Sjögren syndrome - Revision history

Michael: small fix, note redirect

2023-03-02T21:45:57Z

small fix, note redirect

← Older revision		Revision as of 21:45, 2 March 2023
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	The syndrome may be part of another [[connective tissue disorder]], e.g. [[rheumatoid arthritis]], in which case it is called ''secondary Sjögren syndrome''.<ref name=pmid1703737>{{Cite journal \| last1 = Celenligil \| first1 = H. \| last2 = Kansu \| first2 = E. \| last3 = Ruacan \| first3 = S. \| last4 = Eratalay \| first4 = K. \| last5 = Irkeç \| first5 = M. \| title = Characterization of peripheral blood and salivary gland lymphocytes in secondary Sjögren's syndrome. \| journal = Ann Dent \| volume = 49 \| issue = 2 \| pages = 18-22 \| month = \| year = 1990 \| doi = \| PMID = 1703737 }}</ref>		The syndrome may be part of another [[connective tissue disorder]], e.g. [[rheumatoid arthritis]], in which case it is called ''secondary Sjögren syndrome''.<ref name=pmid1703737>{{Cite journal \| last1 = Celenligil \| first1 = H. \| last2 = Kansu \| first2 = E. \| last3 = Ruacan \| first3 = S. \| last4 = Eratalay \| first4 = K. \| last5 = Irkeç \| first5 = M. \| title = Characterization of peripheral blood and salivary gland lymphocytes in secondary Sjögren's syndrome. \| journal = Ann Dent \| volume = 49 \| issue = 2 \| pages = 18-22 \| month = \| year = 1990 \| doi = \| PMID = 1703737 }}</ref>

	Pathologists are likely to this condition as a ''[[labial salivary gland]]'' biopsy.		Pathologists are likely to see this condition as a ''[[labial salivary gland]]'' biopsy.

			''Lip biopsy'' redirects here.

	==General==		==General==

Michael: /* Not suggestive */

2016-03-18T14:41:59Z

Not suggestive

← Older revision		Revision as of 14:41, 18 March 2016
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	Estimated area of salivary gland: 50 mm*mm.		Estimated area of salivary gland: 50 mm*mm.
	Number of foci (~50 lymphocytes): 1.		Number of foci (~50 lymphocytes): 1.
	Plasma cells: ~~not apparent~~.		Plasma cells: few (<10%).
	Fibrosis: none/minimal.		Fibrosis: none/minimal.
	Focus score (number of foci / area x 4 mm*mm) = < 1.		Focus score (number of foci / area x 4 mm*mm) = < 1.

Michael: /* Not suggestive */

2016-03-18T13:39:51Z

Not suggestive

← Older revision		Revision as of 13:39, 18 March 2016
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	<pre>		<pre>
	Minor Salivary Gland, Biopsy:		Minor Salivary Gland, Biopsy:
	- Benign minor salivary gland with one focus of chronic		- Benign minor salivary gland with one focus of chronic lymphocyte
	~~lymphocyte~~ predominant inflammation.		predominant inflammation.
	- Focus score ~~(FS) much~~ less than one; not suggestive of		- Focus score less than one; not suggestive of Sjoegren's disease.
	Sjoegren's disease.

	Comment:		Comment:
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	Plasma cells: not apparent.		Plasma cells: not apparent.
	Fibrosis: none/minimal.		Fibrosis: none/minimal.
	Focus score (~~focus~~ / area x 4 mm*mm) = << 1.		Focus score (number of foci / area x 4 mm*mm) = < 1.

	The findings do not exclude Sjoegren's disease. Clinical and serologic		The findings do not exclude Sjoegren's disease. Clinical and serologic

Michael: /* Not suggestive */

2016-03-18T13:37:46Z

Not suggestive

← Older revision		Revision as of 13:37, 18 March 2016
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	Comment:		Comment:
	Estimated area of salivary gland: 40 mm*mm.		Estimated area of salivary gland: 50 mm*mm.
	Number of foci (~50 lymphocytes): 1.		Number of foci (~50 lymphocytes): 1.
	Plasma cells: not apparent.		Plasma cells: not apparent.
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	Focus score (focus / area x 4 mm*mm) = << 1.		Focus score (focus / area x 4 mm*mm) = << 1.

	The findings do not exclude Sjoegren's disease. Clinical and serologic correlation		The findings do not exclude Sjoegren's disease. Clinical and serologic
	is required.		correlation is required.
	</pre>		</pre>

Michael: /* Sign out */

2016-03-18T13:36:55Z

Sign out

@@ Line 114: / Line 114: @@
 ==Sign out==
 <pre>
 LOWER LIP, BIOPSY:
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 This result needs to be combined with the clinical and serologic criteria used
 to diagnose Sjoegren's disease.
 </pre>

Michael: /* Focus score */

2015-02-23T18:19:34Z

Focus score

← Older revision		Revision as of 18:19, 23 February 2015
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	Calculating the focus score (fs):		Calculating the focus score (fs):
	# Count the significant foci (n).		# Count the significant foci (n).
	# Estimate ~~that~~ area in mm<sup>2</sup> (a).		# Estimate the sample area in mm<sup>2</sup> (a).

	:<math>fs = { n \over a } \times 4 \ mm^2</math>		:<math>fs = { n \over a } \times 4 \ mm^2</math>

Michael: /* Focus score */ fix dimensions

2015-02-23T18:18:12Z

Focus score: fix dimensions

← Older revision		Revision as of 18:18, 23 February 2015
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	# Estimate that area in mm<sup>2</sup> (a).		# Estimate that area in mm<sup>2</sup> (a).

	:<math>fs = { n \over a } \times 4 \ mm</math>		:<math>fs = { n \over a } \times 4 \ mm^2</math>

	====Grading====		====Grading====

Michael: /* Microscopic */ tweak

2014-11-06T05:35:40Z

Microscopic: tweak

← Older revision		Revision as of 05:35, 6 November 2014
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	Features ([[salivary gland]]):<ref name=pmid19323360/>		Features ([[salivary gland]]):<ref name=pmid19323360/>
	*"Significant lymphocytic infiltrate" adjacent to viable [[salivary gland]] (or [[lacrimal gland]]) acini - '''key feature'''.		*"Significant lymphocytic infiltrate" adjacent to viable [[salivary gland]] (or [[lacrimal gland]]) acini - '''key feature'''.
	**"Significant" lymphocytic infiltrate": cluster of >= 50 lymphocytes - '''important'''.		**"Significant lymphocytic infiltrate": cluster of >= 50 lymphocytes - '''important'''.
	***Lymphocytes may be perivascular or periductular.<ref name=pmid12022353/><ref name=pmid8003059>{{Cite journal \| last1 = Daniels \| first1 = TE. \| last2 = Whitcher \| first2 = JP. \| title = Association of patterns of labial salivary gland inflammation with keratoconjunctivitis sicca. Analysis of 618 patients with suspected Sjögren's syndrome. \| journal = Arthritis Rheum \| volume = 37 \| issue = 6 \| pages = 869-77 \| month = Jun \| year = 1994 \| doi = \| PMID = 8003059 }}</ref>		***Lymphocytes may be perivascular or periductular.<ref name=pmid12022353/><ref name=pmid8003059>{{Cite journal \| last1 = Daniels \| first1 = TE. \| last2 = Whitcher \| first2 = JP. \| title = Association of patterns of labial salivary gland inflammation with keratoconjunctivitis sicca. Analysis of 618 patients with suspected Sjögren's syndrome. \| journal = Arthritis Rheum \| volume = 37 \| issue = 6 \| pages = 869-77 \| month = Jun \| year = 1994 \| doi = \| PMID = 8003059 }}</ref>
	***[[Plasma cell]]s should not exceed 10% of the inflammatory infiltrate.<ref name=pmid12022353/>		***[[Plasma cell]]s should not exceed 10% of the inflammatory infiltrate.<ref name=pmid12022353/>

Michael: /* Microscopic */

2013-12-11T17:16:27Z

Microscopic

← Older revision		Revision as of 17:16, 11 December 2013
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	*Diagnosis is based on clinicopathologic correlation; the histology alone is insufficient.		*Diagnosis is based on clinicopathologic correlation; the histology alone is insufficient.

	Images:		===Images===
			<gallery>
			Image:Sjogren_syndrome_%281%29.jpg \| SS - low mag. (WC)
			Image:Sjogren_syndrome_%282%29.jpg \| SS - high mag. (WC)
			</gallery>
			www:
	*[http://img.medscape.com/pi/emed/ckb/rheumatology/329097-1339496-332125-1582482.jpg Sjögren syndrome (medscape.com)].<ref>URL: [http://emedicine.medscape.com/article/332125-workup#aw2aab6b5b6aa http://emedicine.medscape.com/article/332125-workup#aw2aab6b5b6aa]. Accessed on: 24 July 2012.</ref>		*[http://img.medscape.com/pi/emed/ckb/rheumatology/329097-1339496-332125-1582482.jpg Sjögren syndrome (medscape.com)].<ref>URL: [http://emedicine.medscape.com/article/332125-workup#aw2aab6b5b6aa http://emedicine.medscape.com/article/332125-workup#aw2aab6b5b6aa]. Accessed on: 24 July 2012.</ref>
	*[http://commons.wikimedia.org/wiki/File:Sjogren_syndrome_%281%29.jpg SS - low mag. (WC)].
	*[http://commons.wikimedia.org/wiki/File:Sjogren_syndrome_%282%29.jpg SS - high mag. (WC)].

	===Focus score===		===Focus score===

Michael: /* Focus score */

2013-05-03T01:28:14Z

Focus score

← Older revision		Revision as of 01:28, 3 May 2013
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	Features:<ref name=pmid12022353/>		Features:<ref name=pmid12022353/>
	This is nothing more than a count of significant lymphocytic foci per 4 mmmm.		This is nothing more than a count of significant lymphocytic foci per 4 mmmm.
	**Significant: >= 50 lymphocytes, adjacent to salivary gland acini.		**Significant: >= 50 lymphocytes, adjacent to (viable) [[salivary gland]] acini.
	**A ''focus score'' of one or more is considered significant.<ref name=pmid12006334/>		**A ''focus score'' of one or more is considered significant.<ref name=pmid12006334/>