Spironolactone bodies - Revision history

Sarah: /* General */

2015-03-05T11:59:32Z

General

← Older revision		Revision as of 11:59, 5 March 2015
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	*Aldosterone antagonist.		*Aldosterone antagonist.
	*Commonly used anti-hypertensive medication.<ref name=pmid25108298>{{Cite journal \| last1 = Patel \| first1 = KA. \| last2 = Calomeni \| first2 = EP. \| last3 = Nadasdy \| first3 = T. \| last4 = Zynger \| first4 = DL. \| title = Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings. \| journal = Diagn Pathol \| volume = 9 \| issue = 1 \| pages = 147 \| month = Aug \| year = 2014 \| doi = 10.1186/1746-1596-9-147 \| PMID = 25108298 }}</ref>		*Commonly used anti-hypertensive medication.<ref name=pmid25108298>{{Cite journal \| last1 = Patel \| first1 = KA. \| last2 = Calomeni \| first2 = EP. \| last3 = Nadasdy \| first3 = T. \| last4 = Zynger \| first4 = DL. \| title = Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings. \| journal = Diagn Pathol \| volume = 9 \| issue = 1 \| pages = 147 \| month = Aug \| year = 2014 \| doi = 10.1186/1746-1596-9-147 \| PMID = 25108298 }}</ref>
	*May be used to treat hypertension due to primary hyperaldosteronism ~~due~~ to adrenal pathology ~~such as an aldosterone producing~~ hyperplasia or adenoma.		*May be used to treat hypertension due to primary hyperaldosteronism related to adrenal pathology (nodular cortical hyperplasia or adenoma).
	*Other uses include treatment of adult acne harnessing an antiandrogenic activity.		*Other uses include treatment of adult acne harnessing an antiandrogenic activity.

Sarah: /* General */

2015-03-05T11:58:17Z

General

← Older revision		Revision as of 11:58, 5 March 2015
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	Note:		Note:
	*~~Spironolactone is a commonly~~ used anti-hypertensive medication.<ref name=pmid25108298>{{Cite journal \| last1 = Patel \| first1 = KA. \| last2 = Calomeni \| first2 = EP. \| last3 = Nadasdy \| first3 = T. \| last4 = Zynger \| first4 = DL. \| title = Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings. \| journal = Diagn Pathol \| volume = 9 \| issue = 1 \| pages = 147 \| month = Aug \| year = 2014 \| doi = 10.1186/1746-1596-9-147 \| PMID = 25108298 }}</ref>		*Aldosterone antagonist.
			*Commonly used anti-hypertensive medication.<ref name=pmid25108298>{{Cite journal \| last1 = Patel \| first1 = KA. \| last2 = Calomeni \| first2 = EP. \| last3 = Nadasdy \| first3 = T. \| last4 = Zynger \| first4 = DL. \| title = Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings. \| journal = Diagn Pathol \| volume = 9 \| issue = 1 \| pages = 147 \| month = Aug \| year = 2014 \| doi = 10.1186/1746-1596-9-147 \| PMID = 25108298 }}</ref>
			*May be used to treat hypertension due to primary hyperaldosteronism due to adrenal pathology such as an aldosterone producing hyperplasia or adenoma.
			*Other uses include treatment of adult acne harnessing an antiandrogenic activity.

	==Microscopic==		==Microscopic==

Sarah: /* Images */

2015-03-05T11:46:38Z

Images

← Older revision		Revision as of 11:46, 5 March 2015
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	Image:Spironolactone_bodies_high_mag.jpg \| SB - high mag. (WC/Nephron)		Image:Spironolactone_bodies_high_mag.jpg \| SB - high mag. (WC/Nephron)
	Image:Spironolactone_bodies.png \| SB (circled) - cropped high mag. (WC/Nephron)		Image:Spironolactone_bodies.png \| SB (circled) - cropped high mag. (WC/Nephron)
			Image:Adrenal CorticalAdenoma SpironolactoneBodies MP PA.JPG\|Adrenal Cortical Adenoma - Spironolactone Bodies (SKB)
			Image:Adrenal HyperplasticNodule SpironolactoneBodies MP PA.JPG\|Adrenal Nodular Hyperplasia - Spironolactone Bodies (SKB)
	</gallery>		</gallery>

Michael: /* See also */

2014-08-23T01:54:11Z

Michael at 01:53, 23 August 2014

2014-08-23T01:53:47Z

← Older revision		Revision as of 01:53, 23 August 2014
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	'''Spironolactone bodies''' are seen in the context of long-term spironolcatone use.		'''Spironolactone bodies''' are seen in the cortex of the [[adrenal gland]] in the context of long-term spironolcatone use.

	==General==		==General==

Michael: create

2014-08-23T01:52:01Z

create

New page

'''Spironolactone bodies''' are seen in the context of long-term spironolcatone use.

==General==
Etiology:
*Long-term use of spironolactone.

Note:
*Spironolactone is a commonly used anti-hypertensive medication.<ref name=pmid25108298>{{Cite journal | last1 = Patel | first1 = KA. | last2 = Calomeni | first2 = EP. | last3 = Nadasdy | first3 = T. | last4 = Zynger | first4 = DL. | title = Adrenal gland inclusions in patients treated with aldosterone antagonists (Spironolactone/Eplerenone): incidence, morphology, and ultrastructural findings. | journal = Diagn Pathol | volume = 9 | issue = 1 | pages = 147 | month = Aug | year = 2014 | doi = 10.1186/1746-1596-9-147 | PMID = 25108298 }}</ref>

==Microscopic==
Features:<ref name=pmid4131694>{{cite journal |author=Kovacs K, Horvath E, Singer W |title=Fine structure and morphogenesis of spironolactone bodies in the zona glomerulosa of the human adrenal cortex |journal=J. Clin. Pathol. |volume=26 |issue=12 |pages=949-57 |year=1973 |month=December |pmid=4131694 |pmc=477936 |doi= |url=http://jcp.bmj.com/cgi/pmidlookup?view=long&pmid=4131694}}</ref>
*Location: zona glomerulosa (where aldosterone is produced).
*Appearance: eosinophilic spherical laminated whorls.

===Images===
<gallery>
Image:Spironolactone_bodies_high_mag.jpg | SB - high mag. (WC/Nephron)
Image:Spironolactone_bodies.png | SB (circled) - cropped high mag. (WC/Nephron)
</gallery>

==See also==
*[[Adrenal gland]].

==References==
{{Reflist|1}}

[[Category:Adrenal gland]]

← Older revision		Revision as of 01:54, 23 August 2014
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	==See also==		==See also==
	*[[Adrenal gland]].		*[[Adrenal gland]].
			*[[Drug reaction]].

	==References==		==References==