Renal hybrid oncocytic/chromophobe tumour - Revision history

Michael at 15:12, 20 March 2024

2024-03-20T15:12:51Z

← Older revision		Revision as of 15:12, 20 March 2024
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	#* Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle.		#* Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle.
	# Renal oncocytoma with scattered chromophobe cells.		# Renal oncocytoma with scattered chromophobe cells.
	# Large eosinophilic cell with intracytoplasmic vacuoles.		# Large eosinophilic cell with intracytoplasmic vacuoles - this is the evolving entity ''[[eosinophilic vacuolated tumour]]''.
	#* Prominent nucleoli ([[ISUP nucleolar grade]] 3).		#* Prominent nucleoli ([[ISUP nucleolar grade]] 3).
	#* Perinuclear halos (occasional).		#* Perinuclear halos (occasional).

Michael: /* Microscopic */

2021-11-14T16:26:25Z

Microscopic

← Older revision		Revision as of 16:26, 14 November 2021
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	*[[Chromophobe renal cell carcinoma]], eosinophilic variant.		*[[Chromophobe renal cell carcinoma]], eosinophilic variant.
	*[[SDH-deficient renal cell carcinoma]] - lower nuclear grade, not nested.		*[[SDH-deficient renal cell carcinoma]] - lower nuclear grade, not nested.
	*[[Eosinophilic vacuolated tumour]] (evolving entity).		*[[Eosinophilic vacuolated tumour]] - evolving entity.
	*Other [[renal tumours with eosinophilic cytoplasm]].		*Other [[renal tumours with eosinophilic cytoplasm]].
	*[[Renal cell carcinoma, unclassified]].		*[[Renal cell carcinoma, unclassified]].

Michael: /* Microscopic */

2021-11-14T16:26:12Z

Microscopic

← Older revision		Revision as of 16:26, 14 November 2021
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	*[[Renal oncocytoma]] - may have limited chromophobe-like areas (<=5% of tumour).<ref name=pmid21166703>{{Cite journal \| last1 = Trpkov \| first1 = K. \| last2 = Yilmaz \| first2 = A. \| last3 = Uzer \| first3 = D. \| last4 = Dishongh \| first4 = KM. \| last5 = Quick \| first5 = CM. \| last6 = Bismar \| first6 = TA. \| last7 = Gokden \| first7 = N. \| title = Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. \| journal = Histopathology \| volume = 57 \| issue = 6 \| pages = 893-906 \| month = Dec \| year = 2010 \| doi = 10.1111/j.1365-2559.2010.03726.x \| PMID = 21166703 }}</ref>		*[[Renal oncocytoma]] - may have limited chromophobe-like areas (<=5% of tumour).<ref name=pmid21166703>{{Cite journal \| last1 = Trpkov \| first1 = K. \| last2 = Yilmaz \| first2 = A. \| last3 = Uzer \| first3 = D. \| last4 = Dishongh \| first4 = KM. \| last5 = Quick \| first5 = CM. \| last6 = Bismar \| first6 = TA. \| last7 = Gokden \| first7 = N. \| title = Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. \| journal = Histopathology \| volume = 57 \| issue = 6 \| pages = 893-906 \| month = Dec \| year = 2010 \| doi = 10.1111/j.1365-2559.2010.03726.x \| PMID = 21166703 }}</ref>
	*[[Chromophobe renal cell carcinoma]], eosinophilic variant.		*[[Chromophobe renal cell carcinoma]], eosinophilic variant.
	*[[SDH-deficient renal cell carcinoma]] ~~(evolving entity)~~ - lower nuclear grade, not nested.		*[[SDH-deficient renal cell carcinoma]] - lower nuclear grade, not nested.
			*[[Eosinophilic vacuolated tumour]] (evolving entity).
	*Other [[renal tumours with eosinophilic cytoplasm]].		*Other [[renal tumours with eosinophilic cytoplasm]].
	*[[Renal cell carcinoma, unclassified]].		*[[Renal cell carcinoma, unclassified]].

Michael: /* See also */

2018-09-06T14:06:16Z

Michael: /* Images */

2015-12-10T03:03:48Z

Images

← Older revision		Revision as of 03:03, 10 December 2015
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	===Images===		===Images===
			====Case 1====
	<gallery>		<gallery>
	Image: Hybrid tumour of the kidney -- low mag.jpg \| HOCT - low mag.		Image: Hybrid tumour of the kidney -- low mag.jpg \| HOCT - low mag. (WC)
	Image: Hybrid tumour of the kidney -- intermed mag.jpg \| HOCT - intermed. mag.		Image: Hybrid tumour of the kidney -- intermed mag.jpg \| HOCT - intermed. mag. (WC)
	Image: Hybrid tumour of the kidney -- high mag.jpg \| HOCT - high mag.		Image: Hybrid tumour of the kidney -- high mag.jpg \| HOCT - high mag. (WC)
			</gallery>
			====Case 2====
			<gallery>
			Image: Renal hybrid tumour - 2 -- intermed mag.jpg \| HOCT - intermed. mag. (WC)
			Image: Renal hybrid tumour - 2 -- high mag.jpg \| HOCT - high mag. (WC)
			Image: Renal hybrid tumour - 2 -- very high mag.jpg \| HOCT - very high mag. (WC)

			Image: Renal hybrid tumour - nests - 2 -- intermed mag.jpg \| HOCT - intermed. mag. (WC)
			Image: Renal hybrid tumour - nests - 2 -- high mag.jpg \| HOCT - high mag. (WC)
			Image: Renal hybrid tumour - nests - 2 -- very high mag.jpg \| HOCT - very high mag. (WC)
	</gallery>		</gallery>

Michael: /* Sign out */

2015-12-04T04:43:34Z

Sign out

← Older revision		Revision as of 04:43, 4 December 2015
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	Comment:		Comment:
	...		The tumour may be seen in the context of Birt–Hogg–Dubé syndrome.
	</pre>		</pre>

Michael: /* General */

2015-12-04T04:10:14Z

General

← Older revision		Revision as of 04:10, 4 December 2015
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	*Sporadic.		*Sporadic.
	*[[Birt–Hogg–Dubé syndrome]].		*[[Birt–Hogg–Dubé syndrome]].
	*Renal oncocytosis.		*[[Renal oncocytosis]].

	==Microscopic==		==Microscopic==

Michael: /* Sign out */

2015-11-05T14:50:16Z

Sign out

← Older revision		Revision as of 14:50, 5 November 2015
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	- Renal tumour with eosinophilic cytoplasm of undetermined malignant potential		- Renal tumour with eosinophilic cytoplasm of undetermined malignant potential
	in keeping with the so called "hybrid oncocytic/chromophobe tumour", see comment.		in keeping with the so called "hybrid oncocytic/chromophobe tumour", see comment.
			-- Resection margins clear.
	-- Tumour limited to kidney.		-- Tumour limited to kidney.
	~~-- Resection margins clear.~~

	Comment:		Comment:

Michael: /* Molecular */

2015-11-05T14:48:21Z

Molecular

← Older revision		Revision as of 14:48, 5 November 2015
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	==Molecular==		==Molecular==
	*No features characteristic of [[chromophobe RCC]] on array-CGH analysis.<ref name=pmid23708994/>		*No features characteristic of [[chromophobe RCC]] on array-CGH analysis.<ref name=pmid23708994/>

			==Sign out==
			<pre>
			Left Kidney, Partial Nephrectomy:
			- Renal tumour with eosinophilic cytoplasm of undetermined malignant potential
			in keeping with the so called "hybrid oncocytic/chromophobe tumour", see comment.
			-- Tumour limited to kidney.
			-- Resection margins clear.

			Comment:
			...
			</pre>

	==See also==		==See also==

Michael: tweak

2015-11-04T04:18:48Z

tweak

← Older revision		Revision as of 04:18, 4 November 2015
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	\| Caption = Hybrid oncocytic/chromophobe tumour of the kidney. [[H&E stain]].		\| Caption = Hybrid oncocytic/chromophobe tumour of the kidney. [[H&E stain]].
	\| Synonyms = hybrid tumour		\| Synonyms = hybrid tumour
	\| Micro = features of [[renal oncocytoma]] and [[chromophobe renal cell carcinoma]]		\| Micro = features of [[renal oncocytoma]] and [[chromophobe renal cell carcinoma]] - varies by subtype
	\| Subtypes =		\| Subtypes = as per Hes ''et al.'': (1) [[collision tumour]]-type, (2) renal oncocytoma with scattered chromophobe cells-type, (3) large eosinophilic cells with intracytoplasmic vacuoles-type
	\| LMDDx = [[renal oncocytoma]], [[chromophobe renal cell carcinoma]], [[renal cell carcinoma, unclassified]], [[SDH-deficient renal cell carcinoma]], other [[renal tumours with eosinophilic cytoplasm]]		\| LMDDx = [[renal oncocytoma]], [[chromophobe renal cell carcinoma]], [[renal cell carcinoma, unclassified]], [[SDH-deficient renal cell carcinoma]], other [[renal tumours with eosinophilic cytoplasm]]
	\| Stains = Hale's colloidal iron +ve		\| Stains = Hale's colloidal iron +ve

← Older revision		Revision as of 14:06, 6 September 2018
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	*[[Renal tumours with eosinophilic cytoplasm]].		*[[Renal tumours with eosinophilic cytoplasm]].
	*[[Renal oncocytoma]].		*[[Renal oncocytoma]].
			*[[High-grade oncocytic renal tumour]].

	==References==		==References==