Salivary duct carcinoma - Revision history

Michael: /* Images */ rm broken link

2021-07-02T13:35:20Z

Images: rm broken link

← Older revision		Revision as of 13:35, 2 July 2021
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	Image:Salivary duct carcinoma -a- intermed mag.jpg \| SDC - intermed. mag. (WC/Nephron)		Image:Salivary duct carcinoma -a- intermed mag.jpg \| SDC - intermed. mag. (WC/Nephron)
	</gallery>		</gallery>
	~~www:~~
	*[http://www.webpathology.com/image.asp?case=122&n=2 Salivary duct carcinoma (webpathology.com)].

	[[File: 5 3689176038337 sl 1.png\|salivary duct carcinoma]]		[[File: 5 3689176038337 sl 1.png\|salivary duct carcinoma]]

Michael at 20:01, 8 May 2018

2018-05-08T20:01:54Z

← Older revision		Revision as of 20:01, 8 May 2018
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	\| Micro = varied arch. (sheets, nests, cords, [[cribriform]], micropapillary), neoplastic cells line-up around cystic spaces "Roman bridges", nuclear atypia, apocrine snouts, decapitation secretions		\| Micro = varied arch. (sheets, nests, cords, [[cribriform]], micropapillary), neoplastic cells line-up around cystic spaces "Roman bridges", nuclear atypia, apocrine snouts, decapitation secretions
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[carcinoma ex pleomorphic adenoma]] with SDC component, [[ductal carcinoma of the breast]], [[~~Intraductal~~ carcinoma of the salivary gland]]		\| LMDDx = [[carcinoma ex pleomorphic adenoma]] with SDC component, [[ductal carcinoma of the breast]], [[intraductal carcinoma of the salivary gland]]
	\| Stains =		\| Stains =
	\| IHC = LMWK, EMA, CK7, CK19 +ve, AR +ve, BRST2 (GCDFP-15) +ve, HER2 -ve/+ve, p63 -ve		\| IHC = LMWK, EMA, CK7, CK19 +ve, AR +ve, BRST2 (GCDFP-15) +ve, HER2 -ve/+ve, p63 -ve

Michael at 20:01, 8 May 2018

2018-05-08T20:01:47Z

← Older revision		Revision as of 20:01, 8 May 2018
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	\| Micro = varied arch. (sheets, nests, cords, [[cribriform]], micropapillary), neoplastic cells line-up around cystic spaces "Roman bridges", nuclear atypia, apocrine snouts, decapitation secretions		\| Micro = varied arch. (sheets, nests, cords, [[cribriform]], micropapillary), neoplastic cells line-up around cystic spaces "Roman bridges", nuclear atypia, apocrine snouts, decapitation secretions
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[carcinoma ex pleomorphic adenoma]] with SDC component, [[ductal carcinoma of the breast]]		\| LMDDx = [[carcinoma ex pleomorphic adenoma]] with SDC component, [[ductal carcinoma of the breast]], [[Intraductal carcinoma of the salivary gland]]
	\| Stains =		\| Stains =
	\| IHC = LMWK, EMA, CK7, CK19 +ve, AR +ve, BRST2 (GCDFP-15) +ve, HER2 -ve/+ve, p63 -ve		\| IHC = LMWK, EMA, CK7, CK19 +ve, AR +ve, BRST2 (GCDFP-15) +ve, HER2 -ve/+ve, p63 -ve

Michael: /* Microscopic */

2018-05-08T20:01:26Z

Microscopic

← Older revision		Revision as of 20:01, 8 May 2018
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	DDx:		DDx:
	*[[Carcinoma ex pleomorphic adenoma]] with SDC component.		*[[Carcinoma ex pleomorphic adenoma]] with SDC component.
			*[[Intraductal carcinoma of the salivary gland]] - previously referred to as ''low-grade salivary duct carcinoma''.

	===Images===		===Images===

Mitchell: /* Images */ added a case

2016-12-15T15:44:28Z

Images: added a case

← Older revision		Revision as of 15:44, 15 December 2016
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	www:		www:
	*[http://www.webpathology.com/image.asp?case=122&n=2 Salivary duct carcinoma (webpathology.com)].		*[http://www.webpathology.com/image.asp?case=122&n=2 Salivary duct carcinoma (webpathology.com)].

			[[File: 5 3689176038337 sl 1.png\|salivary duct carcinoma]]
			[[File: 5 3689176038337 sl 2.png\|salivary duct carcinoma]]
			[[File: 5 3689176038337 sl 3.png\|salivary duct carcinoma]]
			[[File: 5 3689176038337 sl 4.png\|salivary duct carcinoma]]
			[[File: 5 3689176038337 sl 5.png\|salivary duct carcinoma]]
			[[File: 5 3689176038337 sl 6.png\|salivary duct carcinoma]]


			Salivary duct carcinoma. 59 y man with a 3 cm right superficial parotid mass. A. Low power shows a predominance of patterns similar to in situ, micropapillary (white arrow), Roman bridge (green arrow), cribriform (blue arrow) patterns. B. Careful search reveals occasional invasive bars (arrow). C. The bar comprises the usual invasive pattern of adenocarcinoma, with cancerous cell clusters, isolated glands, incomplete glands, and adjoined/fused glands. Note the lighter color of stromal desmoplasia (arrows). D. The in situ component has more uniform nuclei than the invasive component. Note the comedo necrosis. E. Cancer cells expressed CK7. F. Cancer cell nuclei were positive for androgen receptor. Not shown: tumor was negative for SOX10 and P63.

	===Subtypes===		===Subtypes===

Michael: /* IHC */

2016-02-10T00:58:59Z

IHC

← Older revision		Revision as of 00:58, 10 February 2016
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	==IHC==		==IHC==
	*LMWK, EMA, CK7, CK19 +ve.		*LMWK, EMA, CK7, CK19 +ve.
	*p63 -ve.		*[[p63]] -ve.
	*Androgen receptor +ve (~90% of cases).<ref name=pmid10757407>{{Cite journal \| last1 = Fan \| first1 = CY. \| last2 = Wang \| first2 = J. \| last3 = Barnes \| first3 = EL. \| title = Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 4 \| pages = 579-86 \| month = Apr \| year = 2000 \| doi = \| PMID = 10757407 }}</ref>		*[[Androgen receptor]] +ve (~90% of cases).<ref name=pmid10757407>{{Cite journal \| last1 = Fan \| first1 = CY. \| last2 = Wang \| first2 = J. \| last3 = Barnes \| first3 = EL. \| title = Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature. \| journal = Am J Surg Pathol \| volume = 24 \| issue = 4 \| pages = 579-86 \| month = Apr \| year = 2000 \| doi = \| PMID = 10757407 }}</ref>
	*BRST2 ([[GCDFP-15]]) +ve.		*BRST2 ([[GCDFP-15]]) +ve.
	*HER2 +ve ~21%; use of [[trastuzumab]] (Herceptin) not systematically studied.		*HER2 +ve ~21%; use of [[trastuzumab]] (Herceptin) not systematically studied.

Michael at 02:17, 18 January 2016

2016-01-18T02:17:52Z

← Older revision		Revision as of 02:17, 18 January 2016
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	Curiosity:		Curiosity:
	*PSA +ve/-ve.		*[[PSA]] +ve/-ve.
	*PSAP +ve/-ve.		*[[PSAP]] +ve/-ve.
	*ER-beta +ve.<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf]. Accessed on: 3 April 2012.</ref>		*ER-beta +ve.<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/MajorSalGlands_11protocol.pdf]. Accessed on: 3 April 2012.</ref>
	*ER-alpha -ve (the common ''ER'' stain).		*ER-alpha -ve (the common ''ER'' stain).

Michael: wikify

2015-10-31T03:59:09Z

wikify

← Older revision		Revision as of 03:59, 31 October 2015
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	\| Width =		\| Width =
	\| Caption = Salivary duct carcinoma. [[H&E stain]].		\| Caption = Salivary duct carcinoma. [[H&E stain]].
	\| Micro = varied arch. (sheets, nests, cords, cribriform, micropapillary), neoplastic cells line-up around cystic spaces "Roman bridges", nuclear atypia, apocrine snouts, decapitation secretions		\| Micro = varied arch. (sheets, nests, cords, [[cribriform]], micropapillary), neoplastic cells line-up around cystic spaces "Roman bridges", nuclear atypia, apocrine snouts, decapitation secretions
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[carcinoma ex pleomorphic adenoma]] with SDC component, [[ductal carcinoma of the breast]]		\| LMDDx = [[carcinoma ex pleomorphic adenoma]] with SDC component, [[ductal carcinoma of the breast]]
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	==Microscopic==		==Microscopic==
	Features - resembles ductal breast carcinoma:<ref name=pmid21393874/>		Features - resembles ductal breast carcinoma:<ref name=pmid21393874/>
	*Architecture: sheets, nests, cords, cribriform, micropapillary.		*Architecture: sheets, nests, cords, [[cribriform]], micropapillary.
	*Neoplastic cells line-up around cystic spaces "Roman bridges".		*Neoplastic cells line-up around cystic spaces "Roman bridges".
	*Nuclear atypia (variation in size, shape, staining).		*Nuclear atypia (variation in size, shape, staining).

Michael at 18:32, 15 January 2015

2015-01-15T18:32:15Z

← Older revision		Revision as of 18:32, 15 January 2015
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	\| Gross =		\| Gross =
	\| Grossing =		\| Grossing =
	\| Site = [[salivary gland]]		\| Site = [[salivary gland]] - usu. parotid gland
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =

Michael: tweak

2014-10-01T02:55:19Z

tweak

← Older revision		Revision as of 02:55, 1 October 2014
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	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx = typically male, usu. >50 years old
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
	\| Prevalence =		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads =