Sertoli cell nodule - Revision history

Michael: ITGCN -> GCNIS

2016-03-15T23:56:30Z

ITGCN -> GCNIS

← Older revision		Revision as of 23:56, 15 March 2016
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	TESTICLE, LEFT, ORCHIECTOMY:		TESTICLE, LEFT, ORCHIECTOMY:
	- ATROPHIC TESTICLE WITH SERTOLI CELL NODULES.		- ATROPHIC TESTICLE WITH SERTOLI CELL NODULES.
	- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA.		- NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA).
	- NEGATIVE FOR MALIGNANCY.		- NEGATIVE FOR MALIGNANCY.

Michael: /* IHC */

2014-08-15T02:00:39Z

IHC

← Older revision		Revision as of 02:00, 15 August 2014
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	Other:		Other:
	*PLAP -ve.		*[[PLAP]] -ve.

	==Sign out==		==Sign out==

Michael: /* General */ tweak

2014-07-23T19:28:20Z

General: tweak

← Older revision		Revision as of 19:28, 23 July 2014
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	==General==		==General==
	*Benign proliferation of Sertoli cells - associated with cryptorchidism (undescended testis).		*Benign proliferation of Sertoli cells - associated with [[cryptorchidism]] (undescended testis).
	*Not composed of a clonal cell population, i.e. ''not'' neoplastic; thus, technically, should not be called an ''adenoma''.<ref name=Ref_DCHH227>{{Ref DCHH\|227}}</ref>		*Not composed of a clonal cell population, i.e. ''not'' neoplastic; thus, technically, should not be called an ''adenoma''.<ref name=Ref_DCHH227>{{Ref DCHH\|227}}</ref>

Michael: /* Sign out */

2014-01-21T20:10:32Z

Sign out

← Older revision		Revision as of 20:10, 21 January 2014
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	<pre>		<pre>
	TESTICLE, LEFT, ORCHIECTOMY:		TESTICLE, LEFT, ORCHIECTOMY:
	- ATROPHIC TESTICLE.		- ATROPHIC TESTICLE WITH SERTOLI CELL NODULES.
	- SERTOLI CELL NODULES.
	- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA.		- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA.
	- NEGATIVE FOR MALIGNANCY.		- NEGATIVE FOR MALIGNANCY.

Michael: /* IHC */

2014-01-21T20:07:17Z

IHC

← Older revision		Revision as of 20:07, 21 January 2014
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	Image:Sertoli_cell_nodule_low_mag.jpg \| Sertoli cell nodule - low mag. (WC)		Image:Sertoli_cell_nodule_low_mag.jpg \| Sertoli cell nodule - low mag. (WC)
	</gallery>		</gallery>
	===IHC===		==IHC==
	Features:<ref name=pmid21107095/>		Features:<ref name=pmid21107095/>
	*Alpha-inhibin +ve (5/5 cases).		*Alpha-inhibin +ve (5/5 cases).

Michael at 20:06, 21 January 2014

2014-01-21T20:06:17Z

← Older revision		Revision as of 20:06, 21 January 2014
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			{{ Infobox diagnosis
			\| Name = {{PAGENAME}}
			\| Image = Sertoli_cell_nodule_high_mag.jpg
			\| Width =
			\| Caption = Sertoli cell nodule. [[H&E stain]].
			\| Synonyms = Pick's adenoma, testicular [[tubular adenoma]], tubular adenoma of the testis
			\| Micro = unencapsulated nodules composed of well-formed tubules, +/eosinophilic (hyaline) blob in lumen (centre), cells - vaguely resemble immature Sertoli cells (bland hyperchromatic oval/round nuclei) but are stratified (somewhat like a [[tubular adenoma of the gastrointestinal tract]])
			\| Subtypes =
			\| LMDDx = [[Sertoli cell tumour]], [[sex cord tumour with annular tubules]], [[gonadoblastoma]]
			\| Stains =
			\| IHC = alpha-inhibin +ve, PLAP -ve
			\| EM =
			\| Molecular =
			\| IF =
			\| Gross =
			\| Grossing =
			\| Site = [[testis]]
			\| Assdx =
			\| Syndromes =
			\| Clinicalhx = +/-undescended testis
			\| Signs =
			\| Symptoms =
			\| Prevalence = uncommon in general
			\| Bloodwork =
			\| Rads =
			\| Endoscopy =
			\| Prognosis =
			\| Other =
			\| ClinDDx =
			\| Tx =
			}}
	'''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental.		'''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental.

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	**May contain eosinophilic (hyaline) blob in lumen (centre).		**May contain eosinophilic (hyaline) blob in lumen (centre).
	*Cells - vaguely resemble immature Sertoli cells:		*Cells - vaguely resemble immature Sertoli cells:
	**Bland hyperchromatic oval/round nuclei that are stratified.		**Bland hyperchromatic oval/round nuclei that are stratified - somewhat like a [[tubular adenoma of the gastrointestinal tract]] - '''key feature'''.

	DDx:<ref name=pmid21107095/>		DDx:<ref name=pmid21107095/>

Michael: split-out

2014-01-21T20:00:27Z

split-out

← Older revision		Revision as of 20:00, 21 January 2014
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	~~#redirect [[Testis#Sertoli_cell_nodule]]~~		'''Sertoli cell nodule''', abbreviated '''SCN''', is a benign lesion of the testis that is usually incidental.

			It is also known as '''Pick's adenoma''', '''testicular tubular adenoma''' and '''tubular adenoma of the testis'''.

			==General==
			*Benign proliferation of Sertoli cells - associated with cryptorchidism (undescended testis).
			*Not composed of a clonal cell population, i.e. ''not'' neoplastic; thus, technically, should not be called an ''adenoma''.<ref name=Ref_DCHH227>{{Ref DCHH\|227}}</ref>

			==Gross==
			*Usually an incidental finding, rarely presents as a testicular mass.<ref name=pmid21107095>{{Cite journal \| last1 = Vallangeon \| first1 = BD. \| last2 = Eble \| first2 = JN. \| last3 = Ulbright \| first3 = TM. \| title = Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses. \| journal = Am J Surg Pathol \| volume = 34 \| issue = 12 \| pages = 1874-80 \| month = Dec \| year = 2010 \| doi = 10.1097/PAS.0b013e3181fcab70 \| PMID = 21107095 }}</ref>

			==Microscopic==
			Features:<ref name=Ref_DCHH227>{{Ref DCHH\|227}}</ref><ref>{{cite journal \|author=Ricco R, Bufo P \|title=[Histologic study of 3 cases of so-called tubular adenoma of the testis] \|language=Italian \|journal=Boll. Soc. Ital. Biol. Sper. \|volume=56 \|issue=20 \|pages=2110–5 \|year=1980 \|month=October \|pmid=6109541 \|doi= \|url=}}</ref>
			*Unencapsulated nodules composed of well-formed tubules.
			**May contain eosinophilic (hyaline) blob in lumen (centre).
			*Cells - vaguely resemble immature Sertoli cells:
			**Bland hyperchromatic oval/round nuclei that are stratified.

			DDx:<ref name=pmid21107095/>
			*[[Sertoli cell tumour]].
			*[[Sex cord tumour with annular tubules]].
			*[[Gonadoblastoma]].

			===Images===
			<gallery>
			Image:Sertoli_cell_nodule_high_mag.jpg \| Sertoli cell nodule - high mag. (WC)
			Image:Sertoli_cell_nodule_low_mag.jpg \| Sertoli cell nodule - low mag. (WC)
			</gallery>
			===IHC===
			Features:<ref name=pmid21107095/>
			*Alpha-inhibin +ve (5/5 cases).
			*OCT3/4 -ve (5/5 cases).

			Other:
			*PLAP -ve.

			==Sign out==
			<pre>
			TESTICLE, LEFT, ORCHIECTOMY:
			- ATROPHIC TESTICLE.
			- SERTOLI CELL NODULES.
			- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA.
			- NEGATIVE FOR MALIGNANCY.

			COMMENT:
			The above findings are supported by immunostains. The tubules stain with alpha-inhibin and
			are negative for PLAP.
			</pre>

			==See also==
			*[[Testis]].
			*[[Sertoli cell tumour]].

			==References==
			{{Reflist\|2}}

			[[Category:Testis]]
	[[Category:Diagnosis]]		[[Category:Diagnosis]]

Michael: +cat.

2011-10-22T19:24:29Z

+cat.

← Older revision		Revision as of 19:24, 22 October 2011
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	#redirect [[Testis#Sertoli_cell_nodule]]		#redirect [[Testis#Sertoli_cell_nodule]]

			[[Category:Diagnosis]]

Michael: redirect

2011-08-09T04:26:27Z

redirect

New page

#redirect [[Testis#Sertoli_cell_nodule]]