Squamous cell carcinoma of the penis - Revision history

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2026-02-28T14:44:01Z

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← Older revision		Revision as of 14:44, 28 February 2026
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	invasion is seen. The staging is unchanged.		invasion is seen. The staging is unchanged.
	</pre>		</pre>

			===Micro===
			The sections show a malignant tumour with moderate to severe anisonucleosis. It focally underlies keratinizing epithelium that matures to the surface. Intracellular bridges are present focally. Keratinization is present. Mitotic activity is easily identified.

	==See also==		==See also==

Michael: add main subtypes

2021-09-21T20:19:51Z

add main subtypes

← Older revision		Revision as of 20:19, 21 September 2021
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	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes = HPV-related SCC, Non-HPV-related SCC
	\| LMDDx = [[penile intraepithelial neoplasia]], [[pseudoepitheliomatous hyperplasia]]		\| LMDDx = [[penile intraepithelial neoplasia]], [[pseudoepitheliomatous hyperplasia]]
	\| Stains =		\| Stains =

Michael: /* Microscopic */

2021-09-21T20:15:57Z

Microscopic

← Older revision		Revision as of 20:15, 21 September 2021
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	*[[Penile intraepithelial neoplasia]] (squamous dysplasia).		*[[Penile intraepithelial neoplasia]] (squamous dysplasia).
	*[[Pseudoepitheliomatous hyperplasia]].		*[[Pseudoepitheliomatous hyperplasia]].

			===Subtyping===
			*''Non-HPV-related squamous cell carcinoma.
			**p16 -ve, p53 +ve.{{fact}}
			*''HPV-related squamous cell carcinoma''.
			**p16 +ve, p53 -ve.{{fact}}

	===Grading===		===Grading===

Michael: /* Sign out */

2016-02-23T18:04:24Z

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			===Biopsy===
			<pre>
			Penis, Biopsy:
			- INVASIVE SQUAMOUS CELL CARCINOMA, well differentiated.

			Comment:
			The tumour has differentiated penile intraepithelial neoplasia adjacent to it. The tumour is p16 negative and p53 positive.
			</pre>

			===Resection===
	<pre>		<pre>
	Tip of Penis, Partial Penectomy:		Tip of Penis, Partial Penectomy:

Michael: /* General */

2015-03-17T19:30:42Z

General

← Older revision		Revision as of 19:30, 17 March 2015
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	*Median age ~ 67 years old.		*Median age ~ 67 years old.
	*Usually a good outcome - 5 year cause specific survival ~ 81%.<ref name=pmid24119832/>		*Usually a good outcome - 5 year cause specific survival ~ 81%.<ref name=pmid24119832/>
			*Possible association with sex with animals.<ref>{{Cite journal \| last1 = Zequi \| first1 = Sde C. \| last2 = Guimarães \| first2 = GC. \| last3 = da Fonseca \| first3 = FP. \| last4 = Ferreira \| first4 = U. \| last5 = de Matheus \| first5 = WE. \| last6 = Reis \| first6 = LO. \| last7 = Aita \| first7 = GA. \| last8 = Glina \| first8 = S. \| last9 = Fanni \| first9 = VS. \| title = Sex with animals (SWA): behavioral characteristics and possible association with penile cancer. A multicenter study. \| journal = J Sex Med \| volume = 9 \| issue = 7 \| pages = 1860-7 \| month = Jul \| year = 2012 \| doi = 10.1111/j.1743-6109.2011.02512.x \| PMID = 22023719 }}</ref>

	==Gross==		==Gross==

Michael: /* IHC */

2015-03-04T22:16:55Z

IHC

← Older revision		Revision as of 22:16, 4 March 2015
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	==IHC==		==IHC==
	*p16 +ve - in types associated with [[HPV]] (basaloid SCC, warty SCC and warty-basaloid SCC.<ref name=pmid22367299>{{Cite journal \| last1 = Cubilla \| first1 = AL. \| last2 = Lloveras \| first2 = B. \| last3 = Alemany \| first3 = L. \| last4 = Alejo \| first4 = M. \| last5 = Vidal \| first5 = A. \| last6 = Kasamatsu \| first6 = E. \| last7 = Clavero \| first7 = O. \| last8 = Alvarado-Cabrero \| first8 = I. \| last9 = Lynch \| first9 = C. \| title = Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 6 \| pages = 869-75 \| month = Jun \| year = 2012 \| doi = 10.1097/PAS.0b013e318249c6f3 \| PMID = 22367299 }}</ref>		*p16 +ve - in types associated with [[HPV]] (basaloid SCC, warty SCC and warty-basaloid SCC).<ref name=pmid22367299>{{Cite journal \| last1 = Cubilla \| first1 = AL. \| last2 = Lloveras \| first2 = B. \| last3 = Alemany \| first3 = L. \| last4 = Alejo \| first4 = M. \| last5 = Vidal \| first5 = A. \| last6 = Kasamatsu \| first6 = E. \| last7 = Clavero \| first7 = O. \| last8 = Alvarado-Cabrero \| first8 = I. \| last9 = Lynch \| first9 = C. \| title = Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 6 \| pages = 869-75 \| month = Jun \| year = 2012 \| doi = 10.1097/PAS.0b013e318249c6f3 \| PMID = 22367299 }}</ref>

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Michael: /* IHC */

2015-03-04T22:16:41Z

IHC

← Older revision		Revision as of 22:16, 4 March 2015
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	==IHC==		==IHC==
	*p16 +ve - in types associated with HPV.<ref name=pmid22367299>{{Cite journal \| last1 = Cubilla \| first1 = AL. \| last2 = Lloveras \| first2 = B. \| last3 = Alemany \| first3 = L. \| last4 = Alejo \| first4 = M. \| last5 = Vidal \| first5 = A. \| last6 = Kasamatsu \| first6 = E. \| last7 = Clavero \| first7 = O. \| last8 = Alvarado-Cabrero \| first8 = I. \| last9 = Lynch \| first9 = C. \| title = Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 6 \| pages = 869-75 \| month = Jun \| year = 2012 \| doi = 10.1097/PAS.0b013e318249c6f3 \| PMID = 22367299 }}</ref>		*p16 +ve - in types associated with [[HPV]] (basaloid SCC, warty SCC and warty-basaloid SCC.<ref name=pmid22367299>{{Cite journal \| last1 = Cubilla \| first1 = AL. \| last2 = Lloveras \| first2 = B. \| last3 = Alemany \| first3 = L. \| last4 = Alejo \| first4 = M. \| last5 = Vidal \| first5 = A. \| last6 = Kasamatsu \| first6 = E. \| last7 = Clavero \| first7 = O. \| last8 = Alvarado-Cabrero \| first8 = I. \| last9 = Lynch \| first9 = C. \| title = Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 6 \| pages = 869-75 \| month = Jun \| year = 2012 \| doi = 10.1097/PAS.0b013e318249c6f3 \| PMID = 22367299 }}</ref>
	**Basaloid SCC, warty SCC and warty-basaloid SCC.<ref name=pmid22367299/>

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Michael: /* Sign out */

2015-03-04T22:15:39Z

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← Older revision		Revision as of 22:15, 4 March 2015
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	Image: Squamous carcinoma of the penis - 2 -- high mag.jpg \| Penile SCC - high mag.		Image: Squamous carcinoma of the penis - 2 -- high mag.jpg \| Penile SCC - high mag.
	</gallery>		</gallery>

			==IHC==
			*p16 +ve - in types associated with HPV.<ref name=pmid22367299>{{Cite journal \| last1 = Cubilla \| first1 = AL. \| last2 = Lloveras \| first2 = B. \| last3 = Alemany \| first3 = L. \| last4 = Alejo \| first4 = M. \| last5 = Vidal \| first5 = A. \| last6 = Kasamatsu \| first6 = E. \| last7 = Clavero \| first7 = O. \| last8 = Alvarado-Cabrero \| first8 = I. \| last9 = Lynch \| first9 = C. \| title = Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 6 \| pages = 869-75 \| month = Jun \| year = 2012 \| doi = 10.1097/PAS.0b013e318249c6f3 \| PMID = 22367299 }}</ref>
			**Basaloid SCC, warty SCC and warty-basaloid SCC.<ref name=pmid22367299/>

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Michael: /* Microscopic */

2015-02-09T07:20:47Z

Microscopic

← Older revision		Revision as of 07:20, 9 February 2015
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	DDx:		DDx:
	*[[Penile intraepithelial neoplasia]] (~~PeIN~~).		*[[Penile intraepithelial neoplasia]] (squamous dysplasia).
	*[[Pseudoepitheliomatous hyperplasia]].		*[[Pseudoepitheliomatous hyperplasia]].

Michael at 07:20, 9 February 2015

2015-02-09T07:20:24Z

← Older revision		Revision as of 07:20, 9 February 2015
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	\| Micro =		\| Micro =
	\| Subtypes =		\| Subtypes =
	\| LMDDx = ~~squamous dysplasia~~, [[pseudoepitheliomatous hyperplasia]]		\| LMDDx = [[penile intraepithelial neoplasia]], [[pseudoepitheliomatous hyperplasia]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC =