Renal cell carcinoma with fibromyomatous stroma - Revision history

Michael at 16:39, 6 March 2025

2025-03-06T16:39:41Z

← Older revision		Revision as of 16:39, 6 March 2025
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	\|-		\|-
	\|Renal cell carcinoma with fibromyomatous stroma		\|Renal cell carcinoma with fibromyomatous stroma
	\| +ve box-like{{~~fact~~}}		\| +ve box-like or cup-like<ref name=pmid36611378>{{cite journal \|authors=Stanca S, Boldrini L, Erba PA, Faviana P \|title=Are Renal Cell Carcinoma with Fibromyomatous Stroma (RCC-FMS) and Thyroid-like Follicular Carcinoma of the Kidney (TLFCK) Really Independent Variants? \|journal=Diagnostics (Basel) \|volume=13 \|issue=1 \|pages= \|date=December 2022 \|pmid=36611378 \|pmc=9818596 \|doi=10.3390/diagnostics13010086 \|url=}}</ref>
	\| +ve		\| +ve
	\| +ve		\| +ve

Michael: /* Comparison between some renal tumours with clear cells */

2025-03-06T16:34:40Z

Comparison between some renal tumours with clear cells

← Older revision		Revision as of 16:34, 6 March 2025
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	\|-		\|-
	\|Renal cell carcinoma with fibromyomatous stroma		\|Renal cell carcinoma with fibromyomatous stroma
	\| ?		\| +ve box-like{{fact}}
	\| +ve		\| +ve
	\| +ve		\| +ve

Michael: /* Comparison between some renal tumours with clear cells */

2025-03-06T16:32:42Z

Comparison between some renal tumours with clear cells

← Older revision		Revision as of 16:32, 6 March 2025
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	===Comparison between some renal tumours with clear cells===		===Comparison between some renal tumours with clear cells===
	{\| class="wikitable sortable"		{\| class="wikitable sortable"
	!Tumour		!Tumour
			!CA9
	!CK7		!CK7
	!CD10		!CD10
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	\|-		\|-
	\|Clear cell renal cell carcinoma		\|Clear cell renal cell carcinoma
			\| +ve box-like (complete membrane)
	\| -ve (may be focal)		\| -ve (may be focal)
	\| +ve		\| +ve
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	\|-		\|-
	\|Clear cell papillary renal cell tumour		\|Clear cell papillary renal cell tumour
			\| +ve cup-like
	\| +ve (diffuse)		\| +ve (diffuse)
	\| -ve		\| -ve
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	\| -ve<ref name=pmid37661807>{{cite journal \|authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A \|title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others \|journal=Am J Surg Pathol \|volume=47 \|issue=11 \|pages=1267–1273 \|date=November 2023 \|pmid=37661807 \|doi=10.1097/PAS.0000000000002117 \|url=}}</ref>		\| -ve<ref name=pmid37661807>{{cite journal \|authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A \|title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others \|journal=Am J Surg Pathol \|volume=47 \|issue=11 \|pages=1267–1273 \|date=November 2023 \|pmid=37661807 \|doi=10.1097/PAS.0000000000002117 \|url=}}</ref>
	\|-		\|-
	\|ELOC-mutated renal cell carcinoma		\|ELOC-mutated renal cell carcinoma
			\| +ve box-like
	\| +ve		\| +ve
	\| +ve		\| +ve
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	\|-		\|-
	\|Renal cell carcinoma with fibromyomatous stroma		\|Renal cell carcinoma with fibromyomatous stroma
			\| ?
	\| +ve		\| +ve
	\| +ve		\| +ve
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	\|-		\|-
	\|}		\|}

	==Molecular==		==Molecular==
	*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>		*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>

Michael at 20:32, 21 October 2024

2024-10-21T20:32:34Z

← Older revision		Revision as of 20:32, 21 October 2024
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	*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>		*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>
	**A somewhat non-specific finding as [[Renal neoplasms with TSC/mTOR pathway mutations\|several renal tumours (with a different morphology) have TSC/mTOR pathway mutations]].		**A somewhat non-specific finding as [[Renal neoplasms with TSC/mTOR pathway mutations\|several renal tumours (with a different morphology) have TSC/mTOR pathway mutations]].

			==Sign out==
			===Molecular lacking===
			<pre>
			Right Kidney, Radical Nephrectomy:
			- RENAL CELL CARCINOMA with clear cells, cysts and leiomyomatous stroma, see comment.
			-- Margin clear.
			-- Please see synoptic report for details.

			Comment:
			The tumour stains as follows:
			POSITIVE: CD10 (moderate), EMA (patchy), CK7 (diffuse), PAX8 (diffuse).
			NEGATIVE: CK34betaE12, CK20.

			The differential diagnosis includes: (1) clear cell renal cell carcinoma, (2) RCC with a mTOR pathway mutation, and (3) ELOC-mutated RCC.
			</pre>

	==See also==		==See also==

Michael at 16:08, 30 June 2024

2024-06-30T16:08:20Z

← Older revision		Revision as of 16:08, 30 June 2024
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	==Molecular==		==Molecular==
	*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>		*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>
	**A somewhat non-specific ~~findings~~ as [[Renal neoplasms with TSC/mTOR pathway mutations\|several renal tumours with a different morphology have TSC/mTOR pathway mutations]].		**A somewhat non-specific finding as [[Renal neoplasms with TSC/mTOR pathway mutations\|several renal tumours (with a different morphology) have TSC/mTOR pathway mutations]].

	==See also==		==See also==

Michael at 16:07, 30 June 2024

2024-06-30T16:07:28Z

← Older revision		Revision as of 16:07, 30 June 2024
Line 59:		Line 59:
	==Molecular==		==Molecular==
	*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>		*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>
			**A somewhat non-specific findings as [[Renal neoplasms with TSC/mTOR pathway mutations\|several renal tumours with a different morphology have TSC/mTOR pathway mutations]].

	==See also==		==See also==

Michael at 13:30, 26 March 2024

2024-03-26T13:30:38Z

← Older revision		Revision as of 13:30, 26 March 2024
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	!CD10		!CD10
	!CK34betaE12 (K903)		!CK34betaE12 (K903)
	!GPNMB		![[GPNMB]]
	\|-		\|-
	\|Clear cell renal cell carcinoma		\|Clear cell renal cell carcinoma

Michael at 04:33, 20 March 2024

2024-03-20T04:33:23Z

← Older revision		Revision as of 04:33, 20 March 2024
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	\| -ve		\| -ve
	\|-		\|-
	\|~~TSC/mTOR-mutated renal~~ cell carcinoma		\|Renal cell carcinoma with fibromyomatous stroma
	\| +ve		\| +ve
	\| +ve		\| +ve

Michael at 04:21, 20 March 2024

2024-03-20T04:21:14Z

← Older revision		Revision as of 04:21, 20 March 2024
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	''Renal cell carcinoma with leiomyomatous stroma'' redirects here.		''Renal cell carcinoma with leiomyomatous stroma'' redirects here.

			==General==
			*Rare tumour: 12 in >500 renal cell carcinomas with clear cells.<ref name=pmid36592877/>

	==Microscopic==		==Microscopic==

Michael at 04:13, 20 March 2024

2024-03-20T04:13:49Z

← Older revision		Revision as of 04:13, 20 March 2024
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	\|}		\|}
	==Molecular==		==Molecular==
	*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].		*[[Renal neoplasms with TSC/mTOR pathway mutations\|TSC/mTOR pathway mutation]].<ref name=pmid36592877/>

	==See also==		==See also==