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2018-03-20T02:54:52Z

References

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	[[Category:Diagnosis]]		[[Category:Diagnosis]]
			[[Category:Haematopathology]]

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	~~#redirect~~ [[Thymus~~#Thymic_carcinoma~~]]		'''Thymic carcinoma''' is a malignant tumour of the [[thymus]]. It was previously known as ''thymic tumour type C''.

			==General==
			*Rare.
			*Usually arise ''de novo'', i.e. thymoma is not generally a precursor.
			*Risk factors - possibly: [[smoking]], radiation.<ref name=pmid23319214/>

			==Microscopic==
			Features:<ref name=Ref_WMSP147>{{Ref WMSP\|147}}</ref>
			*Cytologically malignant - variable morphology.
			**[[Squamous cell carcinoma]] is the most common (65-73% of cases<ref name=pmid23319214>{{Cite journal \| last1 = Thomas de Montpréville \| first1 = V. \| last2 = Ghigna \| first2 = MR. \| last3 = Lacroix \| first3 = L. \| last4 = Besse \| first4 = B. \| last5 = Broet \| first5 = P. \| last6 = Dartevelle \| first6 = P. \| last7 = Fadel \| first7 = E. \| last8 = Dorfmuller \| first8 = P. \| title = Thymic carcinomas: clinicopathologic study of 37 cases from a single institution. \| journal = Virchows Arch \| volume = 462 \| issue = 3 \| pages = 307-13 \| month = Mar \| year = 2013 \| doi = 10.1007/s00428-013-1371-y \| PMID = 23319214 }}</ref><ref name=pmid23866799>{{Cite journal \| last1 = Zhao \| first1 = Y. \| last2 = Zhao \| first2 = H. \| last3 = Hu \| first3 = D. \| last4 = Fan \| first4 = L. \| last5 = Shi \| first5 = J. \| last6 = Fang \| first6 = W. \| title = Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases. \| journal = Ann Thorac Surg \| volume = 96 \| issue = 3 \| pages = 1019-24 \| month = Sep \| year = 2013 \| doi = 10.1016/j.athoracsur.2013.04.078 \| PMID = 23866799 }}</ref>).
			*+/-Squamous differentiation.

			Notes:
			*Staging depends on capsular invasion.

			DDx:
			*[[Thymoma]].
			*[[Lung cancer\|Lung carcinoma]].
			*[[Gastrointestinal stromal tumour]].<ref name=pmid23375402>{{Cite journal \| last1 = Rossi \| first1 = V. \| last2 = Donini \| first2 = M. \| last3 = Sergio \| first3 = P. \| last4 = Passalacqua \| first4 = R. \| last5 = Rossi \| first5 = G. \| last6 = Buti \| first6 = S. \| title = When a thymic carcinoma becomes a GIST. \| journal = Lung Cancer \| volume = 80 \| issue = 1 \| pages = 106-8 \| month = Apr \| year = 2013 \| doi = 10.1016/j.lungcan.2013.01.003 \| PMID = 23375402 }}</ref>

			===Images===
			*[http://www.webpathology.com/image.asp?n=1&Case=653 Thymic carcinoma - low mag. (webpathology.com)].
			*[http://www.webpathology.com/image.asp?n=2&Case=653 Thymic carcinoma - high mag. (webpathology.com)].
			*[http://www.webpathology.com/image.asp?n=4&Case=653 Thymic carcinoma - lymphoepithelioma-like - high mag. (webpathology.com)].

			==IHC==
			Features:<ref name=Ref_WMSP147>{{Ref WMSP\|147}}</ref>
			*CD5 +ve (90% of cases<ref name=pmid23319214/>).<ref name=Ref_PBoD708>{{Ref PBoD\|708}}</ref>
			*CD117 +ve (87% of cases<ref name=pmid23319214/>).
			*CD7 +ve.
			*[[TTF-1]] -ve.

			Note:
			*Should stain with [[keratins]].

			==See also==
			*[[Thymus]].

			==References==
			{{Reflist\|1}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2011-10-19T16:31:51Z

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New page

#redirect [[Thymus#Thymic_carcinoma]]

[[Category:Diagnosis]]

Thymic carcinoma - Revision history

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