SMARCB1-deficient renal medullary carcinoma - Revision history

Michael at 02:37, 20 March 2024

2024-03-20T02:37:16Z

← Older revision		Revision as of 02:37, 20 March 2024
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	\| Caption = Renal medullary carcinoma (right of image), reactive urothelium and sickled [[red blood cell]]s. [[H&E stain]]. (WC/Nephron)		\| Caption = Renal medullary carcinoma (right of image), reactive urothelium and sickled [[red blood cell]]s. [[H&E stain]]. (WC/Nephron)
	\| Synonyms =		\| Synonyms =
	\| Micro =		\| Micro = variable architecture (reticular - resembling a ''net'', [[adenoid cystic carcinoma]]-like, [[yolk sac tumour]]-like), [[desmoplastic stroma]] (usu. prominent), drepanocytes (sickled red blood cells)
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[collecting duct carcinoma]], [[yolk sac tumour]], [[hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]], [[ALK translocation renal cell carcinoma]]		\| LMDDx = [[collecting duct carcinoma]], [[yolk sac tumour]], [[hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]], [[ALK translocation renal cell carcinoma]]
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	Features:<ref name=pmid7528470/><ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>		Features:<ref name=pmid7528470/><ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>
	*Variable architecture:		*Variable architecture:
	**Reticular - classic.		**Reticular (resembling a ''net'') - classic.
	**[[Adenoid cystic carcinoma]]-like appearance:		**[[Adenoid cystic carcinoma]]-like appearance:
	***Cystic spaces.		***Cystic spaces.

Michael at 02:34, 20 March 2024

2024-03-20T02:34:15Z

← Older revision		Revision as of 02:34, 20 March 2024
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	*Aggressive/poor prognosis.<ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>		*Aggressive/poor prognosis.<ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>
	*Closely related to [[collecting duct carcinoma]].<ref name=pmid22686875>{{cite journal \|author=Calderaro J, Moroch J, Pierron G, ''et al.'' \|title=SMARCB1/INI1 inactivation in renal medullary carcinoma \|journal=Histopathology \|volume=61 \|issue=3 \|pages=428–35 \|year=2012 \|month=September \|pmid=22686875 \|doi=10.1111/j.1365-2559.2012.04228.x \|url=}}</ref>		*Closely related to [[collecting duct carcinoma]].<ref name=pmid22686875>{{cite journal \|author=Calderaro J, Moroch J, Pierron G, ''et al.'' \|title=SMARCB1/INI1 inactivation in renal medullary carcinoma \|journal=Histopathology \|volume=61 \|issue=3 \|pages=428–35 \|year=2012 \|month=September \|pmid=22686875 \|doi=10.1111/j.1365-2559.2012.04228.x \|url=}}</ref>
	*Associated with high-intensity exercise.<ref name=pmid34885132>{{cite journal \|~~vauthors~~=Shapiro DD, Soeung M, Perelli L, Dondossola E, Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MH, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P \|title=Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies \|journal=Cancers (Basel) \|volume=13 \|issue=23 \|pages= \|date=November 2021 \|pmid=34885132 \|doi=10.3390/cancers13236022 \|url=}}</ref>		*Associated with high-intensity exercise.<ref name=pmid34885132>{{cite journal \|authors=Shapiro DD, Soeung M, Perelli L, Dondossola E, Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MH, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P \|title=Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies \|journal=Cancers (Basel) \|volume=13 \|issue=23 \|pages= \|date=November 2021 \|pmid=34885132 \|doi=10.3390/cancers13236022 \|url=}}</ref>

	Aside:		Aside:

Michael: fix ref

2024-03-20T02:33:56Z

fix ref

← Older revision		Revision as of 02:33, 20 March 2024
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	*Aggressive/poor prognosis.<ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>		*Aggressive/poor prognosis.<ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>
	*Closely related to [[collecting duct carcinoma]].<ref name=pmid22686875>{{cite journal \|author=Calderaro J, Moroch J, Pierron G, ''et al.'' \|title=SMARCB1/INI1 inactivation in renal medullary carcinoma \|journal=Histopathology \|volume=61 \|issue=3 \|pages=428–35 \|year=2012 \|month=September \|pmid=22686875 \|doi=10.1111/j.1365-2559.2012.04228.x \|url=}}</ref>		*Closely related to [[collecting duct carcinoma]].<ref name=pmid22686875>{{cite journal \|author=Calderaro J, Moroch J, Pierron G, ''et al.'' \|title=SMARCB1/INI1 inactivation in renal medullary carcinoma \|journal=Histopathology \|volume=61 \|issue=3 \|pages=428–35 \|year=2012 \|month=September \|pmid=22686875 \|doi=10.1111/j.1365-2559.2012.04228.x \|url=}}</ref>
	*Associated with high-intensity exercise.<ref name=~~pmid22686875~~>{{cite journal \|vauthors=Shapiro DD, Soeung M, Perelli L, Dondossola E, Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MH, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P \|title=Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies \|journal=Cancers (Basel) \|volume=13 \|issue=23 \|pages= \|date=November 2021 \|pmid=34885132 \|doi=10.3390/cancers13236022 \|url=}}</ref>		*Associated with high-intensity exercise.<ref name=pmid34885132>{{cite journal \|vauthors=Shapiro DD, Soeung M, Perelli L, Dondossola E, Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MH, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P \|title=Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies \|journal=Cancers (Basel) \|volume=13 \|issue=23 \|pages= \|date=November 2021 \|pmid=34885132 \|doi=10.3390/cancers13236022 \|url=}}</ref>

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	===Imaging===		===Imaging===
	*Increase muscle surface area (muscle hypertrophy) - due to exercise.<ref name=~~pmid22686875~~/>		*Increase muscle surface area (muscle hypertrophy) - due to exercise.<ref name=pmid34885132/>

	==Microscopic==		==Microscopic==
	Features:<ref name=pmid7528470><ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>		Features:<ref name=pmid7528470/><ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>
	*Variable architecture:		*Variable architecture:
	**Reticular - classic.		**Reticular - classic.

Michael at 02:32, 20 March 2024

2024-03-20T02:32:35Z

← Older revision		Revision as of 02:32, 20 March 2024
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid7528470/><ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>		Features:<ref name=pmid7528470><ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>
	*Variable architecture:		*Variable architecture:
	**Reticular - classic.		**Reticular - classic.

Michael at 01:59, 20 March 2024

2024-03-20T01:59:48Z

← Older revision		Revision as of 01:59, 20 March 2024
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	*Renal medulla.		*Renal medulla.

	==~~Gross~~==		===Imaging===
	~~Imaging:~~
	*Increase muscle surface area (muscle hypertrophy) - due to exercise.<ref name=pmid22686875/>		*Increase muscle surface area (muscle hypertrophy) - due to exercise.<ref name=pmid22686875/>

Michael at 01:58, 20 March 2024

2024-03-20T01:58:51Z

← Older revision		Revision as of 01:58, 20 March 2024
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	==Gross==		==Gross==
			Imaging:
	*Increase muscle surface area (muscle hypertrophy) - due to exercise.<ref name=pmid22686875/>		*Increase muscle surface area (muscle hypertrophy) - due to exercise.<ref name=pmid22686875/>

Michael at 01:58, 20 March 2024

2024-03-20T01:58:22Z

← Older revision		Revision as of 01:58, 20 March 2024
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	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads = muscle hypertrophy (due to exercise)
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = poor		\| Prognosis = poor
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	*Aggressive/poor prognosis.<ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>		*Aggressive/poor prognosis.<ref name=pmid17643096>{{Cite journal \| last1 = Watanabe \| first1 = IC. \| last2 = Billis \| first2 = A. \| last3 = Guimarães \| first3 = MS. \| last4 = Alvarenga \| first4 = M. \| last5 = de Matos \| first5 = AC. \| last6 = Cardinalli \| first6 = IA. \| last7 = Filippi \| first7 = RZ. \| last8 = de Castro \| first8 = MG. \| last9 = Suzigan \| first9 = S. \| title = Renal medullary carcinoma: report of seven cases from Brazil. \| journal = Mod Pathol \| volume = 20 \| issue = 9 \| pages = 914-20 \| month = Sep \| year = 2007 \| doi = 10.1038/modpathol.3800934 \| PMID = 17643096 \|url = http://www.nature.com/modpathol/journal/v20/n9/full/3800934a.html }}</ref>
	*Closely related to [[collecting duct carcinoma]].<ref name=pmid22686875>{{cite journal \|author=Calderaro J, Moroch J, Pierron G, ''et al.'' \|title=SMARCB1/INI1 inactivation in renal medullary carcinoma \|journal=Histopathology \|volume=61 \|issue=3 \|pages=428–35 \|year=2012 \|month=September \|pmid=22686875 \|doi=10.1111/j.1365-2559.2012.04228.x \|url=}}</ref>		*Closely related to [[collecting duct carcinoma]].<ref name=pmid22686875>{{cite journal \|author=Calderaro J, Moroch J, Pierron G, ''et al.'' \|title=SMARCB1/INI1 inactivation in renal medullary carcinoma \|journal=Histopathology \|volume=61 \|issue=3 \|pages=428–35 \|year=2012 \|month=September \|pmid=22686875 \|doi=10.1111/j.1365-2559.2012.04228.x \|url=}}</ref>
			*Associated with high-intensity exercise.<ref name=pmid22686875>{{cite journal \|vauthors=Shapiro DD, Soeung M, Perelli L, Dondossola E, Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MH, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P \|title=Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies \|journal=Cancers (Basel) \|volume=13 \|issue=23 \|pages= \|date=November 2021 \|pmid=34885132 \|doi=10.3390/cancers13236022 \|url=}}</ref>

	Aside:		Aside:
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	*Well circumscribed.		*Well circumscribed.
	*Renal medulla.		*Renal medulla.

			==Gross==
			*Increase muscle surface area (muscle hypertrophy) - due to exercise.<ref name=pmid22686875/>

	==Microscopic==		==Microscopic==

Michael at 01:52, 20 March 2024

2024-03-20T01:52:40Z

← Older revision		Revision as of 01:52, 20 March 2024
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	\| Assdx = [[sickle cell disease]] or sickle cell trait		\| Assdx = [[sickle cell disease]] or sickle cell trait
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx = usu. young adults		\| Clinicalhx = usu. young adults with [[sickle cell disease]] or sickle cell trait
	\| Signs =		\| Signs =
	\| Symptoms =		\| Symptoms =
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	\| Prognosis = poor		\| Prognosis = poor
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = other [[renal tumours]]
	\| Tx =		\| Tx =
	}}		}}
	'''~~Renal~~ medullary carcinoma'''~~, abbreviated '''RMC''',~~ is a rare [[malignant]] [[kidney tumour]] associated with sickle cell trait and a poor prognosis.		'''SMARCB1-deficient renal medullary carcinoma''' is a rare [[malignant]] [[kidney tumour]] associated with sickle cell trait and a poor prognosis.

			It was previously called '''renal medullary carcinoma''', abbreviated '''RMC'''.

	==General==		==General==

Michael: Michael moved page Renal medullary carcinoma to SMARCB1-deficient renal medullary carcinoma: WHO name

2024-03-20T01:50:00Z

Michael moved page Renal medullary carcinoma to SMARCB1-deficient renal medullary carcinoma: WHO name

← Older revision	Revision as of 01:50, 20 March 2024
(No difference)

Michael at 10:25, 13 September 2023

2023-09-13T10:25:49Z

← Older revision		Revision as of 10:25, 13 September 2023
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	\| LMDDx = [[collecting duct carcinoma]], [[yolk sac tumour]], [[hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]], [[ALK translocation renal cell carcinoma]]		\| LMDDx = [[collecting duct carcinoma]], [[yolk sac tumour]], [[hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]], [[ALK translocation renal cell carcinoma]]
	\| Stains =		\| Stains =
	\| IHC = INI1 -ve, PAX8 +ve, cyclin D1 +ve, CK7 +ve, vimentin +ve, EMA +ve		\| IHC = [[SMARCB1]] (INI1) -ve, PAX8 +ve, cyclin D1 +ve, CK7 +ve, vimentin +ve, EMA +ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =