Renal cell carcinoma with sarcomatoid differentiation - Revision history

Michael: /* General */

2015-07-11T02:50:21Z

General

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	==General==		==General==
	Features:<ref name=pmid11224597>{{Cite journal \| last1 = de Peralta-Venturina \| first1 = M. \| last2 = Moch \| first2 = H. \| last3 = Amin \| first3 = M. \| last4 = Tamboli \| first4 = P. \| last5 = Hailemariam \| first5 = S. \| last6 = Mihatsch \| first6 = M. \| last7 = Javidan \| first7 = J. \| last8 = Stricker \| first8 = H. \| last9 = Ro \| first9 = JY. \| title = Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. \| journal = Am J Surg Pathol \| volume = 25 \| issue = 3 \| pages = 275-84 \| month = Mar \| year = 2001 \| doi = \| PMID = 11224597 }}</ref>		Features:<ref name=pmid11224597>{{Cite journal \| last1 = de Peralta-Venturina \| first1 = M. \| last2 = Moch \| first2 = H. \| last3 = Amin \| first3 = M. \| last4 = Tamboli \| first4 = P. \| last5 = Hailemariam \| first5 = S. \| last6 = Mihatsch \| first6 = M. \| last7 = Javidan \| first7 = J. \| last8 = Stricker \| first8 = H. \| last9 = Ro \| first9 = JY. \| title = Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. \| journal = Am J Surg Pathol \| volume = 25 \| issue = 3 \| pages = 275-84 \| month = Mar \| year = 2001 \| doi = \| PMID = 11224597 }}</ref>
	*Not recognized as a distinct entity in 2004 WHO classification.<ref name=pmid16442207>{{Cite journal \| last1 = Lopez-Beltran \| first1 = A. \| last2 = Scarpelli \| first2 = M. \| last3 = Montironi \| first3 = R. \| last4 = Kirkali \| first4 = Z. \| title = 2004 WHO classification of the renal tumors of the adults. \| journal = Eur Urol \| volume = 49 \| issue = 5 \| pages = 798-805 \| month = May \| year = 2006 \| doi = 10.1016/j.eururo.2005.11.035 \| PMID = 16442207 }}</ref>		*'''Not''' recognized as a distinct entity in 2004 WHO classification<ref name=pmid16442207>{{Cite journal \| last1 = Lopez-Beltran \| first1 = A. \| last2 = Scarpelli \| first2 = M. \| last3 = Montironi \| first3 = R. \| last4 = Kirkali \| first4 = Z. \| title = 2004 WHO classification of the renal tumors of the adults. \| journal = Eur Urol \| volume = 49 \| issue = 5 \| pages = 798-805 \| month = May \| year = 2006 \| doi = 10.1016/j.eururo.2005.11.035 \| PMID = 16442207 }}</ref> and after.
	**It is considered an indicator of progression.		**It is considered an indicator of progression.
	**Previously considered a distinct entity.<ref name=pmid22234634/><ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal \| last1 = Cangiano \| first1 = T. \| last2 = Liao \| first2 = J. \| last3 = Naitoh \| first3 = J. \| last4 = Dorey \| first4 = F. \| last5 = Figlin \| first5 = R. \| last6 = Belldegrun \| first6 = A. \| title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. \| journal = J Clin Oncol \| volume = 17 \| issue = 2 \| pages = 523-8 \| month = Feb \| year = 1999 \| doi = \| PMID = 10080595 \| URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref>		**Previously considered a distinct entity.<ref name=pmid22234634/><ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal \| last1 = Cangiano \| first1 = T. \| last2 = Liao \| first2 = J. \| last3 = Naitoh \| first3 = J. \| last4 = Dorey \| first4 = F. \| last5 = Figlin \| first5 = R. \| last6 = Belldegrun \| first6 = A. \| title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. \| journal = J Clin Oncol \| volume = 17 \| issue = 2 \| pages = 523-8 \| month = Feb \| year = 1999 \| doi = \| PMID = 10080595 \| URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref>

Michael: /* See also */

2015-06-24T15:41:57Z

Michael at 21:31, 16 June 2015

2015-06-16T21:31:41Z

← Older revision		Revision as of 21:31, 16 June 2015
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	*[[ISUP nucleolar grade]] ([[Fuhrman grade]]) 4 by definition.		*[[ISUP nucleolar grade]] ([[Fuhrman grade]]) 4 by definition.
	*Most commonly seen in association with [[clear cell renal cell carcinoma]]<ref name=pmid22234634/> or [[chromophobe RCC]].<ref name=pmid15087662>{{Cite journal \| last1 = Cheville \| first1 = JC. \| last2 = Lohse \| first2 = CM. \| last3 = Zincke \| first3 = H. \| last4 = Weaver \| first4 = AL. \| last5 = Leibovich \| first5 = BC. \| last6 = Frank \| first6 = I. \| last7 = Blute \| first7 = ML. \| title = Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 4 \| pages = 435-41 \| month = Apr \| year = 2004 \| doi = \| PMID = 15087662 }}</ref><ref name=pmid9331291>{{Cite journal \| last1 = Akhtar \| first1 = M. \| last2 = Tulbah \| first2 = A. \| last3 = Kardar \| first3 = AH. \| last4 = Ali \| first4 = MA. \| title = Sarcomatoid renal cell carcinoma: the chromophobe connection. \| journal = Am J Surg Pathol \| volume = 21 \| issue = 10 \| pages = 1188-95 \| month = Oct \| year = 1997 \| doi = \| PMID = 9331291 }}</ref>		*Most commonly seen in association with [[clear cell renal cell carcinoma]]<ref name=pmid22234634/> or [[chromophobe RCC]].<ref name=pmid15087662>{{Cite journal \| last1 = Cheville \| first1 = JC. \| last2 = Lohse \| first2 = CM. \| last3 = Zincke \| first3 = H. \| last4 = Weaver \| first4 = AL. \| last5 = Leibovich \| first5 = BC. \| last6 = Frank \| first6 = I. \| last7 = Blute \| first7 = ML. \| title = Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 4 \| pages = 435-41 \| month = Apr \| year = 2004 \| doi = \| PMID = 15087662 }}</ref><ref name=pmid9331291>{{Cite journal \| last1 = Akhtar \| first1 = M. \| last2 = Tulbah \| first2 = A. \| last3 = Kardar \| first3 = AH. \| last4 = Ali \| first4 = MA. \| title = Sarcomatoid renal cell carcinoma: the chromophobe connection. \| journal = Am J Surg Pathol \| volume = 21 \| issue = 10 \| pages = 1188-95 \| month = Oct \| year = 1997 \| doi = \| PMID = 9331291 }}</ref>

			==Gross==
			*White solid area.

			DDx:
			*Degenerative changes.

	==Microscopic==		==Microscopic==

Michael: /* Microscopic */

2015-06-16T21:30:18Z

Microscopic

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	*Retroperitoneal [[sarcoma]].		*Retroperitoneal [[sarcoma]].
	*[[Renal mucinous tubular and spindle cell carcinoma]].		*[[Renal mucinous tubular and spindle cell carcinoma]].
	*[[Renal cell carcinoma, unclassified]].

	===Images===		===Images===

Michael: /* Microscopic */

2015-06-16T21:27:19Z

Microscopic

← Older revision		Revision as of 21:27, 16 June 2015
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	==Microscopic==		==Microscopic==
	Features:<ref name=pmid11224597/>		Features:<ref name=pmid11224597/>
	#~~Renal~~ cell carcinoma.		#Identifiable subtype of [[renal cell carcinoma]], e.g. [[clear cell renal cell carcinoma]], [[chromophobe renal cell carcinoma]], others.
	#Sarcomatoid component:		#Sarcomatoid component:
	#*[[Fibrosarcoma]] - most common.		#*[[Fibrosarcoma]] - most common.
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	*Retroperitoneal [[sarcoma]].		*Retroperitoneal [[sarcoma]].
	*[[Renal mucinous tubular and spindle cell carcinoma]].		*[[Renal mucinous tubular and spindle cell carcinoma]].
			*[[Renal cell carcinoma, unclassified]].

	===Images===		===Images===

Michael: /* General */

2015-06-16T21:24:18Z

General

← Older revision		Revision as of 21:24, 16 June 2015
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	*Worse prognosis when adjusted for [[cancer staging\|stage]].		*Worse prognosis when adjusted for [[cancer staging\|stage]].
	*[[ISUP nucleolar grade]] ([[Fuhrman grade]]) 4 by definition.		*[[ISUP nucleolar grade]] ([[Fuhrman grade]]) 4 by definition.
			*Most commonly seen in association with [[clear cell renal cell carcinoma]]<ref name=pmid22234634/> or [[chromophobe RCC]].<ref name=pmid15087662>{{Cite journal \| last1 = Cheville \| first1 = JC. \| last2 = Lohse \| first2 = CM. \| last3 = Zincke \| first3 = H. \| last4 = Weaver \| first4 = AL. \| last5 = Leibovich \| first5 = BC. \| last6 = Frank \| first6 = I. \| last7 = Blute \| first7 = ML. \| title = Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. \| journal = Am J Surg Pathol \| volume = 28 \| issue = 4 \| pages = 435-41 \| month = Apr \| year = 2004 \| doi = \| PMID = 15087662 }}</ref><ref name=pmid9331291>{{Cite journal \| last1 = Akhtar \| first1 = M. \| last2 = Tulbah \| first2 = A. \| last3 = Kardar \| first3 = AH. \| last4 = Ali \| first4 = MA. \| title = Sarcomatoid renal cell carcinoma: the chromophobe connection. \| journal = Am J Surg Pathol \| volume = 21 \| issue = 10 \| pages = 1188-95 \| month = Oct \| year = 1997 \| doi = \| PMID = 9331291 }}</ref>

	==Microscopic==		==Microscopic==

Michael: +ref

2015-06-16T21:16:07Z

+ref

← Older revision		Revision as of 21:16, 16 June 2015
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	'''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial derived [[kidney tumour]] with malignant mesenchymal differentiation.		'''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial derived [[kidney tumour]] with malignant mesenchymal differentiation.

	These tumours are '''not''' recognized as a distinct type of renal cell carcinoma; they are classified by the non-sarcomatous component. If a renal tumour is purely sarcomatous it is ''[[renal cell carcinoma, unclassified]]''.		These tumours are '''not''' recognized as a distinct type of renal cell carcinoma;<ref name=pmid22234634>{{Cite journal \| last1 = Shuch \| first1 = B. \| last2 = Bratslavsky \| first2 = G. \| last3 = Linehan \| first3 = WM. \| last4 = Srinivasan \| first4 = R. \| title = Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies. \| journal = Oncologist \| volume = 17 \| issue = 1 \| pages = 46-54 \| month = \| year = 2012 \| doi = 10.1634/theoncologist.2011-0227 \| PMID = 22234634 }}</ref> they are classified by the non-sarcomatous component. If a renal tumour is purely sarcomatous it is ''[[renal cell carcinoma, unclassified]]''.

	'''Sarcomatoid renal cell carcinoma''', abbreviated '''sarcomatoid RCC''', redirects here.		'''Sarcomatoid renal cell carcinoma''', abbreviated '''sarcomatoid RCC''', redirects here.
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	*Not recognized as a distinct entity in 2004 WHO classification.<ref name=pmid16442207>{{Cite journal \| last1 = Lopez-Beltran \| first1 = A. \| last2 = Scarpelli \| first2 = M. \| last3 = Montironi \| first3 = R. \| last4 = Kirkali \| first4 = Z. \| title = 2004 WHO classification of the renal tumors of the adults. \| journal = Eur Urol \| volume = 49 \| issue = 5 \| pages = 798-805 \| month = May \| year = 2006 \| doi = 10.1016/j.eururo.2005.11.035 \| PMID = 16442207 }}</ref>		*Not recognized as a distinct entity in 2004 WHO classification.<ref name=pmid16442207>{{Cite journal \| last1 = Lopez-Beltran \| first1 = A. \| last2 = Scarpelli \| first2 = M. \| last3 = Montironi \| first3 = R. \| last4 = Kirkali \| first4 = Z. \| title = 2004 WHO classification of the renal tumors of the adults. \| journal = Eur Urol \| volume = 49 \| issue = 5 \| pages = 798-805 \| month = May \| year = 2006 \| doi = 10.1016/j.eururo.2005.11.035 \| PMID = 16442207 }}</ref>
	**It is considered an indicator of progression.		**It is considered an indicator of progression.
	**Previously considered a distinct entity.<ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal \| last1 = Cangiano \| first1 = T. \| last2 = Liao \| first2 = J. \| last3 = Naitoh \| first3 = J. \| last4 = Dorey \| first4 = F. \| last5 = Figlin \| first5 = R. \| last6 = Belldegrun \| first6 = A. \| title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. \| journal = J Clin Oncol \| volume = 17 \| issue = 2 \| pages = 523-8 \| month = Feb \| year = 1999 \| doi = \| PMID = 10080595 \| URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref>		**Previously considered a distinct entity.<ref name=pmid22234634/><ref name=pmid16442207/><ref name=pmid10080595>{{Cite journal \| last1 = Cangiano \| first1 = T. \| last2 = Liao \| first2 = J. \| last3 = Naitoh \| first3 = J. \| last4 = Dorey \| first4 = F. \| last5 = Figlin \| first5 = R. \| last6 = Belldegrun \| first6 = A. \| title = Sarcomatoid renal cell carcinoma: biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. \| journal = J Clin Oncol \| volume = 17 \| issue = 2 \| pages = 523-8 \| month = Feb \| year = 1999 \| doi = \| PMID = 10080595 \| URL = http://jco.ascopubs.org/content/17/2/523.full }}</ref>
	*Tend to present at higher stage.		*Tend to present at higher stage.
	*Worse prognosis when adjusted for [[cancer staging\|stage]].		*Worse prognosis when adjusted for [[cancer staging\|stage]].

Michael: touch

2015-06-16T11:06:50Z

touch

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	[[Image:Chromophobe renal cell carcinoma with sarcomatoid differentiation -- high mag.jpg\|thumb\|right\|Sarcomatoid differentiation in a [[chromophobe renal cell carcinoma]]. [[H&E stain]].]]		[[Image:Chromophobe renal cell carcinoma with sarcomatoid differentiation -- high mag.jpg\|thumb\|right\|Sarcomatoid differentiation in a [[chromophobe renal cell carcinoma]]. [[H&E stain]].]]
	'''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial derived [[kidney tumour]] with malignant mesenchymal differentiation.		'''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial derived [[kidney tumour]] with malignant mesenchymal differentiation.

Michael: rm broken link, chg image

2015-05-17T11:30:09Z

rm broken link, chg image

← Older revision		Revision as of 11:30, 17 May 2015
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	[[Image:~~Sarcomatoid differentiation in~~ renal cell carcinoma -- ~~very~~ high mag.jpg\|thumb\|right\|Sarcomatoid differentiation in a [[~~clear cell~~ renal cell carcinoma]]. [[H&E stain]].]]		[[Image:Chromophobe renal cell carcinoma with sarcomatoid differentiation -- high mag.jpg\|thumb\|right\|Sarcomatoid differentiation in a [[chromophobe renal cell carcinoma]]. [[H&E stain]].]]
	'''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial derived [[kidney tumour]] with malignant mesenchymal differentiation.		'''Renal cell carcinoma with sarcomatoid differentiation''' is a malignant epithelial derived [[kidney tumour]] with malignant mesenchymal differentiation.

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	</gallery>		</gallery>
	====www====		====www====
	*[http://webpathology.com/image.asp?n=2&Case=70 Sarcomatoid change in RCC (webpathology.com)].
	*[http://jco.ascopubs.org/content/27/2/235/F1.expansion Sarcomatoid changes in CCRCC (ascopubs.org)].<ref name=pmid19064974>{{Cite journal \| last1 = Golshayan \| first1 = AR. \| last2 = George \| first2 = S. \| last3 = Heng \| first3 = DY. \| last4 = Elson \| first4 = P. \| last5 = Wood \| first5 = LS. \| last6 = Mekhail \| first6 = TM. \| last7 = Garcia \| first7 = JA. \| last8 = Aydin \| first8 = H. \| last9 = Zhou \| first9 = M. \| title = Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. \| journal = J Clin Oncol \| volume = 27 \| issue = 2 \| pages = 235-41 \| month = Jan \| year = 2009 \| doi = 10.1200/JCO.2008.18.0000 \| PMID = 19064974 }}</ref>		*[http://jco.ascopubs.org/content/27/2/235/F1.expansion Sarcomatoid changes in CCRCC (ascopubs.org)].<ref name=pmid19064974>{{Cite journal \| last1 = Golshayan \| first1 = AR. \| last2 = George \| first2 = S. \| last3 = Heng \| first3 = DY. \| last4 = Elson \| first4 = P. \| last5 = Wood \| first5 = LS. \| last6 = Mekhail \| first6 = TM. \| last7 = Garcia \| first7 = JA. \| last8 = Aydin \| first8 = H. \| last9 = Zhou \| first9 = M. \| title = Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. \| journal = J Clin Oncol \| volume = 27 \| issue = 2 \| pages = 235-41 \| month = Jan \| year = 2009 \| doi = 10.1200/JCO.2008.18.0000 \| PMID = 19064974 }}</ref>
	*[http://www.scielo.br/img/revistas/ibju/v31n1/1a03f1.jpg Sarcomatoid changes in RCC (scielo.br)].<ref name=pmid15763002>{{Cite journal \| last1 = Dall'Oglio \| first1 = MF. \| last2 = Lieberknecht \| first2 = M. \| last3 = Gouveia \| first3 = V. \| last4 = Sant'Anna \| first4 = AC. \| last5 = Leite \| first5 = KR. \| last6 = Srougi \| first6 = M. \| title = Sarcomatoid differentiation in renal cell carcinoma: prognostic implications. \| journal = Int Braz J Urol \| volume = 31 \| issue = 1 \| pages = 10-6 \| month = \| year = \| doi = \| PMID = 15763002 }}</ref>		*[http://www.scielo.br/img/revistas/ibju/v31n1/1a03f1.jpg Sarcomatoid changes in RCC (scielo.br)].<ref name=pmid15763002>{{Cite journal \| last1 = Dall'Oglio \| first1 = MF. \| last2 = Lieberknecht \| first2 = M. \| last3 = Gouveia \| first3 = V. \| last4 = Sant'Anna \| first4 = AC. \| last5 = Leite \| first5 = KR. \| last6 = Srougi \| first6 = M. \| title = Sarcomatoid differentiation in renal cell carcinoma: prognostic implications. \| journal = Int Braz J Urol \| volume = 31 \| issue = 1 \| pages = 10-6 \| month = \| year = \| doi = \| PMID = 15763002 }}</ref>

Michael: /* Images */

2015-05-17T11:27:44Z

Images

← Older revision		Revision as of 11:27, 17 May 2015
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	===Images===		===Images===
			====Case 1====
	<gallery>		<gallery>
	Image: Sarcomatoid differentiation in renal cell carcinoma -- intermed mag.jpg \| RCC with sarc. diff. - intermed. mag. (WC)		Image: Sarcomatoid differentiation in renal cell carcinoma -- intermed mag.jpg \| RCC with sarc. diff. - intermed. mag. (WC)
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	Image: Clear cell renal cell carcinoma - 2 -- very high mag.jpg \| CCRCC - very high mag. (WC)		Image: Clear cell renal cell carcinoma - 2 -- very high mag.jpg \| CCRCC - very high mag. (WC)
	</gallery>		</gallery>
	www:		====Case 2====
			<gallery>
			Image: Chromophobe renal cell carcinoma with sarcomatoid differentiation -- low mag.jpg \| ChRCC with SD - low mag.
			Image: Chromophobe renal cell carcinoma with sarcomatoid differentiation -- intermed mag.jpg \| ChRCC with SD - intermed. mag.
			Image: Chromophobe renal cell carcinoma with sarcomatoid differentiation -- high mag.jpg \| ChRCC with SD - high mag.

			Image: Chromophobe renal cell carcinoma with sarcomatoid differentiation - alt -- intermed mag.jpg \| ChRCC with SD - intermed. mag.
			Image: Chromophobe renal cell carcinoma with sarcomatoid differentiation - alt -- high mag.jpg \| ChRCC with SD - high mag.
			</gallery>
			====www====
	*[http://webpathology.com/image.asp?n=2&Case=70 Sarcomatoid change in RCC (webpathology.com)].		*[http://webpathology.com/image.asp?n=2&Case=70 Sarcomatoid change in RCC (webpathology.com)].
	*[http://jco.ascopubs.org/content/27/2/235/F1.expansion Sarcomatoid changes in CCRCC (ascopubs.org)].<ref name=pmid19064974>{{Cite journal \| last1 = Golshayan \| first1 = AR. \| last2 = George \| first2 = S. \| last3 = Heng \| first3 = DY. \| last4 = Elson \| first4 = P. \| last5 = Wood \| first5 = LS. \| last6 = Mekhail \| first6 = TM. \| last7 = Garcia \| first7 = JA. \| last8 = Aydin \| first8 = H. \| last9 = Zhou \| first9 = M. \| title = Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. \| journal = J Clin Oncol \| volume = 27 \| issue = 2 \| pages = 235-41 \| month = Jan \| year = 2009 \| doi = 10.1200/JCO.2008.18.0000 \| PMID = 19064974 }}</ref>		*[http://jco.ascopubs.org/content/27/2/235/F1.expansion Sarcomatoid changes in CCRCC (ascopubs.org)].<ref name=pmid19064974>{{Cite journal \| last1 = Golshayan \| first1 = AR. \| last2 = George \| first2 = S. \| last3 = Heng \| first3 = DY. \| last4 = Elson \| first4 = P. \| last5 = Wood \| first5 = LS. \| last6 = Mekhail \| first6 = TM. \| last7 = Garcia \| first7 = JA. \| last8 = Aydin \| first8 = H. \| last9 = Zhou \| first9 = M. \| title = Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. \| journal = J Clin Oncol \| volume = 27 \| issue = 2 \| pages = 235-41 \| month = Jan \| year = 2009 \| doi = 10.1200/JCO.2008.18.0000 \| PMID = 19064974 }}</ref>

← Older revision		Revision as of 15:41, 24 June 2015
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	*[[Kidney tumours]].		*[[Kidney tumours]].
	*[[Renal cell carcinoma with rhabdoid change]].		*[[Renal cell carcinoma with rhabdoid change]].
			*[[Sarcomatoid carcinoma]].

	==References==		==References==