Stomach carcinoma - Revision history

Michael: /* General */

2019-12-12T20:53:59Z

General

← Older revision		Revision as of 20:53, 12 December 2019
Line 47:		Line 47:
	**[[Peutz-Jeghers syndrome]].		**[[Peutz-Jeghers syndrome]].
	**[[Lynch syndrome]].		**[[Lynch syndrome]].
	**[[Gastric adenocarcinoma and proximal polyposis of the stomach]].<ref name=pmid30584346>{{Cite journal \| last1 = Rudloff \| first1 = U. \| title = Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives. \| journal = Clin Exp Gastroenterol \| volume = 11 \| issue = \| pages = 447-459 \| month = \| year = 2018 \| doi = 10.2147/CEG.S163227 \| PMID = 30584346 }}</ref><ref name=pmid21813476>{{Cite journal \| last1 = Worthley \| first1 = DL. \| last2 = Phillips \| first2 = KD. \| last3 = Wayte \| first3 = N. \| last4 = Schrader \| first4 = KA. \| last5 = Healey \| first5 = S. \| last6 = Kaurah \| first6 = P. \| last7 = Shulkes \| first7 = A. \| last8 = Grimpen \| first8 = F. \| last9 = Clouston \| first9 = A. \| title = Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. \| journal = Gut \| volume = 61 \| issue = 5 \| pages = 774-9 \| month = May \| year = 2012 \| doi = 10.1136/gutjnl-2011-300348 \| PMID = 21813476 }}</ref>		**[[Gastric adenocarcinoma and proximal polyposis of the stomach]].<ref name=pmid30584346>{{Cite journal \| last1 = Rudloff \| first1 = U. \| title = Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives. \| journal = Clin Exp Gastroenterol \| volume = 11 \| issue = \| pages = 447-459 \| month = \| year = 2018 \| doi = 10.2147/CEG.S163227 \| PMID = 30584346 }}</ref>

	Note:		Note:

Michael: /* General */

2019-12-12T20:53:34Z

General

← Older revision		Revision as of 20:53, 12 December 2019
Line 47:		Line 47:
	**[[Peutz-Jeghers syndrome]].		**[[Peutz-Jeghers syndrome]].
	**[[Lynch syndrome]].		**[[Lynch syndrome]].
			**[[Gastric adenocarcinoma and proximal polyposis of the stomach]].<ref name=pmid30584346>{{Cite journal \| last1 = Rudloff \| first1 = U. \| title = Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives. \| journal = Clin Exp Gastroenterol \| volume = 11 \| issue = \| pages = 447-459 \| month = \| year = 2018 \| doi = 10.2147/CEG.S163227 \| PMID = 30584346 }}</ref><ref name=pmid21813476>{{Cite journal \| last1 = Worthley \| first1 = DL. \| last2 = Phillips \| first2 = KD. \| last3 = Wayte \| first3 = N. \| last4 = Schrader \| first4 = KA. \| last5 = Healey \| first5 = S. \| last6 = Kaurah \| first6 = P. \| last7 = Shulkes \| first7 = A. \| last8 = Grimpen \| first8 = F. \| last9 = Clouston \| first9 = A. \| title = Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. \| journal = Gut \| volume = 61 \| issue = 5 \| pages = 774-9 \| month = May \| year = 2012 \| doi = 10.1136/gutjnl-2011-300348 \| PMID = 21813476 }}</ref>

	Note:		Note:

Michael at 20:52, 12 December 2019

2019-12-12T20:52:52Z

← Older revision		Revision as of 20:52, 12 December 2019
Line 17:		Line 17:
	\| Site = [[stomach]]		\| Site = [[stomach]]
	\| Assdx =		\| Assdx =
	\| Syndromes = [[hereditary diffuse gastric cancer]], [[familial adenomatous polyposis]], [[Lynch syndrome]], [[Peutz-Jeghers syndrome]], [[Li-Fraumeni syndrome]]		\| Syndromes = [[hereditary diffuse gastric cancer]], [[familial adenomatous polyposis]], [[Lynch syndrome]], [[Peutz-Jeghers syndrome]], [[Li-Fraumeni syndrome]], [[Gastric adenocarcinoma and proximal polyposis of the stomach]] (GAPPS)
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =

Abraham: /* IHC */

2018-09-19T09:36:16Z

IHC

← Older revision		Revision as of 09:36, 19 September 2018
Line 122:		Line 122:

	==IHC==		==IHC==
			*AE1/AE3.
	*CK7 +ve.		*CK7 +ve.
	*CK20 -ve, occasionally +ve.		*CK20 -ve, occasionally +ve.

Michael: /* IHC */

2017-05-19T16:48:20Z

IHC

← Older revision		Revision as of 16:48, 19 May 2017
Line 124:		Line 124:
	*CK7 +ve.		*CK7 +ve.
	*CK20 -ve, occasionally +ve.		*CK20 -ve, occasionally +ve.
			*[[CDX2]] +ve.<ref name=pmid12604886>{{Cite journal \| last1 = Werling \| first1 = RW. \| last2 = Yaziji \| first2 = H. \| last3 = Bacchi \| first3 = CE. \| last4 = Gown \| first4 = AM. \| title = CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. \| journal = Am J Surg Pathol \| volume = 27 \| issue = 3 \| pages = 303-10 \| month = Mar \| year = 2003 \| doi = \| PMID = 12604886 }}</ref>

	Others:		Others:

Michael: /* Intestinal type */

2016-04-29T21:34:18Z

Intestinal type

← Older revision		Revision as of 21:34, 29 April 2016
Line 140:		Line 140:
	===Biopsy===		===Biopsy===
	====Intestinal type====		====Intestinal type====
			<pre>
			Stomach, Biopsy:
			- INVASIVE ADENOCARCINOMA, INTESTINAL TYPE, moderately differentiated.
			- Gastric mucosa with intestinal metaplasia.

			Comment:
			The tumour stains as follows:
			POSITIVE: CK7, CDX2.
			NEGATIVE: CD20.

			HER2 testing has been ordered and will be reported as an addendum.
			</pre>

	<pre>		<pre>
	STOMACH, BIOPSY:		STOMACH, BIOPSY:
	- INVASIVE ADENOCARCINOMA, INTESTINAL TYPE, MODERATELY DIFFERENTIATED.		- INVASIVE ADENOCARCINOMA, INTESTINAL TYPE, MODERATELY DIFFERENTIATED.
	- Gastric mucosa with moderate chronic active inflammation and extensive		- Gastric mucosa with moderate chronic active inflammation and extensive
	intestinal metaplasia.		intestinal metaplasia.
	- Benign small bowel mucosa with erosions.		- Benign small bowel mucosa with erosions.
	</pre>		</pre>

Michael: /* Molecular */

2016-01-11T17:47:20Z

Molecular

← Older revision		Revision as of 17:47, 11 January 2016
Line 132:		Line 132:
	**Poor prognosis - like in breast cancer.		**Poor prognosis - like in breast cancer.
	**Scoring system different than in breast cancer - complete membrane staining is not required.		**Scoring system different than in breast cancer - complete membrane staining is not required.

			==Staging==
			*Sixteen (or more) lymph nodes should be assessed (as per the 7th Ed. of the UICC/AJCC staging).<ref name=pmid24744586>{{Cite journal \| last1 = Deng \| first1 = JY. \| last2 = Liang \| first2 = H. \| title = Clinical significance of lymph node metastasis in gastric cancer. \| journal = World J Gastroenterol \| volume = 20 \| issue = 14 \| pages = 3967-75 \| month = Apr \| year = 2014 \| doi = 10.3748/wjg.v20.i14.3967 \| PMID = 24744586 }}</ref>
			**The 5th Ed. of the UICC/AJCC staging manual stated 15 lymph nodes.<ref name=pmid24744586/>

	==Sign out==		==Sign out==

Michael: /* Gross */

2015-10-15T12:58:47Z

Gross

← Older revision		Revision as of 12:58, 15 October 2015
Line 76:		Line 76:
	*Ulceration with heaped (raised) edges.		*Ulceration with heaped (raised) edges.
	**Appearance of the typical intestinal type tumour.		**Appearance of the typical intestinal type tumour.
	*Diffuse wall thickening with loss of the rugae - called ''linitis plastica''.		*Diffuse wall thickening with loss of the rugae - called ''[[linitis plastica]]''.
	**Typically due to diffuse carcinoma.		**Typically due to diffuse carcinoma.

Michael at 12:58, 15 October 2015

2015-10-15T12:58:24Z

← Older revision		Revision as of 12:58, 15 October 2015
Line 24:		Line 24:
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =
	\| Endoscopy = +/-linitis plastica (diffuse carcinomas), +/-ulcer with heaped (raised) edges (intestinal carcinomas)		\| Endoscopy = +/-[[linitis plastica]] (diffuse carcinomas), +/-ulcer with heaped (raised) edges (intestinal carcinomas)
	\| Prognosis = usually very poor		\| Prognosis = usually very poor
	\| Other =		\| Other =

Michael: /* See also */

2015-09-04T19:46:42Z

← Older revision		Revision as of 19:46, 4 September 2015
Line 171:		Line 171:
	==See also==		==See also==
	*[[Stomach]].		*[[Stomach]].
			*[[Siewert classification]].

	==References==		==References==