Schwannoma - Revision history

Jensflorian: /* Molecular */ update

2022-06-27T09:55:16Z

Molecular: update

← Older revision		Revision as of 09:55, 27 June 2022
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	==Molecular==		==Molecular==
	Overview: <ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>		Overview: <ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>
	* Most common: NF2.		* Most common: NF2 (in Vestibular Schwannoma up to84%).
	* less common: ARID1A, ARID1B, DDR, TSC1, TSC2.		* less common: ARID1A, ARID1B, DDR, TSC1, TSC2, CDC27 and USP8.
	* SH3PXD2A-HTRA1 fusions (10%).		* SH3PXD2A-HTRA1 fusions (10%).

Michael at 23:09, 10 March 2022

2022-03-10T23:09:39Z

← Older revision		Revision as of 23:09, 10 March 2022
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	\| Site = [[soft tissue lesions\|soft tissue]] - [[peripheral nerve sheath tumours]]		\| Site = [[soft tissue lesions\|soft tissue]] - [[peripheral nerve sheath tumours]]
	\| Assdx =		\| Assdx =
	\| Syndromes = [[neurofibromatosis type 2]], [[Carney complex]] (psammomatous melanotic schwannoma)		\| Syndromes = [[neurofibromatosis type 2]], [[Carney complex]] (psammomatous melanotic schwannoma), schwannomatosis
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs =

Jensflorian: /* Molecular */ LZTR1

2018-06-26T09:33:49Z

Molecular: LZTR1

← Older revision		Revision as of 09:33, 26 June 2018
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	*INI1 mosaic pattern in familiar schwannomatosis.<ref>{{Cite journal \| last1 = Caltabiano \| first1 = R. \| last2 = Magro \| first2 = G. \| last3 = Polizzi \| first3 = A. \| last4 = Praticò \| first4 = AD. \| last5 = Ortensi \| first5 = A. \| last6 = D'Orazi \| first6 = V. \| last7 = Panunzi \| first7 = A. \| last8 = Milone \| first8 = P. \| last9 = Maiolino \| first9 = L. \| title = A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. \| journal = Childs Nerv Syst \| volume = 33 \| issue = 6 \| pages = 933-940 \| month = Jun \| year = 2017 \| doi = 10.1007/s00381-017-3340-2 \| PMID = 28365909 }}</ref>		*INI1 mosaic pattern in familiar schwannomatosis.<ref>{{Cite journal \| last1 = Caltabiano \| first1 = R. \| last2 = Magro \| first2 = G. \| last3 = Polizzi \| first3 = A. \| last4 = Praticò \| first4 = AD. \| last5 = Ortensi \| first5 = A. \| last6 = D'Orazi \| first6 = V. \| last7 = Panunzi \| first7 = A. \| last8 = Milone \| first8 = P. \| last9 = Maiolino \| first9 = L. \| title = A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. \| journal = Childs Nerv Syst \| volume = 33 \| issue = 6 \| pages = 933-940 \| month = Jun \| year = 2017 \| doi = 10.1007/s00381-017-3340-2 \| PMID = 28365909 }}</ref>
			* LZTR1-associated vestibular schwannomas.<ref>{{Cite journal \| last1 = Evans \| first1 = DG. \| last2 = Bowers \| first2 = NL. \| last3 = Tobi \| first3 = S. \| last4 = Hartley \| first4 = C. \| last5 = Wallace \| first5 = AJ. \| last6 = King \| first6 = AT. \| last7 = Lloyd \| first7 = SKW. \| last8 = Rutherford \| first8 = SA. \| last9 = Hammerbeck-Ward \| first9 = C. \| title = Schwannomatosis: a genetic and epidemiological study. \| journal = J Neurol Neurosurg Psychiatry \| volume = \| issue = \| pages = \| month = Jun \| year = 2018 \| doi = 10.1136/jnnp-2018-318538 \| PMID = 29909380 }}</ref>


	Molecular subgroups:<ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>		Molecular subgroups:<ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>

Jensflorian: /* Molecular */ INI1

2018-06-26T09:30:04Z

Molecular: INI1

← Older revision		Revision as of 09:30, 26 June 2018
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	* less common: ARID1A, ARID1B, DDR, TSC1, TSC2.		* less common: ARID1A, ARID1B, DDR, TSC1, TSC2.
	* SH3PXD2A-HTRA1 fusions (10%).		* SH3PXD2A-HTRA1 fusions (10%).

			*INI1 mosaic pattern in familiar schwannomatosis.<ref>{{Cite journal \| last1 = Caltabiano \| first1 = R. \| last2 = Magro \| first2 = G. \| last3 = Polizzi \| first3 = A. \| last4 = Praticò \| first4 = AD. \| last5 = Ortensi \| first5 = A. \| last6 = D'Orazi \| first6 = V. \| last7 = Panunzi \| first7 = A. \| last8 = Milone \| first8 = P. \| last9 = Maiolino \| first9 = L. \| title = A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. \| journal = Childs Nerv Syst \| volume = 33 \| issue = 6 \| pages = 933-940 \| month = Jun \| year = 2017 \| doi = 10.1007/s00381-017-3340-2 \| PMID = 28365909 }}</ref>

	Molecular subgroups:<ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>		Molecular subgroups:<ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>
	*Group 1: vestibular (has significant higher rate of 22q loss).		*Group 1: vestibular (has significant higher rate of 22q loss).

Jensflorian: /* Cellular schwannoma */ +defintion

2018-06-26T09:28:17Z

Cellular schwannoma: +defintion

← Older revision		Revision as of 09:28, 26 June 2018
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	====Cellular schwannoma====		====Cellular schwannoma====
	*May mimic [[MPNST]].		*May mimic [[MPNST]].
			*Usu. <4 mitoses in 10 HPF (see [[HPFitis]]).
			*Absence of Verocay bodies.
			*Usu paravertebral location.

	Images:		Images:

Jensflorian: /* General */ +macro

2018-06-26T09:25:27Z

General: +macro

← Older revision		Revision as of 09:25, 26 June 2018
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	*May be a part of [[neurofibromatosis type 2]].		*May be a part of [[neurofibromatosis type 2]].
	*Occurs at all ages.		*Occurs at all ages.

			==Macro==
			*Usu. encapsulated.
			*Cystic.
			*Yellow patches on white surface.
			**Variable lipidization.

	==Microscopic==		==Microscopic==

Jensflorian: /* General */ +clinic

2018-06-26T09:22:06Z

General: +clinic

← Older revision		Revision as of 09:22, 26 June 2018
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	==General==		==General==
	*A common [[neuropathology]] [[CNS tumours\|tumour]] that occasionally shows-up elsewhere.		*A common [[neuropathology]] [[CNS tumours\|tumour]] that occasionally shows-up elsewhere.
	*~~Tumour~~ of tissue surrounding a nerve.		*often encapsulated tumour of tissue surrounding a nerve.
	**Axons adjacent to the tumour are normal... but may be compressed.		**Axons adjacent to the tumour are normal... but may be compressed.
	*May be a part of [[neurofibromatosis type 2]].		*May be a part of [[neurofibromatosis type 2]].
			*Occurs at all ages.

	==Microscopic==		==Microscopic==

Jensflorian: /* Microscopic */ Hybrid nerve sheath tumor

2018-06-26T09:20:26Z

Microscopic: Hybrid nerve sheath tumor

← Older revision		Revision as of 09:20, 26 June 2018
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	*Tumour does ''not'' smear well.<ref>MUN. 24 November 2010.</ref>		*Tumour does ''not'' smear well.<ref>MUN. 24 November 2010.</ref>
	*Antoni A: may look somewhat like scattered matchsticks.		*Antoni A: may look somewhat like scattered matchsticks.
			*Hybrid Schwannoma / [[Neurofibroma]] are overrepresented in hereditary conditions.<ref>{{Cite journal \| last1 = Harder \| first1 = A. \| last2 = Wesemann \| first2 = M. \| last3 = Hagel \| first3 = C. \| last4 = Schittenhelm \| first4 = J. \| last5 = Fischer \| first5 = S. \| last6 = Tatagiba \| first6 = M. \| last7 = Nagel \| first7 = C. \| last8 = Jeibmann \| first8 = A. \| last9 = Bohring \| first9 = A. \| title = Hybrid neurofibroma/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients. \| journal = Am J Surg Pathol \| volume = 36 \| issue = 5 \| pages = 702-9 \| month = May \| year = 2012 \| doi = 10.1097/PAS.0b013e31824d3155 \| PMID = 22446939 }}</ref>


	DDx:		DDx:

Jensflorian: /* Microscopic */ + reticulin

2018-06-26T09:08:54Z

Microscopic: + reticulin

← Older revision		Revision as of 09:08, 26 June 2018
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	*In the GI tract: classically have a ''peripheral lymphoid cuff''.<ref name=pmid15728600>{{cite journal \|author=Levy AD, Quiles AM, Miettinen M, Sobin LH \|title=Gastrointestinal schwannomas: CT features with clinicopathologic correlation \|journal=AJR Am J Roentgenol \|volume=184 \|issue=3 \|pages=797–802 \|year=2005 \|month=March \|pmid=15728600 \|doi= \|url=http://www.ajronline.org/cgi/content/full/184/3/797}}</ref>		*In the GI tract: classically have a ''peripheral lymphoid cuff''.<ref name=pmid15728600>{{cite journal \|author=Levy AD, Quiles AM, Miettinen M, Sobin LH \|title=Gastrointestinal schwannomas: CT features with clinicopathologic correlation \|journal=AJR Am J Roentgenol \|volume=184 \|issue=3 \|pages=797–802 \|year=2005 \|month=March \|pmid=15728600 \|doi= \|url=http://www.ajronline.org/cgi/content/full/184/3/797}}</ref>
	*+/-Hemosiderin deposition within tumour.		*+/-Hemosiderin deposition within tumour.
			*Reticulin stain +ve (around individual cells).

	Notes:		Notes:

Jensflorian: /* Molecular */ methylation profiles

2018-06-26T09:07:53Z

Molecular: methylation profiles

← Older revision		Revision as of 09:07, 26 June 2018
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	* less common: ARID1A, ARID1B, DDR, TSC1, TSC2.		* less common: ARID1A, ARID1B, DDR, TSC1, TSC2.
	* SH3PXD2A-HTRA1 fusions (10%).		* SH3PXD2A-HTRA1 fusions (10%).
			Molecular subgroups:<ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>
			*Group 1: vestibular (has significant higher rate of 22q loss).
			*Group 2: spinal.

	==Sign out==		==Sign out==

← Older revision		Revision as of 09:33, 26 June 2018
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	*INI1 mosaic pattern in familiar schwannomatosis.<ref>{{Cite journal \| last1 = Caltabiano \| first1 = R. \| last2 = Magro \| first2 = G. \| last3 = Polizzi \| first3 = A. \| last4 = Praticò \| first4 = AD. \| last5 = Ortensi \| first5 = A. \| last6 = D'Orazi \| first6 = V. \| last7 = Panunzi \| first7 = A. \| last8 = Milone \| first8 = P. \| last9 = Maiolino \| first9 = L. \| title = A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. \| journal = Childs Nerv Syst \| volume = 33 \| issue = 6 \| pages = 933-940 \| month = Jun \| year = 2017 \| doi = 10.1007/s00381-017-3340-2 \| PMID = 28365909 }}</ref>		*INI1 mosaic pattern in familiar schwannomatosis.<ref>{{Cite journal \| last1 = Caltabiano \| first1 = R. \| last2 = Magro \| first2 = G. \| last3 = Polizzi \| first3 = A. \| last4 = Praticò \| first4 = AD. \| last5 = Ortensi \| first5 = A. \| last6 = D'Orazi \| first6 = V. \| last7 = Panunzi \| first7 = A. \| last8 = Milone \| first8 = P. \| last9 = Maiolino \| first9 = L. \| title = A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. \| journal = Childs Nerv Syst \| volume = 33 \| issue = 6 \| pages = 933-940 \| month = Jun \| year = 2017 \| doi = 10.1007/s00381-017-3340-2 \| PMID = 28365909 }}</ref>
			* LZTR1-associated vestibular schwannomas.<ref>{{Cite journal \| last1 = Evans \| first1 = DG. \| last2 = Bowers \| first2 = NL. \| last3 = Tobi \| first3 = S. \| last4 = Hartley \| first4 = C. \| last5 = Wallace \| first5 = AJ. \| last6 = King \| first6 = AT. \| last7 = Lloyd \| first7 = SKW. \| last8 = Rutherford \| first8 = SA. \| last9 = Hammerbeck-Ward \| first9 = C. \| title = Schwannomatosis: a genetic and epidemiological study. \| journal = J Neurol Neurosurg Psychiatry \| volume = \| issue = \| pages = \| month = Jun \| year = 2018 \| doi = 10.1136/jnnp-2018-318538 \| PMID = 29909380 }}</ref>


	Molecular subgroups:<ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>		Molecular subgroups:<ref>{{Cite journal \| last1 = Agnihotri \| first1 = S. \| last2 = Jalali \| first2 = S. \| last3 = Wilson \| first3 = MR. \| last4 = Danesh \| first4 = A. \| last5 = Li \| first5 = M. \| last6 = Klironomos \| first6 = G. \| last7 = Krieger \| first7 = JR. \| last8 = Mansouri \| first8 = A. \| last9 = Khan \| first9 = O. \| title = The genomic landscape of schwannoma. \| journal = Nat Genet \| volume = 48 \| issue = 11 \| pages = 1339-1348 \| month = 11 \| year = 2016 \| doi = 10.1038/ng.3688 \| PMID = 27723760 }}</ref>