Testicular adrenal rest tumour - Revision history

Michael: /* IHC */

2016-05-25T21:51:33Z

IHC

← Older revision		Revision as of 21:51, 25 May 2016
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	==IHC==		==IHC==
	*Melan A +ve.<ref name=pmid20951518>{{Cite journal \| last1 = Mizukami \| first1 = H. \| last2 = Hamamatsu \| first2 = A. \| last3 = Mori \| first3 = S. \| last4 = Hara \| first4 = S. \| last5 = Kuroda \| first5 = M. \| last6 = Nagai \| first6 = T. \| last7 = Fukunaga \| first7 = T. \| title = Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year. \| journal = Forensic Sci Int \| volume = 206 \| issue = 1-3 \| pages = e71-5 \| month = Mar \| year = 2011 \| doi = 10.1016/j.forsciint.2010.09.017 \| PMID = 20951518 }}</ref>		*Melan A +ve.<ref name=pmid20951518>{{Cite journal \| last1 = Mizukami \| first1 = H. \| last2 = Hamamatsu \| first2 = A. \| last3 = Mori \| first3 = S. \| last4 = Hara \| first4 = S. \| last5 = Kuroda \| first5 = M. \| last6 = Nagai \| first6 = T. \| last7 = Fukunaga \| first7 = T. \| title = Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year. \| journal = Forensic Sci Int \| volume = 206 \| issue = 1-3 \| pages = e71-5 \| month = Mar \| year = 2011 \| doi = 10.1016/j.forsciint.2010.09.017 \| PMID = 20951518 }}</ref>
			*CD56 +ve.<ref name=pmid23984262>{{Cite journal \| last1 = Ali \| first1 = HH. \| last2 = Samkari \| first2 = A. \| last3 = Arabi \| first3 = H. \| title = Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review. \| journal = Avicenna J Med \| volume = 3 \| issue = 1 \| pages = 15-9 \| month = Jan \| year = 2013 \| doi = 10.4103/2231-0770.112789 \| PMID = 23984262 }}</ref>
			*AR -ve.<ref name=pmid23984262/>

	==Molecular==		==Molecular==

Michael: tweak

2015-07-16T04:14:13Z

tweak

← Older revision		Revision as of 04:14, 16 July 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Testicular adrenal rest tumour -- intermed. mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Testicular adrenal rest tumour. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) [[nuclear atypia]]		\| Micro = nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) [[nuclear atypia]]
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	===Images===		===Images===
			====www====
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037253/figure/f4-jrcr-8-2-46/ TART (nih.gov)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037253/figure/f4-jrcr-8-2-46/ TART (nih.gov)].
			====Case====
			<gallery>
			Image: Testicular adrenal rest tumour -- low mag.jpg \| TART - low mag. (WC)
			Image: Testicular adrenal rest tumour -- intermed. mag.jpg \| Image: Testicular adrenal rest tumour -- high mag.jpg \| TART - high mag. (WC)
			Image: Testicular adrenal rest tumour - alt -- intermed. mag.jpg \| TART - intermed. mag. (WC)
			Image: Testicular adrenal rest tumour -- high mag.jpg \| TART - high mag. (WC)
			Image: Testicular adrenal rest tumour -- very high mag.jpg \| TART - very high mag. (WC)

			Image: Testicular adrenal rest tumour - alt -- high mag.jpg \| TART - high mag. (WC)
			Image: Testicular adrenal rest tumour - alt -- very high mag.jpg \| TART - very high mag. (WC)
			</gallery>

	==IHC==		==IHC==

Michael: /* Microscopic */

2015-07-15T04:55:12Z

Microscopic

← Older revision		Revision as of 04:55, 15 July 2015
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	DDx:		DDx:
	*[[Leydig cell tumour]] - history different.		*[[Leydig cell tumour]] - history different.
	*[[Adrenal cortical rest]] - not a sizable mass lesion and not bilateral.{{fact}}		*[[Adrenal cortical rest]] - architecture different, not a sizable mass lesion and not bilateral.{{fact}}

	===Images===		===Images===

Michael at 04:54, 15 July 2015

2015-07-15T04:54:20Z

← Older revision		Revision as of 04:54, 15 July 2015
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	\| Micro = nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) [[nuclear atypia]]		\| Micro = nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) [[nuclear atypia]]
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[Leydig cell tumour]]		\| LMDDx = [[Leydig cell tumour]], [[adrenal cortical rest]]
	\| Stains =		\| Stains =
	\| IHC = melan A +ve		\| IHC = melan A +ve

Michael: /* Microscopic */

2015-07-15T04:53:48Z

Microscopic

← Older revision		Revision as of 04:53, 15 July 2015
Line 53:		Line 53:
	DDx:		DDx:
	*[[Leydig cell tumour]] - history different.		*[[Leydig cell tumour]] - history different.
			*[[Adrenal cortical rest]] - not a sizable mass lesion and not bilateral.{{fact}}

	===Images===		===Images===

Michael: /* Molecular */

2015-07-15T04:13:48Z

Molecular

← Older revision		Revision as of 04:13, 15 July 2015
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	==Molecular==		==Molecular==
	*Molecular characteristics are in keeping with [[adrenal gland\|adrenal tissue]]; however, some Leydig cell markers active.<ref name=pmid25485724>{{Cite journal \| last1 = Smeets \| first1 = EE. \| last2 = Span \| first2 = PN. \| last3 = van Herwaarden \| first3 = AE. \| last4 = Wevers \| first4 = RA. \| last5 = Hermus \| first5 = AR. \| last6 = Sweep \| first6 = FC. \| last7 = Claahsen-van der Grinten \| first7 = HL. \| title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. \| journal = J Clin Endocrinol Metab \| volume = 100 \| issue = 3 \| pages = E524-30 \| month = Mar \| year = 2015 \| doi = 10.1210/jc.2014-2036 \| PMID = 25485724 }}</ref>		*Molecular characteristics are in keeping with [[adrenal gland\|adrenal tissue]]; however, some Leydig cell markers active.<ref name=pmid25485724>{{Cite journal \| last1 = Smeets \| first1 = EE. \| last2 = Span \| first2 = PN. \| last3 = van Herwaarden \| first3 = AE. \| last4 = Wevers \| first4 = RA. \| last5 = Hermus \| first5 = AR. \| last6 = Sweep \| first6 = FC. \| last7 = Claahsen-van der Grinten \| first7 = HL. \| title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. \| journal = J Clin Endocrinol Metab \| volume = 100 \| issue = 3 \| pages = E524-30 \| month = Mar \| year = 2015 \| doi = 10.1210/jc.2014-2036 \| PMID = 25485724 }}</ref>
			*Mutation in CYP21A2 causative of congenital adrenal hyperplasia.<ref name=pmid19531083/>

	==See also==		==See also==

Michael: /* General */

2015-07-15T04:12:24Z

General

← Older revision		Revision as of 04:12, 15 July 2015
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	*Benign.<ref name=pmid25485724>{{Cite journal \| last1 = Smeets \| first1 = EE. \| last2 = Span \| first2 = PN. \| last3 = van Herwaarden \| first3 = AE. \| last4 = Wevers \| first4 = RA. \| last5 = Hermus \| first5 = AR. \| last6 = Sweep \| first6 = FC. \| last7 = Claahsen-van der Grinten \| first7 = HL. \| title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. \| journal = J Clin Endocrinol Metab \| volume = 100 \| issue = 3 \| pages = E524-30 \| month = Mar \| year = 2015 \| doi = 10.1210/jc.2014-2036 \| PMID = 25485724 }}</ref>		*Benign.<ref name=pmid25485724>{{Cite journal \| last1 = Smeets \| first1 = EE. \| last2 = Span \| first2 = PN. \| last3 = van Herwaarden \| first3 = AE. \| last4 = Wevers \| first4 = RA. \| last5 = Hermus \| first5 = AR. \| last6 = Sweep \| first6 = FC. \| last7 = Claahsen-van der Grinten \| first7 = HL. \| title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. \| journal = J Clin Endocrinol Metab \| volume = 100 \| issue = 3 \| pages = E524-30 \| month = Mar \| year = 2015 \| doi = 10.1210/jc.2014-2036 \| PMID = 25485724 }}</ref>
	*May overlap with [[Leydig cell tumour]] - see ''molecular'' section.		*May overlap with [[Leydig cell tumour]] - see ''molecular'' section.
	*Associated with ''congenital adrenal hyperplasia''.		*Associated with ''congenital adrenal hyperplasia'' (abbreviated ''CAH'').
	**Due to mutation in CYP21A2.<ref name=pmid19531083>{{Cite journal \| last1 = Mouritsen \| first1 = A. \| last2 = Jørgensen \| first2 = N. \| last3 = Main \| first3 = KM. \| last4 = Schwartz \| first4 = M. \| last5 = Juul \| first5 = A. \| title = Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation. \| journal = Int J Androl \| volume = 33 \| issue = 3 \| pages = 521-7 \| month = Jun \| year = 2010 \| doi = 10.1111/j.1365-2605.2009.00967.x \| PMID = 19531083 }}</ref>		**Due to mutation in CYP21A2.<ref name=pmid19531083>{{Cite journal \| last1 = Mouritsen \| first1 = A. \| last2 = Jørgensen \| first2 = N. \| last3 = Main \| first3 = KM. \| last4 = Schwartz \| first4 = M. \| last5 = Juul \| first5 = A. \| title = Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation. \| journal = Int J Androl \| volume = 33 \| issue = 3 \| pages = 521-7 \| month = Jun \| year = 2010 \| doi = 10.1111/j.1365-2605.2009.00967.x \| PMID = 19531083 }}</ref>
	**TART prevalence increases with age - one study suggests moderate prevalance at age 10, increasing to 100% of individuals over 16 years of age.<ref>{{Cite journal \| last1 = Claahsen-van der Grinten \| first1 = HL. \| last2 = Dehzad \| first2 = F. \| last3 = Kamphuis-van Ulzen \| first3 = K. \| last4 = de Korte \| first4 = CL. \| title = Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia. \| journal = Horm Res Paediatr \| volume = 82 \| issue = 4 \| pages = 238-44 \| month = \| year = 2014 \| doi = 10.1159/000365570 \| PMID = 25195868 }}</ref>		**TART prevalence increases with age - one study suggests moderate prevalance at age 10, increasing to 100% of individuals with CAH over 16 years of age.<ref>{{Cite journal \| last1 = Claahsen-van der Grinten \| first1 = HL. \| last2 = Dehzad \| first2 = F. \| last3 = Kamphuis-van Ulzen \| first3 = K. \| last4 = de Korte \| first4 = CL. \| title = Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia. \| journal = Horm Res Paediatr \| volume = 82 \| issue = 4 \| pages = 238-44 \| month = \| year = 2014 \| doi = 10.1159/000365570 \| PMID = 25195868 }}</ref>

	Clinical:		Clinical:

Michael at 04:11, 15 July 2015

2015-07-15T04:11:36Z

← Older revision		Revision as of 04:11, 15 July 2015
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	*Benign.<ref name=pmid25485724>{{Cite journal \| last1 = Smeets \| first1 = EE. \| last2 = Span \| first2 = PN. \| last3 = van Herwaarden \| first3 = AE. \| last4 = Wevers \| first4 = RA. \| last5 = Hermus \| first5 = AR. \| last6 = Sweep \| first6 = FC. \| last7 = Claahsen-van der Grinten \| first7 = HL. \| title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. \| journal = J Clin Endocrinol Metab \| volume = 100 \| issue = 3 \| pages = E524-30 \| month = Mar \| year = 2015 \| doi = 10.1210/jc.2014-2036 \| PMID = 25485724 }}</ref>		*Benign.<ref name=pmid25485724>{{Cite journal \| last1 = Smeets \| first1 = EE. \| last2 = Span \| first2 = PN. \| last3 = van Herwaarden \| first3 = AE. \| last4 = Wevers \| first4 = RA. \| last5 = Hermus \| first5 = AR. \| last6 = Sweep \| first6 = FC. \| last7 = Claahsen-van der Grinten \| first7 = HL. \| title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. \| journal = J Clin Endocrinol Metab \| volume = 100 \| issue = 3 \| pages = E524-30 \| month = Mar \| year = 2015 \| doi = 10.1210/jc.2014-2036 \| PMID = 25485724 }}</ref>
	*May overlap with [[Leydig cell tumour]] - see ''molecular'' section.		*May overlap with [[Leydig cell tumour]] - see ''molecular'' section.
	*Associated with congenital adrenal hyperplasia.		*Associated with ''congenital adrenal hyperplasia''.
	**~~Prevalence~~ increases with age - one study suggests moderate prevalance at age 10, increasing to 100% of individuals over 16 years of age.<ref>{{Cite journal \| last1 = Claahsen-van der Grinten \| first1 = HL. \| last2 = Dehzad \| first2 = F. \| last3 = Kamphuis-van Ulzen \| first3 = K. \| last4 = de Korte \| first4 = CL. \| title = Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia. \| journal = Horm Res Paediatr \| volume = 82 \| issue = 4 \| pages = 238-44 \| month = \| year = 2014 \| doi = 10.1159/000365570 \| PMID = 25195868 }}</ref>		**Due to mutation in CYP21A2.<ref name=pmid19531083>{{Cite journal \| last1 = Mouritsen \| first1 = A. \| last2 = Jørgensen \| first2 = N. \| last3 = Main \| first3 = KM. \| last4 = Schwartz \| first4 = M. \| last5 = Juul \| first5 = A. \| title = Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation. \| journal = Int J Androl \| volume = 33 \| issue = 3 \| pages = 521-7 \| month = Jun \| year = 2010 \| doi = 10.1111/j.1365-2605.2009.00967.x \| PMID = 19531083 }}</ref>
			**TART prevalence increases with age - one study suggests moderate prevalance at age 10, increasing to 100% of individuals over 16 years of age.<ref>{{Cite journal \| last1 = Claahsen-van der Grinten \| first1 = HL. \| last2 = Dehzad \| first2 = F. \| last3 = Kamphuis-van Ulzen \| first3 = K. \| last4 = de Korte \| first4 = CL. \| title = Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia. \| journal = Horm Res Paediatr \| volume = 82 \| issue = 4 \| pages = 238-44 \| month = \| year = 2014 \| doi = 10.1159/000365570 \| PMID = 25195868 }}</ref>

	Clinical:		Clinical:

Michael at 02:33, 15 July 2015

2015-07-15T02:33:42Z

← Older revision		Revision as of 02:33, 15 July 2015
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	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = benign
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = other testicular masses
	\| Tx =		\| Tx =
	}}		}}

Michael: tweak

2015-07-15T02:33:00Z

tweak

← Older revision		Revision as of 02:33, 15 July 2015
Line 36:		Line 36:
	*Benign.<ref name=pmid25485724>{{Cite journal \| last1 = Smeets \| first1 = EE. \| last2 = Span \| first2 = PN. \| last3 = van Herwaarden \| first3 = AE. \| last4 = Wevers \| first4 = RA. \| last5 = Hermus \| first5 = AR. \| last6 = Sweep \| first6 = FC. \| last7 = Claahsen-van der Grinten \| first7 = HL. \| title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. \| journal = J Clin Endocrinol Metab \| volume = 100 \| issue = 3 \| pages = E524-30 \| month = Mar \| year = 2015 \| doi = 10.1210/jc.2014-2036 \| PMID = 25485724 }}</ref>		*Benign.<ref name=pmid25485724>{{Cite journal \| last1 = Smeets \| first1 = EE. \| last2 = Span \| first2 = PN. \| last3 = van Herwaarden \| first3 = AE. \| last4 = Wevers \| first4 = RA. \| last5 = Hermus \| first5 = AR. \| last6 = Sweep \| first6 = FC. \| last7 = Claahsen-van der Grinten \| first7 = HL. \| title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. \| journal = J Clin Endocrinol Metab \| volume = 100 \| issue = 3 \| pages = E524-30 \| month = Mar \| year = 2015 \| doi = 10.1210/jc.2014-2036 \| PMID = 25485724 }}</ref>
	*May overlap with [[Leydig cell tumour]] - see ''molecular'' section.		*May overlap with [[Leydig cell tumour]] - see ''molecular'' section.
			*Associated with congenital adrenal hyperplasia.
			**Prevalence increases with age - one study suggests moderate prevalance at age 10, increasing to 100% of individuals over 16 years of age.<ref>{{Cite journal \| last1 = Claahsen-van der Grinten \| first1 = HL. \| last2 = Dehzad \| first2 = F. \| last3 = Kamphuis-van Ulzen \| first3 = K. \| last4 = de Korte \| first4 = CL. \| title = Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia. \| journal = Horm Res Paediatr \| volume = 82 \| issue = 4 \| pages = 238-44 \| month = \| year = 2014 \| doi = 10.1159/000365570 \| PMID = 25195868 }}</ref>

	Clinical:		Clinical: