Sarcoma with CIC-rearrangement - Revision history

Michael: /* IHC */

2022-02-17T18:40:02Z

IHC

← Older revision		Revision as of 18:40, 17 February 2022
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	*ERG +ve.		*ERG +ve.
	*FLI-1 +ve.		*FLI-1 +ve.
	*~~EMA~~ -ve/+ve.<ref name=pmid28197724>{{cite journal \|authors=Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y \|title=Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes \|journal=Virchows Arch \|volume=470 \|issue=4 \|pages=373–380 \|date=April 2017 \|pmid=28197724 \|doi=10.1007/s00428-017-2072-8 \|url=}}</ref>		*CD56 +ve/-ve (5 +ve of 9<ref name=pmid28197724>{{cite journal \|authors=Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y \|title=Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes \|journal=Virchows Arch \|volume=470 \|issue=4 \|pages=373–380 \|date=April 2017 \|pmid=28197724 \|doi=10.1007/s00428-017-2072-8 \|url=}}</ref>).

	==Molecular==		==Molecular==

Michael: /* IHC */

2022-02-17T18:32:28Z

IHC

← Older revision		Revision as of 18:32, 17 February 2022
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	*ERG +ve.		*ERG +ve.
	*FLI-1 +ve.		*FLI-1 +ve.
	*EMA -ve/+ve ~~(7 +ve of 16~~<ref>{{cite journal \|authors=Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y \|title=Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes \|journal=Virchows Arch \|volume=470 \|issue=4 \|pages=373–380 \|date=April 2017 \|pmid=28197724 \|doi=10.1007/s00428-017-2072-8 \|url=}}</ref>).		*EMA -ve/+ve.<ref name=pmid28197724>{{cite journal \|authors=Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y \|title=Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes \|journal=Virchows Arch \|volume=470 \|issue=4 \|pages=373–380 \|date=April 2017 \|pmid=28197724 \|doi=10.1007/s00428-017-2072-8 \|url=}}</ref>

	==Molecular==		==Molecular==

Michael: /* IHC */

2022-02-17T18:30:09Z

IHC

← Older revision		Revision as of 18:30, 17 February 2022
Line 72:		Line 72:
	*ERG +ve.		*ERG +ve.
	*FLI-1 +ve.		*FLI-1 +ve.
			*EMA -ve/+ve (7 +ve of 16<ref>{{cite journal \|authors=Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y \|title=Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes \|journal=Virchows Arch \|volume=470 \|issue=4 \|pages=373–380 \|date=April 2017 \|pmid=28197724 \|doi=10.1007/s00428-017-2072-8 \|url=}}</ref>).

	==Molecular==		==Molecular==

Jensflorian: /* Microscopic */ Image CIC-DUX sarcoma

2020-10-28T11:19:05Z

Microscopic: Image CIC-DUX sarcoma

← Older revision		Revision as of 11:19, 28 October 2020
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	**Irregular spacing of cells.		**Irregular spacing of cells.
	**+/-Big nucleoli.		**+/-Big nucleoli.

			<gallery>
			File:CIC-DUX-sarcoma.jpg \| CIC-DUX rearranged sarcoma in the CNS (WC/jensflorian)
			</gallery>

	DDx:		DDx:

Michael at 01:11, 20 March 2019

2019-03-20T01:11:17Z

← Older revision		Revision as of 01:11, 20 March 2019
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	\| IHC = WT-1 +ve, CD99 +ve/-ve (not strong membranous), ERG +ve, FLI-1 +ve		\| IHC = WT-1 +ve, CD99 +ve/-ve (not strong membranous), ERG +ve, FLI-1 +ve
	\| EM =		\| EM =
	\| Molecular = t(4;19)(q35;q13.1) present, EWSR1 abnormality absent		\| Molecular = CIC rearrangement, e.g. t(4;19)(q35;q13.1) present; EWSR1 abnormality absent
	\| IF =		\| IF =
	\| Gross =		\| Gross =

Michael: /* Images */

2019-03-20T01:10:30Z

Images

← Older revision		Revision as of 01:10, 20 March 2019
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	===Images===		===Images===
	*[~~http~~://www.nature.com/~~modpathol~~/~~journal~~/~~v28~~/~~n1/fig_tab/modpathol201483f1.html~~ CIC-DUX sarcoma - 1 (nature.com)].<ref name=pmid24947144>{{Cite journal \| last1 = Smith \| first1 = SC. \| last2 = Buehler \| first2 = D. \| last3 = Choi \| first3 = EY. \| last4 = McHugh \| first4 = JB. \| last5 = Rubin \| first5 = BP. \| last6 = Billings \| first6 = SD. \| last7 = Balzer \| first7 = B. \| last8 = Thomas \| first8 = DG. \| last9 = Lucas \| first9 = DR. \| title = CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression. \| journal = Mod Pathol \| volume = 28 \| issue = 1 \| pages = 57-68 \| month = Jan \| year = 2015 \| doi = 10.1038/modpathol.2014.83 \| PMID = 24947144 }}</ref>		*[https://www.nature.com/articles/modpathol201483/figures/1 CIC-DUX sarcoma - 1 (nature.com)].<ref name=pmid24947144>{{Cite journal \| last1 = Smith \| first1 = SC. \| last2 = Buehler \| first2 = D. \| last3 = Choi \| first3 = EY. \| last4 = McHugh \| first4 = JB. \| last5 = Rubin \| first5 = BP. \| last6 = Billings \| first6 = SD. \| last7 = Balzer \| first7 = B. \| last8 = Thomas \| first8 = DG. \| last9 = Lucas \| first9 = DR. \| title = CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression. \| journal = Mod Pathol \| volume = 28 \| issue = 1 \| pages = 57-68 \| month = Jan \| year = 2015 \| doi = 10.1038/modpathol.2014.83 \| PMID = 24947144 }}</ref>
	*[http://www.nature.com/modpathol/journal/v28/n1/fig_tab/modpathol201483f2.html CIC-DUX sarcoma - 2 (nature.com)].<ref name=pmid24947144/>		*[http://www.nature.com/modpathol/journal/v28/n1/fig_tab/modpathol201483f2.html CIC-DUX sarcoma - 2 (nature.com)].<ref name=pmid24947144/>
	*[~~http~~://www.~~ncbi~~.~~nlm.nih.gov/pmc~~/articles/~~PMC4338805/figure~~/~~f2-amjcaserep-16-87~~/ Sarcoma with t(4;19) (nih.gov)].<ref name=pmid25683183>{{Cite journal \| last1 = Haidar \| first1 = A. \| last2 = Arekapudi \| first2 = S. \| last3 = DeMattia \| first3 = F. \| last4 = Abu-Isa \| first4 = E. \| last5 = Kraut \| first5 = M. \| title = High-grade undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: emerging entities of soft tissue tumors with unique histopathologic features--a case report and literature review. \| journal = Am J Case Rep \| volume = 16 \| issue = \| pages = 87-94 \| month = \| year = 2015 \| doi = 10.12659/AJCR.892551 \| PMID = 25683183 }}</ref>		*[https://www.nature.com/articles/modpathol201483/figures/2 Sarcoma with t(4;19) (nih.gov)].<ref name=pmid25683183>{{Cite journal \| last1 = Haidar \| first1 = A. \| last2 = Arekapudi \| first2 = S. \| last3 = DeMattia \| first3 = F. \| last4 = Abu-Isa \| first4 = E. \| last5 = Kraut \| first5 = M. \| title = High-grade undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: emerging entities of soft tissue tumors with unique histopathologic features--a case report and literature review. \| journal = Am J Case Rep \| volume = 16 \| issue = \| pages = 87-94 \| month = \| year = 2015 \| doi = 10.12659/AJCR.892551 \| PMID = 25683183 }}</ref>

	==IHC==		==IHC==

Michael: /* Molecular */

2019-03-20T01:08:54Z

Molecular

← Older revision		Revision as of 01:08, 20 March 2019
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	==Molecular==		==Molecular==
	*Rearrangement of CIC gene, e.g. t(4;19)(q35;q13.1).<ref name=pmid22072439>{{Cite journal \| last1 = Italiano \| first1 = A. \| last2 = Sung \| first2 = YS. \| last3 = Zhang \| first3 = L. \| last4 = Singer \| first4 = S. \| last5 = Maki \| first5 = RG. \| last6 = Coindre \| first6 = JM. \| last7 = Antonescu \| first7 = CR. \| title = High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. \| journal = Genes Chromosomes Cancer \| volume = 51 \| issue = 3 \| pages = 207-18 \| month = Mar \| year = 2012 \| doi = 10.1002/gcc.20945 \| PMID = 22072439 }}</ref>~~; CIC-DUX4 fusion.~~		*Rearrangement of CIC gene, e.g. t(4;19)(q35;q13.1); CIC-DUX4 fusion.<ref name=pmid22072439>{{Cite journal \| last1 = Italiano \| first1 = A. \| last2 = Sung \| first2 = YS. \| last3 = Zhang \| first3 = L. \| last4 = Singer \| first4 = S. \| last5 = Maki \| first5 = RG. \| last6 = Coindre \| first6 = JM. \| last7 = Antonescu \| first7 = CR. \| title = High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. \| journal = Genes Chromosomes Cancer \| volume = 51 \| issue = 3 \| pages = 207-18 \| month = Mar \| year = 2012 \| doi = 10.1002/gcc.20945 \| PMID = 22072439 }}</ref>
	*EWSR1 FISH negative.		*EWSR1 FISH negative.

Michael: /* Molecular */

2019-03-20T01:08:29Z

Molecular

← Older revision		Revision as of 01:08, 20 March 2019
Line 70:		Line 70:

	==Molecular==		==Molecular==
	*t(4;19)(q35;q13.1).<ref name=pmid22072439>{{Cite journal \| last1 = Italiano \| first1 = A. \| last2 = Sung \| first2 = YS. \| last3 = Zhang \| first3 = L. \| last4 = Singer \| first4 = S. \| last5 = Maki \| first5 = RG. \| last6 = Coindre \| first6 = JM. \| last7 = Antonescu \| first7 = CR. \| title = High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. \| journal = Genes Chromosomes Cancer \| volume = 51 \| issue = 3 \| pages = 207-18 \| month = Mar \| year = 2012 \| doi = 10.1002/gcc.20945 \| PMID = 22072439 }}</ref>		*Rearrangement of CIC gene, e.g. t(4;19)(q35;q13.1).<ref name=pmid22072439>{{Cite journal \| last1 = Italiano \| first1 = A. \| last2 = Sung \| first2 = YS. \| last3 = Zhang \| first3 = L. \| last4 = Singer \| first4 = S. \| last5 = Maki \| first5 = RG. \| last6 = Coindre \| first6 = JM. \| last7 = Antonescu \| first7 = CR. \| title = High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. \| journal = Genes Chromosomes Cancer \| volume = 51 \| issue = 3 \| pages = 207-18 \| month = Mar \| year = 2012 \| doi = 10.1002/gcc.20945 \| PMID = 22072439 }}</ref>; CIC-DUX4 fusion.
	**CIC-DUX4 fusion.
	*EWSR1 FISH negative.		*EWSR1 FISH negative.

Michael at 01:06, 20 March 2019

2019-03-20T01:06:19Z

← Older revision		Revision as of 01:06, 20 March 2019
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	\| Width =		\| Width =
	\| Caption =		\| Caption =
	\| Synonyms = ~~CIC-DUX sarcoma, undifferentiated small blue round cell sarcoma with t(4;19)~~		\| Synonyms =
	\| Micro = [[small round blue cell tumour]] with focal cytoplasmic clearing +/-zonal necrosis		\| Micro = [[small round blue cell tumour]] with focal cytoplasmic clearing +/-zonal necrosis
	\| Subtypes =		\| Subtypes =

Michael at 01:06, 20 March 2019

2019-03-20T01:06:04Z

← Older revision		Revision as of 01:06, 20 March 2019
Line 4:		Line 4:
	\| Width =		\| Width =
	\| Caption =		\| Caption =
	\| Synonyms = CIC-DUX sarcoma		\| Synonyms = CIC-DUX sarcoma, undifferentiated small blue round cell sarcoma with t(4;19)
	\| Micro = [[small round blue cell tumour]] with focal cytoplasmic clearing +/-zonal necrosis		\| Micro = [[small round blue cell tumour]] with focal cytoplasmic clearing +/-zonal necrosis
	\| Subtypes =		\| Subtypes =