Small cell lymphomas - Revision history

Mark: hive off hairy cell leukemia to its own page

2018-06-16T20:50:45Z

hive off hairy cell leukemia to its own page

← Older revision		Revision as of 20:50, 16 June 2018
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	==Hairy cell leukemia==		==Hairy cell leukemia==
	[[~~File:Bone marrow infiltration by hairy cell leukaemia.jpg\|thumb\|High power magnification of a bone marrow trephine showing infiltration by hairy cell leukaemia.]]~~		See [[Hairy cell leukemia]]
	*Abbreviated ''HCL''.
	~~===General===~~
	*Name comes from appearance on blood smear - cell hairy.
	*Do to the biology, ''dry taps'' are common.<ref name=pmid22499303>{{Cite journal \| last1 = Galani \| first1 = KS. \| last2 = Subramanian \| first2 = PG. \| last3 = Gadage \| first3 = VS. \| last4 = Rahman \| first4 = K. \| last5 = Ashok Kumar \| first5 = MS. \| last6 = Shinde \| first6 = S. \| last7 = Mahadik \| first7 = S. \| last8 = Ansari \| first8 = R. \| last9 = Sengar \| first9 = M. \| title = Clinico-pathological profile of Hairy cell leukemia: critical insights gained at a tertiary care cancer hospital. \| journal = Indian J Pathol Microbiol \| volume = 55 \| issue = 1 \| pages = 61-5 \| month = \| year = \| doi = 10.4103/0377-4929.94858 \| PMID = 22499303 }}</ref>

	~~Clinical:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022]. Accessed on: 20 August 2010.</ref>~~
	*Pancytopenia.
	*Splenic enlargement.
	*No lymphadenopathy.
	*Good prognosis (with treatment), though (likely) not curable.

	~~===Gross===~~
	~~Features:<ref name=Ref_PCPBoD8_326>{{Ref PCPBoD8\|326}}</ref>~~
	*Huge beefy red [[spleen]].
	**Red as white pulp obliterated.

	~~===Microscopic===~~
	~~Features:<ref>URL: [http://emedicine.medscape.com/article/200580-diagnosis http://emedicine.medscape.com/article/200580-diagnosis]. Accessed on: 18 August 2010.</ref>~~
	*Small cells (10-20 micrometers) with "Fried egg"-like appearance:
	**Well-demarcated fuzzy cell borders,
	**Clear/whispy cytoplasm and,
	**Central round nucleus.
	***Peri-nuclear clearing ("water-clear rim"<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022]. Accessed on: 20 August 2010.</ref>) -- '''key feature'''.

	~~DDx:~~
	*[[Hepatosplenic T-cell lymphoma]].

	~~====Images====~~
	~~<gallery>~~
	~~Image:Hairy_cell_leukemia.jpg \| HCL - blood film. (WC)~~
	~~Image:~~Hairy cell leukemia ~~- high mag.jpg \| HCL - high mag. (WC)~~
	~~Image:Hairy_cell_leukemia_-_very_high_mag.jpg \| HCL - very high mag. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=figure&id=A34027 HCL - bone marrow (nlm.nih.gov)] ~~from [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 Holland-Frei Cancer Medicine (nlm.nih.gov)].~~
	*[http://path.upmc.edu/cases/case240.html HCL - several images (upmc.edu)].
	*[http://path.upmc.edu/cases/case691.html HCL - another case with several images (upmc.edu)].
	*[http://webpathology.com/image.asp?case=380&n=3 HCL in the spleen (webpathology.com)].

	~~===IHC===~~
	Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]~~. Accessed on: 20 August 2010.</ref>~~
	*CD20 +ve, CD25 +ve, CD103 +ve.
	*CD5 -ve.

	~~Flow cytometry:~~
	*CD19 +ve, CD11c +ve, FMC7 +ve.

	==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia==		==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia==

Mark: photomicrograph

2018-06-02T09:16:39Z

photomicrograph

← Older revision		Revision as of 09:16, 2 June 2018
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	==Hairy cell leukemia==		==Hairy cell leukemia==
			[[File:Bone marrow infiltration by hairy cell leukaemia.jpg\|thumb\|High power magnification of a bone marrow trephine showing infiltration by hairy cell leukaemia.]]
	*Abbreviated ''HCL''.		*Abbreviated ''HCL''.
	===General===		===General===

Michael: /* Table of B-cell lymphoma */

2014-12-09T07:20:31Z

Table of B-cell lymphoma

← Older revision		Revision as of 07:20, 9 December 2014
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	\|}		\|}

	~~Medium~~ and large cell lymphomas:		Common medium and large cell lymphomas:
	{\| class="wikitable"		{\| class="wikitable"
	! Name		! Name

Michael: /* Marginal zone lymphoma */

2014-09-06T17:28:46Z

Marginal zone lymphoma

← Older revision		Revision as of 17:28, 6 September 2014
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	==Marginal zone lymphoma==		==Marginal zone lymphoma==
	~~===General===~~		{{Main\|Marginal zone lymphoma}}
	*Abbreviated as ''MZL''.
	*Arise in the context chronic infections, e.g. [[Sjögren disease]] ([[salivary gland]]), [[Hashimoto thyroiditis]] ([[thyroid gland]]), [[Helicobacter pylori gastritis]] ([[stomach]]).<ref name=Ref_PCPBoD8_326>{{~~Ref PCPBoD8~~\|~~326~~}}~~</ref>~~

	~~===~~Classification~~===~~		Classification:
	*Comes in three different flavours:		#Extranodal marginal zone lymphoma.
	*#Extranodal marginal zone lymphoma.		#*If in ''mucosa-associated lymphoid tissue'' known as a ''MALT lymphoma'', [[AKA]] ''MALToma''.
	#If in ''mucosa-associated lymphoid tissue'' known as a ''MALT lymphoma'', [[AKA]] ''MALToma''.		#Splenic marginal zone lymphoma (SMZL).
	*#Splenic marginal zone lymphoma (SMZL).		#Nodal marginal zone lymphoma (NMZL).
	*#Nodal marginal zone lymphoma (NMZL).

	~~===Microscopic===~~
	~~Features:~~
	*Small (lymphoid) cells that may be plasma cell-like (plasmacytoid):<ref>URL: [http://surgpathcriteria.stanford.edu/bcell/marginalnodal/printable.html http://surgpathcriteria.stanford.edu/bcell/marginalnodal/printable.html]. Accessed on: 6 March 2012.</ref>
	**+/-Clockface nucleus.
	**+/-Eccentric nucleus.
	*+/-"[[Lymphoepithelial lesion]]" - gastric crypts invaded by a monomorphous population of lymphocytes.<ref name=pmid1452124>{{Cite journal \| last1 = Papadaki \| first1 = L. \| last2 = Wotherspoon \| first2 = AC. \| last3 = Isaacson \| first3 = PG. \| title = The lymphoepithelial lesion of gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): an ultrastructural study. \| journal = Histopathology \| volume = 21 \| issue = 5 \| pages = 415-21 \| month = Nov \| year = 1992 \| doi = \| PMID = 1452124 }}</ref>
	**Features:
	**# Cluster of lymphocytes - three cells or more - '''key feature'''.
	*# Single lymphocytes don't count.
	**# Clearing around the lymphocyte cluster.
	**Not specific for MALT lymphoma, i.e. may be seen in other types of lymphoma.<ref>DB. 6 August 2010.</ref>

	~~DDx:~~
	*Other [[small cell lymphomas]].
	*[[DLBCL]] - should be a distinctive region at low power.{{fact}}

	~~====Images====~~
	~~<gallery>~~
	~~Image:Gastrointestinal_lymphoepithelial_lesion_-_very_high_mag.jpg \| Lymphoepithelial lesion - very high mag. (WC)~~
	~~Image:Gastrointestinal_lymphoepithelial_lesion_-_intermed_mag.jpg \| Lymphoepithelial lesion - intermed. mag. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://path.upmc.edu/cases/case405.html MALT lymphoma - several images (upmc.edu)].
	*[http://www.pathpedia.com/education/eatlas/histopathology/intestine_large/lymphoma_malt-type.aspx MALT lymphoma - several images (pathpedia.com)].

	~~===IHC===~~
	~~Features:<ref>{{Ref Lester\|95}}</ref>~~
	*CD20 +ve.
	*BCL2 +ve.
	*CD21 +ve.
	*CD11c +ve (flow cytometry or laser scanning cytometry - only; not available for paraffin).
	*CD43 +ve/-ve.
	**Typically positive in ''[[mantle cell lymphoma]].

	~~Others:~~
	*CD5 -ve.
	*CD10 -ve.
	*CD23 -ve.

	~~===Molecular===~~
	There are several associated with MALT lymphoma:<ref name=pmid16950858>{{cite journal \|author=Bacon CM, Du MQ, Dogan A \|title=Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists \|journal=J. Clin. Pathol. \|volume=60 \|issue=4 \|pages=361–72 \|year=2007 \|month=April \|pmid=16950858 \|pmc=2001121 \|doi=10.1136/jcp.2005.031146 \|url=}}</ref>
	*t(11;18)(q21;q21) / API2‐MALT1<ref name=Ref_PCPBoD8_170>{{Ref PCPBoD8\|170}}</ref> - most common translocation in MALT lymphoma.<ref name=pmid12406890>{{Cite journal \| last1 = Streubel \| first1 = B. \| last2 = Lamprecht \| first2 = A. \| last3 = Dierlamm \| first3 = J. \| last4 = Cerroni \| first4 = L. \| last5 = Stolte \| first5 = M. \| last6 = Ott \| first6 = G. \| last7 = Raderer \| first7 = M. \| last8 = Chott \| first8 = A. \| title = T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. \| journal = Blood \| volume = 101 \| issue = 6 \| pages = 2335-9 \| month = Mar \| year = 2003 \| doi = 10.1182/blood-2002-09-2963 \| PMID = 12406890 }}
	~~</ref>~~
	*t(14;18)(q32;q21) / IGH‐MALT1.
	**Should not be confused with t(14;18) seen in [[follicular lymphoma]] between IGH-BCL2.<ref name=pmid18359244>{{Cite journal \| last1 = Vitolo \| first1 = U. \| last2 = Ferreri \| first2 = AJ. \| last3 = Montoto \| first3 = S. \| title = Follicular lymphomas. \| journal = Crit Rev Oncol Hematol \| volume = 66 \| issue = 3 \| pages = 248-61 \| month = Jun \| year = 2008 \| doi = 10.1016/j.critrevonc.2008.01.014 \| PMID = 18359244 }}</ref>
	*t(1;14)(p22;q32) / IGH‐BCL10.

	~~The MALT1 associated [[translocations]] can be assessed with an [[ISH]] break apart probe for MALT1~~.

	==Hairy cell leukemia==		==Hairy cell leukemia==

Michael: /* Microscopic */

2014-09-06T17:19:46Z

Microscopic

← Older revision		Revision as of 17:19, 6 September 2014
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	**# Clearing around the lymphocyte cluster.		**# Clearing around the lymphocyte cluster.
	**Not specific for MALT lymphoma, i.e. may be seen in other types of lymphoma.<ref>DB. 6 August 2010.</ref>		**Not specific for MALT lymphoma, i.e. may be seen in other types of lymphoma.<ref>DB. 6 August 2010.</ref>

			DDx:
			*Other [[small cell lymphomas]].
			*[[DLBCL]] - should be a distinctive region at low power.{{fact}}

	====Images====		====Images====

Michael: /* B cell small lymphocytic lymphoma/chronic lymphocytic leukemia */ spli tout

2014-06-10T11:15:30Z

B cell small lymphocytic lymphoma/chronic lymphocytic leukemia: spli tout

← Older revision		Revision as of 11:15, 10 June 2014
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	==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia==		==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia==
	*Abbreviated ''CLL'' and ''SLL''.		{{Main\|B cell small lymphocytic lymphoma/chronic lymphocytic leukemia}}
	~~===General===~~
	*Very common.
	*Good prognosis.

	~~====Richter's transformation====~~
	*CLL/SLL may under go a ''Richter's transformation'' into a high-grade non-Hodgkin's lymphoma (NHL), e.g. [[DLBCL]]:<ref name=pmid16616072>{{~~cite journal~~ \|~~author=Tsimberidou AM, Keating MJ \|title=Richter's transformation in~~ chronic lymphocytic leukemia ~~\|journal=Semin. Oncol. \|volume=33 \|issue=2 \|pages=250–6 \|year=2006 \|month=April \|pmid=16616072 \|doi=10.1053/j.seminoncol.2006.01.016 \|url=~~}}~~</ref>~~
	**Incidence of transformation <5%.
	**Prognosis < 1 year.

	~~===Microscopic===~~
	~~Features in a lymph node:<ref>DG. 17 August 2010.</ref>~~
	*Mixed population of lymphoid cells with "proliferation centers" - '''key feature''':
	*#Larger cells (~ 1.5x the size of resting lymphocyte ~ 12-15 micrometers):
	#Nucleoli.
	#Form (nodular) collections.
	*#Small dark cells (~ size of resting lymphocyte ~ 8-10 micrometers):
	#Predominant population.
	#Lack nucleolus.

	~~====Images====~~
	~~<gallery>~~
	~~Image:Chronic lymphocytic leukemia - low mag.jpg \| CLL - low mag. (WC)~~
	~~Image:Chronic lymphocytic leukemia - intermed mag.jpg \| CLL - intermed. mag. (WC)~~
	~~Image:Chronic lymphocytic leukemia - high mag.jpg \| CLL - high mag. (WC)~~
	~~Image:Chronic lymphocytic leukemia - very high mag.jpg \| CLL - very high mag. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://www.pathologyatlas.ro/chronic-lymphoid-leukemia-liver.php CLL in the liver (pathologyatlas.ro)].
	*[http://path.upmc.edu/cases/case296.html SLL in the parotid - several images (upmc.edu)].
	*[http://path.upmc.edu/cases/case446.html CLL with Richter transformation - several images (upmc.edu)].

	~~===IHC===~~
	*CD20 +ve.
	*CD5 +ve.
	*[[CD23]] +ve -- occasionally negative.<ref>URL: [http://path.upmc.edu/cases/case296/dx.html http://path.upmc.edu/cases/case296/dx.html]. Accessed on: 14 January 2012.</ref>
	*CD43 +ve.

	~~Others:~~
	*Cyclin D1 -ve.

	~~===Molecular===~~
	*Lacks t(11;14) seen in [[mantle cell lymphoma]].

	==Precursor B-cell lymphoblastic lymphoma/leukemia ==		==Precursor B-cell lymphoblastic lymphoma/leukemia ==

Michael at 14:32, 4 February 2014

2014-02-04T14:32:11Z

← Older revision		Revision as of 14:32, 4 February 2014
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	**+/-Clockface nucleus.		**+/-Clockface nucleus.
	**+/-Eccentric nucleus.		**+/-Eccentric nucleus.
	*+/-"Lymphoepithelial lesion" - gastric crypts invaded by a monomorphous population of lymphocytes.<ref name=pmid1452124>{{Cite journal \| last1 = Papadaki \| first1 = L. \| last2 = Wotherspoon \| first2 = AC. \| last3 = Isaacson \| first3 = PG. \| title = The lymphoepithelial lesion of gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): an ultrastructural study. \| journal = Histopathology \| volume = 21 \| issue = 5 \| pages = 415-21 \| month = Nov \| year = 1992 \| doi = \| PMID = 1452124 }}</ref>		*+/-"[[Lymphoepithelial lesion]]" - gastric crypts invaded by a monomorphous population of lymphocytes.<ref name=pmid1452124>{{Cite journal \| last1 = Papadaki \| first1 = L. \| last2 = Wotherspoon \| first2 = AC. \| last3 = Isaacson \| first3 = PG. \| title = The lymphoepithelial lesion of gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): an ultrastructural study. \| journal = Histopathology \| volume = 21 \| issue = 5 \| pages = 415-21 \| month = Nov \| year = 1992 \| doi = \| PMID = 1452124 }}</ref>
	**Features:		**Features:
	**# Cluster of lymphocytes - three cells or more - '''key feature'''.		**# Cluster of lymphocytes - three cells or more - '''key feature'''.

Michael: /* Table of B-cell lymphoma */

2014-01-12T04:30:01Z

Table of B-cell lymphoma

← Older revision		Revision as of 04:30, 12 January 2014
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	\| CD5+, [[CD23]]-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester\|95}}</ref>		\| CD5+, [[CD23]]-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester\|95}}</ref>
	\| t(11;14)(q13;q32) BCL1/IGH<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> (also IGH/BCL1<ref>URL: [http://www.wipo.int/patentscope/search/en/WO2010059499 http://www.wipo.int/patentscope/search/en/WO2010059499]. Accessed on: 26 May 2011.</ref>)		\| t(11;14)(q13;q32) BCL1/IGH<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> (also IGH/BCL1<ref>URL: [http://www.wipo.int/patentscope/search/en/WO2010059499 http://www.wipo.int/patentscope/search/en/WO2010059499]. Accessed on: 26 May 2011.</ref>)
	\| aggressive, poor prognosis<ref name=pmid10583923/>		\| aggressive, poor prognosis<ref name=pmid10583923>{{Cite journal \| last1 = Hankin \| first1 = RC. \| last2 = Hunter \| first2 = SV. \| title = Mantle cell lymphoma. \| journal = Arch Pathol Lab Med \| volume = 123 \| issue = 12 \| pages = 1182-8 \| month = Dec \| year = 1999 \| doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 \| PMID = 10583923 }}</ref>
	\| DDx: [[Castleman disease]]		\| DDx: [[Castleman disease]]
	\|-		\|-

Michael: /* Mantle cell lymphoma */ split out

2013-12-30T02:15:50Z

Mantle cell lymphoma: split out

← Older revision		Revision as of 02:15, 30 December 2013
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	==Mantle cell lymphoma==		==Mantle cell lymphoma==
	*Abbreviated ''MCL''.		*Abbreviated ''MCL''.
	~~===General===~~		{{Main\|Mantle cell lymphoma}}
	*Relatively aggressive - guarded prognosis.<ref name=pmid10583923>{{~~Cite journal~~ \| last1 = Hankin \| first1 = RC. \| last2 = Hunter \| first2 = SV. \| title = Mantle cell lymphoma. \| journal = Arch Pathol Lab Med \| volume = 123 \| issue = 12 \| pages = 1182-8 \| month = Dec \| year = 1999 \| doi = 10.1043/0003-9985(1999)1231182:MCL2.0.CO;2 \| PMID = 10583923 }}</ref>

	~~===Microscopic===~~
	~~Features:<ref>DG. 17 August 2010.</ref>~~
	*Small monomorphic (uniform size, shape and staining) lymphoid population.
	*Abundant mitoses.
	*Scattered epithelioid histiocytes (should not be confused with tingible-body macrophages).
	*Sclerosed blood vessels.

	~~DDx:~~
	*Other small cell lymphomas, esp. marginal zone lymphoma.
	*[[Burkitt's lymphoma]].

	~~====Images====~~
	~~<gallery>~~
	~~Image:Mantle cell lymphoma - low mag.jpg \| MCL - low mag. (WC)~~
	~~Image:Mantle cell lymphoma - intermed mag.jpg \| MCL - intermed. mag. (WC)~~
	~~Image:~~Mantle cell lymphoma ~~- low mag - cyclin D1.jpg \| MCL - low mag. - cyclin D1. (WC)~~
	~~Image:Mantle cell lymphoma - intermed mag - cyclin D1.jpg \| MCL - intermed. mag. - cyclin D1. (WC)~~
	~~</gallery>~~
	~~www:~~
	*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)].

	~~===IHC===~~
	*CD5 +ve.
	**Negative in case reports.<ref>URL: [http://path.upmc.edu/cases/case308/dx.html http://path.upmc.edu/cases/case308/dx.html]. Accessed on: 14 January 2012.</ref>
	*CD43 +ve.
	*Cyclin D1 +ve.
	**[[AKA]] BCL1, AKA CCND1.<ref name=omim168461>{{OMIM\|168461}}~~</ref>~~

	~~Others:~~
	*CD23 -ve.
	**Positive in CLL.

	~~===Molecular===~~
	*t(11;14)(q13;q32) / IGH-CCND1.<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref>

	==Marginal zone lymphoma==		==Marginal zone lymphoma==

Michael: /* Mantle cell lymphoma */

2013-12-30T02:09:51Z

Mantle cell lymphoma

← Older revision		Revision as of 02:09, 30 December 2013
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	*[[Burkitt's lymphoma]].		*[[Burkitt's lymphoma]].

	Images:		====Images====
			<gallery>
			Image:Mantle cell lymphoma - low mag.jpg \| MCL - low mag. (WC)
			Image:Mantle cell lymphoma - intermed mag.jpg \| MCL - intermed. mag. (WC)
			Image:Mantle cell lymphoma - low mag - cyclin D1.jpg \| MCL - low mag. - cyclin D1. (WC)
			Image:Mantle cell lymphoma - intermed mag - cyclin D1.jpg \| MCL - intermed. mag. - cyclin D1. (WC)
			</gallery>
			www:
	*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case441.html MCL - several images (upmc.edu)].