Thrombotic microangiopathy - Revision history

Michael: w

2014-01-11T15:35:24Z

← Older revision		Revision as of 15:35, 11 January 2014
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	\| Tx = dependent on underlying cause		\| Tx = dependent on underlying cause
	}}		}}
	'''Thrombotic microangiopathy''', abbreviated '''TMA''', is a group of disorders affecting small blood vessels. ''Microangiopathic'' is a disease affecting small blood vessels.<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref>		'''Thrombotic microangiopathy''', abbreviated '''TMA''', is a group of disorders affecting small blood vessels. ''Microangiopathic'' is a disease affecting small [[blood vessels]].<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref>

	==Differential diagnosis==		==Differential diagnosis==

Michael at 20:16, 25 December 2013

2013-12-25T20:16:27Z

← Older revision		Revision as of 20:16, 25 December 2013
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	\| Prognosis =		\| Prognosis =
	\| Other =		\| Other =
	\| ClinDDx = DDx for TMA [[malignant hypertension]], [[DIC]], [[APLA]] in [[SLE]], [[scleroderma]] renal crisis, [[HIV]] associated [[TTP]], reaction to chemotherapy, [[calcineurin inhibitor toxicity]]		\| ClinDDx = DDx for TMA: [[malignant hypertension]], [[DIC]], [[APLA]] in [[SLE]], [[scleroderma]] renal crisis, [[HIV]] associated [[TTP]], reaction to chemotherapy, [[calcineurin inhibitor toxicity]]
	\| Tx = dependent on underlying cause		\| Tx = dependent on underlying cause
	}}		}}

Michael at 20:15, 25 December 2013

2013-12-25T20:15:56Z

← Older revision		Revision as of 20:15, 25 December 2013
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	\| Micro = microvascular occlusion with "loose" intimal thickening - fluffy appearing intima, fibrin entrapped RBCs, +/-onion skin-like appearance (chronic change)		\| Micro = microvascular occlusion with "loose" intimal thickening - fluffy appearing intima, fibrin entrapped RBCs, +/-onion skin-like appearance (chronic change)
	\| Subtypes = acute, chronic		\| Subtypes = acute, chronic
	\| LMDDx = [[vasculitis]]		\| LMDDx = [[vasculitis]], small vessel
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =
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	\| Prognosis =		\| Prognosis =
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = DDx for TMA [[malignant hypertension]], [[DIC]], [[APLA]] in [[SLE]], [[scleroderma]] renal crisis, [[HIV]] associated [[TTP]], reaction to chemotherapy, [[calcineurin inhibitor toxicity]]
	\| Tx = dependent on underlying cause		\| Tx = dependent on underlying cause
	}}		}}

Michael at 20:11, 25 December 2013

2013-12-25T20:11:13Z

← Older revision		Revision as of 20:11, 25 December 2013
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	\| Caption = Acute thrombotic microangiopathy. [[H&E stain]].		\| Caption = Acute thrombotic microangiopathy. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = microvascular occlusion with "loose" intimal thickening - fluffy appearing intima, +/-onion skin-like appearance~~, fibrin entrapped RBCs~~		\| Micro = microvascular occlusion with "loose" intimal thickening - fluffy appearing intima, fibrin entrapped RBCs, +/-onion skin-like appearance (chronic change)
	\| Subtypes =		\| Subtypes = acute, chronic
	\| LMDDx = [[vasculitis]]		\| LMDDx = [[vasculitis]]
	\| Stains =		\| Stains =

Michael at 20:09, 25 December 2013

2013-12-25T20:09:17Z

← Older revision		Revision as of 20:09, 25 December 2013
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site =		\| Site = [[blood vessels]] - esp. [[kidney]]
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =

Michael at 20:08, 25 December 2013

2013-12-25T20:08:48Z

← Older revision		Revision as of 20:08, 25 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Acute thrombotic microangiopathy - very high mag.jpg
			\| Width =
			\| Caption = Acute thrombotic microangiopathy. [[H&E stain]].
			\| Synonyms =
			\| Micro = microvascular occlusion with "loose" intimal thickening - fluffy appearing intima, +/-onion skin-like appearance, fibrin entrapped RBCs
			\| Subtypes =
			\| LMDDx = [[vasculitis]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site =
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence =
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx = dependent on underlying cause
			}}
	'''Thrombotic microangiopathy''', abbreviated '''TMA''', is a group of disorders affecting small blood vessels. ''Microangiopathic'' is a disease affecting small blood vessels.<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref>		'''Thrombotic microangiopathy''', abbreviated '''TMA''', is a group of disorders affecting small blood vessels. ''Microangiopathic'' is a disease affecting small blood vessels.<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref>

Michael: /* Images */

2013-12-25T20:04:52Z

Images

← Older revision		Revision as of 20:04, 25 December 2013
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	*[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)].

			Acute changes:
			<gallery>
			Image: Acute thrombotic microangiopathy - high mag.jpg \| High mag.
			Image: Acute thrombotic microangiopathy - very high mag.jpg \| Very high mag.
			Image: Acute thrombotic microangiopathy - pas - high mag.jpg \| High mag.
			Image: Acute thrombotic microangiopathy - pas - very high mag.jpg \| Very high mag.
			</gallery>

	**[http:~~//commons.wikimedia.org/wiki/File~~:~~Acute_thrombotic_microangiopathy_~~-~~_very_high_mag~~.jpg ~~Acute TMA - very high~~ mag~~. (WC)]~~.		Chronic changes:
	**[http://commons.wikimedia.org/wiki/File:~~Acute_thrombotic_microangiopathy_-_pas_-_very_high_mag.jpg Acute TMA - PAS~~ - ~~very~~ high mag~~. (WC)].~~		<gallery>
	**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_intermed_mag.jpg ~~Chronic TMA - PAS - intermed.~~ mag~~. (WC)]~~.		Image: Thrombotic microangiopathy - intermed mag.jpg \| Intermed. mag.
	**[http://commons.wikimedia.org/wiki/File:~~Thrombotic_microangiopathy_~~-~~_very_high_mag~~.jpg ~~Chronic TMA - PAS - very~~ high mag. ~~(WC)].~~		Image: Thrombotic microangiopathy - high mag.jpg \| High mag.
			Image: Thrombotic microangiopathy - very high mag.jpg \| Very high mag.
			</gallery>

	==See also==		==See also==

Michael: /* Microscopic */

2013-12-25T20:03:54Z

Microscopic

← Older revision		Revision as of 20:03, 25 December 2013
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	*Early finding: endothelial cell swelling.		*Early finding: endothelial cell swelling.

	Images:		===Images===
	*www:		www:
	**[http://www.nature.com/ki/journal/v60/n3/fig_tab/4492492f5.html Thrombotic microangiopathy (nature.com)].<ref name=pmid11532079>{{Cite journal \| last1 = Ruggenenti \| first1 = P. \| last2 = Noris \| first2 = M. \| last3 = Remuzzi \| first3 = G. \| title = Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. \| journal = Kidney Int \| volume = 60 \| issue = 3 \| pages = 831-46 \| month = Sep \| year = 2001 \| doi = 10.1046/j.1523-1755.2001.060003831.x \| PMID = 11532079 }}</ref>		*[http://www.nature.com/ki/journal/v60/n3/fig_tab/4492492f5.html Thrombotic microangiopathy (nature.com)].<ref name=pmid11532079>{{Cite journal \| last1 = Ruggenenti \| first1 = P. \| last2 = Noris \| first2 = M. \| last3 = Remuzzi \| first3 = G. \| title = Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. \| journal = Kidney Int \| volume = 60 \| issue = 3 \| pages = 831-46 \| month = Sep \| year = 2001 \| doi = 10.1046/j.1523-1755.2001.060003831.x \| PMID = 11532079 }}</ref>
	**[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)].
	*[[WC]]:

	**[http://commons.wikimedia.org/wiki/File:Acute_thrombotic_microangiopathy_-_very_high_mag.jpg Acute TMA - very high mag. (WC)].		**[http://commons.wikimedia.org/wiki/File:Acute_thrombotic_microangiopathy_-_very_high_mag.jpg Acute TMA - very high mag. (WC)].
	**[http://commons.wikimedia.org/wiki/File:Acute_thrombotic_microangiopathy_-_pas_-_very_high_mag.jpg Acute TMA - PAS - very high mag. (WC)].		**[http://commons.wikimedia.org/wiki/File:Acute_thrombotic_microangiopathy_-_pas_-_very_high_mag.jpg Acute TMA - PAS - very high mag. (WC)].

Michael: /* Microscopic */ more

2012-03-25T14:01:33Z

Microscopic: more

← Older revision		Revision as of 14:01, 25 March 2012
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	**[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)].		**[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)].
	*[[WC]]:		*[[WC]]:
			**[http://commons.wikimedia.org/wiki/File:Acute_thrombotic_microangiopathy_-_very_high_mag.jpg Acute TMA - very high mag. (WC)].
	**[http://commons.wikimedia.org/wiki/File:Acute_thrombotic_microangiopathy_-_pas_-_very_high_mag.jpg Acute TMA - PAS - very high mag. (WC)].		**[http://commons.wikimedia.org/wiki/File:Acute_thrombotic_microangiopathy_-_pas_-_very_high_mag.jpg Acute TMA - PAS - very high mag. (WC)].
	**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_intermed_mag.jpg Chronic TMA - intermed. mag. (WC)].		**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_intermed_mag.jpg Chronic TMA - PAS - intermed. mag. (WC)].
	**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_very_high_mag.jpg Chronic TMA - very high mag. (WC)].		**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_very_high_mag.jpg Chronic TMA - PAS - very high mag. (WC)].

	==See also==		==See also==

Michael: /* Microscopic */

2012-03-11T15:24:10Z

Microscopic

← Older revision		Revision as of 15:24, 11 March 2012
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	**[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)].		**[http://path.upmc.edu/cases/case683.html Probable APLA syndrome - several images (upmc.edu)].
	*[[WC]]:		*[[WC]]:
	**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_intermed_mag.jpg TMA - intermed. mag. (WC)].		**[http://commons.wikimedia.org/wiki/File:Acute_thrombotic_microangiopathy_-_pas_-_very_high_mag.jpg Acute TMA - PAS - very high mag. (WC)].
	**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_very_high_mag.jpg TMA - very high mag. (WC)].		**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_intermed_mag.jpg Chronic TMA - intermed. mag. (WC)].
			**[http://commons.wikimedia.org/wiki/File:Thrombotic_microangiopathy_-_very_high_mag.jpg Chronic TMA - very high mag. (WC)].

	==See also==		==See also==