Renal oncocytoma - Revision history

Michael at 13:41, 19 June 2024

2024-06-19T13:41:50Z

← Older revision		Revision as of 13:41, 19 June 2024
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	*PAX2 +ve.<ref name=pmid17210525>{{cite journal \|author=Memeo L, Jhang J, Assaad AM, ''et al.'' \|title=Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma \|journal=Am. J. Clin. Pathol. \|volume=127 \|issue=2 \|pages=225–9 \|year=2007 \|month=February \|pmid=17210525 \|doi=10.1309/9KWEA4W9Y94D1AEE \|url=http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525}}</ref>		*PAX2 +ve.<ref name=pmid17210525>{{cite journal \|author=Memeo L, Jhang J, Assaad AM, ''et al.'' \|title=Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma \|journal=Am. J. Clin. Pathol. \|volume=127 \|issue=2 \|pages=225–9 \|year=2007 \|month=February \|pmid=17210525 \|doi=10.1309/9KWEA4W9Y94D1AEE \|url=http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525}}</ref>
	**Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.		**Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.
	*AMACR -ve<ref name=pmid26925847>{{Cite journal \| last1 = Lüders \| first1 = C. \| last2 = Kristiansen \| first2 = G. \| title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. \| journal = Pathologe \| volume = 37 \| issue = 2 \| pages = 153-8 \| month = Mar \| year = 2016 \| doi = 10.1007/s00292-016-0145-0 \| PMID = 26925847 }}</ref> or variable.<ref>{{Cite journal \| last1 = Wobker \| first1 = S.E.\| last2 = Williamson \| first2 = S.R. \| title = Modern Pathologic Diagnosis of Renal Oncocytoma \| journal = \| volume = \| issue = \| pages = \| month = \| year = 2017 \| doi = 10.15586/jkcvhl.2017.96 \| PMID = 29090117}}</ref>		*AMACR -ve<ref name=pmid26925847>{{Cite journal \| last1 = Lüders \| first1 = C. \| last2 = Kristiansen \| first2 = G. \| title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. \| journal = Pathologe \| volume = 37 \| issue = 2 \| pages = 153-8 \| month = Mar \| year = 2016 \| doi = 10.1007/s00292-016-0145-0 \| PMID = 26925847 }}</ref> or variable.<ref>{{Cite journal \| last1 = Wobker \| first1 = S.E.\| last2 = Williamson \| first2 = S.R. \| title = Modern Pathologic Diagnosis of Renal Oncocytoma \| journal = J Kidney Cancer VHL \| volume = 4 \| issue = 4 \| pages = 1-12 \| month = Oct \| year = 2017 \| doi = 10.15586/jkcvhl.2017.96 \| PMID = 29090117}}</ref>
	*Vimentin -ve.<ref name=pmid26925847/>		*Vimentin -ve.<ref name=pmid26925847/>

Michael at 13:40, 19 June 2024

2024-06-19T13:40:29Z

← Older revision		Revision as of 13:40, 19 June 2024
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	*PAX2 +ve.<ref name=pmid17210525>{{cite journal \|author=Memeo L, Jhang J, Assaad AM, ''et al.'' \|title=Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma \|journal=Am. J. Clin. Pathol. \|volume=127 \|issue=2 \|pages=225–9 \|year=2007 \|month=February \|pmid=17210525 \|doi=10.1309/9KWEA4W9Y94D1AEE \|url=http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525}}</ref>		*PAX2 +ve.<ref name=pmid17210525>{{cite journal \|author=Memeo L, Jhang J, Assaad AM, ''et al.'' \|title=Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma \|journal=Am. J. Clin. Pathol. \|volume=127 \|issue=2 \|pages=225–9 \|year=2007 \|month=February \|pmid=17210525 \|doi=10.1309/9KWEA4W9Y94D1AEE \|url=http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525}}</ref>
	**Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.		**Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.
	*AMACR -ve.<ref name=pmid26925847>{{Cite journal \| last1 = Lüders \| first1 = C. \| last2 = Kristiansen \| first2 = G. \| title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. \| journal = Pathologe \| volume = 37 \| issue = 2 \| pages = 153-8 \| month = Mar \| year = 2016 \| doi = 10.1007/s00292-016-0145-0 \| PMID = 26925847 }}</ref>		*AMACR -ve<ref name=pmid26925847>{{Cite journal \| last1 = Lüders \| first1 = C. \| last2 = Kristiansen \| first2 = G. \| title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. \| journal = Pathologe \| volume = 37 \| issue = 2 \| pages = 153-8 \| month = Mar \| year = 2016 \| doi = 10.1007/s00292-016-0145-0 \| PMID = 26925847 }}</ref> or variable.<ref>{{Cite journal \| last1 = Wobker \| first1 = S.E.\| last2 = Williamson \| first2 = S.R. \| title = Modern Pathologic Diagnosis of Renal Oncocytoma \| journal = \| volume = \| issue = \| pages = \| month = \| year = 2017 \| doi = 10.15586/jkcvhl.2017.96 \| PMID = 29090117}}</ref>
	*Vimentin -ve.<ref name=pmid26925847/>		*Vimentin -ve.<ref name=pmid26925847/>

Michael at 15:05, 18 April 2024

2024-04-18T15:05:22Z

← Older revision		Revision as of 15:05, 18 April 2024
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	![[GATA3]]		![[GATA3]]
	\|-		\|-
	\| Renal ~~oncoctyoma~~		\| Renal oncocytoma
	\| -ve †		\| -ve †
	\| +ve		\| +ve

Michael: /* IHC */

2024-04-18T05:22:38Z

IHC

← Older revision		Revision as of 05:22, 18 April 2024
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	A panel:		A panel:
	*CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]], GATA-3.		*CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]], GATA-3.

			===Comparison between some renal tumours with eosinophilic cytoplasm===
			{\| class="wikitable sortable"
			!Tumour
			![[CK7]]
			![[CD117]]
			![[GATA3]]
			\|-
			\| Renal oncoctyoma
			\| -ve †
			\| +ve
			\| -ve/+ve
			\|-
			\| [[Chromophobe renal cell carcinoma]]
			\| +ve ‡
			\| +ve
			\| -ve
			\|-
			\| [[Low-grade oncocytic tumour]]
			\| +ve
			\| -ve
			\| +ve
			\|-
			\|}
			† may have scattered positive cells<br>
			‡ diffuse and strong

	==Sign out==		==Sign out==

Michael at 19:16, 1 March 2024

2024-03-01T19:16:45Z

← Older revision		Revision as of 19:16, 1 March 2024
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	*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>		*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>
	**ChRCC also +ve.		**ChRCC also +ve.
	*GATA-3 -ve.		*GATA-3 usually -ve (38 cases negative of 47 cases).<ref name=pmid2431520>{{cite journal \|authors=Gonzalez-Roibon N, Faraj SF, Munari E, Bezerra SM, Albadine R, Sharma R, Argani P, Allaf ME, Netto GJ \|title=Comprehensive profile of GATA binding protein 3 immunohistochemical expression in primary and metastatic renal neoplasms \|journal=Hum Pathol \|volume=45 \|issue=2 \|pages=244–8 \|date=February 2014 \|pmid=24315206 \|doi=10.1016/j.humpath.2013.08.020 \|url=}}</ref>
	**+ve in [[low-grade oncocytic renal tumour]].		**+ve in [[low-grade oncocytic renal tumour]].

Michael at 19:13, 1 March 2024

2024-03-01T19:13:13Z

← Older revision		Revision as of 19:13, 1 March 2024
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	*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>		*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>
	**ChRCC also +ve.		**ChRCC also +ve.
			*GATA-3 -ve.
			**+ve in [[low-grade oncocytic renal tumour]].

	Others:		Others:
Line 115:		Line 117:

	A panel:		A panel:
	*CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]].		*CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]], GATA-3.

	==Sign out==		==Sign out==

Michael: /* Microscopic */

2022-03-29T15:11:12Z

Microscopic

← Older revision		Revision as of 15:11, 29 March 2022
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	*Cells arranged in nests.		*Cells arranged in nests.
	*Nuclei uniform and round.<ref name=Ref_GUP302>{{Ref GUP\|302}}</ref>		*Nuclei uniform and round.<ref name=Ref_GUP302>{{Ref GUP\|302}}</ref>
	**Slightly enlarged nuclei, but '''no significant''' pleomorphism (size variation) - '''important'''.		**Slightly enlarged nuclei, but '''no significant''' pleomorphism (size variation) - '''important'''.‡

	Notes:		Notes:
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	**Focal clear cell changes ~15% of cases.		**Focal clear cell changes ~15% of cases.
	**Hemorrhage.		**Hemorrhage.
			*‡ Focal "degenerative" atypia can be present; it is reported in ~20% of cases.<ref>{{cite journal \|authors=Tickoo SK, Amin MB \|title=Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis \|journal=Am J Clin Pathol \|volume=110 \|issue=6 \|pages=782–7 \|date=December 1998 \|pmid=9844591 \|doi=10.1093/ajcp/110.6.782 \|url=}}</ref>

	DDx:		DDx:

Michael: /* IHC */

2018-09-06T13:10:10Z

IHC

← Older revision		Revision as of 13:10, 6 September 2018
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	*[[CK7]] -ve<ref name=pmid17683191>{{Cite journal \| last1 = Liu \| first1 = L. \| last2 = Qian \| first2 = J. \| last3 = Singh \| first3 = H. \| last4 = Meiers \| first4 = I. \| last5 = Zhou \| first5 = X. \| last6 = Bostwick \| first6 = DG. \| title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 8 \| pages = 1290-7 \| month = Aug \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 \| PMID = 17683191 }}</ref>/+ve (cytoplasmic).		*[[CK7]] -ve<ref name=pmid17683191>{{Cite journal \| last1 = Liu \| first1 = L. \| last2 = Qian \| first2 = J. \| last3 = Singh \| first3 = H. \| last4 = Meiers \| first4 = I. \| last5 = Zhou \| first5 = X. \| last6 = Bostwick \| first6 = DG. \| title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 8 \| pages = 1290-7 \| month = Aug \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 \| PMID = 17683191 }}</ref>/+ve (cytoplasmic).
	**[[Chromophobe renal cell carcinoma]] = cell membrane +ve.		**[[Chromophobe renal cell carcinoma]] = cell membrane +ve.
	**Based on mRNA ~~studies~~ it was suggested that <50% CK7 immunostaining favours oncocytoma.<ref name=pmid16927643>{{Cite journal \| last1 = Adley \| first1 = BP. \| last2 = Papavero \| first2 = V. \| last3 = Sugimura \| first3 = J. \| last4 = Teh \| first4 = BT. \| last5 = Yang \| first5 = XJ. \| title = Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. \| journal = Anal Quant Cytol Histol \| volume = 28 \| issue = 4 \| pages = 228-36 \| month = Aug \| year = 2006 \| doi = \| PMID = 16927643 }}</ref>		**Based on a mRNA study it was suggested that <50% CK7 immunostaining favours oncocytoma.<ref name=pmid16927643>{{Cite journal \| last1 = Adley \| first1 = BP. \| last2 = Papavero \| first2 = V. \| last3 = Sugimura \| first3 = J. \| last4 = Teh \| first4 = BT. \| last5 = Yang \| first5 = XJ. \| title = Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. \| journal = Anal Quant Cytol Histol \| volume = 28 \| issue = 4 \| pages = 228-36 \| month = Aug \| year = 2006 \| doi = \| PMID = 16927643 }}</ref>
	*PAX8 +ve.<ref name=pmid22135028>{{Cite journal \| last1 = Hu \| first1 = Y. \| last2 = Hartmann \| first2 = A. \| last3 = Stoehr \| first3 = C. \| last4 = Zhang \| first4 = S. \| last5 = Wang \| first5 = M. \| last6 = Tacha \| first6 = D. \| last7 = Montironi \| first7 = R. \| last8 = Lopez-Beltran \| first8 = A. \| last9 = Cheng \| first9 = L. \| title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. \| journal = J Clin Pathol \| volume = 65 \| issue = 3 \| pages = 254-6 \| month = Mar \| year = 2012 \| doi = 10.1136/jclinpath-2011-200508 \| PMID = 22135028 }}</ref>		*PAX8 +ve.<ref name=pmid22135028>{{Cite journal \| last1 = Hu \| first1 = Y. \| last2 = Hartmann \| first2 = A. \| last3 = Stoehr \| first3 = C. \| last4 = Zhang \| first4 = S. \| last5 = Wang \| first5 = M. \| last6 = Tacha \| first6 = D. \| last7 = Montironi \| first7 = R. \| last8 = Lopez-Beltran \| first8 = A. \| last9 = Cheng \| first9 = L. \| title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. \| journal = J Clin Pathol \| volume = 65 \| issue = 3 \| pages = 254-6 \| month = Mar \| year = 2012 \| doi = 10.1136/jclinpath-2011-200508 \| PMID = 22135028 }}</ref>
	*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>		*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>

Michael: /* IHC */ <50%

2018-09-06T13:09:48Z

IHC: <50%

← Older revision		Revision as of 13:09, 6 September 2018
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	==IHC==		==IHC==
	*[[CK7]] -ve<ref name=pmid17683191>{{Cite journal \| last1 = Liu \| first1 = L. \| last2 = Qian \| first2 = J. \| last3 = Singh \| first3 = H. \| last4 = Meiers \| first4 = I. \| last5 = Zhou \| first5 = X. \| last6 = Bostwick \| first6 = DG. \| title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 8 \| pages = 1290-7 \| month = Aug \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 \| PMID = 17683191 }}</ref>/+ve (cytoplasmic) .		*[[CK7]] -ve<ref name=pmid17683191>{{Cite journal \| last1 = Liu \| first1 = L. \| last2 = Qian \| first2 = J. \| last3 = Singh \| first3 = H. \| last4 = Meiers \| first4 = I. \| last5 = Zhou \| first5 = X. \| last6 = Bostwick \| first6 = DG. \| title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 8 \| pages = 1290-7 \| month = Aug \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 \| PMID = 17683191 }}</ref>/+ve (cytoplasmic).
	**[[Chromophobe renal cell carcinoma]] = cell membrane +ve.		**[[Chromophobe renal cell carcinoma]] = cell membrane +ve.
			**Based on mRNA studies it was suggested that <50% CK7 immunostaining favours oncocytoma.<ref name=pmid16927643>{{Cite journal \| last1 = Adley \| first1 = BP. \| last2 = Papavero \| first2 = V. \| last3 = Sugimura \| first3 = J. \| last4 = Teh \| first4 = BT. \| last5 = Yang \| first5 = XJ. \| title = Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. \| journal = Anal Quant Cytol Histol \| volume = 28 \| issue = 4 \| pages = 228-36 \| month = Aug \| year = 2006 \| doi = \| PMID = 16927643 }}</ref>
	*PAX8 +ve.<ref name=pmid22135028>{{Cite journal \| last1 = Hu \| first1 = Y. \| last2 = Hartmann \| first2 = A. \| last3 = Stoehr \| first3 = C. \| last4 = Zhang \| first4 = S. \| last5 = Wang \| first5 = M. \| last6 = Tacha \| first6 = D. \| last7 = Montironi \| first7 = R. \| last8 = Lopez-Beltran \| first8 = A. \| last9 = Cheng \| first9 = L. \| title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. \| journal = J Clin Pathol \| volume = 65 \| issue = 3 \| pages = 254-6 \| month = Mar \| year = 2012 \| doi = 10.1136/jclinpath-2011-200508 \| PMID = 22135028 }}</ref>		*PAX8 +ve.<ref name=pmid22135028>{{Cite journal \| last1 = Hu \| first1 = Y. \| last2 = Hartmann \| first2 = A. \| last3 = Stoehr \| first3 = C. \| last4 = Zhang \| first4 = S. \| last5 = Wang \| first5 = M. \| last6 = Tacha \| first6 = D. \| last7 = Montironi \| first7 = R. \| last8 = Lopez-Beltran \| first8 = A. \| last9 = Cheng \| first9 = L. \| title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. \| journal = J Clin Pathol \| volume = 65 \| issue = 3 \| pages = 254-6 \| month = Mar \| year = 2012 \| doi = 10.1136/jclinpath-2011-200508 \| PMID = 22135028 }}</ref>
	*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>		*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>

Michael: +liver

2017-06-21T19:01:41Z

+liver

← Older revision		Revision as of 19:01, 21 June 2017
Line 6:		Line 6:
	\| Micro = abundant eosinophilic cytoplasm - slightly granular, cells arranged in nests, nuclei uniform and round without significant pleomorphism		\| Micro = abundant eosinophilic cytoplasm - slightly granular, cells arranged in nests, nuclei uniform and round without significant pleomorphism
	\| Subtypes =		\| Subtypes =
	\| LMDDx = [[chromophobe renal cell carcinoma]] eosinophilic variant, [[clear cell renal cell carcinoma]] eosinophilic variant, [[papillary renal cell carcinoma]] oncocytic variant, [[tubulocystic carcinoma of the kidney]], other [[renal tumours with eosinophilic cytoplasm]]		\| LMDDx = [[chromophobe renal cell carcinoma]] eosinophilic variant, [[clear cell renal cell carcinoma]] eosinophilic variant, [[papillary renal cell carcinoma]] oncocytic variant, [[tubulocystic carcinoma of the kidney]], other [[renal tumours with eosinophilic cytoplasm]], benign [[liver]]
	\| Stains = [[Hale's colloidal iron]] -ve		\| Stains = [[Hale's colloidal iron]] -ve
	\| IHC = CK7 -ve/cytoplasmic +ve, CD117 +ve, [[PAX8]] +ve		\| IHC = CK7 -ve/cytoplasmic +ve, CD117 +ve, [[PAX8]] +ve
Line 70:		Line 70:
	*[[Tubulocystic carcinoma of the kidney]].		*[[Tubulocystic carcinoma of the kidney]].
	*Other [[renal tumours with eosinophilic cytoplasm]].		*Other [[renal tumours with eosinophilic cytoplasm]].
			*Benign [[liver]].

	===Images===		===Images===

← Older revision		Revision as of 13:10, 6 September 2018
Line 100:		Line 100:
	*[[CK7]] -ve<ref name=pmid17683191>{{Cite journal \| last1 = Liu \| first1 = L. \| last2 = Qian \| first2 = J. \| last3 = Singh \| first3 = H. \| last4 = Meiers \| first4 = I. \| last5 = Zhou \| first5 = X. \| last6 = Bostwick \| first6 = DG. \| title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 8 \| pages = 1290-7 \| month = Aug \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 \| PMID = 17683191 }}</ref>/+ve (cytoplasmic).		*[[CK7]] -ve<ref name=pmid17683191>{{Cite journal \| last1 = Liu \| first1 = L. \| last2 = Qian \| first2 = J. \| last3 = Singh \| first3 = H. \| last4 = Meiers \| first4 = I. \| last5 = Zhou \| first5 = X. \| last6 = Bostwick \| first6 = DG. \| title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. \| journal = Arch Pathol Lab Med \| volume = 131 \| issue = 8 \| pages = 1290-7 \| month = Aug \| year = 2007 \| doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 \| PMID = 17683191 }}</ref>/+ve (cytoplasmic).
	**[[Chromophobe renal cell carcinoma]] = cell membrane +ve.		**[[Chromophobe renal cell carcinoma]] = cell membrane +ve.
	**Based on mRNA ~~studies~~ it was suggested that <50% CK7 immunostaining favours oncocytoma.<ref name=pmid16927643>{{Cite journal \| last1 = Adley \| first1 = BP. \| last2 = Papavero \| first2 = V. \| last3 = Sugimura \| first3 = J. \| last4 = Teh \| first4 = BT. \| last5 = Yang \| first5 = XJ. \| title = Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. \| journal = Anal Quant Cytol Histol \| volume = 28 \| issue = 4 \| pages = 228-36 \| month = Aug \| year = 2006 \| doi = \| PMID = 16927643 }}</ref>		**Based on a mRNA study it was suggested that <50% CK7 immunostaining favours oncocytoma.<ref name=pmid16927643>{{Cite journal \| last1 = Adley \| first1 = BP. \| last2 = Papavero \| first2 = V. \| last3 = Sugimura \| first3 = J. \| last4 = Teh \| first4 = BT. \| last5 = Yang \| first5 = XJ. \| title = Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. \| journal = Anal Quant Cytol Histol \| volume = 28 \| issue = 4 \| pages = 228-36 \| month = Aug \| year = 2006 \| doi = \| PMID = 16927643 }}</ref>
	*PAX8 +ve.<ref name=pmid22135028>{{Cite journal \| last1 = Hu \| first1 = Y. \| last2 = Hartmann \| first2 = A. \| last3 = Stoehr \| first3 = C. \| last4 = Zhang \| first4 = S. \| last5 = Wang \| first5 = M. \| last6 = Tacha \| first6 = D. \| last7 = Montironi \| first7 = R. \| last8 = Lopez-Beltran \| first8 = A. \| last9 = Cheng \| first9 = L. \| title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. \| journal = J Clin Pathol \| volume = 65 \| issue = 3 \| pages = 254-6 \| month = Mar \| year = 2012 \| doi = 10.1136/jclinpath-2011-200508 \| PMID = 22135028 }}</ref>		*PAX8 +ve.<ref name=pmid22135028>{{Cite journal \| last1 = Hu \| first1 = Y. \| last2 = Hartmann \| first2 = A. \| last3 = Stoehr \| first3 = C. \| last4 = Zhang \| first4 = S. \| last5 = Wang \| first5 = M. \| last6 = Tacha \| first6 = D. \| last7 = Montironi \| first7 = R. \| last8 = Lopez-Beltran \| first8 = A. \| last9 = Cheng \| first9 = L. \| title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. \| journal = J Clin Pathol \| volume = 65 \| issue = 3 \| pages = 254-6 \| month = Mar \| year = 2012 \| doi = 10.1136/jclinpath-2011-200508 \| PMID = 22135028 }}</ref>
	*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>		*[[CD117]] +ve.<ref>{{Cite journal \| last1 = Krüger \| first1 = S. \| last2 = Sotlar \| first2 = K. \| last3 = Kausch \| first3 = I. \| last4 = Horny \| first4 = HP. \| title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. \| journal = Oncology \| volume = 68 \| issue = 2-3 \| pages = 269-75 \| month = \| year = 2005 \| doi = 10.1159/000086783 \| PMID = 16015044 }}</ref>