoma (sciencephoto.com)].		*[http://www.sciencephoto.com/media/253251/enlarge Thymoma (sciencephoto.com)].

			Note:
			*The line between ''thymoma'' and ''persistent normal thymus in the adult'' is not well-defined in the radiologic context.<ref name=pmid25925358>{{Cite journal \| last1 = Araki \| first1 = T. \| last2 = Nishino \| first2 = M. \| last3 = Gao \| first3 = W. \| last4 = Dupuis \| first4 = J. \| last5 = Hunninghake \| first5 = GM. \| last6 = Murakami \| first6 = T. \| last7 = Washko \| first7 = GR. \| last8 = O'Connor \| first8 = GT. \| last9 = Hatabu \| first9 = H. \| title = Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking. \| journal = Eur Radiol \| volume = 26 \| issue = 1 \| pages = 15-24 \| month = Jan \| year = 2016 \| doi = 10.1007/s00330-015-3796-y \| PMID = 25925358 }}</ref>

	==Microscopic==		==Microscopic==

Mitchell: /* Images */ Added a type b1 thymoma with stains

2016-12-14T18:38:50Z

Images: Added a type b1 thymoma with stains

← Older revision		Revision as of 18:38, 14 December 2016
Line 108:		Line 108:
	Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.		Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.
	</gallery>		</gallery>
			[[File:5 404717367 sl 1.png\|Thymoma type B1]]
			[[File:5 404717367 sl 2.png\|Thymoma type B1]]
			[[File:5 404717367 sl 3.png\|Thymoma type B1]]
			[[File:5 404717367 sl 4.png\|Thymoma type B1]]
			[[File:5 404717367 sl 5.png\|Thymoma type B1]]
			[[File:5 404717367 sl 6.png\|Thymoma type B1]]

			Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive.

	===Staging===		===Staging===
	{{Main\|Thymic staging}}		{{Main\|Thymic staging}}

Michael at 20:44, 5 May 2016

2016-05-05T20:44:17Z

← Older revision		Revision as of 20:44, 5 May 2016
Line 119:		Line 119:

	A panel:		A panel:
	*TdT, CD1a, CD3, CD5, CD20, Ki-67, CD117, p63, CK5/6.		*TdT, CD1a, CD3, CD5, CD20, Ki-67, CD117, [[p63]], [[CK5/6]].

	==Sign out==		==Sign out==

Michael at 02:33, 21 December 2015

2015-12-21T02:33:05Z

← Older revision		Revision as of 02:33, 21 December 2015
Line 13:		Line 13:
	\| Molecular =		\| Molecular =
	\| IF =		\| IF =
	\| Gross =		\| Gross = light brown/tan, usually encapsulated
	\| Grossing =		\| Grossing =
	\| Staging = [[thymus staging]]		\| Staging = [[thymus staging]]

Michael at 02:32, 21 December 2015

2015-12-21T02:32:18Z

← Older revision		Revision as of 02:32, 21 December 2015
Line 1:		Line 1:
	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Thymoma type B1 -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Thymoma (right of image) and remnant of normal thymus (left of image). [[H&E stain]]. (WC)
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro =
Line 75:		Line 75:
	Note:		Note:
	*Neoplastic cells derived from the thymus with cytologic features of malignancy are [[thymic carcinoma]]s.		*Neoplastic cells derived from the thymus with cytologic features of malignancy are [[thymic carcinoma]]s.

	~~Images:~~
	~~<gallery>~~
	~~Image:Thymoma_type_B1_(1).JPG \| Thymoma Type B1. (WC/KGH)~~
	~~Image:Thymoma_B1_(2).JPG \| Thymoma Type B1. (WC/KGH)~~
	~~Image:Thymoma_B1_(3)_CK_CAM5-2.JPG \| Thymoma Type B1 - CAM5.2. (WC/KGH)~~
	~~</gallery>~~

	==Gross==		==Gross==
Line 104:		Line 97:
	===Images===		===Images===
	<gallery>		<gallery>
	Image:Thymoma_B1_~~%282%29~~.JPG \| Thymoma (WC)		Image:Thymoma_type_B1_(1).JPG \| Thymoma Type B1. (WC/KGH)
			Image:Thymoma_B1_(2).JPG \| Thymoma Type B1. (WC/KGH)
			Image:Thymoma_B1_(3)_CK_CAM5-2.JPG \| Thymoma Type B1 - CAM5.2. (WC/KGH)
			</gallery>
			<gallery>
			Image: Thymoma type B1 -- low mag.jpg \| Thymoma B1 - low mag.
			Image: Thymoma type B1 -- intermed mag.jpg \| Thymoma B1 - intermed. mag.
			Image: Thymoma type B1 -- high mag.jpg \| Thymoma B1 - high mag.
			Image: Thymoma type B1 -- very high mag.jpg \| Thymoma B1 - very high mag.
			Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.
	</gallery>		</gallery>
	===Staging===		===Staging===

← Older revision		Revision as of 03:58, 1 November 2024
Line 112:		Line 112:
	Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.		Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.
	</gallery>		</gallery>
	[[File:5 404717367 sl 1.png\|Thymoma type B1]]		====Case====
	[[File:5 404717367 sl 2.png\|Thymoma type B1]]		<gallery>
	[[File:5 404717367 sl 3.png\|Thymoma type B1]]		File:5 404717367 sl 1.png\|Thymoma type B1
	[[File:5 404717367 sl 4.png\|Thymoma type B1]]		File:5 404717367 sl 2.png\|Thymoma type B1
	[[File:5 404717367 sl 5.png\|Thymoma type B1]]		File:5 404717367 sl 3.png\|Thymoma type B1
	[[File:5 404717367 sl 6.png\|Thymoma type B1]]		File:5 404717367 sl 4.png\|Thymoma type B1
			File:5 404717367 sl 5.png\|Thymoma type B1
			File:5 404717367 sl 6.png\|Thymoma type B1
			</gallery>
	Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive.		Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive.

← Older revision		Revision as of 18:29, 22 October 2019
Line 149:		Line 149:
	==See also==		==See also==
	*[[Thymus]].		*[[Thymus]].
			*[[Thymus staging]].

	==References==		==References==

← Older revision		Revision as of 18:38, 14 December 2016
Line 108:		Line 108:
	Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.		Image: Thymoma type B1 - alt -- very high mag.jpg \| Thymoma B1 - very high mag.
	</gallery>		</gallery>
			[[File:5 404717367 sl 1.png\|Thymoma type B1]]
			[[File:5 404717367 sl 2.png\|Thymoma type B1]]
			[[File:5 404717367 sl 3.png\|Thymoma type B1]]
			[[File:5 404717367 sl 4.png\|Thymoma type B1]]
			[[File:5 404717367 sl 5.png\|Thymoma type B1]]
			[[File:5 404717367 sl 6.png\|Thymoma type B1]]

			Thymoma type B1 in a 33 y man, 384 gram 9 x 10 x 8 cm. A. Blue tumor shows a starry sky pattern (red square), as well as occasional fibrous bands (red arrows). B. Epithelial component, impossible to see on H&E at lower power, is readily identified, here with immunostain for CK7. C. CK7 positivity favors B over type A. Note that where the nuclei are visible the tumor cells are round, proving type B. The predominance of lymphoid cells makes this tumor B1. D. Lymphoid cells are uniform and small. Arrows show the tangible body macrophages that gave the low power starry sky appearance. E. Lymphoid cells are CD5 positive. F. Lymphoid cells are TdT positive.

	===Staging===		===Staging===
	{{Main\|Thymic staging}}		{{Main\|Thymic staging}}