Signet ring cell carcinoma - Revision history

Michael: /* Microscopic */

2024-03-25T23:49:28Z

Microscopic

← Older revision		Revision as of 23:49, 25 March 2024
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	**Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated.		**Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated.
	*[[Gastric xanthoma]].		*[[Gastric xanthoma]].
	*[[~~Crypt~~ cell ~~carcinoma~~]] (goblet cell carcinoid).<ref name=pmid22933998>{{Cite journal \| last1 = Pericleous \| first1 = M. \| last2 = Lumgair \| first2 = H. \| last3 = Baneke \| first3 = A. \| last4 = Morgan-Rowe \| first4 = L. \| last5 = E Caplin \| first5 = M. \| last6 = Luong \| first6 = TV. \| last7 = Thirlwell \| first7 = C. \| last8 = Gillmore \| first8 = R. \| last9 = Toumpanakis \| first9 = C. \| title = Appendiceal goblet cell carcinoid tumour: a case of unexpected lung metastasis. \| journal = Case Rep Oncol \| volume = 5 \| issue = 2 \| pages = 332-8 \| month = May \| year = 2012 \| doi = 000339607 \| PMID = 22933998 }}</ref>		*[[Goblet cell adenocarcinoma]] (''crypt cell carcinoma'' or ''goblet cell carcinoid'').<ref name=pmid22933998>{{Cite journal \| last1 = Pericleous \| first1 = M. \| last2 = Lumgair \| first2 = H. \| last3 = Baneke \| first3 = A. \| last4 = Morgan-Rowe \| first4 = L. \| last5 = E Caplin \| first5 = M. \| last6 = Luong \| first6 = TV. \| last7 = Thirlwell \| first7 = C. \| last8 = Gillmore \| first8 = R. \| last9 = Toumpanakis \| first9 = C. \| title = Appendiceal goblet cell carcinoid tumour: a case of unexpected lung metastasis. \| journal = Case Rep Oncol \| volume = 5 \| issue = 2 \| pages = 332-8 \| month = May \| year = 2012 \| doi = 000339607 \| PMID = 22933998 }}</ref>
	*Ischemic mucosal changes - cells within the lumen.<ref name=pmid22082777>{{Cite journal \| last1 = Dhingra \| first1 = S. \| last2 = Wang \| first2 = H. \| title = Nonneoplastic signet-ring cell change in gastrointestinal and biliary tracts: a pitfall for overdiagnosis. \| journal = Ann Diagn Pathol \| volume = 15 \| issue = 6 \| pages = 490-6 \| month = Dec \| year = 2011 \| doi = 10.1016/j.anndiagpath.2011.07.006 \| PMID = 22082777 }}</ref>		*Ischemic mucosal changes - cells within the lumen.<ref name=pmid22082777>{{Cite journal \| last1 = Dhingra \| first1 = S. \| last2 = Wang \| first2 = H. \| title = Nonneoplastic signet-ring cell change in gastrointestinal and biliary tracts: a pitfall for overdiagnosis. \| journal = Ann Diagn Pathol \| volume = 15 \| issue = 6 \| pages = 490-6 \| month = Dec \| year = 2011 \| doi = 10.1016/j.anndiagpath.2011.07.006 \| PMID = 22082777 }}</ref>

Michael: /* General */

2022-04-23T15:15:07Z

General

← Older revision		Revision as of 15:15, 23 April 2022
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	*The name comes from the shape of cells. They look like signet rings that are lying flat on the ground and one is looking from above - see microscopic section.		*The name comes from the shape of cells. They look like signet rings that are lying flat on the ground and one is looking from above - see microscopic section.

	===~~Differential diagnosis~~===		===Anatomical Site===
	It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref>		It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref>
	*[[Esophagus]] >50% signet ring cells.<ref>URL: [https://clinicaltrials.gov/ct2/show/NCT01824966 https://clinicaltrials.gov/ct2/show/NCT01824966]. Accessed on: April 23, 2022.</ref>		*[[Esophagus]].
			**>50% signet ring cells - as per a study definition.<ref>URL: [https://clinicaltrials.gov/ct2/show/NCT01824966 https://clinicaltrials.gov/ct2/show/NCT01824966]. Accessed on: April 23, 2022.</ref>
	*[[Stomach]].		*[[Stomach]].
	*[[Small intestine]]		*[[Small intestine]]

Michael: /* Differential diagnosis */

2022-04-23T15:14:12Z

Differential diagnosis

← Older revision		Revision as of 15:14, 23 April 2022
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	===Differential diagnosis===		===Differential diagnosis===
	It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref>		It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref>
			*[[Esophagus]] >50% signet ring cells.<ref>URL: [https://clinicaltrials.gov/ct2/show/NCT01824966 https://clinicaltrials.gov/ct2/show/NCT01824966]. Accessed on: April 23, 2022.</ref>
	*[[Stomach]].		*[[Stomach]].
	*[[Small intestine]]		*[[Small intestine]]

Michael: /* IHC */

2021-08-05T17:27:21Z

IHC

← Older revision		Revision as of 17:27, 5 August 2021
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	==IHC==		==IHC==
	*AE1/AE3 +ve.		*AE1/AE3 +ve.
	*CK7 +ve.		*CK7 +ve (usually).

	==See also==		==See also==

Michael: /* Stains */

2021-08-05T17:26:39Z

Stains

← Older revision		Revision as of 17:26, 5 August 2021
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	==Stains==		==Stains==
			*Alcian blue-PAS stain +ve (stomach and colorectum).<ref name=pmid23573317>{{Cite journal \| last1 = Terada \| first1 = T. \| title = An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: I. Cytokeratin profile in 42 cases. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 4 \| pages = 703-10 \| month = \| year = 2013 \| doi = \| PMID = 23573317 }}</ref>
	*PAS stain +ve.		*PAS stain +ve.
	*~~Alcian blue~~-~~PAS stain +~~ve (stomach ~~and colorectum~~).~~<ref name=pmid23573317>~~{{Cite journal \| last1 = Terada \| first1 = T. \| title = An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: I. Cytokeratin profile in 42 cases. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 4 \| pages = 703-10 \| month = \| year = 2013 \| doi = \| PMID = 23573317 }}~~</ref>~~		*[[Mucicarmine stain]] -ve (stomach).{{fact}}

	Note:		Note:
	*[[Mucicarmine stain]] -ve (stomach).{{fact}}
	*Mucin staining varies somewhat by the anatomical site.<ref name=pmid16740030>{{cite journal \|authors=Nguyen MD, Plasil B, Wen P, Frankel WL \|title=Mucin profiles in signet-ring cell carcinoma \|journal=Arch Pathol Lab Med \|volume=130 \|issue=6 \|pages=799–804 \|date=June 2006 \|pmid=16740030 \|doi=10.5858/2006-130-799-MPISCC \|url=}}</ref>		*Mucin staining varies somewhat by the anatomical site.<ref name=pmid16740030>{{cite journal \|authors=Nguyen MD, Plasil B, Wen P, Frankel WL \|title=Mucin profiles in signet-ring cell carcinoma \|journal=Arch Pathol Lab Med \|volume=130 \|issue=6 \|pages=799–804 \|date=June 2006 \|pmid=16740030 \|doi=10.5858/2006-130-799-MPISCC \|url=}}</ref>

Michael: /* Stains */ tweak

2021-08-05T17:26:09Z

Stains: tweak

← Older revision		Revision as of 17:26, 5 August 2021
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	==Stains==		==Stains==
	*PAS stain +ve.		*PAS stain +ve.
	*Alcian blue-PAS stain +ve.<ref name=pmid23573317>{{Cite journal \| last1 = Terada \| first1 = T. \| title = An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: I. Cytokeratin profile in 42 cases. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 4 \| pages = 703-10 \| month = \| year = 2013 \| doi = \| PMID = 23573317 }}</ref>		*Alcian blue-PAS stain +ve (stomach and colorectum).<ref name=pmid23573317>{{Cite journal \| last1 = Terada \| first1 = T. \| title = An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: I. Cytokeratin profile in 42 cases. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 4 \| pages = 703-10 \| month = \| year = 2013 \| doi = \| PMID = 23573317 }}</ref>

	Note:		Note:
	*[[Mucicarmine stain]] -ve.{{fact}}		*[[Mucicarmine stain]] -ve (stomach).{{fact}}
			*Mucin staining varies somewhat by the anatomical site.<ref name=pmid16740030>{{cite journal \|authors=Nguyen MD, Plasil B, Wen P, Frankel WL \|title=Mucin profiles in signet-ring cell carcinoma \|journal=Arch Pathol Lab Med \|volume=130 \|issue=6 \|pages=799–804 \|date=June 2006 \|pmid=16740030 \|doi=10.5858/2006-130-799-MPISCC \|url=}}</ref>

	==IHC==		==IHC==

Michael: tweak

2021-08-05T17:21:12Z

tweak

← Older revision		Revision as of 17:21, 5 August 2021
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	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[serous fat atrophy]], benign histiocytes ([[mucocele]], [[gastric xanthoma\|xanthoma]])		\| LMDDx = [[serous fat atrophy]], benign histiocytes ([[mucocele]], [[gastric xanthoma\|xanthoma]])
	\| Stains = ~~[[mucicarmine stain]],~~ [[PAS stain]]		\| Stains = [[PAS stain]]
	\| IHC = pankeratin +ve, CD68 -ve		\| IHC = pankeratin +ve, CD68 -ve
	\| EM =		\| EM =
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	*PAS stain +ve.		*PAS stain +ve.
	*Alcian blue-PAS stain +ve.<ref name=pmid23573317>{{Cite journal \| last1 = Terada \| first1 = T. \| title = An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: I. Cytokeratin profile in 42 cases. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 4 \| pages = 703-10 \| month = \| year = 2013 \| doi = \| PMID = 23573317 }}</ref>		*Alcian blue-PAS stain +ve.<ref name=pmid23573317>{{Cite journal \| last1 = Terada \| first1 = T. \| title = An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: I. Cytokeratin profile in 42 cases. \| journal = Int J Clin Exp Pathol \| volume = 6 \| issue = 4 \| pages = 703-10 \| month = \| year = 2013 \| doi = \| PMID = 23573317 }}</ref>

			Note:
			*[[Mucicarmine stain]] -ve.{{fact}}

	==IHC==		==IHC==

Michael: +SR

2017-11-16T15:20:11Z

+SR

← Older revision		Revision as of 15:20, 16 November 2017
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	*Signet ring cell carcinoma are notoriously easy to miss in a small biopsy.		*Signet ring cell carcinoma are notoriously easy to miss in a small biopsy.
	**It has been said that there are two types of pathologists... those that have missed SRCCs ''and'' those that will miss SRCCs.		**It has been said that there are two types of pathologists... those that have missed SRCCs ''and'' those that will miss SRCCs.
	*The name comes from the shape of cells. They look like signet rings that are lying flat on the ground and one is looking from above.		*The name comes from the shape of cells. They look like signet rings that are lying flat on the ground and one is looking from above - see microscopic section.
	~~[[Image: Medieval Signet Ring (FindID 226489).jpg\|right\|100px\|A medieval signet ring. On the left it is lying flat and looks similar to the so called signet ring cells. (WC)]]~~
	===Differential diagnosis===		===Differential diagnosis===
	It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref>		It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref>
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	===Images===		===Images===
			<gallery>
			Image:Medieval Signet Ring (FindID 226489).jpg\|A medieval signet ring. On the left it is lying flat and looks similar to a so called signet ring cell. (WC/Staves)
			</gallery>
	====www====		====www====
	*[http://www.engravingarts.com/sales/LVX2.jpg Signet rings (engravingarts.com)].		*[http://www.engravingarts.com/sales/LVX2.jpg Signet rings (engravingarts.com)].

Michael: /* General */

2017-11-16T15:10:35Z

General

← Older revision		Revision as of 15:10, 16 November 2017
Line 40:		Line 40:
	*Signet ring cell carcinoma are notoriously easy to miss in a small biopsy.		*Signet ring cell carcinoma are notoriously easy to miss in a small biopsy.
	**It has been said that there are two types of pathologists... those that have missed SRCCs ''and'' those that will miss SRCCs.		**It has been said that there are two types of pathologists... those that have missed SRCCs ''and'' those that will miss SRCCs.
			*The name comes from the shape of cells. They look like signet rings that are lying flat on the ground and one is looking from above.
			[[Image: Medieval Signet Ring (FindID 226489).jpg\|right\|100px\|A medieval signet ring. On the left it is lying flat and looks similar to the so called signet ring cells. (WC)]]
	===Differential diagnosis===		===Differential diagnosis===
	It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref>		It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref>

Michael: /* General */

2017-11-16T15:04:29Z

General

← Older revision		Revision as of 15:04, 16 November 2017
Line 38:		Line 38:

	==General==		==General==
	*It has been said that there are two types of pathologists... those that have missed SRCCs ''and'' those that will miss SRCCs.		*Signet ring cell carcinoma are notoriously easy to miss in a small biopsy.
			**It has been said that there are two types of pathologists... those that have missed SRCCs ''and'' those that will miss SRCCs.

	===Differential diagnosis===		===Differential diagnosis===