Soft tissue lesions - Revision history

Michael: /* Morphohistologic patterns */

2015-11-03T12:50:05Z

Morphohistologic patterns

← Older revision		Revision as of 12:50, 3 November 2015
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	==Morphohistologic patterns==		==Morphohistologic patterns==
	{{Main\|~~Basics#Morphologic_patterns~~}}		{{Main\|Morphologic patterns}}
	{\| class="wikitable sortable" style="margin-left:auto;margin-right:auto"		{\| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
	! Name		! Name

Michael: /* Morphohistologic patterns */ fix sp.

2015-10-26T05:29:20Z

Morphohistologic patterns: fix sp.

← Older revision		Revision as of 05:29, 26 October 2015
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	\| [[Image:Malignant_peripheral_nerve_sheath_tumour_-_intermed_mag.jpg \|thumb\|center\|150px \|Herring bone. (WC)]]		\| [[Image:Malignant_peripheral_nerve_sheath_tumour_-_intermed_mag.jpg \|thumb\|center\|150px \|Herring bone. (WC)]]
	\|-		\|-
	\| ~~Fasicular~~		\| Fascicular
	\| the long axis of the (spindle) cells are perpendicular to one another in adjacent bundles of cells		\| the long axis of the (spindle) cells are perpendicular to one another in adjacent bundles of cells
	\| [[leiomyoma]], [[leiomyosarcoma]]		\| [[leiomyoma]], [[leiomyosarcoma]]
	\| [[Image:Cutaneous_leiomyosarcoma_-_high_mag.jpg \|thumb\|center\|150px\| ~~Fasicular~~ pattern. (WC)]]		\| [[Image:Cutaneous_leiomyosarcoma_-_high_mag.jpg \|thumb\|center\|150px\| Fascicular pattern. (WC)]]
	\|-		\|-
	\| Biphasic		\| Biphasic

Michael: /* Extrarenal malignant rhabdoid tumour */ split out

2015-04-04T02:53:28Z

Extrarenal malignant rhabdoid tumour: split out

← Older revision		Revision as of 02:53, 4 April 2015
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	==Extrarenal malignant rhabdoid tumour==		==Extrarenal malignant rhabdoid tumour==
	*Essentially identical to ''[[renal malignant rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>		*Essentially identical to ''[[renal malignant rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>
	~~===General===~~		{{Main\|Extrarenal malignant rhabdoid tumour}}
	*Usually children < 2 years old.
	*Very poor prognosis ~ mean survival in one series 9 months.<ref name=pmid25085603>{{~~Cite journal~~ \| last1 = Uwineza \| first1 = A. \| last2 = Gill \| first2 = H. \| last3 = Buckley \| first3 = P. \| last4 = Owens \| first4 = C. \| last5 = Capra \| first5 = M. \| last6 = O'Sullivan \| first6 = C. \| last7 = McDermott \| first7 = M. \| last8 = Brett \| first8 = F. \| last9 = Farrell \| first9 = M. \| title = Rhabdoid tumor: the Irish experience 1986-2013. \| journal = Cancer Genet \| volume = 207 \| issue = 9 \| pages = 398-402 \| month = Sep \| year = 2014 \| doi = 10.1016/j.cancergen.2014.05.015 \| PMID = 25085603 }}</ref>
	*In the CNS it is known as ''[[atypical teratoid-rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>~~
	*Variable architecture.
	*Round cells.
	*Eccentric vesicular nucleus.
	*Prominent [[nucleolus]] -- '''key feature'''.

	~~DDx:~~
	*[[Desmoplastic small round cell tumour]].<ref name=pmid25133149>{{Cite journal \| last1 = Liang \| first1 = L. \| last2 = Tatevian \| first2 = N. \| last3 = Bhattacharjee \| first3 = M. \| last4 = Tsao \| first4 = K. \| last5 = Hicks \| first5 = J. \| title = Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation. \| journal = World J Clin Cases \| volume = 2 \| issue = 8 \| pages = 367-72 \| month = Aug \| year = 2014 \| doi = 10.12998/wjcc.v2.i8.367 \| PMID = 25133149 }}</ref>
	*Rhabdoid [[melanoma]].<ref name=pmid24551314>{{Cite journal \| last1 = Ishida \| first1 = M. \| last2 = Iwai \| first2 = M. \| last3 = Yoshida \| first3 = K. \| last4 = Kagotani \| first4 = A. \| last5 = Okabe \| first5 = H. \| title = Rhabdoid melanoma: a case report with review of the literature. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 2 \| pages = 840-3 \| month = \| year = 2014 \| doi = \| PMID = 24551314 }}</ref>

	~~===IHC===~~
	*INI1 ([[SMARCB1]]) -ve.
	**[[AKA]] BAF47.

	Others:<ref name=pmid25623976>{{Cite journal \| last1 = Wang \| first1 = H. \| last2 = Ma \| first2 = Y. \| last3 = Li \| first3 = J. \| last4 = Zhang \| first4 = D. \| last5 = Wu \| first5 = B. \| last6 = Fang \| first6 = C. \| last7 = Chen \| first7 = L. \| title = [Extrarenal malignant rhabdoid ~~tumor of childhood: a clinicopathologic analysis of 8 cases]. \| journal = Zhonghua Bing Li Xue Za Zhi \| volume = 43 \| issue = 12 \| pages = 805-8 \| month = Dec \| year = 2014 \| doi = \| PMID = 25623976~~ }}~~</ref>~~
	*Vimentin +ve.
	*EMA +ve.
	*AE1/AE3 +ve.
	*CAM5.2 +ve.

	==Ewing sarcoma/PNET==		==Ewing sarcoma/PNET==

Michael: /* Microscopic */

2015-04-02T17:46:38Z

Microscopic

← Older revision		Revision as of 17:46, 2 April 2015
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	DDx:		DDx:
	*[[Desmoplastic small round cell tumour]].<ref name=pmid25133149>{{Cite journal \| last1 = Liang \| first1 = L. \| last2 = Tatevian \| first2 = N. \| last3 = Bhattacharjee \| first3 = M. \| last4 = Tsao \| first4 = K. \| last5 = Hicks \| first5 = J. \| title = Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation. \| journal = World J Clin Cases \| volume = 2 \| issue = 8 \| pages = 367-72 \| month = Aug \| year = 2014 \| doi = 10.12998/wjcc.v2.i8.367 \| PMID = 25133149 }}</ref>		*[[Desmoplastic small round cell tumour]].<ref name=pmid25133149>{{Cite journal \| last1 = Liang \| first1 = L. \| last2 = Tatevian \| first2 = N. \| last3 = Bhattacharjee \| first3 = M. \| last4 = Tsao \| first4 = K. \| last5 = Hicks \| first5 = J. \| title = Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation. \| journal = World J Clin Cases \| volume = 2 \| issue = 8 \| pages = 367-72 \| month = Aug \| year = 2014 \| doi = 10.12998/wjcc.v2.i8.367 \| PMID = 25133149 }}</ref>
			*Rhabdoid [[melanoma]].<ref name=pmid24551314>{{Cite journal \| last1 = Ishida \| first1 = M. \| last2 = Iwai \| first2 = M. \| last3 = Yoshida \| first3 = K. \| last4 = Kagotani \| first4 = A. \| last5 = Okabe \| first5 = H. \| title = Rhabdoid melanoma: a case report with review of the literature. \| journal = Int J Clin Exp Pathol \| volume = 7 \| issue = 2 \| pages = 840-3 \| month = \| year = 2014 \| doi = \| PMID = 24551314 }}</ref>

	===IHC===		===IHC===

Michael: /* Microscopic */

2015-04-02T16:51:19Z

Microscopic

← Older revision		Revision as of 16:51, 2 April 2015
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	*Eccentric vesicular nucleus.		*Eccentric vesicular nucleus.
	*Prominent [[nucleolus]] -- '''key feature'''.		*Prominent [[nucleolus]] -- '''key feature'''.

			DDx:
			*[[Desmoplastic small round cell tumour]].<ref name=pmid25133149>{{Cite journal \| last1 = Liang \| first1 = L. \| last2 = Tatevian \| first2 = N. \| last3 = Bhattacharjee \| first3 = M. \| last4 = Tsao \| first4 = K. \| last5 = Hicks \| first5 = J. \| title = Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation. \| journal = World J Clin Cases \| volume = 2 \| issue = 8 \| pages = 367-72 \| month = Aug \| year = 2014 \| doi = 10.12998/wjcc.v2.i8.367 \| PMID = 25133149 }}</ref>

	===IHC===		===IHC===

Michael: /* Extrarenal malignant rhabdoid tumour */

2015-04-02T16:47:15Z

Extrarenal malignant rhabdoid tumour

← Older revision		Revision as of 16:47, 2 April 2015
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	*Essentially identical to ''[[renal malignant rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>		*Essentially identical to ''[[renal malignant rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>
	===General===		===General===
	*~~Usu.~~ children < 2 years old.		*Usually children < 2 years old.
	*Very poor prognosis.		*Very poor prognosis ~ mean survival in one series 9 months.<ref name=pmid25085603>{{Cite journal \| last1 = Uwineza \| first1 = A. \| last2 = Gill \| first2 = H. \| last3 = Buckley \| first3 = P. \| last4 = Owens \| first4 = C. \| last5 = Capra \| first5 = M. \| last6 = O'Sullivan \| first6 = C. \| last7 = McDermott \| first7 = M. \| last8 = Brett \| first8 = F. \| last9 = Farrell \| first9 = M. \| title = Rhabdoid tumor: the Irish experience 1986-2013. \| journal = Cancer Genet \| volume = 207 \| issue = 9 \| pages = 398-402 \| month = Sep \| year = 2014 \| doi = 10.1016/j.cancergen.2014.05.015 \| PMID = 25085603 }}</ref>
	*In the CNS it is known as ''[[atypical teratoid-rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>		*In the CNS it is known as ''[[atypical teratoid-rhabdoid tumour]]''.<ref name=Ref_WMSP627>{{Ref WMSP\|627}}</ref>

Michael: /* Extrarenal malignant rhabdoid tumour */ more ihc

2015-04-02T16:40:39Z

Extrarenal malignant rhabdoid tumour: more ihc

← Older revision		Revision as of 16:40, 2 April 2015
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	===IHC===		===IHC===
	*INI1 (SMARCB1) -ve.		*INI1 ([[SMARCB1]]) -ve.
	**AKA BAF47.		**[[AKA]] BAF47.

			Others:<ref name=pmid25623976>{{Cite journal \| last1 = Wang \| first1 = H. \| last2 = Ma \| first2 = Y. \| last3 = Li \| first3 = J. \| last4 = Zhang \| first4 = D. \| last5 = Wu \| first5 = B. \| last6 = Fang \| first6 = C. \| last7 = Chen \| first7 = L. \| title = [Extrarenal malignant rhabdoid tumor of childhood: a clinicopathologic analysis of 8 cases]. \| journal = Zhonghua Bing Li Xue Za Zhi \| volume = 43 \| issue = 12 \| pages = 805-8 \| month = Dec \| year = 2014 \| doi = \| PMID = 25623976 }}</ref>
			*Vimentin +ve.
			*EMA +ve.
			*AE1/AE3 +ve.
			*CAM5.2 +ve.

	==Ewing sarcoma/PNET==		==Ewing sarcoma/PNET==

Rudolf: /* Lymph node metastases in sarcomas */

2014-10-07T19:42:58Z

Lymph node metastases in sarcomas

← Older revision		Revision as of 19:42, 7 October 2014
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	*[[epithelioid sarcoma\|'''E'''pitheliod sarcoma]].		*[[epithelioid sarcoma\|'''E'''pitheliod sarcoma]].
	*[[fibrosarcoma\|'''F'''ibrosarcoma]].		*[[fibrosarcoma\|'''F'''ibrosarcoma]].
	*[[pleomorphic undifferentiated sarcoma\|'''M'''alignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma]].		*[[pleomorphic undifferentiated sarcoma\|'''M'''alignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma)]].
	*[[synovial sarcoma\|'''S'''ynovial cell sarcoma]].		*[[synovial sarcoma\|'''S'''ynovial cell sarcoma]].

Michael: /* Angiomatoid fibrous histiocytoma */ split out

2014-06-03T04:06:07Z

Angiomatoid fibrous histiocytoma: split out

← Older revision		Revision as of 04:06, 3 June 2014
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	=Tumours of uncertain differentiation=		=Tumours of uncertain differentiation=
	==Angiomatoid fibrous histiocytoma==		==Angiomatoid fibrous histiocytoma==
	~~===General===~~		{{Main\|Angiomatoid fibrous histiocytoma}}
	*Rarely metastasizes.
	*Children & young adults.

	~~===Microscopic===~~
	~~Features:<ref name=Ref_WMSP624-5>~~{{~~Ref WMSP~~\|~~624-5}}</ref>~~
	*Cystic spaces with blood - simulates a vascular neoplasm.<ref name=pmid228836>{{Cite journal \| last1 = Enzinger \| first1 = FM. \| title = Angiomatoid ~~malignant~~ fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. \| journal = Cancer \| volume = 44 \| issue = 6 \| pages = 2147-57 \| month = Dec \| year = 1979 \| doi = \| PMID = 228836 }}</ref>
	*Epithelioid to spindle cells.
	**May have a histiocytic appearance.<ref>URL: [http://dermatology.cdlib.org/1605/1_case_reports/4_09-00041/patrizi.html http://dermatology.cdlib.org/1605/1_case_reports/4_09-00041/patrizi.html]. Accessed on: 15 November 2011.</ref>
	*Inflammation.
	**Lymphoid cuff<ref name=pmid20154033/> - lymphocytes around periphery of lesion.
	*Hemorrhage.

	~~Note:~~
	*The first impression may be that it is [[granuloma\|granulomatous inflammation]]; however, the cytoplasm doesn't fit (it isn't bubbly and it isn't sheet-like), and the nuclei aren't quite right (few footprint shaped nuclei).

	~~====Images====~~
	~~<gallery>~~
	~~Image:Angiomatoid_fibrous_histiocytoma_-_intermed_mag.jpg \| AFH - intermed. mag. (WC/Nephron)~~
	~~Image:Angiomatoid_fibrous_histiocytoma_-_high_mag.jpg \| AFH - high mag. (WC/Nephron)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.sarcomaimages.com/index.php?v=Angiomatoid-Fibrous-Histiocytoma AFH (sarcomaimages.com)].
	*[http://jcp.bmj.com/content/63/2/124/F1.large.jpg AFH (bmj.com)].<ref name=pmid20154033>{{Cite journal \| last1 = Matsumura \| first1 = T. \| last2 = Yamaguchi \| first2 = T. \| last3 = Tochigi \| first3 = N. \| last4 = Wada \| first4 = T. \| last5 = Yamashita \| first5 = T. \| last6 = Hasegawa \| first6 = T. \| title = Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. \| journal = J Clin Pathol \| volume = 63 \| issue = 2 \| pages = 124-8 \| month = Feb \| year = 2010 \| doi = 10.1136/jcp.2009.072256 \| PMID = 20154033 \| url = http://jcp.bmj.com/content/63/2/124.full }}
	~~</ref>~~
	*[http://path.upmc.edu/cases/case512.html AFH - several images (upmc.edu)].

	~~===IHC===~~
	~~Features:<ref name=Ref_WMSP624-5>{{Ref WMSP\|624-5~~}}~~</ref>~~
	*CD68 +ve.
	*CD57 +ve.
	*Desmin +ve.
	*Vimentin +ve.

	~~===Molecular===~~
	~~AFH has recurrent [[translocations]]:~~
	*t(12;16) FUS/ATF1.
	*t(12;22) EWS/ATF1.

	==Aggressive angiomyxoma==		==Aggressive angiomyxoma==

Michael: /* Granulocytic sarcoma */ split out

2014-04-05T21:02:02Z

Granulocytic sarcoma: split out

← Older revision		Revision as of 21:02, 5 April 2014
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	*Common alternate terms: extramedullary leukemia,<ref name=pmid21795742>{{Cite journal \| last1 = Bakst \| first1 = RL. \| last2 = Tallman \| first2 = MS. \| last3 = Douer \| first3 = D. \| last4 = Yahalom \| first4 = J. \| title = How I treat extramedullary acute myeloid leukemia. \| journal = Blood \| volume = 118 \| issue = 14 \| pages = 3785-93 \| month = Oct \| year = 2011 \| doi = 10.1182/blood-2011-04-347229 \| PMID = 21795742 }}</ref> myeloid sarcoma, chloroma.		*Common alternate terms: extramedullary leukemia,<ref name=pmid21795742>{{Cite journal \| last1 = Bakst \| first1 = RL. \| last2 = Tallman \| first2 = MS. \| last3 = Douer \| first3 = D. \| last4 = Yahalom \| first4 = J. \| title = How I treat extramedullary acute myeloid leukemia. \| journal = Blood \| volume = 118 \| issue = 14 \| pages = 3785-93 \| month = Oct \| year = 2011 \| doi = 10.1182/blood-2011-04-347229 \| PMID = 21795742 }}</ref> myeloid sarcoma, chloroma.
	*Other terms:<ref name=pmid21556238>{{Cite journal \| last1 = Eom \| first1 = KS. \| last2 = Kim \| first2 = TY. \| title = Intraparenchymal myeloid sarcoma and subsequent spinal myeloid sarcoma for acute myeloblastic leukemia. \| journal = J Korean Neurosurg Soc \| volume = 49 \| issue = 3 \| pages = 171-4 \| month = Mar \| year = 2011 \| doi = 10.3340/jkns.2011.49.3.171 \| PMID = 21556238 \| PMC = 3085814 \| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085814/ }}</ref> myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, or myelosarcoma.		*Other terms:<ref name=pmid21556238>{{Cite journal \| last1 = Eom \| first1 = KS. \| last2 = Kim \| first2 = TY. \| title = Intraparenchymal myeloid sarcoma and subsequent spinal myeloid sarcoma for acute myeloblastic leukemia. \| journal = J Korean Neurosurg Soc \| volume = 49 \| issue = 3 \| pages = 171-4 \| month = Mar \| year = 2011 \| doi = 10.3340/jkns.2011.49.3.171 \| PMID = 21556238 \| PMC = 3085814 \| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085814/ }}</ref> myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, or myelosarcoma.
			{{Main\|Granulocytic sarcoma}}
	~~===General===~~
	*Soft tissue manifestation of [[acute myeloid leukemia]].<ref name=pmid21556238/>

	~~===Microscopic===~~
	~~Features:~~
	*Cluster of atypical small blue cells in [[soft tissue lesions\|~~soft tissue]].~~

	~~Note:~~
	*May mimic [[small cell carcinoma]], large cell lymphomas ([[DLBCL]], [[ALCL]]), [[small round cell tumour]]s.

	~~====Images====~~
	~~<gallery>~~
	~~Image:Chloroma - intermed mag.jpg \| Chloroma - intermed. mag. (WC)~~
	~~Image:Chloroma_-_high_mag.jpg \| Chloroma - high mag. (WC)~~
	~~Image:Chloroma_-_very_high_mag.jpg \| Chloroma - very high mag. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://path.upmc.edu/cases/case306/micro.html Granulocytic sarcoma ~~- several crappy images (upmc.edu)].~~
	*[http://path.upmc.edu/cases/case379.html Myeloid sarcoma - several images (upmc.edu)].

	~~===Sign out===~~
	*It is prudent to mention ''acute myeloid leukemia'' somewhere in the report to ensure the appropriate referral is made.

	=See also=		=See also=

← Older revision		Revision as of 19:42, 7 October 2014
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	*[[epithelioid sarcoma\|'''E'''pitheliod sarcoma]].		*[[epithelioid sarcoma\|'''E'''pitheliod sarcoma]].
	*[[fibrosarcoma\|'''F'''ibrosarcoma]].		*[[fibrosarcoma\|'''F'''ibrosarcoma]].
	*[[pleomorphic undifferentiated sarcoma\|'''M'''alignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma]].		*[[pleomorphic undifferentiated sarcoma\|'''M'''alignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma)]].
	*[[synovial sarcoma\|'''S'''ynovial cell sarcoma]].		*[[synovial sarcoma\|'''S'''ynovial cell sarcoma]].