Rosai-Dorfman disease - Revision history

Alessandro: CD68 positive

2020-06-02T15:25:18Z

CD68 positive

← Older revision		Revision as of 15:25, 2 June 2020
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	\| LMDDx = other specific [[histiocytoses]] ([[Langerhans cell histiocytosis]], [[Erdheim-Chester disease]]), specific infections ([[rhinoscleroma]], [[xanthogranulomatous pyelonephritis]]), [[sinus histiocytosis]]		\| LMDDx = other specific [[histiocytoses]] ([[Langerhans cell histiocytosis]], [[Erdheim-Chester disease]]), specific infections ([[rhinoscleroma]], [[xanthogranulomatous pyelonephritis]]), [[sinus histiocytosis]]
	\| Stains =		\| Stains =
	\| IHC = CD68 -ve, S-100 +ve, CD1a -ve		\| IHC = CD68 +ve, S-100 +ve, CD1a -ve
	\| EM =		\| EM =
	\| Molecular =		\| Molecular =

Michael: re-arr

2020-05-25T15:26:43Z

re-arr

← Older revision		Revision as of 15:26, 25 May 2020
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	Image:Emperipolesis_-_very_high_mag.jpg \| Emperipolesis in SHML (WC)		Image:Emperipolesis_-_very_high_mag.jpg \| Emperipolesis in SHML (WC)
	Image:Rosai-Dorfman_disease_-_very_high_mag.jpg \| Rosai-Dorfman disease (WC)		Image:Rosai-Dorfman_disease_-_very_high_mag.jpg \| Rosai-Dorfman disease (WC)
	~~Image:Rosai-dorfman.jpg \| Rosai-Dorfman disease - S-100 showing emperipolesis (WC)~~
	</gallery>		</gallery>
	====Case 2====		====Case 2====
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	*CD1a -ve.		*CD1a -ve.
	**CD1a +ve in [[Langerhans cell histiocytosis]].		**CD1a +ve in [[Langerhans cell histiocytosis]].

			===Images===
			<gallery>
			Image:Rosai-dorfman.jpg \| Rosai-Dorfman disease - S-100 showing emperipolesis (WC/AFIP)
			</gallery>

	==See also==		==See also==

Michael: /* Images */ +another case

2020-05-24T18:33:31Z

Images: +another case

← Older revision		Revision as of 18:33, 24 May 2020
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	===Images===		===Images===
			====Case 1====
	<gallery>		<gallery>
	Image:Emperipolesis_-_very_high_mag.jpg \| Emperipolesis in SHML (WC)		Image:Emperipolesis_-_very_high_mag.jpg \| Emperipolesis in SHML (WC)
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	Image:Rosai-dorfman.jpg \| Rosai-Dorfman disease - S-100 showing emperipolesis (WC)		Image:Rosai-dorfman.jpg \| Rosai-Dorfman disease - S-100 showing emperipolesis (WC)
	</gallery>		</gallery>
	www:		====Case 2====
			<gallery>
			Image: Rosai-Dorfman disease of parotid gland -- low mag.jpg \| RDD - low mag.
			Image: Rosai-Dorfman disease of parotid gland -- intermed mag.jpg \| RDD - intermed. mag.
			Image: Rosai-Dorfman disease of parotid gland -- high mag.jpg \| RDD - high mag.
			Image: Rosai-Dorfman disease of parotid gland - alt -- high mag.jpg \| RDD - high mag.
			Image: Rosai-Dorfman disease of parotid gland -- very high mag.jpg \| RDD - very high mag.
			</gallery>
			====www====
	*[http://path.upmc.edu/cases/case318.html RDD - case 1 - several images (upmc.edu)].		*[http://path.upmc.edu/cases/case318.html RDD - case 1 - several images (upmc.edu)].
	*[http://path.upmc.edu/cases/case338.html RDD - case 2 - several images of breast (upmc.edu)].		*[http://path.upmc.edu/cases/case338.html RDD - case 2 - several images of breast (upmc.edu)].

Michael: touch

2015-02-01T08:11:49Z

touch

← Older revision		Revision as of 08:11, 1 February 2015
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Emperipolesis_-_very_high_mag.jpg		\| Image = Emperipolesis_-_very_high_mag.jpg
	\| Width =		\| Width =
	\| Caption = Rosai-Dorfman disease. H&E stain.		\| Caption = Rosai-Dorfman disease. H&E stain.

Michael: /* Microscopic */

2014-07-07T15:33:35Z

Microscopic

← Older revision		Revision as of 15:33, 7 July 2014
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	****Prominent nucleolus - visible with 10x objective.		****Prominent nucleolus - visible with 10x objective.
	***Abundant cytoplasm.		***Abundant cytoplasm.
	*Emperipolesis (from ''Greek'': ''em'' = inside, ''peri'' = around, ''polemai'' = wander about<ref>Stedman's Medical Dictionary. 27th Ed.</ref>):		*[[Emperipolesis]] (from ''Greek'': ''em'' = inside, ''peri'' = around, ''polemai'' = wander about<ref>Stedman's Medical Dictionary. 27th Ed.</ref>):
	**Histiocytes contain other whole cells: neutrophils, lymphocytes, plasma cells.		**Histiocytes contain other whole cells: neutrophils, lymphocytes, plasma cells.
	***The "eaten" cell is within a vacuole;<ref>{{cite journal \|author=Viswanathan P, Raghunathan K, Majhi U, Pandit RV, Shanthi R, Rajkumar T\|title=Emperipolesis : an electron microscopic characteristic in RDD (Rosai-Dorfaman disease) : a case report \|volume= \|issue=1\|pages=14-6 \|year=1997 \|month= \|pmid= \|doi= \|url=http://www.ijmpo.org/article.asp?issn=0971-5851;year=1997;volume=18;issue=1;spage=14;epage=16;aulast=Viswanathan;type=0}}</ref> thus, it should have a clear halo around it.		***The "eaten" cell is within a vacuole;<ref>{{cite journal \|author=Viswanathan P, Raghunathan K, Majhi U, Pandit RV, Shanthi R, Rajkumar T\|title=Emperipolesis : an electron microscopic characteristic in RDD (Rosai-Dorfaman disease) : a case report \|volume= \|issue=1\|pages=14-6 \|year=1997 \|month= \|pmid= \|doi= \|url=http://www.ijmpo.org/article.asp?issn=0971-5851;year=1997;volume=18;issue=1;spage=14;epage=16;aulast=Viswanathan;type=0}}</ref> thus, it should have a clear halo around it.

Michael: /* Gross */

2013-12-01T21:18:17Z

Gross

← Older revision		Revision as of 21:18, 1 December 2013
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	==Gross==		==Gross==
	*Skin: nodules.<ref name=pmid23739703/>		*Skin: nodules.<ref name=pmid23739703/>

			Note:
			*Reported at many sites.

	==Microscopic==		==Microscopic==

Michael: /* IHC */ +ref

2013-12-01T21:17:02Z

IHC: +ref

← Older revision		Revision as of 21:17, 1 December 2013
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	==IHC==		==IHC==
			Features:<ref name=pmid18504582>{{Cite journal \| last1 = Hartmann \| first1 = S. \| last2 = Kriener \| first2 = S. \| last3 = Hansmann \| first3 = ML. \| title = [Diagnostic spectrum of reactive lymph node changes]. \| journal = Pathologe \| volume = 29 \| issue = 4 \| pages = 253-63 \| month = Jul \| year = 2008 \| doi = 10.1007/s00292-008-1003-5 \| PMID = 18504582 }}</ref>
	*CD68 +ve.		*CD68 +ve.
	*S-100 +ve.		*S-100 +ve.

Michael at 21:15, 1 December 2013

2013-12-01T21:15:53Z

← Older revision		Revision as of 21:15, 1 December 2013
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	\| Molecular =		\| Molecular =
	\| IF =		\| IF =
	\| Gross =		\| Gross = nodules (skin)
	\| Grossing =		\| Grossing =
	\| Site = [[lymph node]]s - see ''[[lymph node pathology]]''		\| Site = [[skin]], [[lymph node]]s - see ''[[lymph node pathology]]''
	\| Assdx =		\| Assdx =
	\| Syndromes =		\| Syndromes =
	\| Clinicalhx =		\| Clinicalhx =
	\| Signs =		\| Signs = fever, lymphadenopathy
	\| Symptoms =		\| Symptoms =
	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork = leukocytosis with neurophilia
	\| Rads =		\| Rads =
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis =		\| Prognosis = usually self-limited, benign
	\| Other =		\| Other =
	\| ClinDDx = }}		\| ClinDDx = lymphoma, infections with lymphadenopathy }}
	'''Rosai-Dorfman disease''', abbreviated '''RDD''', is a rare [[lymph node pathology]].		'''Rosai-Dorfman disease''', abbreviated '''RDD''', is a rare [[lymph node pathology]].

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	==General==		==General==
	*Super rare.		*Super rare.
	*Prognosis - good.<ref name=pmid23739703/>		*Prognosis - good, usually self-limited.<ref name=pmid23739703/>

	Clinical findings:<ref name=pmid19668942>{{Cite journal \| last1 = Landim \| first1 = FM. \| last2 = Rios \| first2 = Hde O. \| last3 = Costa \| first3 = CO. \| last4 = Feitosa \| first4 = RG. \| last5 = Rocha Filho \| first5 = FD. \| last6 = Costa \| first6 = AA. \| title = Cutaneous Rosai-Dorfman disease. \| journal = An Bras Dermatol \| volume = 84 \| issue = 3 \| pages = 275-8 \| month = Jul \| year = 2009 \| doi = \| PMID = 19668942 }}</ref><ref name=pmid23739703>{{Cite journal \| last1 = Leal \| first1 = PA. \| last2 = Adriano \| first2 = AL. \| last3 = Breckenfeld \| first3 = MP. \| last4 = Costa \| first4 = IS. \| last5 = de Sousa \| first5 = AR. \| last6 = Gonçalves \| first6 = Hde S. \| title = Rosai-Dorfman disease presenting with extensive cutaneous manifestation - case report. \| journal = An Bras Dermatol \| volume = 88 \| issue = 2 \| pages = 256-9 \| month = \| year = \| doi = 10.1590/S0365-05962013000200014 \| PMID = 23739703 }}</ref>		Clinical findings:<ref name=pmid19668942>{{Cite journal \| last1 = Landim \| first1 = FM. \| last2 = Rios \| first2 = Hde O. \| last3 = Costa \| first3 = CO. \| last4 = Feitosa \| first4 = RG. \| last5 = Rocha Filho \| first5 = FD. \| last6 = Costa \| first6 = AA. \| title = Cutaneous Rosai-Dorfman disease. \| journal = An Bras Dermatol \| volume = 84 \| issue = 3 \| pages = 275-8 \| month = Jul \| year = 2009 \| doi = \| PMID = 19668942 }}</ref><ref name=pmid23739703>{{Cite journal \| last1 = Leal \| first1 = PA. \| last2 = Adriano \| first2 = AL. \| last3 = Breckenfeld \| first3 = MP. \| last4 = Costa \| first4 = IS. \| last5 = de Sousa \| first5 = AR. \| last6 = Gonçalves \| first6 = Hde S. \| title = Rosai-Dorfman disease presenting with extensive cutaneous manifestation - case report. \| journal = An Bras Dermatol \| volume = 88 \| issue = 2 \| pages = 256-9 \| month = \| year = \| doi = 10.1590/S0365-05962013000200014 \| PMID = 23739703 }}</ref>
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	*Leukocytosis with neutrophilia.		*Leukocytosis with neutrophilia.
	*Polyclonal gammaglobulinemia.		*Polyclonal gammaglobulinemia.

			==Gross==
			*Skin: nodules.<ref name=pmid23739703/>

	==Microscopic==		==Microscopic==

Michael: /* General */

2013-12-01T21:11:37Z

General

← Older revision		Revision as of 21:11, 1 December 2013
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	==General==		==General==
	*Super rare.		*Super rare.
	*Prognosis - good.		*Prognosis - good.<ref name=pmid23739703/>

	Clinical findings:<ref name=pmid19668942>{{Cite journal \| last1 = Landim \| first1 = FM. \| last2 = Rios \| first2 = Hde O. \| last3 = Costa \| first3 = CO. \| last4 = Feitosa \| first4 = RG. \| last5 = Rocha Filho \| first5 = FD. \| last6 = Costa \| first6 = AA. \| title = Cutaneous Rosai-Dorfman disease. \| journal = An Bras Dermatol \| volume = 84 \| issue = 3 \| pages = 275-8 \| month = Jul \| year = 2009 \| doi = \| PMID = 19668942 }}</ref>		Clinical findings:<ref name=pmid19668942>{{Cite journal \| last1 = Landim \| first1 = FM. \| last2 = Rios \| first2 = Hde O. \| last3 = Costa \| first3 = CO. \| last4 = Feitosa \| first4 = RG. \| last5 = Rocha Filho \| first5 = FD. \| last6 = Costa \| first6 = AA. \| title = Cutaneous Rosai-Dorfman disease. \| journal = An Bras Dermatol \| volume = 84 \| issue = 3 \| pages = 275-8 \| month = Jul \| year = 2009 \| doi = \| PMID = 19668942 }}</ref><ref name=pmid23739703>{{Cite journal \| last1 = Leal \| first1 = PA. \| last2 = Adriano \| first2 = AL. \| last3 = Breckenfeld \| first3 = MP. \| last4 = Costa \| first4 = IS. \| last5 = de Sousa \| first5 = AR. \| last6 = Gonçalves \| first6 = Hde S. \| title = Rosai-Dorfman disease presenting with extensive cutaneous manifestation - case report. \| journal = An Bras Dermatol \| volume = 88 \| issue = 2 \| pages = 256-9 \| month = \| year = \| doi = 10.1590/S0365-05962013000200014 \| PMID = 23739703 }}</ref>
	*Fever.		*Fever.
	*Leukocytosis with neutrophilia.		*Leukocytosis with neutrophilia.

Michael at 21:08, 1 December 2013

2013-12-01T21:08:57Z

← Older revision		Revision as of 21:08, 1 December 2013
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	\| Width =		\| Width =
	\| Caption = Rosai-Dorfman disease. H&E stain.		\| Caption = Rosai-Dorfman disease. H&E stain.
	\| Micro = sinus histiocytosis - histiocytes have a singular large round nucleus with a prominent nucleolus (visible with 10x objective); emperipolesis		\| Micro = sinus histiocytosis with histiocytes have a singular large round nucleus (~2x the size of a lymphocyte) with a prominent nucleolus (visible with 10x objective); emperipolesis
	\| Subtypes =		\| Subtypes =
	\| LMDDx = other specific [[histiocytoses]] ([[Langerhans cell histiocytosis]], [[Erdheim-Chester disease]]), specific infections ([[rhinoscleroma]], [[xanthogranulomatous pyelonephritis]]), [[sinus histiocytosis]]		\| LMDDx = other specific [[histiocytoses]] ([[Langerhans cell histiocytosis]], [[Erdheim-Chester disease]]), specific infections ([[rhinoscleroma]], [[xanthogranulomatous pyelonephritis]]), [[sinus histiocytosis]]