Sinus histiocytosis - Revision history

Michael: /* Microscopic */

2014-10-22T03:50:56Z

Microscopic

← Older revision		Revision as of 03:50, 22 October 2014
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	Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>		Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>
	*Sinuses distended with histiocytes - '''key feature'''.		*Sinuses distended with histiocytes - '''key feature'''.
	**Histocytes: abundant foamy cytoplasm, +/-[[anthracotic pigment]] or [[yellow bodies]].		**Histocytes: abundant foamy cytoplasm, +/-[[anthracotic pigment]] and/or [[yellow bodies]].
	*[[Plasma cell]]s increased.		*[[Plasma cell]]s increased.

Michael: /* Microscopic */

2014-10-22T03:50:38Z

Microscopic

← Older revision		Revision as of 03:50, 22 October 2014
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	Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>		Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>
	*Sinuses distended with histiocytes - '''key feature'''.		*Sinuses distended with histiocytes - '''key feature'''.
	**Histocytes: abundant foamy cytoplasm, +/-[[anthracotic pigment]].		**Histocytes: abundant foamy cytoplasm, +/-[[anthracotic pigment]] or [[yellow bodies]].
	*[[Plasma cell]]s increased.		*[[Plasma cell]]s increased.

Michael: /* Microscopic */

2013-12-31T13:11:15Z

Microscopic

← Older revision		Revision as of 13:11, 31 December 2013
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	*[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus.		*[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus.
	*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment.		*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment.
	*[[Lymph node metastasis]] - usually not difficult if one compares ~~with~~ the germinal center macrophages and the primary tumour.		*[[Lymph node metastasis]] - usually not difficult to exclude, esp. if one compares the germinal center macrophages and the primary tumour.

	===Images===		===Images===

Michael: fix sp.

2013-12-31T13:09:21Z

fix sp.

← Older revision		Revision as of 13:09, 31 December 2013
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = ~~varaible~~		\| Clinicalhx = variable
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =

Michael: /* Microscopic */

2013-12-01T21:29:43Z

Microscopic

← Older revision		Revision as of 21:29, 1 December 2013
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	Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>		Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>
	*Sinuses distended with histiocytes - '''key feature'''.		*Sinuses distended with histiocytes - '''key feature'''.
	**Histocytes: abundant foamy cytoplasm, +/-~~anthrocotic~~ pigment.		**Histocytes: abundant foamy cytoplasm, +/-[[anthracotic pigment]].
	*[[Plasma cell]]s increased.		*[[Plasma cell]]s increased.

Michael at 21:28, 1 December 2013

2013-12-01T21:28:22Z

← Older revision		Revision as of 21:28, 1 December 2013
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	\| Width =		\| Width =
	\| Caption = Sinus histiocytosis. [[H&E stain]].		\| Caption = Sinus histiocytosis. [[H&E stain]].
	\| Micro =		\| Micro = sinuses distended with histiocytes without atypia
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[Rosai-Dorfman disease]], [[dermatopathic lymphadenopathy]], [[lymph node metastasis]]		\| LMDDx = [[Rosai-Dorfman disease]], [[dermatopathic lymphadenopathy]], [[lymph node metastasis]]
	\| Stains =		\| Stains =
	\| IHC =		\| IHC = CD68 +ve, S-100 -ve, pankeratin -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: +infobox

2013-12-01T21:26:24Z

+infobox

← Older revision		Revision as of 21:26, 1 December 2013
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Sinus histiocytosis -- intermed mag.jpg
			\| Width =
			\| Caption = Sinus histiocytosis. [[H&E stain]].
			\| Micro =
			\| Subtypes =
			\| LMDDx = [[Rosai-Dorfman disease]], [[dermatopathic lymphadenopathy]], [[lymph node metastasis]]
			\| Stains =
			\| IHC =
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[lymph node]] - see ''[[lymph node pathology]]''
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = varaible
			\| Signs =
			\| Symptoms =
			\| Prevalence = common
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis = benign
			\| Other =
			\| ClinDDx = other causes of lymphadenopathy esp. [[lymphoma]], [[lymph node metastasis]]
			}}
	'''Sinus histiocytosis''', abbreviated '''SH''', is a common finding in [[lymph nodes]].		'''Sinus histiocytosis''', abbreviated '''SH''', is a common finding in [[lymph nodes]].

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	*CD68 +ve.		*CD68 +ve.
	*S-100 -ve.		*S-100 -ve.
			*Pankeratin -ve.
			**Used to excluded metastatic carcinoma.

	==Sign out==		==Sign out==

Michael: /* Microscopic */

2013-12-01T15:54:07Z

Microscopic

← Older revision		Revision as of 15:54, 1 December 2013
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	DDx:		DDx:
	*[[Rosai-Dorfman disease]] - ~~histiocyte nuclei~~ large (~2-3x lymphocyte) ~~and round~~ with a prominent nucleolus.		*[[Rosai-Dorfman disease]] - histiocytes have a large round nucleus (~2-3x the size of a lymphocyte) with a prominent nucleolus.
	*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment.		*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment.
	*[[Lymph node metastasis]] - usually not difficult if one compares with the germinal center macrophages and the primary tumour.		*[[Lymph node metastasis]] - usually not difficult if one compares with the germinal center macrophages and the primary tumour.

Michael at 15:49, 1 December 2013

2013-12-01T15:49:54Z

← Older revision		Revision as of 15:49, 1 December 2013
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	*Benign.		*Benign.
	*Non-specific finding.		*Non-specific finding.
			*Frequently associated with infections and neoplasia.<ref name=pmid18504582>{{Cite journal \| last1 = Hartmann \| first1 = S. \| last2 = Kriener \| first2 = S. \| last3 = Hansmann \| first3 = ML. \| title = [Diagnostic spectrum of reactive lymph node changes]. \| journal = Pathologe \| volume = 29 \| issue = 4 \| pages = 253-63 \| month = Jul \| year = 2008 \| doi = 10.1007/s00292-008-1003-5 \| PMID = 18504582 }}</ref>
	*Reported in association with hip replacements.<ref name=pmid8279630>{{Cite journal \| last1 = Albores-Saavedra \| first1 = J. \| last2 = Vuitch \| first2 = F. \| last3 = Delgado \| first3 = R. \| last4 = Wiley \| first4 = E. \| last5 = Hagler \| first5 = H. \| title = Sinus histiocytosis of pelvic lymph nodes after hip replacement. A histiocytic proliferation induced by cobalt-chromium and titanium. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 1 \| pages = 83-90 \| month = Jan \| year = 1994 \| doi = \| PMID = 8279630 }}		*Reported in association with hip replacements.<ref name=pmid8279630>{{Cite journal \| last1 = Albores-Saavedra \| first1 = J. \| last2 = Vuitch \| first2 = F. \| last3 = Delgado \| first3 = R. \| last4 = Wiley \| first4 = E. \| last5 = Hagler \| first5 = H. \| title = Sinus histiocytosis of pelvic lymph nodes after hip replacement. A histiocytic proliferation induced by cobalt-chromium and titanium. \| journal = Am J Surg Pathol \| volume = 18 \| issue = 1 \| pages = 83-90 \| month = Jan \| year = 1994 \| doi = \| PMID = 8279630 }}
	</ref>		</ref>

			==Gross==
			*+/-Enlargement of lymph node.<ref name=pmid2051659>{{Cite journal \| last1 = Saito \| first1 = T. \| last2 = Kuwahara \| first2 = A. \| last3 = Kaketani \| first3 = K. \| last4 = Hirao \| first4 = E. \| last5 = Miyahara \| first5 = M. \| last6 = Shimoda \| first6 = K. \| last7 = Kobayashi \| first7 = M. \| title = Preoperative assessment of cervical lymph node involvement in esophageal cancer. \| journal = Jpn J Surg \| volume = 21 \| issue = 2 \| pages = 145-53 \| month = Mar \| year = 1991 \| doi = \| PMID = 2051659 }}</ref>

	==Microscopic==		==Microscopic==
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	*[[Rosai-Dorfman disease]] - histiocyte nuclei large (~2-3x lymphocyte) and round with a prominent nucleolus.		*[[Rosai-Dorfman disease]] - histiocyte nuclei large (~2-3x lymphocyte) and round with a prominent nucleolus.
	*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment.		*[[Dermatopathic lymphadenopathy]] - histiocytes have (melanin) pigment.
	*[[Lymph node metastasis]] - usually not difficult if one compares with the ~~primary tumour and~~ germinal center macrophages.		*[[Lymph node metastasis]] - usually not difficult if one compares with the germinal center macrophages and the primary tumour.

	===Images===		===Images===
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	Image: Sinus histiocytosis - deep -- high mag.jpg \| SH - high mag.		Image: Sinus histiocytosis - deep -- high mag.jpg \| SH - high mag.
	</gallery>		</gallery>

			==IHC==
			*CD68 +ve.
			*S-100 -ve.

	==Sign out==		==Sign out==
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	==References==		==References==
	{{Reflist\|1}}		{{Reflist\|2}}

	[[Category:Diagnosis]]		[[Category:Diagnosis]]
	[[Category:Lymph node pathology]]		[[Category:Lymph node pathology]]

Michael at 03:46, 1 December 2013

2013-12-01T03:46:48Z

← Older revision		Revision as of 03:46, 1 December 2013
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	Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>		Features:<ref name=Ref_ILNP179>{{Ref_ILNP\|179}}</ref>
	*Sinuses distended with histiocytes - '''key feature'''.		*Sinuses distended with histiocytes - '''key feature'''.
			**Histocytes: abundant foamy cytoplasm, +/-anthrocotic pigment.
	*[[Plasma cell]]s increased.		*[[Plasma cell]]s increased.