SMARCB1-deficient sinonasal carcinoma - Revision history

Michael: /* IHC */

2020-01-03T15:42:58Z

IHC

← Older revision		Revision as of 15:42, 3 January 2020
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	==IHC==		==IHC==
	*SMARCB1 (INI1) -ve.<ref name=pmid28291122/>		*SMARCB1 (INI1) -ve (definitional).<ref name=pmid28291122/>
			*Pankeratin +ve ~ 97% +ve.<ref name=pmid28291122/>
			*CK5 +ve ~ 64% +ve.<ref name=pmid28291122/>
			*P63 +ve ~ 55% +ve.<ref name=pmid28291122/>
			*CK7 -ve/+ve ~ 48% +ve.<ref name=pmid28291122/>
			*NUT -ve.<ref name=pmid28291122/>

	==See also==		==See also==

Michael at 15:10, 16 May 2019

2019-05-16T15:10:46Z

← Older revision		Revision as of 15:10, 16 May 2019
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	'''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the [[head and neck pathology\|head and neck]] with loss of [[SMARCB1]] staining.<ref name=pmid28291122>{{Cite journal \| last1 = Agaimy \| first1 = A. \| last2 = Hartmann \| first2 = A. \| last3 = Antonescu \| first3 = CR. \| last4 = Chiosea \| first4 = SI. \| last5 = El-Mofty \| first5 = SK. \| last6 = Geddert \| first6 = H. \| last7 = Iro \| first7 = H. \| last8 = Lewis \| first8 = JS. \| last9 = Märkl \| first9 = B. \| title = SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. \| journal = Am J Surg Pathol \| volume = 41 \| issue = 4 \| pages = 458-471 \| month = Apr \| year = 2017 \| doi = 10.1097/PAS.0000000000000797 \| PMID = 28291122 }}</ref>		'''SMARCB1-deficient sinonasal carcinoma''' (also '''INI-1-deficient carcinomas of the sinonasal tract''') is a rare malignant tumour of the [[head and neck pathology\|head and neck]] with loss of [[SMARCB1]] staining.<ref name=pmid28291122>{{Cite journal \| last1 = Agaimy \| first1 = A. \| last2 = Hartmann \| first2 = A. \| last3 = Antonescu \| first3 = CR. \| last4 = Chiosea \| first4 = SI. \| last5 = El-Mofty \| first5 = SK. \| last6 = Geddert \| first6 = H. \| last7 = Iro \| first7 = H. \| last8 = Lewis \| first8 = JS. \| last9 = Märkl \| first9 = B. \| title = SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. \| journal = Am J Surg Pathol \| volume = 41 \| issue = 4 \| pages = 458-471 \| month = Apr \| year = 2017 \| doi = 10.1097/PAS.0000000000000797 \| PMID = 28291122 }}</ref>

	==General==		==General==

Michael: /* Microscopic */

2019-04-09T20:48:23Z

Microscopic

← Older revision		Revision as of 20:48, 9 April 2019
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	*[[Sinonasal undifferentiated carcinoma]] (SNUC).		*[[Sinonasal undifferentiated carcinoma]] (SNUC).
	*[[Squamous cell carcinoma of the head and neck]].		*[[Squamous cell carcinoma of the head and neck]].
			*[[NUT carcinoma]].

	==IHC==		==IHC==

Michael at 04:33, 18 March 2019

2019-03-18T04:33:31Z

← Older revision		Revision as of 04:33, 18 March 2019
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	'''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the [[head and neck pathology\|head and neck]] with loss of [[SMARCB1]] staining.<ref name=pmid28291122>{{Cite journal \| last1 = Agaimy \| first1 = A. \| last2 = Hartmann \| first2 = A. \| last3 = Antonescu \| first3 = CR. \| last4 = Chiosea \| first4 = SI. \| last5 = El-Mofty \| first5 = SK. \| last6 = Geddert \| first6 = H. \| last7 = Iro \| first7 = H. \| last8 = Lewis \| first8 = JS. \| last9 = Märkl \| first9 = B. \| title = SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. \| journal = Am J Surg Pathol \| volume = 41 \| issue = 4 \| pages = 458-471 \| month = Apr \| year = 2017 \| doi = 10.1097/PAS.0000000000000797 \| PMID = 28291122 }}</ref>		'''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the [[head and neck pathology\|head and neck]] with loss of [[SMARCB1]] staining.<ref name=pmid28291122>{{Cite journal \| last1 = Agaimy \| first1 = A. \| last2 = Hartmann \| first2 = A. \| last3 = Antonescu \| first3 = CR. \| last4 = Chiosea \| first4 = SI. \| last5 = El-Mofty \| first5 = SK. \| last6 = Geddert \| first6 = H. \| last7 = Iro \| first7 = H. \| last8 = Lewis \| first8 = JS. \| last9 = Märkl \| first9 = B. \| title = SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. \| journal = Am J Surg Pathol \| volume = 41 \| issue = 4 \| pages = 458-471 \| month = Apr \| year = 2017 \| doi = 10.1097/PAS.0000000000000797 \| PMID = 28291122 }}</ref>

			==General==
			*Rare - large series from 2017 has 39 cases.<ref name=pmid28291122/>
			*Large age range (19-89 years old).
			*Often present at high stage T3 or T4.
			*Aggressive clinical course.

			==Gross==
			*Most often in ethmoid sinus +/- nasal cavity.

	==Microscopic==		==Microscopic==
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	DDx:		DDx:
	*[[~~SNUC~~]].		*[[Sinonasal undifferentiated carcinoma]] (SNUC).
	*[[Squamous cell carcinoma of the head and neck]].		*[[Squamous cell carcinoma of the head and neck]].

Michael: /* Microscopic */

2019-03-18T04:26:14Z

Microscopic

← Older revision		Revision as of 04:26, 18 March 2019
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid28291122/>		Features:<ref name=pmid28291122/>
	*Pagetoid spread of plasmacytoid or rhabdoid cells.		*Pagetoid spread of plasmacytoid or [[rhabdoid]] cells.
	*Cyst/pseudocyst like spaces.		*Cyst/pseudocyst like spaces.
	*Lack squamous dysplasia.		*Lack squamous dysplasia.
	*Lack of carcinoma in situ.		*Lack of carcinoma-in-situ.

	DDx:		DDx:

Michael: /* Microscopic */

2019-03-18T04:25:17Z

Microscopic

← Older revision		Revision as of 04:25, 18 March 2019
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid28291122/>		Features:<ref name=pmid28291122/>
	*Pagetoid spread.		*Pagetoid spread of plasmacytoid or rhabdoid cells.
			*Cyst/pseudocyst like spaces.
			*Lack squamous dysplasia.
			*Lack of carcinoma in situ.

	DDx:		DDx:

Michael at 00:56, 18 March 2019

2019-03-18T00:56:16Z

← Older revision		Revision as of 00:56, 18 March 2019
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	'''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the [[head and neck pathology\|head and neck]] with loss of [[SMARCB1]] staining.<ref>{{Cite journal \| last1 = Agaimy \| first1 = A. \| last2 = Hartmann \| first2 = A. \| last3 = Antonescu \| first3 = CR. \| last4 = Chiosea \| first4 = SI. \| last5 = El-Mofty \| first5 = SK. \| last6 = Geddert \| first6 = H. \| last7 = Iro \| first7 = H. \| last8 = Lewis \| first8 = JS. \| last9 = Märkl \| first9 = B. \| title = SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. \| journal = Am J Surg Pathol \| volume = 41 \| issue = 4 \| pages = 458-471 \| month = Apr \| year = 2017 \| doi = 10.1097/PAS.0000000000000797 \| PMID = 28291122 }}</ref>		'''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the [[head and neck pathology\|head and neck]] with loss of [[SMARCB1]] staining.<ref name=pmid28291122>{{Cite journal \| last1 = Agaimy \| first1 = A. \| last2 = Hartmann \| first2 = A. \| last3 = Antonescu \| first3 = CR. \| last4 = Chiosea \| first4 = SI. \| last5 = El-Mofty \| first5 = SK. \| last6 = Geddert \| first6 = H. \| last7 = Iro \| first7 = H. \| last8 = Lewis \| first8 = JS. \| last9 = Märkl \| first9 = B. \| title = SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. \| journal = Am J Surg Pathol \| volume = 41 \| issue = 4 \| pages = 458-471 \| month = Apr \| year = 2017 \| doi = 10.1097/PAS.0000000000000797 \| PMID = 28291122 }}</ref>

			==Microscopic==
			Features:<ref name=pmid28291122/>
			*Pagetoid spread.

			DDx:
			*[[SNUC]].
			*[[Squamous cell carcinoma of the head and neck]].

			==IHC==
			*SMARCB1 (INI1) -ve.<ref name=pmid28291122/>

	==See also==		==See also==

Michael: Created page with "'''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the head and neck with loss of SMARCB1 staining.{{Cite journal..."

2019-03-18T00:53:51Z

Created page with "'''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the head and neck with loss of SMARCB1 staining.<ref>{{Cite journal..."

New page

'''SMARCB1-deficient sinonasal carcinoma''' is a rare malignant tumour of the [[head and neck pathology|head and neck]] with loss of [[SMARCB1]] staining.<ref>{{Cite journal | last1 = Agaimy | first1 = A. | last2 = Hartmann | first2 = A. | last3 = Antonescu | first3 = CR. | last4 = Chiosea | first4 = SI. | last5 = El-Mofty | first5 = SK. | last6 = Geddert | first6 = H. | last7 = Iro | first7 = H. | last8 = Lewis | first8 = JS. | last9 = Märkl | first9 = B. | title = SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity. | journal = Am J Surg Pathol | volume = 41 | issue = 4 | pages = 458-471 | month = Apr | year = 2017 | doi = 10.1097/PAS.0000000000000797 | PMID = 28291122 }}</ref>

==See also==
*[[Head and neck pathology]].

==References==
{{Reflist|1}}

[[Category:Diagnosis]]