Squamous cell carcinoma of the uterine cervix - Revision history

Abraham: /* IHC */

2017-08-15T13:58:31Z

IHC

← Older revision		Revision as of 13:58, 15 August 2017
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	==IHC==		==IHC==
			*CK7, p63, p16 +ve (except verrucous variant)
	*Factor VIII - to look for [[LVI]].		*Factor VIII - to look for [[LVI]].

Michael: /* Biopsy */

2014-03-25T18:25:23Z

Biopsy

← Older revision		Revision as of 18:25, 25 March 2014
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	-- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED.		-- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED.
	-- LYMPHOVASCULAR INVASION NOT APPARENT.		-- LYMPHOVASCULAR INVASION NOT APPARENT.
			</pre>

			<pre>
			LESION, UTERINE CERVIX, BIOPSY:
			- INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, FRAGMENTED.
			- PLEASE SEE TUMOUR SUMMARY.

			TUMOUR SUMMARY - UTERINE CERVIX
			Specimen: Cervix.
			Procedure: Biopsy.
			Tumour Site: Cannot be determined.
			Tumour Size: Cannot be determined - see comment.
			Histologic Type: Squamous cell carcinoma, keratinizing.
			Histologic Grade: G2: Moderately differentiated.
			Stromal Invasion: Extent cannot be assessed - see comment.
			Lymph-Vascular Invasion: Not identified.

			Comment:
			The tissue submitted is essentially all tumour. The largest fragment measures 1.2 x 1.4 cm
			in the plane of section. Fragmentation and lack of normal histology preclude orientation.
			As both the in plane dimensions exceed 0.7 cm, this is at least a pT1b.
	</pre>		</pre>

Michael: /* Sign out */

2014-03-25T13:18:09Z

Sign out

← Older revision		Revision as of 13:18, 25 March 2014
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	==Sign out==		==Sign out==
			===Biopsy===
	Early invasive SCC - things to report:		Early invasive SCC - things to report:
	*Depth of invasion.		*Depth of invasion.
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	-- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED.		-- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED.
	-- LYMPHOVASCULAR INVASION NOT APPARENT.		-- LYMPHOVASCULAR INVASION NOT APPARENT.
			</pre>

			===TAH-BSO===
			<pre>
			UTERUS, CERVIX, RIGHT AND LEFT OVARIES AND BILATERAL UTERINE TUBES, TOTAL HYSTERECTOMY AND
			BILATERAL SALPINGO-OOPHORECTOMY:
			- INVASIVE SQUAMOUS CELL CARCINOMA, pT1a1, pNx.
			-- MARGINS NEGATIVE FOR MALIGNANCY.
			-- PLEASE SEE TUMOUR SUMMARY.
			- PROLIFERATIVE ENDOMETRIUM.
			- UTERINE LEIOMYOMAS.
			- UTERINE TUBES WITH CHANGES COMPATIBLE WITH LIGATION, NO SIGNIFICANT PATHOLOGY.
			- OVARIES WITHOUT SIGNIFICANT PATHOLOGY.
	</pre>		</pre>

Michael: /* Sign out */

2014-02-23T14:36:48Z

Sign out

← Older revision		Revision as of 14:36, 23 February 2014
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	*Length of tumour.		*Length of tumour.
	*Number of blocks with tumour.		*Number of blocks with tumour.
	*LVI.		*[[Lymphovascular invasion]] (LVI).
	*Margins.		*Margins.

Michael: tweak

2014-02-23T14:35:25Z

tweak

← Older revision		Revision as of 14:35, 23 February 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Cervical squamous cell carcinoma in situ.jpg
			\| Width =
			\| Caption = Cervical squamous cell carcinoma in situ. [[H&E stain]].
			\| Synonyms =
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[squamous metaplasia of the uterine cervix]], [[high-grade squamous intraepithelial lesion]]
			\| Stains =
			\| IHC = p16 +ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross = white lesion ~ usu. close to transformation zone
			\| Grossing =
			\| Site = [[uterine cervix]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = most common cervical malignancy
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = usu. good, dependent on stage
			\| Other =
			\| ClinDDx =
			\| Tx = cervical cone, radical hysterectomy
			}}
	'''Squamous cell carcinoma of the uterine cervix''', also '''cervical squamous cell carcinoma''', is the most common primary malignancy of the [[uterine cervix]].		'''Squamous cell carcinoma of the uterine cervix''', also '''cervical squamous cell carcinoma''', is the most common primary malignancy of the [[uterine cervix]].

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	*Nuclear atypia.		*Nuclear atypia.

	SCC of the cervix versus ~~CIN III~~:		SCC of the cervix versus [[high-grade squamous intraepithelial lesion]] (carcinoma in situ):
	Invasive cancer look for:		Invasive cancer look for:
	*Eosinophilia.		*Eosinophilia.
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	===Images===		===Images===
	<gallery>		<gallery>
	Image:~~Ca_in_situ,_cervix_2~~.jpg\|SCC in situ. (WC)		Image:Cervical squamous cell carcinoma in situ.jpg\|SCC in situ. (WC)
	</gallery>		</gallery>
	www:		www:

Michael: /* General */

2014-02-23T14:07:42Z

General

← Older revision		Revision as of 14:07, 23 February 2014
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	*[[Human papillomavirus]] (HPV) infection, esp. "high risk HPV".		*[[Human papillomavirus]] (HPV) infection, esp. "high risk HPV".
	**HPV 16 closely assoc. with SCC.<ref name=pmid15551313>{{Cite journal \| last1 = De Boer \| first1 = MA. \| last2 = Peters \| first2 = LA. \| last3 = Aziz \| first3 = MF. \| last4 = Siregar \| first4 = B. \| last5 = Cornain \| first5 = S. \| last6 = Vrede \| first6 = MA. \| last7 = Jordanova \| first7 = ES. \| last8 = Fleuren \| first8 = GJ. \| title = Human papillomavirus type 18 variants: histopathology and E6/E7 polymorphisms in three countries. \| journal = Int J Cancer \| volume = 114 \| issue = 3 \| pages = 422-5 \| month = Apr \| year = 2005 \| doi = 10.1002/ijc.20727 \| PMID = 15551313 }}</ref>		**HPV 16 closely assoc. with SCC.<ref name=pmid15551313>{{Cite journal \| last1 = De Boer \| first1 = MA. \| last2 = Peters \| first2 = LA. \| last3 = Aziz \| first3 = MF. \| last4 = Siregar \| first4 = B. \| last5 = Cornain \| first5 = S. \| last6 = Vrede \| first6 = MA. \| last7 = Jordanova \| first7 = ES. \| last8 = Fleuren \| first8 = GJ. \| title = Human papillomavirus type 18 variants: histopathology and E6/E7 polymorphisms in three countries. \| journal = Int J Cancer \| volume = 114 \| issue = 3 \| pages = 422-5 \| month = Apr \| year = 2005 \| doi = 10.1002/ijc.20727 \| PMID = 15551313 }}</ref>

			==Gross==
			*White lesion.
			*Firm.

			===Images===
			<gallery>
			Image:Squamous carcinoma of the cervix.jpg \| SCC of cervix. (WC)
			</gallery>

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */

2014-02-23T14:05:55Z

Microscopic

← Older revision		Revision as of 14:05, 23 February 2014
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	DDx:		DDx:
	* [[Squamous metaplasia of the uterine cervix]] - if you can trace the squamous cells from a gland to the surface it is less likely to be invasive cancer.<ref>[http://www.nature.com/modpathol/journal/v15/n3/pdf/3880520a.pdf http://www.nature.com/modpathol/journal/v15/n3/pdf/3880520a.pdf]</ref>		* [[Squamous metaplasia of the uterine cervix]] - if you can trace the squamous cells from a gland to the surface it is less likely to be invasive cancer.<ref>[http://www.nature.com/modpathol/journal/v15/n3/pdf/3880520a.pdf http://www.nature.com/modpathol/journal/v15/n3/pdf/3880520a.pdf]</ref>
	*[[~~CIN III~~]] +/- endocervical gland involvement.		*[[High-grade squamous intraepithelial lesion]] +/- endocervical gland involvement.

	===Images===		===Images===

Michael: split out

2014-02-23T14:00:56Z

split out

← Older revision		Revision as of 14:00, 23 February 2014
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	~~#redirect~~ [[~~Uterine_cervix#Squamous_cell_carcinoma_of_the_uterine_cervix~~]]		'''Squamous cell carcinoma of the uterine cervix''', also '''cervical squamous cell carcinoma''', is the most common primary malignancy of the [[uterine cervix]].

			==General==
			*Most common type of cervical cancer.

			Risk factors:
			*Low socioeconomic status.
			*Smoking.
			*Early first intercourse.
			*High risk partners.
			*[[Human papillomavirus]] (HPV) infection, esp. "high risk HPV".
			**HPV 16 closely assoc. with SCC.<ref name=pmid15551313>{{Cite journal \| last1 = De Boer \| first1 = MA. \| last2 = Peters \| first2 = LA. \| last3 = Aziz \| first3 = MF. \| last4 = Siregar \| first4 = B. \| last5 = Cornain \| first5 = S. \| last6 = Vrede \| first6 = MA. \| last7 = Jordanova \| first7 = ES. \| last8 = Fleuren \| first8 = GJ. \| title = Human papillomavirus type 18 variants: histopathology and E6/E7 polymorphisms in three countries. \| journal = Int J Cancer \| volume = 114 \| issue = 3 \| pages = 422-5 \| month = Apr \| year = 2005 \| doi = 10.1002/ijc.20727 \| PMID = 15551313 }}</ref>

			==Microscopic==
			Features:
			*Squamous differentiation.
			**+/-Intracellular bridges.
			**Scant-to-moderate cytoplasm.
			*Penetration of basement membrane.
			**May be challenging to determine.
			*Nuclear atypia.

			SCC of the cervix versus CIN III:
			Invasive cancer look for:
			*Eosinophilia.
			*Extra large nuclei, i.e. nuclei 5x normal size.
			*Stromal inflammation (lymphocytes, plasma cells).
			*Long rete ridges.
			*Numerous beeds/blobs of epithelial cells that seem unlikely to be rete ridges.
			*[[Desmoplastic stroma]] - increased cellularity, spindle cell morphology.

			DDx:
			* [[Squamous metaplasia of the uterine cervix]] - if you can trace the squamous cells from a gland to the surface it is less likely to be invasive cancer.<ref>[http://www.nature.com/modpathol/journal/v15/n3/pdf/3880520a.pdf http://www.nature.com/modpathol/journal/v15/n3/pdf/3880520a.pdf]</ref>
			*[[CIN III]] +/- endocervical gland involvement.

			===Images===
			<gallery>
			Image:Ca_in_situ,_cervix_2.jpg\|SCC in situ. (WC)
			</gallery>
			www:
			*[http://sunnybrook.ca/uploads/cx_microinv_scc_S10-5249_6.jpg Microinvasive cervical SCC - low mag. (sunnybrook.ca)].<ref name=sb_cx_scc/>
			*[http://sunnybrook.ca/uploads/cx_microinv_scc_S10-5249_7.jpg Microinvasive cervical SCC - high mag. (sunnybrook.ca)].<ref name=sb_cx_scc>URL: [http://sunnybrook.ca/content/?page=dept-labs-apath-gynpath-imgat-cvx-mal-microiscc http://sunnybrook.ca/content/?page=dept-labs-apath-gynpath-imgat-cvx-mal-microiscc]. Accessed on: 2 May 2013.</ref>
			*[http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/ASSETS/Slide329SCClp_small.JPG Cervical SCC - low mag. (ucsf.edu)].<ref name=uscf>URL: [http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/homepage.htm]. Accessed on: 2 May 2013.</ref>
			*[http://missinglink.ucsf.edu/lm/IDS_107_Cervix_Ovary_Uterus/ASSETS/Slide329SCChp.JPG Cervical SCC - high mag. (uscf.edu)].

			===Grading===
			Divided into:<ref>{{Ref PBoD\|1077}}</ref>
			#Well-differentiated (keratinizing).
			#Moderately differentiated (nonkeratinizing).
			#Poorly differentiated.

			===Depth measurement===
			*Basement membrane (where it invades) to deepest point.

			Note:
			*Stage Ib - clinical diagnosis.
			**Definition of stage Ib: clinically visible.
			====FIGO====
			Microinvasive SCC as per FIGO:
			*Depth < 5 mm.
			*Width < 7 mm.
			*+/-Vascular invasion.

			====SGO====
			Microinvasive SCC as per The Society of Gynecologic Oncologists (SGO):
			*<= 3 mm.
			*Negative for [[vascular invasion]].

			Note:
			*The SGO criteria the prefered by North American gynecologists.

			==IHC==
			*Factor VIII - to look for [[LVI]].

			==Sign out==
			Early invasive SCC - things to report:
			*Depth of invasion.
			*Length of tumour.
			*Number of blocks with tumour.
			*LVI.
			*Margins.

			<pre>
			UTERINE CERVIX, BIOPSY:
			- FRAGMENTS OF INVASIVE SQUAMOUS CELL CARCINOMA.
			-- DEPTH OF INVASION AND LENTH OF TUMOUR CANNOT BE ASSESSED.
			-- LYMPHOVASCULAR INVASION NOT APPARENT.
			</pre>

			==See also==
			*[[Uterine cervix]].
			*[[Squamous cell carcinoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Uterine cervix]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2012-04-29T14:15:08Z

redirect

New page

#redirect [[Uterine_cervix#Squamous_cell_carcinoma_of_the_uterine_cervix]]

[[Category:Diagnosis]]