Squamous cell carcinoma of the esophagus - Revision history

Michael at 16:54, 28 October 2021

2021-10-28T16:54:35Z

← Older revision		Revision as of 16:54, 28 October 2021
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[esophagus]] - proximal or mid portion		\| Site = [[esophagus]] - usually proximal or mid portion
	\| Assdx = [[squamous dysplasia of the esophagus]], [[alcohol]], [[smoking]]		\| Assdx = [[squamous dysplasia of the esophagus]], [[alcohol]], [[smoking]]
	\| Syndromes =		\| Syndromes =

Michael: tweak

2014-02-23T12:24:21Z

tweak

← Older revision		Revision as of 12:24, 23 February 2014
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	==Microscopic==		==Microscopic==
	Features - atypical squamous cells with ~~invading~~ through the basement membrane.		Features - atypical squamous cells with invasion through the basement membrane:
	*Cytology:		*Cytology:
	**Nucleus - typical central.		**Nucleus - typical central.
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	*[[Squamous dysplasia of the esophagus]].		*[[Squamous dysplasia of the esophagus]].
	*[[Adenocarcinoma of the esophagus]].		*[[Adenocarcinoma of the esophagus]].
			*[[metastasis\|Metastatic]] carcinoma.

	===Images===		===Images===

Michael: ix

2014-02-22T03:53:12Z

← Older revision		Revision as of 03:53, 22 February 2014
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	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[squamous dysplasia of the esophagus]]		\| LMDDx = [[squamous dysplasia of the esophagus]]
	\| Stains = CK5/6 +ve~~, p63 +ve~~		\| Stains =
	~~\| IHC =~~		\| IHC = p63 +'ve, CK5/6 +'ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael at 03:31, 22 February 2014

2014-02-22T03:31:08Z

← Older revision		Revision as of 03:31, 22 February 2014
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	\| Other =		\| Other =
	\| ClinDDx = benign [[esophageal stricture]]		\| ClinDDx = benign [[esophageal stricture]]
	\| Tx = usu. surgery - if feasible		\| Tx = usu. surgery - if feasible, chemotherapy, radiation
	}}		}}
	'''Squamous cell carcinoma of the esophagus''' is a relatively uncommon form of esophageal cancer.		'''Squamous cell carcinoma of the esophagus''' is a relatively uncommon form of esophageal cancer.

Michael: /* General */

2014-02-22T03:30:50Z

General

← Older revision		Revision as of 03:30, 22 February 2014
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	*Dysphagia of solid and liquids.		*Dysphagia of solid and liquids.
	*Weight loss.		*Weight loss.
			*Multimodal treatment - surgery, chemotherapy and radiation.<ref name=pmid24480403>{{Cite journal \| last1 = Bass \| first1 = GA. \| last2 = Furlong \| first2 = H. \| last3 = O'Sullivan \| first3 = KE. \| last4 = Hennessy \| first4 = TP. \| last5 = Walsh \| first5 = TN. \| title = Chemoradiotherapy, with adjuvant surgery for local control, confers a durable survival advantage in adenocarcinoma and squamous cell carcinoma of the oesophagus. \| journal = Eur J Cancer \| volume = \| issue = \| pages = \| month = Jan \| year = 2014 \| doi = 10.1016/j.ejca.2013.12.022 \| PMID = 24480403 }}</ref>

	==Gross==		==Gross==

Michael: +image

2014-02-22T03:27:32Z

+image

← Older revision		Revision as of 03:27, 22 February 2014
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image =		\| Image = Esophageal_squamous_cell_carcinoma_-_a1_--_high_mag.jpg
	\| Width =		\| Width =
	\| Caption =		\| Caption = Esophageal squamous cell carcinoma. [[H&E stain]].
	\| Synonyms =		\| Synonyms =
	\| Micro = atypical cells ~~with a squamoid differentation~~ invading into the lamina propria		\| Micro = atypical squamous cells invading into the lamina propria
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[~~Squamous~~ dysplasia of the esophagus]]		\| LMDDx = [[squamous dysplasia of the esophagus]]
	\| Stains = CK5/6 +ve, p63 +ve		\| Stains = CK5/6 +ve, p63 +ve
	\| IHC =		\| IHC =
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	\| Grossing =		\| Grossing =
	\| Site = [[esophagus]] - proximal or mid portion		\| Site = [[esophagus]] - proximal or mid portion
	\| Assdx =		\| Assdx = [[squamous dysplasia of the esophagus]], [[alcohol]], [[smoking]]
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms = dysphagia of solid and liquids
	\| Prevalence = uncommon		\| Prevalence = uncommon
	\| Bloodwork =		\| Bloodwork =
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	*Reflux is ''not'' a risk factor for esophageal SCC.		*Reflux is ''not'' a risk factor for esophageal SCC.
	**It is a risk factor indirectly for [[esophageal adenocarcinoma]].		**It is a risk factor indirectly for [[esophageal adenocarcinoma]].

			Clinical:
			*Dysphagia of solid and liquids.
			*Weight loss.

	==Gross==		==Gross==

Michael at 03:23, 22 February 2014

2014-02-22T03:23:54Z

← Older revision		Revision as of 03:23, 22 February 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image =
			\| Width =
			\| Caption =
			\| Synonyms =
			\| Micro = atypical cells with a squamoid differentation invading into the lamina propria
			\| Subtypes =
			\| LMDDx = [[Squamous dysplasia of the esophagus]]
			\| Stains = CK5/6 +ve, p63 +ve
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[esophagus]] - proximal or mid portion
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx =
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = poor
			\| Other =
			\| ClinDDx = benign [[esophageal stricture]]
			\| Tx = usu. surgery - if feasible
			}}
	'''Squamous cell carcinoma of the esophagus''' is a relatively uncommon form of esophageal cancer.		'''Squamous cell carcinoma of the esophagus''' is a relatively uncommon form of esophageal cancer.

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	*Food with nitrosamines.		*Food with nitrosamines.
	*Burning-hot beverages.		*Burning-hot beverages.
			**Disputed.<ref>{{Cite journal \| last1 = Zamora-Ros \| first1 = R. \| last2 = Luján-Barroso \| first2 = L. \| last3 = Bueno-de-Mesquita \| first3 = HB. \| last4 = Dik \| first4 = VK. \| last5 = Boeing \| first5 = H. \| last6 = Steffen \| first6 = A. \| last7 = Tjønneland \| first7 = A. \| last8 = Olsen \| first8 = A. \| last9 = Bech \| first9 = BH. \| title = Tea and coffee consumption and risk of esophageal cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. \| journal = Int J Cancer \| volume = \| issue = \| pages = \| month = Feb \| year = 2014 \| doi = 10.1002/ijc.28789 \| PMID = 24535727 }}</ref>

	Note:		Note:
	*Reflux is ''not'' a risk factor for esophageal SCC.		*Reflux is ''not'' a risk factor for esophageal SCC.
	**It is a risk factor indirectly for [[esophageal adenocarcinoma]].		**It is a risk factor indirectly for [[esophageal adenocarcinoma]].

			==Gross==
			*Mass in the esophagus - classically proximal or mid portion.

	==Microscopic==		==Microscopic==
	:~~See ''[[~~Squamous ~~carcinoma]]''~~.		Features - atypical squamous cells with invading through the basement membrane.
			*Cytology:
			**Nucleus - typical central.
			***+/-Mitoses.
			**Cytoplasm - "dense-appearing", typically eosinophilic (may be intensely eosinophilic).
			*+/-Squamous whorls.

	Note:		Note:
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	DDx:		DDx:
			*Reactive changes.
	*[[Squamous dysplasia of the esophagus]].		*[[Squamous dysplasia of the esophagus]].
			*[[Adenocarcinoma of the esophagus]].

	===Images===		===Images===
			<gallery>
			Image: Esophageal squamous cell carcinoma -- intermed mag.jpg \| Esophageal SCC - intermed. mag.
			Image: Esophageal squamous cell carcinoma -- high mag.jpg \| Esophageal SCC - high mag.
			Image: Esophageal squamous cell carcinoma -- very high mag.jpg \| Esophageal SCC - very high mag.
			</gallery>
			<gallery>
			Image: Esophageal squamous cell carcinoma - a1 -- high mag.jpg \| Esophageal SCC - high mag.
			Image: Esophageal squamous cell carcinoma - a2 -- high mag.jpg \| Esophageal SCC - high mag.
			Image: Esophageal squamous cell carcinoma - a3 -- high mag.jpg \| Esophageal SCC - high mag.
			Image: Esophageal squamous cell carcinoma - a1 -- very high mag.jpg \| Esophageal SCC - very high mag.
			</gallery>
			www:
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544238/figure/fig08/ Carcinoma in situ (nih.gov)].<ref name=pmid23330004>{{Cite journal \| last1 = Terada \| first1 = T. \| title = A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 2 \| pages = 191-8 \| month = \| year = 2013 \| doi = \| PMID = 23330004 }}</ref>		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544238/figure/fig08/ Carcinoma in situ (nih.gov)].<ref name=pmid23330004>{{Cite journal \| last1 = Terada \| first1 = T. \| title = A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 2 \| pages = 191-8 \| month = \| year = 2013 \| doi = \| PMID = 23330004 }}</ref>
	*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544238/figure/fig09/ Squamous cell carcinoma of the esophagus (nih.gov)].		*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544238/figure/fig09/ Squamous cell carcinoma of the esophagus (nih.gov)].

Michael: /* Sign out */

2014-02-20T16:01:25Z

Sign out

← Older revision		Revision as of 16:01, 20 February 2014
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	==Sign out==		==Sign out==
	<pre>		<pre>
	~~ESOPHGAUS~~, BIOPSY:		ESOPHAGUS, BIOPSY:
	- INVASIVE SQUAMOUS CELL CARCINOMA, KERATINIZING, MODERATELY DIFFERENTIATED.		- INVASIVE SQUAMOUS CELL CARCINOMA, KERATINIZING, MODERATELY DIFFERENTIATED.

Michael: split out

2014-02-17T04:14:00Z

split out

← Older revision		Revision as of 04:14, 17 February 2014
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	~~#redirect [[Esophagus#Squamous_cell_carcinoma_of_the_esophagus]]~~		'''Squamous cell carcinoma of the esophagus''' is a relatively uncommon form of esophageal cancer.

			It is also known as '''esophageal squamous cell carcinoma''', abbreviated '''esophageal SCC'''.

			''Squamous cell carcinoma'', also ''squamous carcinoma'', is discussed in general terms in the ''[[squamous cell carcinoma]]'' article.

			==General==
			*Like squamous cell carcinoma elsewhere.

			Risk factors:<ref name=Ref_APBR104>{{Ref APBR\|104 Q1}}</ref>
			*[[Ethanol abuse\|Alcohol consumption]].
			*[[Smoking\|Tobacco use]].
			*Food with nitrosamines.
			*Burning-hot beverages.

			Note:
			*Reflux is ''not'' a risk factor for esophageal SCC.
			**It is a risk factor indirectly for [[esophageal adenocarcinoma]].

			==Microscopic==
			:See ''[[Squamous carcinoma]]''.

			Note:
			*Just to make things confusing, the ''Staging'' of early SCC differs from that of early adenocarcinoma!

			DDx:
			*[[Squamous dysplasia of the esophagus]].

			===Images===
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544238/figure/fig08/ Carcinoma in situ (nih.gov)].<ref name=pmid23330004>{{Cite journal \| last1 = Terada \| first1 = T. \| title = A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 2 \| pages = 191-8 \| month = \| year = 2013 \| doi = \| PMID = 23330004 }}</ref>
			*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544238/figure/fig09/ Squamous cell carcinoma of the esophagus (nih.gov)].

			==Sign out==
			<pre>
			ESOPHGAUS, BIOPSY:
			- INVASIVE SQUAMOUS CELL CARCINOMA, KERATINIZING, MODERATELY DIFFERENTIATED.

			COMMENT:
			Benign squamous epithelium at least partially overlies the invasive squamous
			cell carcinoma; this may mask the true extent of the lesion on endoscopy.
			</pre>

			===Micro===
			The sections show a squamous mucosa with focal moderate atypia of the squamous cells,
			keratinization and easily identified mitotic figures. The atypical cells are partially
			covered by benign squamous cells, and there is a very sharp transition between the cells
			with atypia and those without. The atypical squamous cells extend into the subepithelial tissue in irregularly shaped nests and cords. A small amount of benign muscle is present.

			==See also==
			*[[Esophagus]].
			*[[Squamous cell carcinoma]].

			==References==
			{{Reflist\|2}}

			[[Category:Esophagus]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: redirect

2012-04-20T20:12:21Z

redirect

New page

#redirect [[Esophagus#Squamous_cell_carcinoma_of_the_esophagus]]

[[Category:Diagnosis]]