Renal mucinous tubular and spindle cell carcinoma - Revision history

Michael at 22:47, 29 May 2025

2025-05-29T22:47:43Z

← Older revision		Revision as of 22:47, 29 May 2025
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	\| Micro = mucin (foamy macrophages) - may be scant, spindle cells, small tubules - lined by cuboidal epithelium		\| Micro = mucin (foamy macrophages) - may be scant, spindle cells, small tubules - lined by cuboidal epithelium
	\| Subtypes =		\| Subtypes =
	\| LMDDx = sarcomatoid [[papillary renal cell carcinoma]], [[papillary renal cell carcinoma]], [[metanephric adenoma]]		\| LMDDx = sarcomatoid [[papillary renal cell carcinoma]], [[papillary renal cell carcinoma]], [[ALK-rearranged renal cell carcinoma]], [[metanephric adenoma]]
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve, AMACR +ve, CD10 -ve, AE1/AE3 +ve		\| IHC = CK7 +ve, AMACR +ve, CD10 -ve, AE1/AE3 +ve
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	*Sarcomatoid [[papillary renal cell carcinoma]]<ref name=pmid18941398>{{cite journal \|author=Dhillon J, Amin MB, Selbs E, Turi GK, Paner GP, Reuter VE \|title=Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change \|journal=Am. J. Surg. Pathol. \|volume=33 \|issue=1 \|pages=44–9 \|year=2009 \|month=January \|pmid=18941398 \|doi=10.1097/PAS.0b013e3181829ed5 \|url=}}</ref> (papillary renal cell carcinoma with [[sarcomatoid RCC\|sarcomatoid differentiation]]).		*Sarcomatoid [[papillary renal cell carcinoma]]<ref name=pmid18941398>{{cite journal \|author=Dhillon J, Amin MB, Selbs E, Turi GK, Paner GP, Reuter VE \|title=Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change \|journal=Am. J. Surg. Pathol. \|volume=33 \|issue=1 \|pages=44–9 \|year=2009 \|month=January \|pmid=18941398 \|doi=10.1097/PAS.0b013e3181829ed5 \|url=}}</ref> (papillary renal cell carcinoma with [[sarcomatoid RCC\|sarcomatoid differentiation]]).
	*[[Papillary renal cell carcinoma]].		*[[Papillary renal cell carcinoma]].
			*[[ALK-rearranged renal cell carcinoma]].<ref>{{cite journal \|authors=Kai K, Tobu S, Kido S, Mikami S, Takeuchi K, Dobashi A, Togashi Y, Noguchi M, Aishima S \|title=ALK rearrangement-associated renal cell carcinoma morphologically mimicking mucinous tubular and spindle cell carcinoma: a case report \|journal=Diagn Pathol \|volume=17 \|issue=1 \|pages=52 \|date=June 2022 \|pmid=35718773 \|pmc=9206751 \|doi=10.1186/s13000-022-01238-z \|url=}}</ref>
	*[[Metanephric adenoma]].		*[[Metanephric adenoma]].

Michael: /* IHC */ fix ref

2019-12-20T20:08:29Z

IHC: fix ref

← Older revision		Revision as of 20:08, 20 December 2019
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	Note:		Note:
	*Immunophenotype overlaps with [[papillary renal cell carcinoma]].<ref name=pmid{{Cite journal \| last1 = Paner \| first1 = GP. \| last2 = Srigley \| first2 = JR. \| last3 = Radhakrishnan \| first3 = A. \| last4 = Cohen \| first4 = C. \| last5 = Skinnider \| first5 = BF. \| last6 = Tickoo \| first6 = SK. \| last7 = Young \| first7 = AN. \| last8 = Amin \| first8 = MB. \| title = Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. \| journal = Am J Surg Pathol \| volume = 30 \| issue = 1 \| pages = 13-9 \| month = Jan \| year = 2006 \| doi = \| PMID = 16330937 }}>{{Cite journal \| last1 = Paner \| first1 = GP. \| last2 = Srigley \| first2 = JR. \| last3 = Radhakrishnan \| first3 = A. \| last4 = Cohen \| first4 = C. \| last5 = Skinnider \| first5 = BF. \| last6 = Tickoo \| first6 = SK. \| last7 = Young \| first7 = AN. \| last8 = Amin \| first8 = MB. \| title = Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. \| journal = Am J Surg Pathol \| volume = 30 \| issue = 1 \| pages = 13-9 \| month = Jan \| year = 2006 \| doi = \| PMID = 16330937 }}</ref>		*Immunophenotype overlaps with [[papillary renal cell carcinoma]].<ref name=pmid16330937>{{Cite journal \| last1 = Paner \| first1 = GP. \| last2 = Srigley \| first2 = JR. \| last3 = Radhakrishnan \| first3 = A. \| last4 = Cohen \| first4 = C. \| last5 = Skinnider \| first5 = BF. \| last6 = Tickoo \| first6 = SK. \| last7 = Young \| first7 = AN. \| last8 = Amin \| first8 = MB. \| title = Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. \| journal = Am J Surg Pathol \| volume = 30 \| issue = 1 \| pages = 13-9 \| month = Jan \| year = 2006 \| doi = \| PMID = 16330937 }}</ref>

	==Sign out==		==Sign out==

Michael: /* IHC */

2017-12-17T16:42:36Z

IHC

← Older revision		Revision as of 16:42, 17 December 2017
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	*[[p63]] -ve.		*[[p63]] -ve.
	*[[CK20]] -ve.<ref name=pmid17058608>{{Cite journal \| last1 = Arias \| first1 = LF. \| last2 = Blanco \| first2 = J. \| last3 = Hernández \| first3 = S. \| last4 = Bocardo \| first4 = G. \| last5 = González \| first5 = L. \| title = [Immunohistochemical profile and clinical features of mucinous tubular and spindle renal cell carcinoma]. \| journal = Actas Urol Esp \| volume = 30 \| issue = 7 \| pages = 649-54 \| month = \| year = \| doi = \| PMID = 17058608 }}</ref>		*[[CK20]] -ve.<ref name=pmid17058608>{{Cite journal \| last1 = Arias \| first1 = LF. \| last2 = Blanco \| first2 = J. \| last3 = Hernández \| first3 = S. \| last4 = Bocardo \| first4 = G. \| last5 = González \| first5 = L. \| title = [Immunohistochemical profile and clinical features of mucinous tubular and spindle renal cell carcinoma]. \| journal = Actas Urol Esp \| volume = 30 \| issue = 7 \| pages = 649-54 \| month = \| year = \| doi = \| PMID = 17058608 }}</ref>
			*[[CD57]] +ve.<ref name=pmid18459456>{{Cite journal \| last1 = Okoń \| first1 = K. \| last2 = Klimkowska \| first2 = A. \| last3 = Pawelec \| first3 = A. \| last4 = Dobrowolski \| first4 = Z. \| last5 = Kohla \| first5 = Z. \| last6 = Stachura \| first6 = J. \| title = Immunophenotype and cytogenetics of mucinous tubular and spindle cell carcinoma of the kidney. \| journal = Pol J Pathol \| volume = 58 \| issue = 4 \| pages = 227-33 \| month = \| year = 2007 \| doi = \| PMID = 18459456 }}</ref><ref name=pmid14989744>{{Cite journal \| last1 = Kuroda \| first1 = N. \| last2 = Nakamura \| first2 = S. \| last3 = Miyazaki \| first3 = E. \| last4 = Hayashi \| first4 = Y. \| last5 = Taguchi \| first5 = T. \| last6 = Hiroi \| first6 = M. \| last7 = Yamasaki \| first7 = Y. \| last8 = Shuin \| first8 = T. \| last9 = Enzan \| first9 = H. \| title = Low-grade tubular-mucinous renal neoplasm with neuroendocrine differentiation: a histological, immunohistochemical and ultrastructural study. \| journal = Pathol Int \| volume = 54 \| issue = 3 \| pages = 201-7 \| month = Mar \| year = 2004 \| doi = 10.1111/j.1440-1827.2004.01608.x \| PMID = 14989744 }}</ref>
			*CK19 +ve.<ref name=pmid14989744/>

	Note:		Note:

Michael at 20:54, 5 May 2016

2016-05-05T20:54:45Z

← Older revision		Revision as of 20:54, 5 May 2016
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	Others:		Others:
	*~~PAX-8~~ +ve.		*[[PAX8]] +ve.
	*CAM5.2 +ve.		*[[CAM5.2]] +ve.
	*p63 -ve.		*[[p63]] -ve.
	*CK20 -ve.<ref name=pmid17058608>{{Cite journal \| last1 = Arias \| first1 = LF. \| last2 = Blanco \| first2 = J. \| last3 = Hernández \| first3 = S. \| last4 = Bocardo \| first4 = G. \| last5 = González \| first5 = L. \| title = [Immunohistochemical profile and clinical features of mucinous tubular and spindle renal cell carcinoma]. \| journal = Actas Urol Esp \| volume = 30 \| issue = 7 \| pages = 649-54 \| month = \| year = \| doi = \| PMID = 17058608 }}</ref>		*[[CK20]] -ve.<ref name=pmid17058608>{{Cite journal \| last1 = Arias \| first1 = LF. \| last2 = Blanco \| first2 = J. \| last3 = Hernández \| first3 = S. \| last4 = Bocardo \| first4 = G. \| last5 = González \| first5 = L. \| title = [Immunohistochemical profile and clinical features of mucinous tubular and spindle renal cell carcinoma]. \| journal = Actas Urol Esp \| volume = 30 \| issue = 7 \| pages = 649-54 \| month = \| year = \| doi = \| PMID = 17058608 }}</ref>

	Note:		Note:

Michael at 03:55, 27 March 2016

2016-03-27T03:55:27Z

← Older revision		Revision as of 03:55, 27 March 2016
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	{{ Infobox diagnosis		{{ Infobox diagnosis
	\| Name = {{PAGENAME}}		\| Name = {{PAGENAME}}
	\| Image = Renal mucinous tubular and spindle cell carcinoma -- high mag.jpg		\| Image = Renal mucinous tubular and spindle cell carcinoma - 2 -- high mag.jpg
	\| Width =		\| Width =
	\| Caption = Renal mucinous tubular and spindle cell carcinoma. [[H&E stain]].		\| Caption = Renal mucinous tubular and spindle cell carcinoma. [[H&E stain]].
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	===Images===		===Images===
			====Case 1====
			<gallery>
			Image: Renal mucinous tubular and spindle cell carcinoma - 2 -- very low mag.jpg \| RMTSCC - very low mag.
			Image: Renal mucinous tubular and spindle cell carcinoma - 2 -- low mag.jpg \| RMTSCC - low mag.
			Image: Renal mucinous tubular and spindle cell carcinoma - 2 -- intermed mag.jpg \| RMTSCC - intermed. mag.
			Image: Renal mucinous tubular and spindle cell carcinoma - 2 -- high mag.jpg \| RMTSCC - high mag.
			Image: Renal mucinous tubular and spindle cell carcinoma - 2 -- very high mag.jpg \| RMTSCC - very high mag.
			Image: Renal mucinous tubular and spindle cell carcinoma - 2 alt -- very high mag.jpg \| RMTSCC - very high mag.
			</gallery>
			====Case 2====
	<gallery>		<gallery>
	Image: Renal mucinous tubular and spindle cell carcinoma -- low mag.jpg \| RMTSCC - low mag.		Image: Renal mucinous tubular and spindle cell carcinoma -- low mag.jpg \| RMTSCC - low mag.

Michael at 06:42, 1 March 2016

2016-03-01T06:42:42Z

← Older revision		Revision as of 06:42, 1 March 2016
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	*Greyish-yellow or tan-yellow.		*Greyish-yellow or tan-yellow.
	*Well-circumscribed.		*Well-circumscribed.

			Note:
			*Imaging characteristics overlap with [[papillary renal cell carcinoma]].<ref name=pmid25395040/>

	==Microscopic==		==Microscopic==

Michael at 06:41, 1 March 2016

2016-03-01T06:41:27Z

← Older revision		Revision as of 06:41, 1 March 2016
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	\| Prevalence = rare		\| Prevalence = rare
	\| Bloodwork =		\| Bloodwork =
	\| Rads =		\| Rads = features overlap with [[papillary renal cell carcinoma]]
	\| Endoscopy =		\| Endoscopy =
	\| Prognosis = good		\| Prognosis = good
	\| Other =		\| Other =
	\| ClinDDx =		\| ClinDDx = other [[kidney tumours]]
	\| Tx = surgical excision		\| Tx = surgical excision
	}}		}}

Michael: /* General */

2016-03-01T06:32:03Z

General

← Older revision		Revision as of 06:32, 1 March 2016
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	==General==		==General==
	*Rare<ref name=pmid19494850>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref> - largest reported series (2015) is 19 cases.<ref name=pmid25395040/>		*Rare<ref name=pmid19494850>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref> - largest reported series (published in 2015) has 19 cases.<ref name=pmid25395040/>
	*Accepted by WHO in 2004 as a separate entity.<ref name=pmid19805959>{{cite journal \|author=Geramizadeh B, Salehipour M, Moradi A \|title=Mucinous tubular and spindle cell carcinoma of kidney: a rare case report and review of the literature \|journal=Indian J Pathol Microbiol \|volume=52 \|issue=4 \|pages=514–6 \|year=2009 \|pmid=19805959 \|doi=10.4103/0377-4929.56144 \|url=}}</ref>		*Accepted by WHO in 2004 as a separate entity.<ref name=pmid19805959>{{cite journal \|author=Geramizadeh B, Salehipour M, Moradi A \|title=Mucinous tubular and spindle cell carcinoma of kidney: a rare case report and review of the literature \|journal=Indian J Pathol Microbiol \|volume=52 \|issue=4 \|pages=514–6 \|year=2009 \|pmid=19805959 \|doi=10.4103/0377-4929.56144 \|url=}}</ref>
	*Relatively good prognosis.		*Relatively good prognosis.

Michael: /* General */

2016-03-01T06:31:29Z

General

← Older revision		Revision as of 06:31, 1 March 2016
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	==General==		==General==
	*Rare.<ref name=pmid19494850>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref>		*Rare<ref name=pmid19494850>{{Cite journal \| last1 = Srigley \| first1 = JR. \| last2 = Delahunt \| first2 = B. \| title = Uncommon and recently described renal carcinomas. \| journal = Mod Pathol \| volume = 22 Suppl 2 \| issue = \| pages = S2-S23 \| month = Jun \| year = 2009 \| doi = 10.1038/modpathol.2009.70 \| PMID = 19494850 }}</ref> - largest reported series (2015) is 19 cases.<ref name=pmid25395040/>
	*Accepted by WHO in 2004 as a separate entity.<ref name=pmid19805959>{{cite journal \|author=Geramizadeh B, Salehipour M, Moradi A \|title=Mucinous tubular and spindle cell carcinoma of kidney: a rare case report and review of the literature \|journal=Indian J Pathol Microbiol \|volume=52 \|issue=4 \|pages=514–6 \|year=2009 \|pmid=19805959 \|doi=10.4103/0377-4929.56144 \|url=}}</ref>		*Accepted by WHO in 2004 as a separate entity.<ref name=pmid19805959>{{cite journal \|author=Geramizadeh B, Salehipour M, Moradi A \|title=Mucinous tubular and spindle cell carcinoma of kidney: a rare case report and review of the literature \|journal=Indian J Pathol Microbiol \|volume=52 \|issue=4 \|pages=514–6 \|year=2009 \|pmid=19805959 \|doi=10.4103/0377-4929.56144 \|url=}}</ref>
	*Relatively good prognosis.		*Relatively good prognosis.
			**In a series of 19 patients: one died, one developed mets, one recurred (post-ablation) and was salvaged by surgery, one observed... remaining 15 cured by surgery or ablation.<ref name=pmid25395040>{{Cite journal \| last1 = Kenney \| first1 = PA. \| last2 = Vikram \| first2 = R. \| last3 = Prasad \| first3 = SR. \| last4 = Tamboli \| first4 = P. \| last5 = Matin \| first5 = SF. \| last6 = Wood \| first6 = CG. \| last7 = Karam \| first7 = JA. \| title = Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes. \| journal = BJU Int \| volume = 116 \| issue = 1 \| pages = 85-92 \| month = Jul \| year = 2015 \| doi = 10.1111/bju.12992 \| PMID = 25395040 }}</ref>

	==Gross==		==Gross==

Michael at 06:20, 1 March 2016

2016-03-01T06:20:31Z

← Older revision		Revision as of 06:20, 1 March 2016
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	\| Micro = mucin (foamy macrophages) - may be scant, spindle cells, small tubules - lined by cuboidal epithelium		\| Micro = mucin (foamy macrophages) - may be scant, spindle cells, small tubules - lined by cuboidal epithelium
	\| Subtypes =		\| Subtypes =
	\| LMDDx =		\| LMDDx = sarcomatoid [[papillary renal cell carcinoma]], [[papillary renal cell carcinoma]], [[metanephric adenoma]]
	\| Stains =		\| Stains =
	\| IHC = CK7 +ve, AMACR +ve, CD10 -ve, AE1/AE3 +ve		\| IHC = CK7 +ve, AMACR +ve, CD10 -ve, AE1/AE3 +ve
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	*Sarcomatoid [[papillary renal cell carcinoma]]<ref name=pmid18941398>{{cite journal \|author=Dhillon J, Amin MB, Selbs E, Turi GK, Paner GP, Reuter VE \|title=Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change \|journal=Am. J. Surg. Pathol. \|volume=33 \|issue=1 \|pages=44–9 \|year=2009 \|month=January \|pmid=18941398 \|doi=10.1097/PAS.0b013e3181829ed5 \|url=}}</ref> (papillary renal cell carcinoma with [[sarcomatoid RCC\|sarcomatoid differentiation]]).		*Sarcomatoid [[papillary renal cell carcinoma]]<ref name=pmid18941398>{{cite journal \|author=Dhillon J, Amin MB, Selbs E, Turi GK, Paner GP, Reuter VE \|title=Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change \|journal=Am. J. Surg. Pathol. \|volume=33 \|issue=1 \|pages=44–9 \|year=2009 \|month=January \|pmid=18941398 \|doi=10.1097/PAS.0b013e3181829ed5 \|url=}}</ref> (papillary renal cell carcinoma with [[sarcomatoid RCC\|sarcomatoid differentiation]]).
	*[[Papillary renal cell carcinoma]].		*[[Papillary renal cell carcinoma]].
			*[[Metanephric adenoma]].

	===Grading===		===Grading===