Squamous cell carcinoma of the lung - Revision history

Michael at 17:22, 20 December 2016

2016-12-20T17:22:08Z

← Older revision		Revision as of 17:22, 20 December 2016
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	\| LMDDx = [[lung adenocarcinoma]], [[non-small cell lung carcinoma]], metastatic [[squamous cell carcinoma]], others		\| LMDDx = [[lung adenocarcinoma]], [[non-small cell lung carcinoma]], metastatic [[squamous cell carcinoma]], others
	\| Stains =		\| Stains =
	\| IHC = p40 +ve, p63 +ve, TTF-1 -ve, CK7 -ve		\| IHC = [[p40]] +ve, [[p63]] +ve, [[TTF-1]] -ve, CK7 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: more

2016-12-16T17:31:34Z

← Older revision		Revision as of 17:31, 16 December 2016
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	==Sign out==		==Sign out==
			<pre>
			Lung, Right Upper Lobe, Core Biopsy:
			- SQUAMOUS CELL CARCINOMA.

			COMMENT:
			The tumour stains as follows:
			POSITIVE: p40, CK5/6.
			NEGATIVE: TTF-1, napsin.
			</pre>

			===Block letters===
	<pre>		<pre>
	LUNG, RIGHT UPPER LOBE, BIOPSY:		LUNG, RIGHT UPPER LOBE, BIOPSY:

Michael: /* Lung SCC versus metastatic bladder carcinoma */

2016-07-05T16:32:32Z

Lung SCC versus metastatic bladder carcinoma

← Older revision		Revision as of 16:32, 5 July 2016
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	*[[Napsin]] -ve.		*[[Napsin]] -ve.

	===Lung SCC versus metastatic bladder carcinoma===		===Lung SCC versus metastatic bladder urothelial carcinoma===
	As per Gruver ''et al.'':<ref name=pmid23106579>{{Cite journal \| last1 = Gruver \| first1 = AM. \| last2 = Amin \| first2 = MB. \| last3 = Luthringer \| first3 = DJ. \| last4 = Westfall \| first4 = D. \| last5 = Arora \| first5 = K. \| last6 = Farver \| first6 = CF. \| last7 = Osunkoya \| first7 = AO. \| last8 = McKenney \| first8 = JK. \| last9 = Hansel \| first9 = DE. \| title = Selective immunohistochemical markers to distinguish between metastatic high-grade urothelial carcinoma and primary poorly differentiated invasive squamous cell carcinoma of the lung. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 11 \| pages = 1339-46 \| month = Nov \| year = 2012 \| doi = 10.5858/arpa.2011-0575-OA \| PMID = 23106579 }}</ref>		As per Gruver ''et al.'':<ref name=pmid23106579>{{Cite journal \| last1 = Gruver \| first1 = AM. \| last2 = Amin \| first2 = MB. \| last3 = Luthringer \| first3 = DJ. \| last4 = Westfall \| first4 = D. \| last5 = Arora \| first5 = K. \| last6 = Farver \| first6 = CF. \| last7 = Osunkoya \| first7 = AO. \| last8 = McKenney \| first8 = JK. \| last9 = Hansel \| first9 = DE. \| title = Selective immunohistochemical markers to distinguish between metastatic high-grade urothelial carcinoma and primary poorly differentiated invasive squamous cell carcinoma of the lung. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 11 \| pages = 1339-46 \| month = Nov \| year = 2012 \| doi = 10.5858/arpa.2011-0575-OA \| PMID = 23106579 }}</ref>
	{\| class="wikitable sortable"		{\| class="wikitable sortable"

Michael: /* Lung SCC versus metastatic bladder carcinoma */

2016-07-05T16:30:21Z

Lung SCC versus metastatic bladder carcinoma

← Older revision		Revision as of 16:30, 5 July 2016
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	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	! IHC		! IHC
	! Lung SCC		! Lung <Br>SCC
	! Bladder [[urothelial carcinoma\|UCC]]		! Bladder <br>[[urothelial carcinoma\|UCC]]
	\|-		\|-
	\| CK7		\| CK7
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	\|-		\|-
	\| Uroplakin III		\| Uroplakin III
	\| 0%		\| 0% +ve
	\| 14%		\| 14% +ve
	\|}		\|}

Michael: /* IHC */

2016-07-05T16:29:25Z

IHC

← Older revision		Revision as of 16:29, 5 July 2016
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	**Positive in [[adenocarcinoma of the lung]].		**Positive in [[adenocarcinoma of the lung]].

	SCC versus adenocarcinoma:		===SCC versus adenocarcinoma===
	*p40 +ve.		*p40 +ve.
	*CK5/6 +ve.		*CK5/6 +ve.
	*TTF-1 -ve.		*TTF-1 -ve.
	*[[Napsin]] -ve.		*[[Napsin]] -ve.

			===Lung SCC versus metastatic bladder carcinoma===
			As per Gruver ''et al.'':<ref name=pmid23106579>{{Cite journal \| last1 = Gruver \| first1 = AM. \| last2 = Amin \| first2 = MB. \| last3 = Luthringer \| first3 = DJ. \| last4 = Westfall \| first4 = D. \| last5 = Arora \| first5 = K. \| last6 = Farver \| first6 = CF. \| last7 = Osunkoya \| first7 = AO. \| last8 = McKenney \| first8 = JK. \| last9 = Hansel \| first9 = DE. \| title = Selective immunohistochemical markers to distinguish between metastatic high-grade urothelial carcinoma and primary poorly differentiated invasive squamous cell carcinoma of the lung. \| journal = Arch Pathol Lab Med \| volume = 136 \| issue = 11 \| pages = 1339-46 \| month = Nov \| year = 2012 \| doi = 10.5858/arpa.2011-0575-OA \| PMID = 23106579 }}</ref>
			{\| class="wikitable sortable"
			! IHC
			! Lung SCC
			! Bladder [[urothelial carcinoma\|UCC]]
			\|-
			\| CK7
			\| 33% +ve
			\| 100% +ve
			\|-
			\| CK20
			\| 7% +ve
			\| 54% +ve
			\|-
			\| GATA-3
			\| 23% +ve
			\| 78% +ve
			\|-
			\| Desmoglein-3
			\| 87% +ve
			\| 11% +ve
			\|-
			\| CK14
			\| 77% +ve
			\| 32% +ve
			\|-
			\| Uroplakin III
			\| 0%
			\| 14%
			\|}

	==Sign out==		==Sign out==

Michael: /* Grading */

2016-03-23T16:39:39Z

Grading

← Older revision		Revision as of 16:39, 23 March 2016
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	There is no consensus on how grading of lung SCC should be done; however, a three tiered system is suggested in the CAP protocol,<ref name=cap_protocol_v3400>URL: [http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf]. Version: 3.4.0.0. Accessed on: 23 March 2016.</ref> and some older data is suggestive that such a system for lung SCC can be predictive.<ref name=pmid7092385>{{Cite journal \| last1 = Chung \| first1 = CK. \| last2 = Zaino \| first2 = R. \| last3 = Stryker \| first3 = JA. \| last4 = O'Neill \| first4 = M. \| last5 = DeMuth \| first5 = WE. \| title = Carcinoma of the lung: evaluation of histological grade and factors influencing prognosis. \| journal = Ann Thorac Surg \| volume = 33 \| issue = 6 \| pages = 599-604 \| month = Jun \| year = 1982 \| doi = \| PMID = 7092385 }}</ref>		There is no consensus on how grading of lung SCC should be done; however, a three tiered system is suggested in the CAP protocol,<ref name=cap_protocol_v3400>URL: [http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf]. Version: 3.4.0.0. Accessed on: 23 March 2016.</ref> and some older data is suggestive that such a system for lung SCC can be predictive.<ref name=pmid7092385>{{Cite journal \| last1 = Chung \| first1 = CK. \| last2 = Zaino \| first2 = R. \| last3 = Stryker \| first3 = JA. \| last4 = O'Neill \| first4 = M. \| last5 = DeMuth \| first5 = WE. \| title = Carcinoma of the lung: evaluation of histological grade and factors influencing prognosis. \| journal = Ann Thorac Surg \| volume = 33 \| issue = 6 \| pages = 599-604 \| month = Jun \| year = 1982 \| doi = \| PMID = 7092385 }}</ref>

	~~Grading~~ system ~~- as~~ loosely defined by the CAP protocol (version 3.4.0.0):<ref name=cap_protocol_v3400/>		The grading system loosely defined by the CAP protocol (version 3.4.0.0):<ref name=cap_protocol_v3400/>
	*Grade 1 (well differentiated) - extensive keratinization.		*Grade 1 (well differentiated) - extensive keratinization.
	*Grade 2 (moderately differentiated) - some keratinization.		*Grade 2 (moderately differentiated) - some keratinization.

Michael: /* Grading */

2016-03-23T16:39:17Z

Grading

← Older revision		Revision as of 16:39, 23 March 2016
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	===Grading===		===Grading===
	There is no consensus on how grading of lung SCC should be done; however, a three tiered system is suggested in the CAP protocol,<ref>URL: [http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf]. Version: 3.4.0.0. Accessed on: 23 March 2016.</ref> and some older data suggestive it can be predictive.<ref name=pmid7092385>{{Cite journal \| last1 = Chung \| first1 = CK. \| last2 = Zaino \| first2 = R. \| last3 = Stryker \| first3 = JA. \| last4 = O'Neill \| first4 = M. \| last5 = DeMuth \| first5 = WE. \| title = Carcinoma of the lung: evaluation of histological grade and factors influencing prognosis. \| journal = Ann Thorac Surg \| volume = 33 \| issue = 6 \| pages = 599-604 \| month = Jun \| year = 1982 \| doi = \| PMID = 7092385 }}</ref>		There is no consensus on how grading of lung SCC should be done; however, a three tiered system is suggested in the CAP protocol,<ref name=cap_protocol_v3400>URL: [http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf]. Version: 3.4.0.0. Accessed on: 23 March 2016.</ref> and some older data is suggestive that such a system for lung SCC can be predictive.<ref name=pmid7092385>{{Cite journal \| last1 = Chung \| first1 = CK. \| last2 = Zaino \| first2 = R. \| last3 = Stryker \| first3 = JA. \| last4 = O'Neill \| first4 = M. \| last5 = DeMuth \| first5 = WE. \| title = Carcinoma of the lung: evaluation of histological grade and factors influencing prognosis. \| journal = Ann Thorac Surg \| volume = 33 \| issue = 6 \| pages = 599-604 \| month = Jun \| year = 1982 \| doi = \| PMID = 7092385 }}</ref>

			Grading system - as loosely defined by the CAP protocol (version 3.4.0.0):<ref name=cap_protocol_v3400/>
	*Grade 1 (well differentiated) - extensive keratinization.		*Grade 1 (well differentiated) - extensive keratinization.
	*Grade 2 (moderately differentiated) - some keratinization.		*Grade 2 (moderately differentiated) - some keratinization.

Michael: /* Microscopic */

2016-03-23T16:37:24Z

Microscopic

← Older revision		Revision as of 16:37, 23 March 2016
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	*[[Non-small cell lung carcinoma]] - diagnosis should be avoided if possible.		*[[Non-small cell lung carcinoma]] - diagnosis should be avoided if possible.
	*[[Small cell carcinoma of the lung]] - for ''basaloid squamous cell carcinoma''.		*[[Small cell carcinoma of the lung]] - for ''basaloid squamous cell carcinoma''.

			===Grading===
			There is no consensus on how grading of lung SCC should be done; however, a three tiered system is suggested in the CAP protocol,<ref>URL: [http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf]. Version: 3.4.0.0. Accessed on: 23 March 2016.</ref> and some older data suggestive it can be predictive.<ref name=pmid7092385>{{Cite journal \| last1 = Chung \| first1 = CK. \| last2 = Zaino \| first2 = R. \| last3 = Stryker \| first3 = JA. \| last4 = O'Neill \| first4 = M. \| last5 = DeMuth \| first5 = WE. \| title = Carcinoma of the lung: evaluation of histological grade and factors influencing prognosis. \| journal = Ann Thorac Surg \| volume = 33 \| issue = 6 \| pages = 599-604 \| month = Jun \| year = 1982 \| doi = \| PMID = 7092385 }}</ref>
			*Grade 1 (well differentiated) - extensive keratinization.
			*Grade 2 (moderately differentiated) - some keratinization.
			*Grade 3 (poorly differentiated) - no/little keratinization.

	===Images===		===Images===

Michael: +images

2016-01-09T05:59:04Z

+images

← Older revision		Revision as of 05:59, 9 January 2016
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = ~~Squamous~~ carcinoma ~~lung cytology~~.~~gif~~		\| Image = Lung squamous carcinoma -- intermed mag.jpg
	\| Width =		\| Width =
	\| Caption = Squamous cell carcinoma of the lung. [[~~Pap~~ stain]].		\| Caption = Squamous cell carcinoma of the lung. [[H&E stain]].
	\| Synonyms = squamous carcinoma of the lung		\| Synonyms = squamous carcinoma of the lung
	\| Micro =		\| Micro =
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	*+/-Small nucleolus.		*+/-Small nucleolus.
	*Intracellular bridges - classic.		*Intracellular bridges - classic.

			Note:
			*[[Lymphovascular invasion]] (LVI) is relatively common in small tumours. In one series of NSLC tumours less than 2 cm the prevalence of LVI was 16%.<ref>{{cite journal \|author=Tao H, Hayashi T, Sano F, ''et al.'' \|title=Prognostic impact of lymphovascular invasion compared with that of visceral pleural invasion in patients with pN0 non-small-cell lung cancer and a tumor diameter of 2 cm or smaller \|journal=J. Surg. Res. \|volume=185 \|issue=1 \|pages=250–4 \|year=2013 \|month=November \|pmid=23830361 \|doi=10.1016/j.jss.2013.05.104 \|url=}}</ref>
			**Unlike in [[lung adenocarcinoma]], LVI in lung SCC does ''not'' seem to increase the risk of distant metastases and death.<ref name=pmid22617241>{{cite journal \|author=Higgins KA, Chino JP, Ready N, ''et al.'' \|title=Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy \|journal=J Thorac Oncol \|volume=7 \|issue=7 \|pages=1141–7 \|year=2012 \|month=July \|pmid=22617241 \|doi=10.1097/JTO.0b013e3182519a42 \|url=}}</ref>

	DDx:		DDx:
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	*[[Small cell carcinoma of the lung]] - for ''basaloid squamous cell carcinoma''.		*[[Small cell carcinoma of the lung]] - for ''basaloid squamous cell carcinoma''.

	~~Note~~:		===Images===
	*[[Lymphovascular invasion]] (~~LVI~~) ~~is relatively common in small tumours. In one series of NSLC tumours less than 2 cm the prevalence of LVI was 16%~~.~~<ref>{{cite journal~~ \|~~author=Tao H, Hayashi T, Sano F, ''et al~~.~~'' \|title=Prognostic impact of lymphovascular invasion compared with that of visceral pleural invasion in patients with pN0 non~~-~~small~~-~~cell lung cancer and a tumor diameter of 2 cm or smaller~~ \|~~journal=J~~. ~~Surg~~. ~~Res~~. \|~~volume=185~~ \|~~issue=1 \|pages=250–4 \|year=2013 \|month=November \|pmid=23830361 \|doi=10~~.~~1016/j~~.~~jss~~.~~2013~~.~~05.104 \|url=}}~~</~~ref~~>		<gallery>
	**Unlike in [[lung adenocarcinoma]], LVI in lung SCC does ''not'' seem to increase the risk of distant metastases and death.<ref name=~~pmid22617241>{{cite journal \|author~~=~~Higgins KA, Chino JP, Ready N, ''et al.'' \|title~~=~~Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy \|journal~~=~~J Thorac Oncol \|volume~~=~~7 \|issue~~=~~7 \|pages~~=~~1141–7 \|year~~=~~2012~~ \|~~month=July \|pmid=22617241 \|doi=10~~.~~1097/JTO.0b013e3182519a42 \|url=}}~~</~~ref~~>		Image: Lung squamous carcinoma -- very low mag.jpg \| Lung SCC - very low mag. (WC)
			Image: Lung squamous carcinoma -- low mag.jpg \| Lung SCC - low mag. (WC)
			Image: Lung squamous carcinoma -- intermed mag.jpg \| Lung SCC - intermed. mag. (WC)
			Image: Lung squamous carcinoma -- high mag.jpg \| Lung SCC - high mag. (WC)
			Image: Lung squamous carcinoma - alt -- low mag.jpg \| Lung SCC - low mag. (WC)
			Image: Lung squamous carcinoma - alt -- intermed mag.jpg \| Lung SCC - intermed. mag. (WC)
			</gallery>
			====Cytology====
			<gallery>
			Image: Squamous carcinoma lung cytology.gif \| Lung SCC - cytology. (WC)
			</gallery>

	==IHC==		==IHC==

Michael at 02:05, 18 November 2015

2015-11-18T02:05:46Z

← Older revision		Revision as of 02:05, 18 November 2015
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
			\| Staging = [[lung cancer staging]]
	\| Site = [[lung]] - see [[lung tumours]]		\| Site = [[lung]] - see [[lung tumours]]
	\| Assdx =		\| Assdx =