Seminoma - Revision history

Michael: /* Microsopic */

2025-06-11T20:20:10Z

Microsopic

← Older revision		Revision as of 20:20, 11 June 2025
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	*[[Testicular scar]] - seminomas may regress spontaneously.		*[[Testicular scar]] - seminomas may regress spontaneously.
	*[[Testicular atrophy]] - esp. for intertubular predominant seminoma.<ref name=pmid15316315>{{Cite journal \| last1 = Henley \| first1 = JD. \| last2 = Young \| first2 = RH. \| last3 = Wade \| first3 = CL. \| last4 = Ulbright \| first4 = TM. \| title = Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 9 \| pages = 1163-8 \| month = Sep \| year = 2004 \| doi = \| PMID = 15316315 }}</ref>		*[[Testicular atrophy]] - esp. for intertubular predominant seminoma.<ref name=pmid15316315>{{Cite journal \| last1 = Henley \| first1 = JD. \| last2 = Young \| first2 = RH. \| last3 = Wade \| first3 = CL. \| last4 = Ulbright \| first4 = TM. \| title = Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 9 \| pages = 1163-8 \| month = Sep \| year = 2004 \| doi = \| PMID = 15316315 }}</ref>
	*[[Diffuse large B-cell lymphoma]] - may be OCT4 +ve and SALL4 +ve.<ref name=pmid27035612>{{cite journal \|authors=Williams AS, Shawwa A, Merrimen J, Dakin Haché K \|title=Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma: An Analysis of 145 Consecutive Cases and Testicular Lymphomas \|journal=Am J Surg Pathol \|volume=40 \|issue=7 \|pages=950–7 \|date=July 2016 \|pmid=27035612 \|doi=10.1097/PAS.0000000000000648 \|url=}}</ref>		*[[Diffuse large B-cell lymphoma]] - may be OCT4 +ve and rarely SALL4 +ve.<ref name=pmid27035612>{{cite journal \|authors=Williams AS, Shawwa A, Merrimen J, Dakin Haché K \|title=Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma: An Analysis of 145 Consecutive Cases and Testicular Lymphomas \|journal=Am J Surg Pathol \|volume=40 \|issue=7 \|pages=950–7 \|date=July 2016 \|pmid=27035612 \|doi=10.1097/PAS.0000000000000648 \|url=}}</ref>

	===Images===		===Images===

Michael at 20:18, 11 June 2025

2025-06-11T20:18:31Z

← Older revision		Revision as of 20:18, 11 June 2025
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	\| Micro = fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus), lymphocytic infiltrate (common), +/-[[syncytiotrophoblast]]s (rare), +/-granulomas (uncommon)		\| Micro = fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus), lymphocytic infiltrate (common), +/-[[syncytiotrophoblast]]s (rare), +/-granulomas (uncommon)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[embryonal carcinoma]], [[GCNIS]], [[mixed germ cell tumour]], [[granulomatous orchitis]], [[testicular scar]], [[atrophic testis]]		\| LMDDx = [[embryonal carcinoma]], [[GCNIS]], [[mixed germ cell tumour]], [[granulomatous orchitis]], [[testicular scar]], [[atrophic testis]], [[diffuse large B-cell lymphoma]]
	\| Stains =		\| Stains =
	\| IHC = OCT4 +ve, [[CD117]] +ve, CD30 -ve		\| IHC = OCT4 +ve, [[CD117]] +ve, CD30 -ve
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	*[[Testicular scar]] - seminomas may regress spontaneously.		*[[Testicular scar]] - seminomas may regress spontaneously.
	*[[Testicular atrophy]] - esp. for intertubular predominant seminoma.<ref name=pmid15316315>{{Cite journal \| last1 = Henley \| first1 = JD. \| last2 = Young \| first2 = RH. \| last3 = Wade \| first3 = CL. \| last4 = Ulbright \| first4 = TM. \| title = Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 9 \| pages = 1163-8 \| month = Sep \| year = 2004 \| doi = \| PMID = 15316315 }}</ref>		*[[Testicular atrophy]] - esp. for intertubular predominant seminoma.<ref name=pmid15316315>{{Cite journal \| last1 = Henley \| first1 = JD. \| last2 = Young \| first2 = RH. \| last3 = Wade \| first3 = CL. \| last4 = Ulbright \| first4 = TM. \| title = Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 9 \| pages = 1163-8 \| month = Sep \| year = 2004 \| doi = \| PMID = 15316315 }}</ref>
			*[[Diffuse large B-cell lymphoma]] - may be OCT4 +ve and SALL4 +ve.<ref name=pmid27035612>{{cite journal \|authors=Williams AS, Shawwa A, Merrimen J, Dakin Haché K \|title=Expression of OCT4 and SALL4 in Diffuse Large B-cell Lymphoma: An Analysis of 145 Consecutive Cases and Testicular Lymphomas \|journal=Am J Surg Pathol \|volume=40 \|issue=7 \|pages=950–7 \|date=July 2016 \|pmid=27035612 \|doi=10.1097/PAS.0000000000000648 \|url=}}</ref>

	===Images===		===Images===

Michael at 19:24, 12 April 2022

2022-04-12T19:24:49Z

← Older revision		Revision as of 19:24, 12 April 2022
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	'''Seminoma''' is a common [[testis\|testicular]] [[germ cell tumour]].		'''Seminoma''' is a common [[testis\|testicular]] [[germ cell tumour]].

	It should ''not'' be confused with ~~the unrelated tumour called~~ ''[[spermatocytic ~~seminoma~~]]''.		It should ''not'' be confused with ''[[spermatocytic tumour]]'' (previously known as ''spermatocytic seminoma'').

	==General==		==General==
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	A general panel:<ref name=pmid24832161>{{cite journal \|author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR \|title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference \|journal=Am. J. Surg. Pathol. \|volume=38 \|issue=8 \|pages=e50–9 \|year=2014 \|month=August \|pmid=24832161 \|doi=10.1097/PAS.0000000000000233 \|url=}}</ref>		A general panel:<ref name=pmid24832161>{{cite journal \|author=Ulbright TM, Tickoo SK, Berney DM, Srigley JR \|title=Best practices recommendations in the application of immunohistochemistry in testicular tumors: report from the international society of urological pathology consensus conference \|journal=Am. J. Surg. Pathol. \|volume=38 \|issue=8 \|pages=e50–9 \|year=2014 \|month=August \|pmid=24832161 \|doi=10.1097/PAS.0000000000000233 \|url=}}</ref>
	*OCT4 +ve.		*OCT4 +ve.
	**Choriocarcinoma, yolk sac tumour and spermatocytic ~~seminoma~~ all -ve.		**Choriocarcinoma, yolk sac tumour and [[spermatocytic tumour]] all -ve.
	*CD117 +ve.		*CD117 +ve.
	**-ve in embryonal carcinoma.		**-ve in embryonal carcinoma.

Michael at 19:20, 13 February 2022

2022-02-13T19:20:52Z

← Older revision		Revision as of 19:20, 13 February 2022
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	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence =
	\| Bloodwork = LDH elevated, beta-hCG elevated ~~(not common)~~		\| Bloodwork = LDH elevated, beta-hCG normal or slightly elevated
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =

Michael: /* General */

2022-02-13T19:20:14Z

General

← Older revision		Revision as of 19:20, 13 February 2022
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	*Elevated serum LDH.		*Elevated serum LDH.
	*Normal serum alpha fetoprotein.		*Normal serum alpha fetoprotein.
	*Usually normal beta-hCG.		*Usually normal beta-hCG ''or'' slightly elevated.<ref name=pmid9311009>{{cite journal \|authors=Hori K, Uematsu K, Yasoshima H, Yamada A, Sakurai K, Ohya M \|title=Testicular seminoma with human chorionic gonadotropin production \|journal=Pathol Int \|volume=47 \|issue=9 \|pages=592–9 \|date=September 1997 \|pmid=9311009 \|doi=10.1111/j.1440-1827.1997.tb04547.x \|url=}}</ref>

	Note:		Note:

Michael: /* Sign out */

2017-02-11T15:14:19Z

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← Older revision		Revision as of 15:14, 11 February 2017
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	<pre>		<pre>
	Testis, Left, Radical Orchiectomy:		Testis, Left, Radical Orchiectomy:
	- SEMINOMA (pure).		- SEMINOMA (pure).
	-- Margins clear.		-- Margins clear.
	-- Please see synoptic report.		-- Please see synoptic report.
	</pre>		</pre>

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	<pre>		<pre>
	RETROPERITONEAL SOFT TISSUE, RIGHT, CORE BIOPSY:		RETROPERITONEAL SOFT TISSUE, RIGHT, CORE BIOPSY:
	- SEMINOMA.		- SEMINOMA.
	</pre>		</pre>

Michael: /* Sign out */

2017-02-11T15:13:50Z

Sign out

← Older revision		Revision as of 15:13, 11 February 2017
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	==Sign out==		==Sign out==
			<pre>
			Right Testicle, Radical Orchitectomy:
			- SEMINOMA (pure).
			-- Margins clear.
			-- Germ cell neoplasia in situ (intratubular germ cell neoplasia) present.
			-- Please see synoptic report.
			- Background testis consists of Sertoli cells only, NEGATIVE for spermatogenesis.
			</pre>

	<pre>		<pre>
	Testis, Left, Radical Orchiectomy:		Testis, Left, Radical Orchiectomy:

Michael at 17:02, 8 January 2017

2017-01-08T17:02:57Z

← Older revision		Revision as of 17:02, 8 January 2017
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	\| LMDDx = [[embryonal carcinoma]], [[GCNIS]], [[mixed germ cell tumour]], [[granulomatous orchitis]], [[testicular scar]], [[atrophic testis]]		\| LMDDx = [[embryonal carcinoma]], [[GCNIS]], [[mixed germ cell tumour]], [[granulomatous orchitis]], [[testicular scar]], [[atrophic testis]]
	\| Stains =		\| Stains =
	\| IHC = ~~OCT3~~ +ve, CD117 +ve, CD30 -ve		\| IHC = OCT4 +ve, [[CD117]] +ve, CD30 -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: /* Additional notes */

2017-01-08T17:02:20Z

Additional notes

← Older revision		Revision as of 17:02, 8 January 2017
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	*OCT3/4 +ve.<ref name=pmid20438407>{{Cite journal \| last1 = Emerson \| first1 = RE. \| last2 = Ulbright \| first2 = TM. \| title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. \| journal = Pathology \| volume = 42 \| issue = 4 \| pages = 344-55 \| month = Jun \| year = 2010 \| doi = 10.3109/00313021003767355 \| PMID = 20438407 }}</ref>		*OCT3/4 +ve.<ref name=pmid20438407>{{Cite journal \| last1 = Emerson \| first1 = RE. \| last2 = Ulbright \| first2 = TM. \| title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. \| journal = Pathology \| volume = 42 \| issue = 4 \| pages = 344-55 \| month = Jun \| year = 2010 \| doi = 10.3109/00313021003767355 \| PMID = 20438407 }}</ref>
	**Also +ve in embryonal carcinoma.<ref name=pmid18045648>{{Cite journal \| last1 = Iczkowski \| first1 = KA. \| last2 = Butler \| first2 = SL. \| last3 = Shanks \| first3 = JH. \| last4 = Hossain \| first4 = D. \| last5 = Schall \| first5 = A. \| last6 = Meiers \| first6 = I. \| last7 = Zhou \| first7 = M. \| last8 = Torkko \| first8 = KC. \| last9 = Kim \| first9 = SJ. \| title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. \| journal = Hum Pathol \| volume = 39 \| issue = 2 \| pages = 275-81 \| month = Feb \| year = 2008 \| doi = 10.1016/j.humpath.2007.07.002 \| PMID = 18045648 }}</ref>		**Also +ve in embryonal carcinoma.<ref name=pmid18045648>{{Cite journal \| last1 = Iczkowski \| first1 = KA. \| last2 = Butler \| first2 = SL. \| last3 = Shanks \| first3 = JH. \| last4 = Hossain \| first4 = D. \| last5 = Schall \| first5 = A. \| last6 = Meiers \| first6 = I. \| last7 = Zhou \| first7 = M. \| last8 = Torkko \| first8 = KC. \| last9 = Kim \| first9 = SJ. \| title = Trials of new germ cell immunohistochemical stains in 93 extragonadal and metastatic germ cell tumors. \| journal = Hum Pathol \| volume = 39 \| issue = 2 \| pages = 275-81 \| month = Feb \| year = 2008 \| doi = 10.1016/j.humpath.2007.07.002 \| PMID = 18045648 }}</ref>
			*[[PLAP]] +ve.
			**Largely replaced by ''OCT4'' or ''OCT3/4'' - which is more sensitive.<ref name=pmid15725806 >{{Cite journal \| last1 = Hattab \| first1 = EM. \| last2 = Tu \| first2 = PH. \| last3 = Wilson \| first3 = JD. \| last4 = Cheng \| first4 = L. \| title = OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. \| journal = Am J Surg Pathol \| volume = 29 \| issue = 3 \| pages = 368-71 \| month = Mar \| year = 2005 \| doi = \| PMID = 15725806 }}</ref>

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Michael: /* Images */

2016-12-17T04:12:29Z

Images

← Older revision		Revision as of 04:12, 17 December 2016
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	Image: Testicular seminoma (1) nodal metastasis.jpg \| Seminoma in LN. (WC/KGH)		Image: Testicular seminoma (1) nodal metastasis.jpg \| Seminoma in LN. (WC/KGH)
	Image: Testicular seminoma (2) nodal metastasis.jpg \| Seminoma in LN. (WC/KGH)		Image: Testicular seminoma (2) nodal metastasis.jpg \| Seminoma in LN. (WC/KGH)
			</gallery>
			====Seminoma with granulomas====
			<gallery>
			Image: Seminoma with granulomas -- intermed mag.jpg \| Seminoma with granulomas - intermed. mag.
			Image: Seminoma with granulomas -- high mag.jpg \| Seminoma with granulomas - high mag.
			Image: Seminoma with granulomas -- very high mag.jpg \| Seminoma with granulomas - very high mag.
			Image: Seminoma with granulomas --- low mag.jpg \| Seminoma with granulomas - low mag.
			Image: Seminoma with granulomas --- intermed mag.jpg \| Seminoma with granulomas - intermed. mag.
			Image: Seminoma with granulomas --- high mag.jpg \| Seminoma with granulomas - high mag.
			Image: Seminoma with granulomas --- very high mag.jpg \| Seminoma with granulomas - very high mag.
	</gallery>		</gallery>

← Older revision		Revision as of 04:12, 17 December 2016
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	Image: Testicular seminoma (1) nodal metastasis.jpg \| Seminoma in LN. (WC/KGH)		Image: Testicular seminoma (1) nodal metastasis.jpg \| Seminoma in LN. (WC/KGH)
	Image: Testicular seminoma (2) nodal metastasis.jpg \| Seminoma in LN. (WC/KGH)		Image: Testicular seminoma (2) nodal metastasis.jpg \| Seminoma in LN. (WC/KGH)
			</gallery>
			====Seminoma with granulomas====
			<gallery>
			Image: Seminoma with granulomas -- intermed mag.jpg \| Seminoma with granulomas - intermed. mag.
			Image: Seminoma with granulomas -- high mag.jpg \| Seminoma with granulomas - high mag.
			Image: Seminoma with granulomas -- very high mag.jpg \| Seminoma with granulomas - very high mag.
			Image: Seminoma with granulomas --- low mag.jpg \| Seminoma with granulomas - low mag.
			Image: Seminoma with granulomas --- intermed mag.jpg \| Seminoma with granulomas - intermed. mag.
			Image: Seminoma with granulomas --- high mag.jpg \| Seminoma with granulomas - high mag.
			Image: Seminoma with granulomas --- very high mag.jpg \| Seminoma with granulomas - very high mag.
	</gallery>		</gallery>