Spleen - Revision history

Michael: /* Splenic enlargement */

2016-09-07T12:50:35Z

Splenic enlargement

← Older revision		Revision as of 12:50, 7 September 2016
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	=Splenic enlargement=		=Splenic enlargement=
			:''Splenomegaly'' redirects here.''
	*[[Portal hypertension]] (often due to [[cirrhosis]]).		*[[Portal hypertension]] (often due to [[cirrhosis]]).
	*Lymphoma - see below.		*Lymphoma - see below.

Michael: /* Gross pathology */

2016-09-07T12:49:00Z

Gross pathology

← Older revision		Revision as of 12:49, 7 September 2016
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	=Gross pathology=		=Gross pathology=
	The [[grossing]] of the spleen is dealt with in [[splenectomy grossing]].		The [[grossing]] of the spleen is dealt with in [[splenectomy grossing]].
	==Overview==		===Overview of classic gross findings===
	{\| class = "wikitable sortable"		{\| class = "wikitable sortable"
	! Terminology		! Terminology

Michael: /* Gross pathology */

2016-09-07T12:48:36Z

Gross pathology

← Older revision		Revision as of 12:48, 7 September 2016
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	=Gross pathology=		=Gross pathology=
			The [[grossing]] of the spleen is dealt with in [[splenectomy grossing]].
			==Overview==
	{\| class = "wikitable sortable"		{\| class = "wikitable sortable"
	! Terminology		! Terminology

Michael: /* Immune thrombocytopenic purpura */ +splenogonadal fusion

2015-04-27T00:47:45Z

Immune thrombocytopenic purpura: +splenogonadal fusion

← Older revision		Revision as of 00:47, 27 April 2015
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	{{Main\|Immune thrombocytopenic purpura}}		{{Main\|Immune thrombocytopenic purpura}}
	Spleens are removed for this.		Spleens are removed for this.

			==Splenogonadal fusion==
			{{Main\|Splenogonadal fusion}}

	=See also=		=See also=

Michael: /* IHC */

2014-09-13T08:11:21Z

IHC

← Older revision		Revision as of 08:11, 13 September 2014
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	*CD8 -ve.		*CD8 -ve.
	*NK cell-associated antigens +ve:<ref name=pmid9191001/>		*NK cell-associated antigens +ve:<ref name=pmid9191001/>
	**CD56,<ref name=pmid15458516>{{Cite journal \| last1 = Niitsu \| first1 = N. \| last2 = Kohri \| first2 = M. \| last3 = Togano \| first3 = T. \| last4 = Nakamine \| first4 = H. \| last5 = Nakamura \| first5 = S. \| last6 = Iwabuchi \| first6 = K. \| last7 = Higashihara \| first7 = M. \| title = Development of hepatosplenic gammadelta T-cell lymphoma with pancytopenia during early pregnancy: a case report and review of the literature. \| journal = Eur J Haematol \| volume = 73 \| issue = 5 \| pages = 367-71 \| month = Nov \| year = 2004 \| doi = 10.1111/j.1600-0609.2004.00300.x \| PMID = 15458516 }}</ref> CD11c, CD16.		**[[CD56]],<ref name=pmid15458516>{{Cite journal \| last1 = Niitsu \| first1 = N. \| last2 = Kohri \| first2 = M. \| last3 = Togano \| first3 = T. \| last4 = Nakamine \| first4 = H. \| last5 = Nakamura \| first5 = S. \| last6 = Iwabuchi \| first6 = K. \| last7 = Higashihara \| first7 = M. \| title = Development of hepatosplenic gammadelta T-cell lymphoma with pancytopenia during early pregnancy: a case report and review of the literature. \| journal = Eur J Haematol \| volume = 73 \| issue = 5 \| pages = 367-71 \| month = Nov \| year = 2004 \| doi = 10.1111/j.1600-0609.2004.00300.x \| PMID = 15458516 }}</ref> CD11c, CD16.
	*Effector proteins +ve.<ref name=pmid9191001>{{Cite journal \| last1 = Salhany \| first1 = KE. \| last2 = Feldman \| first2 = M. \| last3 = Kahn \| first3 = MJ. \| last4 = Peritt \| first4 = D. \| last5 = Schretzenmair \| first5 = RD. \| last6 = Wilson \| first6 = DM. \| last7 = DiPaola \| first7 = RS. \| last8 = Glick \| first8 = AD. \| last9 = Kant \| first9 = JA. \| title = Hepatosplenic gammadelta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation. \| journal = Hum Pathol \| volume = 28 \| issue = 6 \| pages = 674-85 \| month = Jun \| year = 1997 \| doi = \| PMID = 9191001 }}</ref>		*Effector proteins +ve.<ref name=pmid9191001>{{Cite journal \| last1 = Salhany \| first1 = KE. \| last2 = Feldman \| first2 = M. \| last3 = Kahn \| first3 = MJ. \| last4 = Peritt \| first4 = D. \| last5 = Schretzenmair \| first5 = RD. \| last6 = Wilson \| first6 = DM. \| last7 = DiPaola \| first7 = RS. \| last8 = Glick \| first8 = AD. \| last9 = Kant \| first9 = JA. \| title = Hepatosplenic gammadelta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation. \| journal = Hum Pathol \| volume = 28 \| issue = 6 \| pages = 674-85 \| month = Jun \| year = 1997 \| doi = \| PMID = 9191001 }}</ref>
	**Perforin, granzyme B, TIA-1, Fas ligand.		**Perforin, granzyme B, TIA-1, Fas ligand.

Michael at 02:12, 23 August 2014

2014-08-23T02:12:36Z

← Older revision		Revision as of 02:12, 23 August 2014
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			[[Image:Gray1188.png\|thumb\|300px\|Spleen.]]
	The '''spleen''' is a forgotten organ.		The '''spleen''' is a forgotten organ.

Michael: /* Red pulp benign */

2014-07-10T16:06:20Z

Red pulp benign

← Older revision		Revision as of 16:06, 10 July 2014
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	**[[Budd-Chiari syndrome]] (AKA hepatic vein obstruction).		**[[Budd-Chiari syndrome]] (AKA hepatic vein obstruction).
	**Splenic vein thrombosis.		**Splenic vein thrombosis.
	*Congestive heart failure.		*[[Congestive heart failure]].
			*[[Acute splenitis]].

	===Red pulp malignant===		===Red pulp malignant===

Michael: /* Myelolipoma of the spleen */

2014-05-06T03:36:28Z

Myelolipoma of the spleen

← Older revision		Revision as of 03:36, 6 May 2014
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	==Myelolipoma of the spleen==		==Myelolipoma of the spleen==
	{{Main\|Myelolipoma}}		{{Main\|Myelolipoma}}

			==Immune thrombocytopenic purpura==
			{{Main\|Immune thrombocytopenic purpura}}
			Spleens are removed for this.

	=See also=		=See also=

Michael: /* Follicular dendritic cell tumour */

2014-04-25T12:01:05Z

Follicular dendritic cell tumour

← Older revision		Revision as of 12:01, 25 April 2014
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	==Follicular dendritic cell tumour==		==Follicular dendritic cell tumour==
			*[[AKA]] ''follicular dendritic cell sarcoma''.
	{{Main\|Follicular dendritic cell sarcoma}}		{{Main\|Follicular dendritic cell sarcoma}}

Michael: /* Follicular dendritic cell tumour */ split out

2014-04-25T11:58:18Z

Follicular dendritic cell tumour: split out

← Older revision		Revision as of 11:58, 25 April 2014
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	==Follicular dendritic cell tumour==		==Follicular dendritic cell tumour==
	*Abbreviated ''FDCT''.		{{Main\|Follicular dendritic cell sarcoma}}
	*[[AKA]] ''follicular dendritic cell sarcoma'' (abbreviated ''FDCS''),<ref name=pmid17515347>{{~~Cite journal \| last1 = Leipsic \| first1 = JA. \| last2 = McAdams~~ \| ~~first2 = HP. \| last3 = Sporn \| first3 = TA. \| title =~~ Follicular dendritic cell sarcoma ~~of the mediastinum. \| journal = AJR Am J Roentgenol \| volume = 188 \| issue = 6 \| pages = W554-6 \| month = Jun \| year = 2007 \| doi = 10.2214/AJR.04.1530 \| PMID = 17515347~~ }}~~</ref> ''dendritic reticulum cell sarcoma'', (???) ''follicular dendritic cell neoplasm''. (???)~~
	~~===General===~~
	*Very rare.
	*Behave like a low-grade sarcoma.<ref name=pmid9606805>{{Cite journal \| last1 = Perez-Ordoñez \| first1 = B. \| last2 = Rosai \| first2 = J. \| title = Follicular dendritic cell tumor: review of the entity. \| journal = Semin Diagn Pathol \| volume = 15 \| issue = 2 \| pages = 144-54 \| month = May \| year = 1998 \| doi = \| PMID = 9606805 }}</ref>
	*Reported association with [[Castleman disease]] (hyaline-vascular type).<ref name=pmid9606805/>

	~~===Microscopic===~~
	~~Features:<ref name=pmid9606805/>~~
	*Oval or spindle-shaped cellular & nuclear morphology.
	*Variable architecture (sheets, fascicles, whorles, storiform pattern).
	*Nuclei:
	**Small nucleoli.
	**Clear or dispersed chromatin.
	*Multinucleated cells.
	*Interspersed small lymphocytes - '''distinctive feature'''.
	*+/-Necrosis.
	*+/-Marked nuclear atypia.
	*+/-Abundant mitoses.

	~~DDx:~~
	*[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal \| last1 = Alexiev \| first1 = BA. \| last2 = Sailey \| first2 = CJ. \| last3 = McClure \| first3 = SA. \| last4 = Ord \| first4 = RA. \| last5 = Zhao \| first5 = XF. \| last6 = Papadimitriou \| first6 = JC. \| title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. \| journal = Diagn Pathol \| volume = 2 \| issue = \| pages = 7 \| month = \| year = 2007 \| doi = 10.1186/1746-1596-2-7 \| PMID = 17324277 \| url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref>
	*[[Spindle cell lesions]].

	~~====Images====~~
	*[http://www.ajronline.org/content/188/6/W554/F7.expansion FDCS (ajronline.org)].<ref name=pmid17515347/>
	*[http://www.webpathology.com/image.asp?case=391&n=1 DRCS (webpathology.com)].
	*[http://path.upmc.edu/cases/case55/dx.html FDCT - several crappy images (upmc.edu)].
	*[http://path.upmc.edu/cases/case399.html FDCS - several images (upmc.edu)].

	~~===IHC===~~
	~~Features:<ref name=pmid9606805/>~~
	*CD21 +ve.
	*CD35 +ve.
	*Ki-M4p +ve
	*Ki-FDRC1p +ve.
	*Vimentin +ve.

	*S-100 +ve/-ve.
	*Muscle-specific actin +ve/-ve.
	*EMA +ve/-ve.

	==Hepatosplenic T-cell lymphoma==		==Hepatosplenic T-cell lymphoma==